CRISPR and the Future of Human Evolution

[@besmart]

Enjoy part 4 of our human ancestry series! Here's a look at the future. Do you think CRISPR will change human evolution?

[@Hunt3rseeker]

This is the point where we go from animals, human beings, to something else. What, I do not know, but something grand.

[@TheDigitalZero]

To xenomorphs? ;)

[@ericvulgate]

we will still be human. evolution doesn't make things change into 'something else'- whatever we might become we will still be human, just as we are still mammals, and apes, and chordates.

[@TylerMatthewHarris]

It's Okay To Be Smart memetics will become even more relevant if this happens.

[@BlueImation]

It's Okay To Be Smart hello!🔈

[@Asama7]

"I like to order one muscular baby with two blue eyes and blond hair". Hospitals in the future

[@hellpwnage6665]

osama al-enzi aka a super saiyan

[@Kunumbah1]

QuerkyBren Your mom would be happy too. The son she always wanted 😄.

[@leaveme3559]

Looks like everyone in the future will be tall blue eyed muscular....and quite possibly dark and mysterious

[@BlueFrenzy]

I rise the stakes: "I like to order one baby with laser in the eyes and wireless brain telepathy".

[@ILNSuryaChandra]

@@BlueFrenzy I will order a baby who can levitate, teleport, shoot lasers from eyes, shape shift etc..jack jack

[@AN1MATEK]

There's definitely some top secret humans experiments going in some shady nation, I don't think everybody is passing out on being pioneer.

[@gregoriikatastrov7472]

It's not even top secret. China is already experimenting and dont give a fck what other nations thinks about it ;) (yeah i know its an old comment and you probably already know that, you are among a "smart people", as Joe calls us after all.)

[@Ivan.A.Churlyuski]

The year before your comment the US military agency DARPA invested $100m in an CRISPR program to extinct certain genes.

[@The231447LucidDevTeam]

I think we should just research it

[@safetydave720]

Wuhan China, and Area 51

[@africanhistory]

Israel

[@Mangofretchen]

"I'll sell my inventions so that everyone can be superheroes. *Everyone* can be super! And when everyone's super... [laughs maniacally] *no one* will be." -Syndrome

[@dommyWommy82]

Perfect

[@everysubonepushup]

I was just watching incredibles

[@smrutishikharath3025]

👏🏻👏🏻👏🏻👏🏻😤😤😤

[@amcghie7]

I believe this comes to the old analogy "Science provides the keys, but it is humanity that decides what doors to open." Technologies like these are incredible developments in science, however with these developments they can be both used for morally good and bad things - similar to the development of nuclear technologies 80 years ago. We need to be careful here in how this is used.

[@carlapatriciarodriguesbarr8322]

Poderiam passar este vidio para português. Gostaria de saber Est á técnicas para curar doenças .

[@fluffycatgaming5775]

I agree

[@tuele4302]

And don't forget moral standards change from person to person, society to society, historical era to historical era.

[@maxmitchell8180]

@@tuele4302 this is the most ethical way of implementing eugenics :)

[@prapanthebachelorette6803]

Agree

[@menohaveaname]

"Dad, I can't believe you didn't give me big eyes and a cute dimples. All the other dads gave their daughters cute dimples..."

[@Mochi_Kiti]

"Well honey, we didn't want you to look like all those *other kids* we wanted you to be special."

[@barnaliadhikary9421]

My mom gave me fair skin complexion & small nose 🤗

[@unkind6070]

​@@barnaliadhikary9421 what do you mean fair skin? All skin colors are amazing

[@treyrandolph4720]

in the immortal words of Dr. Ian: "Your scientists were so preoccupied with whether or not they could, they didn’t stop to think if they should."

[@diablo.the.cheater]

Scientists should not stop to think if they should, because they have better thing to think about, the ones to think about those should or shouldn't are not scientist but the phylisophers.

[@silentwatching9069]

"Live will find a Way." and it might surprise us. If we try to improve what Nature selected to be best in a Million years Long Experiment - we might get a nasty surprise.

[@arrghh0]

Thank you so much for these. You're sincerely an awesome human being for what you do. It's channels like this that have motivated me, at age 27, to go back to college and actually go for a Microbiology/Molecular Biology major, so I can do my part to help advance things like this. All the kudos to you, sir.

