COVID Vaccines

[@DeTrOiTXX12]

Fantastic information, that must have been a lot of work breaking everything down like that!

[@Aphelia.]

Thanks for the explanation. I couldn't have asked for a better video to understand how (Covid-19) vaccines work. I hope KZbin finally recognizes the importance of this channel and more people can be informed.

[@adamriaz8203]

Honestly I cannot thank you enough for making these amazing animations and explaining concepts in an almost perfect amount of detail. Always a pleasure to watch and extremely helpful!

[@AbdurrahmanAlanezi]

Excellent .. amazing illustration!

[@ericulric223]

"We've seen this dude before," excellent (humor and information). This must be hard work because it comes off so seamless.

[@jamesgodfrey2102]

Thank You for taking the time to produce this video.

[@mariatorres9789]

Tell me why my 21 year old military son, had a heart attack.

[@DoctorKlioze]

kzbin.info/www/bejne/g2aol4uYhNKNatE This may help. I hope your son is doing OK.

[@mariatorres9789]

@@DoctorKlioze He didn't have SarsCov2 when he had the heart attack, in fact, they even thought it must be drug & wouldn't believe he didn't use drugs, until after his blood panel came back. Why did you give me a video about the virus, when HE DIDN'T HAVE COVID, but he did have those damn shots?

[@DoctorKlioze]

@@mariatorres9789 I suspect from your comments you really haven't watched either video. The first one on the vaccines was published on December 7 of 2020, 4 days prior to the FDA's granting emergency use authorization (EUA) for the Moderna product. In that video, I simply explained the development and proposed mechanism of action for these novel genetic vaccines and how they differ from standard vaccines. At that time, I never suspected that the vaccine would be deemed mandatory The second video was published much later (Nov 17 2021) and again explains how the vaccine works but also goes into some detail of why the vaccine (especially the spike protein) could potentially cause myositis, stroke and heart attack (predominately due to induced inflammation of the vessels caused by the spike protein itself). The brief summary of the virus in the beginning was just an intro to review the major surface proteins of the virus and why the selected spike protein for the genetic vaccines was potentially problematic.

[@mariatorres9789]

@@DoctorKlioze I did watch them, I just don't know why there aren't any regular vaccines, you know, ones that DON'T have mRNA tech? Why aren't there any normal vaccines? Another kid in his troop, has pericarditis and immune system problems now, & has been in & out of the hospital for 1 1/2 yrs. Completely healthy young men, before. My son is built like a lumberjack, 6'2" solid muscle, athletic, intelligent, and now he's had a heart attack. It's completely outrageous these things are still on the shelf! And now approved, for SMALL CHILDREN. Sigh- I appreciate your response, and yes, I get how the virus works, and what the *vaccines* are, and the mechanisms. Thank you. Goodnight-

[@lw1zfog]

cohencidence theory ! all £ULL¥T€$T€D & totally $A£€ & €££€CTIV€ ..... HONEST !

[@דליהרייפן]

THIS ANIMATION IS A MASTERPIECE. THANK YOU VERY MUCH

[@lkandia]

Fabulous video Dr. Klioz. Keep up the great work!

[@DrickRT]

The animations explain the subject very well. Thanks!

[@Neloish]

Now this is what I call quality content.

[@MetalGuitarClips]

Is there a chance of over expression in host cells that results in some form of autoimmune response?

[@allisonkirshner5602]

This is the best video I have see regarding these Vaccinations.

[@iceboys7404]

Wow, this was excellent! Very concise, clear, easy to understand, and packed with all the necessary information - thank you!

[@MicaeArchangel]

I learn that the B cells, T cells, and mononuclear phagocytic support and protect us from different virus. This video affects me and other people around the world by telling us about how vaccine work to protect us from the virus. This video helps me more aware about how different cell in our body work when we get a vaccine.

[@ChacUayabXoc]

14:00 Those last words hit me hard. I feared so.

