Cystic Fibrosis - ∆F508 mutation of CFTR

[@MusicMasterX15]

Normally, the three DNA base pairs A-T-C (paired with T-A-G on the opposite strand) at the gene's 507th position form the template for the mRNA codon A-U-C for isoleucine, while the three DNA base pairs T-T-T (paired with A-A-A) at the adjacent 508th position form the template for the codon U-U-U for phenylalanine.[2] The ΔF508 mutation is a deletion of the C-G pair from position 507 along with the first two T-A pairs from position 508, leaving the DNA sequence A-T-T (paired with T-A-A) at position 507, which is transcribed into the mRNA codon A-U-U. Since A-U-U also codes for isoleucine, position 507's amino acid does not change, and the mutation's net effect is equivalent to a deletion ("Δ") of the sequence resulting in the codon for phenylalanine at position 508.[3]

[@MusicMasterX15]

So it does effect 2 pairs, but only has a net change of deleting the 508th protein

[@shesbizypdcast]

THANK YOU

[@Sarnai_skincare_studio]

This video is so good ! Thank you ! exactly what I was looking for to understand CF.

[@Squawk_Box]

This was brilliant! Thanks!

[@eghonghonomonbude4643]

Thank you very much sir; God bless you sir. More knowledge and understanding to you sir.

[@maryamshakeel8093]

Please tell what resource do you use ? please reply

[@lukemclaurin4641]

Loved the video, really helped with understanding for me. If you don't mind wondering, what source did you use? I'm just wondering if I can use this for a school assignment. Thanks!

[@maryamshakeel8093]

yes please tell us what resource you use?

[@asadfasf3918]

Thank you very much,great work.

[@Xocrot]

i once told by my doctor “in what part do you have cf?” LOL

[@ninamaitra8767]

Amazing!! Thank you so much!

[@javis566]

thank you so much for this

[@kathyc3005]

Thank you so much! Great explanation!

[@monochromaticbullet190]

I have cystic fibrosis T5 allele and I’m getting no information from my doctor,, any advice?

[@SoundCreation01]

Plain and nice.

[@ricodsanchez6792]

nice vid

[@mizzannie001]

good vid :)