[@Jamess0090]

And how’s life going five years later? Did you successfully completed the degree?

[@TimwiTerby]

Instead of “unnatural selection”, I feel you should have called it “artificial selection”, which is more to the point. The word “unnatural” has negative connotations and cultural baggage.

[@EduardoHerrera-fr6bd]

and also arbitrary mutation, not 'random' because it is not entirely random

[@ritwikreddy5670]

@@EduardoHerrera-fr6bd mutation is entirely random

[@ritwikreddy5670]

@@EduardoHerrera-fr6bd mutation is like throwing a dice. When or where the dice is thrown is not random, but the end product is completely random. Technically nothing is entirely random but I think you get my point.

[@EduardoHerrera-fr6bd]

@@ritwikreddy5670 yeah, i guess my comment was implicitly denying that but i didn't mean that. as a worldbuilder, this topic is very important for me

[@paradox9265]

Timwi Heizmann it is pretty negative though... like ordering a more good-looking baby or something?? What u want, a robot?

[@ahmednagy7571]

I watched already in kurzesgat but I will still watch it in your voice

[@aristerosgiatros8742]

Ahmed Nagy same bruh

[@MegaMGstudios]

Ahmed Nagy both are amazing, i need to watch both

[@scrollogy5847]

Same

[@koko-oz7jf]

OMG IS IT HIM????

[@KaiserMattTygore927]

"It will never ever ever lead to superpowers" well not with THAT attitude.

[@bridgettewalker3739]

I learned about cut and splice technology in AP bio this year, it was really interesting! It's definitely something cool to read into.

[@tonywooten596]

I want to find out why it's called palindromic

[@chatgptnewslive2023]

Mice with human jeans. 😂

[@k1esther1w]

I found this channel about a week ago and watched several of your videos. Although I do not understand everything I am enjoying learning and watching. Thanks for the videos, keep them coming.

[@superj1e2z6]

The question is can CRISPR make crispier chicken skin?

[@emperortunalirius2753]

superj1e2z6 yes it can

[@thewitheringproduction1761]

yes it can.

[@bluedwarf1699]

superj1e2z6 hopefully not while the chicken is alive though.

[@Scoville95]

+Gotrek Gurnisson that'd be fucked up 😂 you'd have a bunch of people running around chasing crispy chickens 😂 could u imagine!

[@SchmegmaOnToast]

who knows, editing chicken genes might end up with cripy chicken, instead.

[@Borderlands808]

I just want to breath underwater. Give me gills!!!

[@Ardkun00]

You can choose argonian as your race.

[@60secondsuccess39]

I love the possibilities that this unveils. Curing disease? Curing malignant mutation? All of this is great, I just worry about the eugenic implications of this. Does anybody have any similar ideas?

[@josefernandez1077]

I think that this is a slippery slope. In the short run, the curing of disease is fantastic. But in the long run, the potential to modify somatic appearance is quite frightening. Edit: I clicked off onto your channel and I was pleasantly surprised.

[@Rowow]

So selecting sperm from specific males for specific traits in a sperm bank is fine but CRISPR is not? So getting a abortion due to health defects or other issues that can be seen during embryo development is fine by CRISPR is not? So on and so forth. The only different between the two is that one is slightly more "natural" then the other. The outcome is the same or better. You just have a hypocritical view point and fail to understand the failure in your logic rather then opening your mind to the countless lives and humanities progression in society that will happen.

[@morgangreen2526]

60 Second Success Another worry for me is overpopulation. In light of that, eugenics in itself does not worry me much.

[@morgangreen2526]

Humans are prone to fucking up in the vain of making *our* world more comfortable; Human genetic selection has the potential to be one of the worst fuck ups.

[@60secondsuccess39]

robert karas I think there are two separate arguments here. The first of which we agree on; using CRISPR and other genetic marker detection systems to deal with potential health defects, is good. The second question is more morally ambiguous. I'm worried about the potential class divide that CRISPR could create. We are approaching a time, where through the means of a (potentially) expensive embryonic procedure, it is possible to create physically superior humans. Who's to say that this doesn't create a divide in the human race? Genetically engineered vs. non-genetically engineered. I think that this divide is already coming in terms of physical technological enhancements. These procedures are going to create an objective divide between classes. This is conflict theory on steroids. This is how anarchy is formed.