[@ex8280]

Damnit, my horse paste only last 2 years.

[@troythexrayboy]

Gr8 vid Dr. Klioze!

[@MatteoGravino]

Thanks for the excellent presentation. I have two questions. Firstly, it is known that the translation is dependent on the mRNA transcription and nuclear export, because during these events the nascent mRNA is assembled with proteins to form messenger ribonucleoprotein (mRNP) complexes and some of these proteins have a role in translation initiation and translation termination. Giving that the mRNA encoding for the SARS-CoV-2 spike protein is never going into the nucleus, how it can be properly assembled into mRNPs and indeed translated? Secondly, it is known that the process of mRNA localisation in the cytoplasm and in subcellular compartments it is important for the regulation of translation and protein expression at specific sites, and for the mRNA turnover. Also, the mRNA cellular localisation is dependent on the mRNA nuclear history. So, how can the mRNA for the spike protein of SARS-CoV-2 can be correctly localised within the cell giving that is lacking of nuclear history?

[@scottklioze1160]

Wow, Matteo! You sound like an expert on this topic! Those are great questions. Unfortunately I don't have a great answer. In fact, I don't have any answer! I hadn't heard of the nuclear history as a prerequisite for mRNA protein production until now. I seem to recall that cellular immunity may depend on some nuclear participation of the host cells (protein transport through nuclear pores) but cellular immunity was nuclear independent. Any geneticists or cell biologist out there that can shed some light on this?

mRNPs are primarily for mRNA trafficking to the cytoplasm and protection against degradation and not major contributors to RNA translation. Additionally, some forms of RNA are known to have enzymatic activity, which can allow RNA to both self cleave (cut itself into smaller fragments) as well as steal proteins like the 5' cap from host RNAs. Second, RNA nuclear history is associated with pre-mRNA, which is naturally transcribed in the nucleus and plays a bigger role in gene expression (protein production level) than cytoplasm translation. Essentially, this history is associated with the RNA processing an excision of introns (non-coding regions of DNA found in genes) and can influence gene expression depending on where and how much intron is left in the mRNA. Therefore, the concept of mRNA nuclear history, has no bearing on viral RNA or mRNA vaccines, as they are preprocessed foreign RNAs, that are designed to hijack the cells translation machinery for their reproduction.

[@Earl-q6j]

I checked each question with our famous chat Ai speed readers. the answer to your second question is very interesting.

[@MatteoGravino]

@@Earl-q6j Hi, that's great! If you can, let us know the AI's replies.

[@cgmoran91]

Amazing. I can't wait to watch more videos. I also looking forward to showing it to my Bio students as well as my Genetics and Biotech students. To any teacher out there. Many are using Edpuzzle. I do for my videos. Here is another way to challenge your students. Instead of you making an Edpuzzle. Give them an assignment to watch the video and write edpuzzle questions. They did a great job. Some were so good that I used them on their formal quiz. Again I am enjoying these videos and will check out more.

[@saigonpunkid]

This is the best explaination video I've seen so far.

[@mountainman0004]

Peter McCullough MD of Dallas Texas

[@BeeWithSunglasses]

covid: *INTENSE SWEATING* I think they found me

[@davidwiles7475]

Do we know whether or not an over reaction might occur within the mRNA vaccinated host that would produce an antibody enhancement in the host resulting in death?

[@DoctorKlioze]

What your describing is basically an anaphylactic reaction. Although rare, there are reported cases of anaphylaxis with the mRNA vaccines (4.7 cases/million vaccines for Pfizer and 2.5 cases/million vaccines for Moderna). I don't know if these reported cases were related to an additive in the vaccine, the carrier lipid nanno particle or the spike protein itself, however.

[@saralechak5834]

this guy is a con artist with a agenda

Antibody dependent enhancement (ADE) is extremely rare and has never been observed for this virus or any of the vaccines that have been released. I'd be happy to address this topic further if you have any additional questions.

