Cushing Syndrome, Causes, Signs and Symptoms, Diagnosis and Treatment.

.
Chapters
0:00 Introduction
1:10 Causes of Cushing
2:58 Symptoms of Cushing
4:15 Diagnosis of Cushing
4:47 Treatment of Cushing
Cushing's syndrome is the collection of signs and symptoms due to prolonged exposure to glucocorticoids such as cortisol.[3][8][9] Signs and symptoms may include high blood pressure, abdominal obesity but with thin arms and legs, reddish stretch marks, a round red face, a fat lump between the shoulders, weak muscles, weak bones, acne, and fragile skin that heals poorly.[2] Women may have more hair and irregular menstruation.[2] Occasionally there may be changes in mood, headaches, and a chronic feeling of tiredness.[2]
Cushing's syndrome is caused by either excessive cortisol-like medication such as prednisone or a tumor that either produces or results in the production of excessive cortisol by the adrenal glands.[10] Cases due to a pituitary adenoma are known as Cushing's disease, which is the second most common cause of Cushing's syndrome after medication.[3] A number of other tumors may also cause Cushing's.[3][11] Some of these are associated with inherited disorders such as multiple endocrine neoplasia type 1 and Carney complex.[7] Diagnosis requires a number of steps.[4] The first step is to check the medications a person takes.[4] The second step is to measure levels of cortisol in the urine, saliva or in the blood after taking dexamethasone.[4] If this test is abnormal, the cortisol may be measured late at night.[4] If the cortisol remains high, a blood test for ACTH may be done.[4]
Most cases can be treated and cured.[6] If due to medications, these can often be slowly decreased if still required or slowly stopped.[5][12] If caused by a tumor, it may be treated by a combination of surgery, chemotherapy, and/or radiation.[5] If the pituitary was affected, other medications may be required to replace its lost function.[5] With treatment, life expectancy is usually normal.[6] Some, in whom surgery is unable to remove the entire tumor, have an increased risk of death.[13]

[@reneemansini7687]

Worst time of my life before diagnosis! Took 2 years to get it! Gained 80 lbs, moon face, buffalo hump, skin thinning, headaches, sleep disturbances, blood pressure 200/100 ( put on 5 meds, still high)! Was told just getting older 😮 finally diagnosed self with Cushing and demanded testing! Raging Cushings! Large tumor on adrenal gland. Had it removed along with partial kidney removal. Do not give up, keep searching for answers. Have never felt completely cured but tons better!

[@MedicalCentric]

I'm sorry to hear about your struggles, but I'm glad you advocated for yourself and found some relief. Your perseverance is inspiring.

[@LAFITZ10]

did you ever use Ozempic?

[@rmartinez4165]

I put on 85 lbs in 2 years!!! Doctors keep telling me to lose weight!! I am a wreck!! I have bone loss, excessive fatigue, sweating, insomnia!!! I broke my back last summer because of bone loss!! I have scoliosis!! I kept telling my doctors something was wrong. They kept saying I was over eating & lazy😢 This is inspite of the fact that I have had an adrenal gland tumor for over 5 years!!! They have been gaslighting me!!!🤬🤬🤬 Because of cancer & severe wreck, I have been given large doses of cortisone for the past few years to top it off!! I had a complete meltdown last month, a doctor finally listened to me & diagnosed me with Cushings!!! Hopefully I get the tumor removed soon!!! Your story sounds so much like mine!!!😢😢

[@reneemansini7687]

@@rmartinez4165 it sure does! I feel so bad for you! I made them check me too! We have got to advocate for ourselves! Praying for you, keep me informed!

[@kehindesobowale8851]

I am 3 years in remission of cushings syndrome.. if are experiencing any of the symptoms mentioned PLEASE get it checked immediately out to eliminate any long term threats

[@AdnanKhan-dg8qt]

What symptoms did u have specifically and how did u get it tested?

[@kehindesobowale8851]

@@AdnanKhan-dg8qt I had lots of tests, I was diabetic, hypertensive and over weight amongst most things, i just had very a vigilant consultant who referred me to a better hospital to get tested and after numerous MRIs and CT scans they found tumour on the pituitary gland, then i had surgery and I've been fine, the only lasting effect is that I'm not as strong as before, but I'm going to the gym constantly to better my fitness.

[@elysianbridgetownaccommodation]

​@@kehindesobowale8851 so it can be missed on first scans? How could you be taken seriously if they don't see it first im worried this is what will happen

[@kehindesobowale8851]

@Elysian Bridgetown Accommodation that's the thing you don't know, I just had a very vigilante doctor who tried different options because they kept upping the dosage of my blood pressure meds, it was almost like the process of elimination, then she just said it might be rare but let me test you for cushings because i was all sorts of meds that weren't helping and she was right.

[@boredinczechia4382]

I have all of them.

[@reilly_the_potato7589]

this is so informative. this might explain everything for me

[@aaminafarheen0000]

Awesome explaination

[@kennedymwansa761]

Thanks for the video

[@humanseeksjustice8830]

Your animations are amazing. Do you creat them?

[@abdirashidabdiwahab8927]

Thanks for your information

[@florabraswell9744]

Thank you for your excellent video explaining Cushing 🙏❤️

[@MedicalCentric]

Glad it was helpful!

[@hawaaeedami8692]

Could you share sources or articles used in this video, please.

[@hameezaalvi1576]

Good effort keep it up

[@aubreysharp8384]

As someone who has been on heavy steroids for 16 years straight and has a hump i am intruiged

[@stephss]

Omg, is this my solution after 49 years of suffering?

[@juneebennett22]

Wow, me too. My life has been made a mess by this. Doctors are of no use whatsoever at all.