[@laszlowisniewski]

ive read and watched some really technical articles and videos on the CRISPR CAS-9 system and genome editing. this video realllllly breaks it down into digestible chunks! great watch

[@Master_Therion]

BUT HEY, IT'S JUST A THEORY, A *GENE* THEORY.

[@hussainattai4638]

Thanks for watching!!

[@TUSH4R451]

Thanks for watching!

[@yahschild9348]

Master Therion how is this evolving of any sort?

[@mistermccoolface1361]

Master Therion haha! i get it! *tightens noose*

[@martinstip9]

it's not a theory it's real

[@billmalcolm4291]

I could go for a larger, faster prefrontal cortex. Figure that should help improve my higher executive functions. Fewer Ige antibodies would be nice too (thanks for your allergies episode). Love your work IOTBS and PBS!

[@seanclarkdesign]

This was one of the most epic videos you've done guys. Thank you so much for what you do.

[@briethey-them9542]

It was my first day back to school and I guarantee the 4 videos in this series taught me more than I'm going to learn all school year. Definitely subscribers OK no now.

[@radio_static6222]

That designer-baby thing reminded me a lot of the movie Gattaca

[@ericvulgate]

that's our near future.

[@axue4248]

Ehhhh... tbf the Gattaca world didnt seem like that bad of a place to live in given that ur a genetically modified human. I mean I would personally like to have a child while not having the fear of passing on some of my negative traits to my child. Though I can see a massive issue with a lack of genetic diversity as everyone just follows a 'template' for the ideal person, sorta like how Korean beauty standards have lead to an ideal face that people have cosmetic surgery to attain.

[@whydoievenbothertoputthish2199]

i heared they could scan a baby in the woumb to check if it has an extra chromosone so they can remove it so the whole designer baby is closer than you think

[@JoyStar]

Never heard of that movie, would you recommend it?

[@georgiajaw]

JoyStar Yes. Gattaca is a really good movie. Kind of sad too.

[@patriciamartinez1783]

This information is really interesting, as a student in the area of biological science, CRISPR is a subject that causes me many questions. As you mentioned, this technique can be used to cure illnesses, however in the wrong hands it could also be used for human edition, getting into a problem with our ethics. It is a topic that will always be in discussion, due to the benefits that we can obtain. Although it sounds like something futuristic, it is something that is happening today.

[@PikaPetey]

furries rejoice when this technology becomes mainstream. or the world becomes G A T A C A

[@eternalbastion7454]

Pikapetey Animations yiffers' rejoice.... 😁😁😁😁😁😁

[@LimeyLassen]

CATTACA

[@cauchyhorizon5983]

I gotcha covered, Pikapetey. I'm already working on a wolf/human genome.

[@eternalbastion7454]

The Improbable Space it's gonna be Renamon taking the world by storm all over again. 😂😂😂😂

[@jamesha175]

human ewok hybrids?

[@MrUmbraya]

Best video yet. Very easy to understand and a clear presentation of ethics without taking sides. Keep it up!

[@FZ8Yamaha]

I love how this video gets me excited about the future!

[@ΑναστασιοςΖαχαρογιαννης]

Best KZbin Channel out there. Your videos, sir, give me chills!

[@654pedro123]

Humans already have the power to shape their children's lives for good and bad. How is giving those children good traits bad for them?

[@andrewlamore72]

It's not so much about giving children what we think are good traits, but instead it's about designing someone for a specific task. For example, with crispr we could breed babies that are stronger than everyone else, but force them into jobs as laborers or soldiers. What most people are afraid of is the rich using their money to create a breed of humans naturally smarter than everyone else, thus putting humans into two camps: dumb and poor or smart and rich, and there wouldn't be anything the dumb and poor people could do about it.

[@user-cw9lf3gl6x]

654pedro123 "Hey, look, it's trending now to have babies with smooth-pale skin and blue eyes, let's design our baby that way!" And long behold every baby that generation will look the same. Good luck using pheromones only to find your companion.

[@ESPmrBrough]

the only people who think fat people are beautiful are fat people in denial, and fetishists.

[@vinny5638]

+Mr Blank My parents already molded my life after someone else wanting me to be a theological professor or pastor. BILLIONS of humans lives are predetermined in HUNDREDS of ways by governments, arranged marriages, etc and almost NONE of them are positive. Now we have a way to create babies with better traits and you think its bad because of a subjective view of perfection? Dude what?