[@morris5439]

I wanna to know what kind of body cells will take up those mRNA? Are those cells being specifically selected or randomly absorbed? Once those body cells start marking the viral protein and display on their surface, will the T-cell treat them as foreign and attack those cell also? Just like rejection in transplantation?

[@alanpatterson2759]

I wondered the same question, key point he assumes below that the spike proteins once made are released from the host cell, which would be the better of the other outcome where the host cell actually displayed the spike protein on its own surface thus setting up an auto immune response!

[@morris5439]

@@alanpatterson2759 In my understand, every protein made in our cell will be displayed on the cell surface, this is how our body to distinguish virus-infected cell from normal one as long as the virus enter their lytic cycle. Maybe the dosage are carefully monitored that the auto-immune response is negligible. Time will tell.

[@alanpatterson2759]

@@morris5439 would it also be true that the nano lipid coat wont distinguish between any body cells but just go to random cells, unless the nano lipid coat is made specific

[@syiarinassilmisfather7532]

Nano partikel akan ditelan oleh makrofag,lalu makrofag akan menampilkan di MHC kemudian dikenali sel T. Sel T mengenalkan ke sel B. Sel B akan membentuk antibodi dan sel memori sesuai dengan protein yang ditampilkan MHC makrofag.

[@earlrobinson5911]

@@syiarinassilmisfather7532 Makrofag yang menelan lipid menghancurkan isi yang dibawa di dalam lipid. Kode tidak akan diproses dalam makrofag. Namun mereka akan menyajikan protein lonjakan pada MHCII mereka yang berasal dari sel-sel otot yang mereka hancurkan dan makan ketika mereka menemukan satu yang membuat protein asing. Macrophages that swallow lipids destroy the contents carried inside the lipid. The code will not be processed in the macrophage. They will however present spike protein on their MHCII that come from muscle cells that they destroy and eat when they find one making the foreign protein.

[@muhammedsheriff5351]

It is amazing to see how MRNA and RNA is how most of our vaccines are made. It is also crazy to see how lipids play a big role in transporting and protecting the MRNA vaccine.

[@LauraEllen999]

This is such a well done video! The ONE thumbs down is proof that trolls really do exist. Thanks so much for making this.

[@wallrider4194]

9:57 bacteriophage 💀

[@melonychacon7095]

RNA and DNA takes an important part in how the vaccine is created it helps map out our cells and how they can help fight the virus. We should beware every person will have different symptoms when they get the vaccine. Not everyone's body system is the same, so we will react differently. The end goal is for everyone to get better so we can get out of this pandemic.

[@andyolsensovereignbeing.6211]

What about exosomes

[@DoctorKlioze]

Good point! I talk a little bit about them on the video "Mesenchymal Stem Cells" I uploaded about 3 weeks ago. Looks very promising as a potential therapy, especially for immunomodulation.

[@josephjorgensen3282]

So if you get the vaccine and your booster is it better to actually come in contact with this virus ever so often so your body uses this and keeps remembering it’s important if this is a dumb question I apologize just trying to understand thank you

[@shelleysekula967]

Excellent video.

[@priyanshirawal7102]

This video is amazing and informative. Stay safe.

[@ThebigZczc5]

So how are the spike proteins being released from the cells that uptake the lipid nanoparticles? Do the cells recognize them as non-human and exocytosize them? How is their digestion in the cell avoided?

[@DoctorKlioze]

All great questions. I assume the immune response begins once the spike protein is released from the cell via exocystosis. I do not believe the cell has an innate ability to ingest or destroy the foreign protein internally but simply treats it as another protein structure or enzyme that it was instructed to make from the cytoplasmic mRNA.

[@alanpatterson2759]

@@DoctorKlioze My question is once the spike protein is made by the host cell, does it display the spike protein on the host cell or does it release the spike protein via exocystosis? You assume!

@@alanpatterson2759 More than likely cell surface presentation, as it would require some additional cell/enzyme activity to release the protein from the cell surface.

