Cori cycle

The Cori cycle - This lecture explains about the cori cycle. Core cycle is a process of how our body supplies glucose to the cell by converting it to lactose. The Cori cycle (also known as the Lactic acid cycle), named after its discoverers, Carl Ferdinand Cori and Gerty Cori, refers to the metabolic pathway in which lactate produced by anaerobic glycolysis in the muscles moves to the liver and is converted to glucose, which then returns to the muscles and is metabolized.
The body is very efficient in that lactic acid is sent in the blood (5) to the liver which can convert it back to pyruvic acid (6) and then to glucose through gluconeogenesis (8). The glucose can enter the blood (9) and be carried to muscles and immediately used.
Lactate is transported back to the liver where it is converted into pyruvate by the Cori cycle using the enzyme lactate dehydrogenase.Pyruvate, the first designated substrate of the gluconeogenic pathway, can then be used to generate glucose.
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[@AbAb-mm3og]

Wonderfully explained. Thank you very much. Is neogenesis somehow involved in raising triglyceride levels? Sorry if this is a stupid question, but I hope I can get an answer. Also, I didn't understand how the muscle differentiates between the first Glucose and the one that the liver sends after converting Pyr to Glu. Thank you

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Please .can I ask qusition . It's regarding renger lactate fluid .it can be used for diabetic patient or not . Ist indicated it contraindicated

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[@mathurasingh7410]

Sir plz explain me how net 4ATP are produced during Cori cycle.

[@atreya7706]

How LDH can form lactic acid and pyruvate too?

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Which hormones control cori cycle??

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Gluconeogenesis k bad Jo glucose bna kia wo muscle ko energy dyga ya wo B's serf bn jata hai aur dobara liver k pas Chala jata hai

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Can cori cycle result in liver glycogen formation?

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Sir what about pH when lactic acid passes to liver through blood vessels??

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[@sambhavikumar5205]

Given that glucose uptake in muscle cells is predominantly via insulin-mediated GLUT4, how is the glucose being exported back to muscle cells taken up? e.g. during explosive exercise when insulin concentrations are low?

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During exercise glucose is needed and is burnt

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[@Torcsen]

If the cori pathway is activated by the lack of oxygen and glucose is produced from lactate/pyruvate and put back in the muscle cells; when the cells still are lacking oxygen, how can the cell still produce ATP?

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[@_anamika9]

But still it is been converting into glucose which the muscle already had 🙄 if the muscle lacks ATP then there should be production of ATP not Glucose , that muscle already have glucose 😶 Sir please explain , I have not understood 🙏

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glucose is converted to lactic acid in the absence of oxygen

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