[@castorpolux9050]

"good traits"

[@magal.oliveira682]

I found this chanel some days ago... now I love it! 😍

[@loganhamilton4246]

Hey, Joe! I've heard this topic come up several times and am very interested in it. I'm just a bit in two minds about the ethics of CRISPR. Could you make a follow - up video on that topic please?? 👍

[@thaikeaugusto4356]

This channel ia simply amazing... Thank you very much for your beautiful work!

[@TheNewsDepot]

We will. CRISPR is so cheap and easy to use relative to other options that less economically sound countries, like North Korea, will eventually create "super soldiers" and "Super citiznes" to gain an edge over more powerful countries. It's not a matter of if, but when.

[@InvokingPeace]

outstanding presentation, really entertaining to watch as well, you're my favourite science-channel at this point

[@aditpatel2474]

We need to make Crispr make trees take in large amounts of carbon dioxide

[@l.tc.5032]

Adit Patel it's literally the easiest way to fix climate change. I have no idea why we don't do it now.

[@mcgrudo]

It could have a dangerous run away effect like expelling too much oxygen. Insects would be the size of trucks if the oxygen level rose to a certain level :O

[@drizzelkun]

how do u imagine trees work? like they just suck up all the co2 and then everything is fine ? nani?

[@Jan-hu1hk]

but trees and plants need co2, so it wont be wise to take out too much

[@MikiDii1]

idea channel just made a video about this too! I love it when the pbs channels connect with each other

[@chubbsmasterson]

0:20 Some...BODY ONCE TOLD ME....

[@morgangreen2526]

Christopher Luke the world was macaroni...

[@faze_d4nk775]

the world is gonna roll me

[@pizzamandhx]

She was lookin' kinda dumb with her finger and her thumb

[@faze_d4nk775]

In the shape of an "L" on her forehead

[@ObjectsInMotion]

Christopher Luke Well the years start coming *and they don't stop coming*

[@belletran5403]

I think for this to have a positive impact and little to no unethical use, its use needs to be extremely transparent to the public maybe some government regulation. (also i'm so glad people are becoming aware and this video exist! i remember trying to explain this to people three years ago and they didn't believe it!)

[@tjep997]

Let's do it! Curing all diseases sounds good to me!

[@zertilus]

So much work gets put into these videos, good stuff guys. Thanks so much for the informative, entertaining content!

[@Garium87]

Most parents don't want a purple-eyed hulk with the IQ of Tesla. Most parents want simply the best for their children and they are smart enough not to go to the extreme. And I don't see the problem if someone who isn't really sick but let's say is bold, or short, or maybe has a rather low IQ, doesn't want his child to have the same kind of problems to deal with. I doubt that the child will blame his parents for changing such obvious, disadvantages. To be able to prevent your child from a disadvantage and then to choose not to, *that* is the morally questionable decision, in my eyes.

[@marianghobreialmakeup]

I loveeeee your channel you opened my eyes to alot of things i didn't know before thank you so much

[@Kaikaku]

I think it's not a question if we will, cause we will. What is technologically possible, will be tried out sooner or later.

[@blueberhys]

Don't you just love it when he says "STAY CURIOUS."

[@tarrakis]

"What if only the rich can afford to edit genes?" What if? Really? ;)

[@tuele4302]

"So what?" is the question. People naturally want the best for their children. If they already choose private schools or fancy extracurricular activities, this seems natural.

[@tarrakis]

@@tuele4302 Capitalism at its best. Or worst.

[@tuele4302]

@@tarrakis At its best for sure. It is normal and adaptive to pursue the best interest of our children.

[@tarrakis]

Of course we are going tu pursue the best interest for our children. But what about people who can't afford it? Eg: Healthcare

[@tuele4302]

@@tarrakis What about them? Why should children of a given couple suffer because some parents of other children cannot do certain things? Children deserve the best from their parents.

[@MrGuykgk]

Favourite video so far! Awesome stuff, love the little animations they're hilarious!

[@sciyay]

That makeover game in real life would be amazing.

[@starcoreart]

pefcoy "amazing"? You're joking, right?