[@zehravigna4873]

When they apply the vaccine on the arm, in which part of the cell they drop the mRNA, nucleus or cytoplsme ?

[@anheyang7545]

The cytoplasm

[@zehravigna4873]

@@anheyang7545 How can they be sur ? May be the needle can go into the nucleus.

[@anheyang7545]

@@zehravigna4873 The use of the mRNA is to instruct the ribosomes in the cytoplasms to make surface proteins of the cronovirus to incur an immune response to build immunity

[@anheyang7545]

@@zehravigna4873 and the needle is bigger than the nucleus itself.

[@wallrider4194]

14:18 crush it.

[@AnnMitt]

Well done! Fantastic!

[@tomporter114]

Everyone needs to watch this video

[@zehravigna4873]

I didn't understand why they put the mRNA in a lipid enveloppe. If they didn't put it in an enveloppe what would happen ?

[@DoctorKlioze]

Without the virus itself, a viral vector or the lipid nanoparticle, there is no way for the mRNA to make into the host cytoplasm. The molecule would just be degraded and destroyed.

[@samE-hs7sv]

I love the way you broke this information down to better understand the vaccine. BIOL 1408

[@jessicagonzales5333]

This video demonstrated us every single detail in how the vaccines are created. I see that RNA and DNA takes an important part in how vaccine is created. We should all be aware that every person will have different symptoms when they get the shot. Not everyone body system is the same; therefore, we all have different reactions to every vaccine.

[@farshads3367]

Thank you for not being reduced to an advertisement video for pharma industry. most useful video perhaps on the whole youtube about how Covid19 works and how does different vaccines work. I wonder with these genetic vaccines with the lipid "envelope", what sorts of cells will be used as the producing factories for the mRNA of the S protein?

[@kosovircek]

What would happen if the actual virus didn't have any proteins on its membrane, like the genetic lipid nanoparticle vaccine but with the mRNA to make an entire new one ? Can our body defend against something like that? Or such a virus can't exist for some reason?

[@rogerscottcathey]

Look up prions.

[@DoctorKlioze]

Basically it would be like getting an infection with the virulent form of the virus. The entire genomic sequence of the virus is 30,000 bases with the first 20,000 dedicated to RNA dependent RNA Polymerase or RNA replicase, a key protein for viral replication. The RNA replicase can then make copies of the genomic and subgenomic portions of the viral genetic code allowing full viral replication. Now it may be possible to load the nanoparticles with the subgenomic sequences of all 4 surface proteins allowing a full immunologic response but eliminating the ability to replicate and reproduce the virus itself. Great question!

[@kosovircek]

@@DoctorKlioze I was thinking of a virus completely without surface proteins, my logic being if the lipid nanoparticle alone can "inject" mRNA (for replication of more viruses without surface proteins, just lipid spheres with RNA inside them) into the cell and the immune system identifies viruses and infected cells by checking their surface proteins would such a virus be completely undefendable by our immune system? Or maybe would such a virus cause the immune system to start attacking all lipid spheres without any surface proteins (other lipid transport vehicles)? Or am i misunderstanding something completely and such a virus is not feasible because i can't really find and answer on google?

[@DoctorKlioze]

@@kosovircek The immune system responds to foreign protein antigens on the surface of bacteria and viruses. It may be feasible to insert the entire 30K genomic sequence into the lipid nanosphere but that would be identical to getting a SARS-CoV2 infection from another person (except a lot more expensive). The goal with any immunization is to expose the immune system to antigens but eliminate or reduce the risk of infection. If I understand correctly, what you're proposing is basically to introduce the entire genomic sequence into the host without the viral coat (which its only job is to protect and deliver the mRNA to the cytoplasm). I'm not sure if I see the utility. Remember, if you already tested positive for SARS-CoV2 this season or you had a fulminant COVID-19 infection, you're basically immunized for the season! Does that make sense?