[@annemontgomery3890]

Get your cortisol tested. I've had to go through almost a year of testing before they were able to exclude the other things, like PCOS etc. To be fair, i am in the early stages. Cannot sleep, exhausted all the time, gain weight despite being a low calorie diet (with a dietician) and exercising a lot. But my glucose, A1C, and insulin are fine.

[@anthony7737]

I'm wondering about something. If I could get some advice. I am having a blood cortisol test AM and PM. If i come home after the AM test and sleep for 2 hours, would that affect the PM test results? Thanks for any help that could be offered

[@carolinasousa365]

hey, pharmacy student here, could you share your sources? I have to do an assignment about cushings but the teacher is 1 week late on the theory classes so i'll only have this class after i have to submit the assignment, and the class is where the teacher send us links and articles for us to read

[@AimisSuccess-cb5ce]

I think i have Cushing syndrome bcz i have buffalo hump. Is exercise and diet can help to fight with this disease ?

[@kaylamartinez1111]

I need to see a doctor ASAP

[@kdog05__]

Go see a Endocrinologist.

[@Aurora-qn2dx]

I think i have this.. terrible terrible fatigue ,hairloss and weight gain..but i dont have the buffalo hump. my cortisol is high at 8am..how do i know if its in my brain or adrenals? Thyroid antibodies High and i also have insulin resistence.

[@EverAllison]

I would ask to get MRI of your brain and abdomen with and without contrast, it’ll help to check if there are tumors on your pituitary, adrenals, etc.

[@anujbhardwaj3960]

Aurora you feel anxious all the time and hungry all the time

[@ameegrant6055]

Try to Get an special MRI of the Pituitary gland. Regular brain MRI doesn’t show pituitary tumors. So ask an Endocrinologist to give you a prescription for Pituitary tumor MRI

[@german_lifestyle_tajbakhsh7282]

I have many symptoms specifically high blood pressure and kidney pain and irritability with severe weight gain and retinal vein occlusion

[@MedicalCentric]

These symptoms may indicate a serious underlying condition; it's crucial to consult with a healthcare professional for a comprehensive evaluation and appropriate treatment plan.

[@german_lifestyle_tajbakhsh7282]

@@MedicalCentric after one year of examination they don’t find anything in Germany! They have not checked for cushing and many other possibilities

[@reetpabla990]

Could you share your animations?

[@glory-annbalajadiabaile7326]

👏❤️

[@echastee]

Getting an MRI today because I recently was diagnosed with PCOS but something is not matching up and they think I could have a tumor. I have so many symptoms of having some kind of pituitary tumor so I can't wait to find out. I had regular periods my whole life. Then they stopped. I am having other symptoms. So I can't wait to find out if I have this brain tumor.

[@Gabilai92]

Please update us. Wishing you the best ! I am on the same boat as you….I am getting tested tomorrow. Wishing you the best!

[@echastee]

@@Gabilai92 no tumors. So that's good but I'm still trying to figure some stuff out.

[@echastee]

@@Gabilai92 let me know how it goes for you

[@Gabilai92]

@@echastee will do, it could be something else you know? just keep pestering your docs, your a paying customer!

[@alexisasheep6554]

Seems like I have both so that's fun

[@sidra-sl4hs]

5:17 pleaseeee someone explain i dont get it how glucocorticoids medications are used in suppressing the disease

[@hawaaeedami8692]

No you get it wrong, he means the normal cortisol production in the body is suppressed by glucocorticoid medications ( in the patients with asthma or other conditions taking glucocorticoids) so a sudden stoppage may lead to serious problems, therefore he recommends gradual decrease of the doses instead of unexpected stopping, so normal cortisol productions in the body functioning again.

[@itzashcrax]

Im 14, i have not much fat but on my stomace upper and lower l, thighs and calfs but my arms are skinny, my skin bruises easily but i have sensitive skin, purpley strech marks on my thighs, weaknes is upper arms and mood swings and a couple more but idk if it this or something simular or js hormones

[@nehakashyap6987]

Hey any update regarding this ??

[@rrmother3748]

If it’s not Cushing’s, look into Ehlers-Danlos Syndrome, as well as Small Fiber Neuropathy. There’s quite a bit of overlap. So sorry you’re not feeling good. Hugs~

[@Steph737]

The pain

[@MedicalCentric]

sorry about that. You should visit a doctor.

[@Alcoholpad]

I have a lot of worries because I’m a single mom 😢 don’t know where my son would go if I need surgery.

[@kaxar6954]

Can you arrange for him to stay with family? Depending on your country there maybe a hotline that can provide advice or support.

[@kdog05__]

I have Cushing's and I'm 16.

[@Pdrock2001]

Stay in there brother I wish for your better health .

[@AdnanKhan-dg8qt]

Hey how r u now?

[@carolmacan6788]

Fasting and keto/low carb can help ....or waterfast😉

[@kipo3kx]

Seems like this is what in suffering from with the extreme high blood pressure

[@MedicalCentric]

Please visit a doctor.

[@insertusername3778]

Anyone diagnosed with this who didn't have moon face and buffalo hump ?

[@dandushruthi2921]

Is it possible to cure cushing disease with medicines????

[@petitpois8813]

Yes.

[@annemontgomery3890]

They usually cure it by surgery because that eliminates the cause. There's also something called pseudo-cushings that has the same symptoms,but they don't know the cause, and those often get medication. The meds are pretty invasive as well, though, as you're still messing with hormones.

[@thatstrami]

​@@petitpois8813what do you mean yes? No there's no medicines that cure Cushing's

[@derangedjordz4253]

i was 14 when i first had it

[@riandraagustian5057]

hows ur body now??then how many years or months it takes to get normal again

[@derangedjordz4253]

Im good now, i just remember it took forverver to sit on the ground again.@@riandraagustian5057