[@Cadwaladr]

1:26 I realise this is a global average, so it may have been different in the west, but it made me think of my great great great grandmother. She was born in 1815, and on her 35th birthday she said she had reached middle age, and "spoke of 70 as the age of man", as my great great grandfather later wrote. That was news to him, and he never forgot it.

[@redmondokelly2464]

0:20 You look beautiful

[@Bloopdoop95]

He made my dream boy.

[@WarisAmirMohammad]

he looks just like Bart from Simpsons

[@MrPianoMatt12]

From tip to toe, that's a bart

[@evilmatt91]

Looks like Piccolo's mentally challenged cousin

[@jamiehughes5573]

Special Needs cannon

[@dkennell998]

Best explanation of CRISPR I've seen so far!

[@marcos186cy]

2:08 dat pun almost killed me

[@tamoghnabio]

i am a scientist and i work on CRISPR CAS9 .. and you said correctly that we have the power to change targets but still i am dealing with off target effects so we are far far away fron editing human genome for designer babies.... lets focus on diseases for now

[@besmart]

Yeah I didn't even bring up the off-target effects. That's been a primary hurdle for most gene editing technologies, accidentally editing things you don't want to edit. But when you say "we are far far away" remember that "we" means any nation who agrees to a moratorium on human CRISPR testing until these issues are worked out and researched. There's no international treaty of CRISPR, just some handshake agreements, and CRISPR really is easy enough to use that a rogue nation might decide to go ahead even if the rest of the world says no. It's a possibility!

[@tamoghnabio]

Yaa i agree to that point that there should be some regulations to these powerful biological advance methods to safeguard the intrests of everyone...

[@FrustratedBaboon]

Stop my aging so I can help speed up this research. Aging should be taken care of first.

[@paigemittelbrunn4621]

This is such a cool channel!! You make learning super fun. Definitely gonna subscribe!

[@WWZenaDo]

I have a feeling there may be some unpleasant side effects from selecting appearances based on transient human fads. It's possible that changing everyone's hair to blonde (for example) will bring with it the shortened life span, higher vulnerability to skin cancers & thinner bones that many blondes are prone to.

[@MysticMylesZ]

1:55 mutation might not, but evolutionary traits like climbing walls may as well be; tho we can mimic that one with tools like: Adhesives based on gecko skin

[@juki0h391]

in the near future, two human species will walk among earth , organic humans vs genetically modified humans. going to be interesting which one will win out.

[@drakan4769]

don't forget the cyborgs

[@alaapsarkar]

genetically modified cyborgs also!

[@Kunumbah1]

Don't forget the ground people

[@dannyp2970]

and the rat people.

[@self-crownedroyalty6712]

But genetically modified humans are organic. I mean everything is modified so i see no difference, except you know one side has more power and control to their own genome.

[@Ivan.A.Churlyuski]

The year is 2080 and the hologram advertisement outside the high speed rail reads “CRISPR Inc: Adapting to life on Mars.”

[@marcelloascani]

awesome

[@tanyag2499]

@I ok

[@XTeaOrCrumpetsX]

I'd recommend reading "Brave New World" if you want more information on the ethics. I think it is important that we have differences in human characteristics and traits.

[@Preuen-zs1fz]

4:10 "Cancer hunter" feel like calling a cancer hunter when I read KZbin comments from creationists

[@gabriellerausch594]

Psalm 139:13-14 13 For You formed my inmost being; You knit me together in my mother's womb. 14 I will praise You, for I am fearfully and wonderfully made.

[@vicokhangtravel]

I want to CRISPR my male pattern baldness so do other billions people out there.

[@feynstein1004]

As a fellow MPB victim, I agree. But I don't think it's happening anytime soon. Unfortunately.

[@alexrees8002]

dear its ok to be smart tho I am only 10 years old you have inspired me to think outside the box and make learning fun you make it interesting and exciting thank you and I am looking forward to more

[@krishnarao4290]

being an Asian, I like the video at 0:07, I dreamt of that all my life!! 😢😢😢

[@yawhbrawh6984]

this has been done since 2012, but it's amazing to see another break down on it

[@geiss747]

so basically people could get near to immortality?