[@DoctorKlioze]

@@rogerscottcathey Good point...

[@lw1zfog]

whooops ! you didn’t ‘trust the science’, you trusted the TV. now you ARE ‘the research

[@DoctorKlioze]

Are you referring to the video or to all those who took the vaccine?

[@gbsh9149]

and you dont tell what happened to this 12 year old son of his gardener do you??

[@DoctorKlioze]

Actually we do know a little about the boy and his life. His name was James Phipps and Jenner later gave Phipps and his family a cottage in Berkley. Phipps attended Jenner's funeral on 3 February 1823 and Phipps himself died 30 years later in 1853. They are both buried in St. Mary's church in Berkley.

[@AH-le3py]

Is there a relationship between covid virus and blood type. O positive r protected against covid virus.

[@DoctorKlioze]

That's a great question! Research that came out last year during the early thralls of the SARS-CoV2 panic suggested that certain blood types may be more susceptible to COVID-19 with a SARS-CoV2 infection. This was based on an in-vitro (outside the body) study that suggested that the receptor binding domain (RBD) on the viral surface had a predilection for the A-type antigenic protein found on respiratory endothelial cells in patients with A-type blood. Subsequent retrospective studies suggested that patients with the A blood group had a 50% higher chance of a severe COVID-19 response over B and O with O the least likely. In March of 2021, a population based cohort study out of Ontario, Canada was published that retrospectively evaluated 225.556 adults and children with documented blood type screening from 1-2007 to 12-2019 who subsequently had SARS-CoV2 testing between 1-15-20 & 6-30-2020. Their results suggested that O negative blood types MAY BE associated with a slightly lower risk of SARS-CoV2 infection and severe COVID-19 illness but admitted some study limitations. Based on our current understanding of the virus and the epidemiologic information we've collected over the past year, I personally wouldn't put too much credence into the ABO and Rh blood group as reliable protection against a severe COVID-19 response with SARS-CoV2. IMO, Even if you're O negative, your best bet is to lose weight, stay in shape, eat right get a good nights sleep and a little bit of sunshine everyday. On the contrary, If you're obese, diabetic, hypertensive with renal insufficiency, your blood type may have a minimal impact on your clinical course but I wouldn't bet the farm on that...

[@zehravigna4873]

Do they remove the RNA polymerase of the virus which is in the vaccine ?

[@DoctorKlioze]

The genetic code in the vaccine is called sub-genomic since it does not include the entire viral genome (otherwise it would be called genomic). The first 20,000 RNA bases of the viral genome encodes for RNA dependent RNA Polymerase or Replicase which allows for cytoplasmic RNA replication. This portion of the genome is NOT included in the vaccine so their is no RNA replication. Does that make sense?

[@zehravigna4873]

@@DoctorKlioze Thank you.

[@zehravigna4873]

@@DoctorKlioze Thank you, I understood.

[@dj89784]

@@DoctorKlioze Hello dr.I lost my sense of smell before 10 days now.I have no other symptoms.First two days i couldnt smell anyithing.I could taste salty,sweet and sour but taste is not as it was before.From third day till now strange things are happening.In the morning when i wake up i cant smell anyithing,after 5 minutes of walking i am starting to smell not 100% but around 60 to 70%.I can smell most of the stuff but i cant smell for example onions,garlic,gas,poo(sorry for writing this but..).At the evening when i lay down my smell starts to decrese to around 10 to 20%.After night my troath is extremly dry,my mouth is extremly dry and my tounge is white.I have clear nose it is not blocked .Im using nose spray few times a day when i inject it i cant feel that fluid going thro and into my troath so i can spit it out it stays somewhere up there i just cant clear out my nose with that fluid.After i eat a meal i cant really tell after that i ate at all.Feeling in the mouth is like i just washed my teeth and mouth.I cant feel that i ate anyithing..I dont know what to do i did not test on covid because it will be same for me if im positive or not.Sorry on my English im from Croatia..

[@iceboys7404]

@@dj89784 I had covid a few months ago and lost my sense of smell entirely for two weeks, and then it came back slowly, a little bit more every day, and now, 3 months later, I can smell everything normally again - well, maybe not quite normally, it's a little off, but not much. So just be patient.

[@davenkarendoyle5244]

HALF TRUTHS‼️

[@DoctorKlioze]

Which half don't you believe?

[@davenkarendoyle5244]

@@DoctorKlioze 🧐🤔 BELIEF IS THE ENEMY OF TRUTH❗️ SUMBUDDY TEACHN N PREACHN WHAT SUMONE TAUGHT THEM DOES NOT MAKE ANYTHING TRUE EXCEPT IN MINDS WILLING TO BELIEVE❗️ TRUTH IS ONLY THAT WHICH IS REAL /FACTUAL /PROVEN❗️ PEOPLE BELIEVE OR PLACE TRUST IN ILLUSIONS❗️ SUMONE WRITING WORDS IN A BOOK DOES NOT MAKE THESE WORDS TRUE‼️ PEOPLE FABRICATE STORYS AND THEN BELIEVE THEM⁉️ "TRUTH" IS ALL THAT THERE IS❗️ ANYTHING LESS DOES NOT EXIST OR IS NOT REAL❗️ IF A LIFE IS BASED ON ONES BELIEF AND NOT TRUTH THEN IT THEN IS NOT REAL NOR DOES IT EXIST‼️ AND THUS ... I DO NOT "BELIEVE" AND I THEREFOR CAN NOT SAY WHAT PART I " BELIEVE " - AS I EITHER KNOW OR I DO NOT❗️‼️ EVIDENCE PROFF TESTS OR IN DEPTH RESEARCH ARE REQUIRED TO GUIDE ONES LIFE BY THYSELF‼️ ONE MUST BE THE AUTHOR OF ONES LIFE AND NOT GIVE OR GRANT THAT AUTHOR-ITY TO OTHERS‼️❗️ PLUS "IF" WE CHOOSE TO WRITE IT FOR OURSELF WE TOO CHOOSE IF IT IS FICTION OR NON-FICTION NOVEL OR PAMPHLET❓⁉️ TO THINE OWN SELF BE TRUE THEN AS NIGHT FOLLOWS DAY ONE CAN NOT BE BUT TRUTHFUL TO ALL MEN🤔 " ... BUT LET A MAN FIRST EXAMINE HIMSELF THEN HE CAN SEE CLEARLY TO REMOVE THE SPEC THAT IS IN AN OTHERS EYE ... " """YOU SHALL KNOW THE TRUTH AND IT WILL SET YOU FREE""" THE TRUTH DOES NOT ONES BELIEF❗️ SEEK TRUTH🙏BE FREE [e-mail]

[@davenkarendoyle5244]

kzbin.info/www/bejne/bIfJe2N4f9unbbs

[@DoctorKlioze]

@@davenkarendoyle5244 In between the gross misspellings of "somebody", "teaching", "preaching" and "someone" I think I agree with your basic premise of belief and truth. Facts are universal and non-negotiable. They are based in truth as supported by the rigorous process of experimentation, observation and collaboration with all parties agreeing on the outcomes to prove causation. If your beliefs, no matter how moronically dogmatic they may be, contradict the facts, your beliefs are wrong regardless of your emotional investment in the same. This video is based on the contemporary facts of immunology and immunization as we currently understand the science. If there is a segment you disagree with, please enlighten the rest of us with your knowledge on the subject and I'll happily addend this comment.

[@BILLYBOBB3080]

Hey I have silicone in my nose from this shot.

[@aliyah6339]

After watching this video, I can understand the vaccine a little more. This virus is very dangerous so I hope that this vaccine will work well.

[@wakamedesuga]

x anitbodies, 〇 antibodies...

[@ritabaccellini714]

Evil