[@Mochu_s_Junkyard]

@Psywriter Pls you clearly dont know what are u talking about @Geisseboeckli Yes, que celular aging is caused by the phisical wear of the telomere that protecs our DNA (as the aglets do in our shoes), something that evolution hasn't fixed because it was REALLY unusual that someone could die due to the problems with an advanced age when... a small cut could kill you before Peniciline. So yes, we will able in a distant future to enlarge Telomeres with CRISPR in form of vacinations or at least that is what the science community thinks, but this could come in a far far time

[@Felixkeeg]

I wouldn't mind elongating my life span a little bit. Theres so much to learn, to see and to research.

[@Elduque40]

a platypus? Perry the platypus

[@eternalbastion7454]

Elduque40 Curse you perry the platypus !!!!😁😁😁😁😁

[@aristerosgiatros8742]

Elduque40 platypus---- platyPUSSIES

[@iwatchedtoomuchsaikik8949]

Dr. Doofinsmerts

[@sparkers70]

One of your best videos so far. Fascinating stuff. :)

[@justsomestranger4894]

How would the people working on CRISPR feel if some parents wanted to select for their future child to have something like deafness instead of against it?

[@gregoriikatastrov7472]

Can you imagine the people that will make their lives more difficult because of no reason? After all they would have to nurse that deaf baby for at least 18 years. Thats kinda dumb idea. And surely there will be some kind of regulations on this process.

[@finderskeepers8]

Exactly. D/deaf or HoH people are part of a culture. Removing deafness or blindness would be removing the culture. It is a struggle in society mostly due to inaccessibility.

[@caseyrayharris.esquire489]

I really hope we use this for the greater good, not greater profitability. We could enhance our intellect and figure out a solution to many problems both naturally occurring and man made

[@princekyros]

Well, I would've wanted to be a blue eyed muscular baby :(

[@MalBeats]

Disappointed to see this came out 7 years ago and there are still no kids with superpowers

[@CreeepsMind]

2:10 "Mice with human jeans"

[@alecwinner]

I'd sign up for this in a second, cure my genetic mutation and like half the problems in my life, from constant pain, to inability to walk properly would be cured instantly. Sign me up

[@Chrispmiller84]

I hate it when someone says "doubled life expectancy." They're almost always taking about human life span, and it's relation to increased medical advancements. Life span hasn't changed all the much for the past couple thousand years. Medical advancements help lower infant mortality rates and the risk of death in medical situations, but it hasn't increased life span by a significant amount.

[@JeremyStringham]

Chris i have the same pet pev when people talk about life expectancy. I wish people would stop quoting it, because it miss leads people. Glad you brought this up.

[@timothye.2902]

yea. Basically, if you lived past age 6, you were very, very likely (statistically) to live past 60. Modern medicine and living conditions have mostly increased survivability of the 0-5, not the 61+

[@hglundahl]

At 1:26 I see this in the picture: _"31-35 years around 1900 (global average)"_ 1) How sure can one be of that average? 2) How much better off were long lived countries so to speak than shortlived ones? 3) It is the life expectancy at birth and is therefore affected by infant mortality, right? 4) How much of it can be projected back to, for instance, Middle Ages, for which we are certain we do not have such statistics? 5) How much did the life expectancy sink due to industrialism before it rose? I mean, smokier environments, less physical welfare for illpaid workers than before farming became too unlucrative for many, etc?

[@johnbartholf777]

Not "if we will," "when we will."

[@hannahcerrina2494]

my highschool already has implimented crspr into our science class, we added firefly genes to a bacteria to make it glow.

[@thelethalmoo]

how long until we can design our own genes and be able to predetermine exactly how to change what for what effect... I say worry about the ethics later, it's gonna happen eventually. peoples idea of what is wrong and right seem to change based on what science is like at the time... I want glow in the dark ears and no one can stop me

[@saishkhanna]

Do more of this series

[@burdogashi3922]

I wold sat with this technology. Take away life threatening jeans like cancer. But parents get no say in what to make the kid look or act like

[@melvinpariyadan4884]

i am so scared, all places where i go i see life threatening jeans. lets remove those with CRISPR

[@Angela-pj5xy]

Sometimes life threatening genes and life saving genes are the same genes, just look as sickle cell, it both protects from malaria (still a major global killer) and it causes "genetic disease". This isn't all that simple.

[@jordan938__]

Why Are His Videos Soooooooooooooooooooooooooooo Good??? Edit:Make This Popular pls :)

[@Ibnblackbird]

last time I was this early Iris was still alive on flash

[@Ibnblackbird]

White Gangster Panda I'm so sorry brother. I'm so sorry

[@feynstein1004]

Lmao mate. Don't worry. She's in the last episode.

[@lukaspxixixixixi3626]

wow thank you so much joe. I'm planning a biology lesson on crispr/cas for school at the moment and stole a few of your ideas =)

[@shridharjoshi5602]

where is my never on time squad at

[@christiandevey3898]

Killer Pyjamas that's me in a nutshell

[@needsomesuga]

Killer Pyjamas wow I'm so early

[@JJJ2_00]

You called?

[@Ahguang85]

the graphics are really neat!

[@melvinpariyadan4884]

Is it ever possible to change the genetic information, so that we can stop random mutation? I think random mutation always uses a minimalist approach, so if we evolve too efficiently by changing genetics ourselves, random mutations might try to bring us backk to the more minimalist style or the clash between our changings and random mutations would cause unwanted results.....p.s this video is the only thing i know about CRISPR so nothing what am saying might be facts.

[@MisterDewong]

Melvin Pariyadan Cool idea. I don't know if CRISPR would be used to do this though. I think this would be more of a genetic "protective barrier" of some sort. Genetic mutations occur randomly when our cells replicate DNA in order to divide which would be the biggest problem in the way. As far as we know, our genes don't want to randomly mutate. Although, would we want to stop this from happening? After all, we are human due to random mutations and natural selection.

[@melvinpariyadan4884]

Mel hooprah thanks for the good reply. You're right! I now just realised how important random mutation is. OMG i don't want it to go away now, that would bury is too deep in a dystopia

[@captainanime4719]

You have got yourself a new subscriber

[@taranciucgabrielradu]

Welp, with great power comes great responsibility

[@unvergebeneid]

The thing is, even if the majority of countries on earth outlaw designer babies, it takes only one country to allow it and people who can afford it will go there to get their genetically enhanced offspring. How long do you think other countries will watch their own citizens who abide by local law to be hopelessly outcompeted by kids who are incredibly smart, strong, good-looking and charismatic by birth?

[@Sixsince-dd2eu]

_"Mice with human jeans."_

[@dermonch7959]

Cool vid. Currently there are a few limitations to this technology. Scientist already called for a more nuanced approach and a discussion about the ethical implications. I think the pros outweigh the cons- so go for it! I would`nt mind taking it a step further: Somewhere in the future, when the process is researched enough, Enhancement should be embraced and tried out. If the free will of participants is preserved i don`t see a problem. Just keep genetic safety copys! :D

[@DGP406]

what kind of parent wouldn't want his\her baby to be safe from cancer or diabetes?

[@Gerpar_]

Anti-Vaxers

[@dsmerda]

Hello, can I ask you, what is the name of the song that you used from APM music library around 4:30 of this video? I cannot find it. Thanks for your time, nice work, by the way.

[@morgangreen2526]

Eugenics?

[@thewitheringproduction1761]

not really because you aren't killing anyone with bad genes or stopping them from breeding.

[@morgangreen2526]

the withering production Eugenics is not about elimination of sections of the gene pool. Eugenics is the belief that there are superior and inferior gene expressions in humanity. CRISPR rides on such a belief being true, which is somewhat true.

[@BlueSun_]

"Somewhat true" is the understatement of the year.

[@Blackmark52]

I don't understand why eugenics itself is of any concern. Humanity should be striving to improve itself and considering how fast we are changing our environment -- and may even need to adapt to entirely new environments such as the harshness of space -- evolution just isn't going to cut it. Genome editing techniques may be one of the most important tools we have to ensure the continued existence of humanity. It seems to me that the bad rep of eugenics comes from archaic implementations of times past and primitive understanding of what genetics actually is.

[@morgangreen2526]

Blackmark52 I am concerned about human error

[@ruzzelladrian907]

Try showing this video to a bunch of Baptist School students, and for sure they'll find this video outrageous.

[@RandomUploader7]

We will create soldiers. I guarantee it.

[@saandyyvh6682]

This is very interesting! Customizable children. It would be interesting to think about what genes could lead the gene popularity contest, how it would change our diversity, and perhaps even body type. Like in a totally sci-fi setting, what if it's socially looked down upon if your child is NOT like the rest?