Cytochrome P450 Enzyme System: Inducers & Inhibitors

Hepatic cytochrome P450 enzymes can either induce or inhibit the metabolism of certain drugs, and this alters the concentration levels of certain drugs. I got over a few high-yield subtypes. In the end, I go over some practice Qs. This video is for education purposes only. Enjoy this as part of the PMHNP Certification Exam Review Course and as always Happy Learning!
If you liked this video or found it helpful, give it a like, subscribe, and share to show your support!
Chapters:
00:00 What do I cover in this video?
00:23 What are Inhibitors and how does it affect the drugs?
01:19 What are Inducers and how does it affect the drugs?
01:46 List of Inhibitors with mnemonic
02:24 List of Inducers with mnemonic
02:51 What worked best for me with Inhibitors and inducers?
05:30 Medications that induce Depression or Mania
06:55 Q & A Time! Buckle-Down.
08:35 Ready for 5 more Q's?
11:54 Comment to let me know what videos you would like me to do next. :")
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Cytochrome P450 Enzyme System: Inducers & Inhibitors
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[@dallas44forlife65]

I added to the inhibitors: Do ( depakote) be careful cause Covid feels overweeningly gross Always ( alcohol/acute) keep nana safe !

[@madil5974]

omg thank you so much for sharing this. I love all your videos and I learned SO MUCH today

[@PMHNP101]

Happy to hear that. Glad it was helpful!

[@markysmith1234]

Love your videos. Thank you. I didn't think NSAIDs (Ibuprofen) inhibited Lithium-which isn't metabolized by the liver-but instead, decreased it's excretion from the kidneys thereby raising lithium levels

[@PMHNP101]

Thank you 🙏

[@ahmedmemon7756]

Great great video.

[@PMHNP101]

Thank you! Glad you enjoyed it.

[@evieparatore1527]

I want to tell you I will testing sometime in July and your posts have been amazing!!!!! Please keep up the good work, we appreciate 😀

[@PMHNP101]

That’s great! Thank you for the kind words. Anything in particular you would want me to cover next?

[@Adaughtersheart-Isa53]

@@PMHNP101 Do you have one on what NTs do and in what part of the brain or major attributes/and or fxn of regions of the cortex, limbic system, relevant nervous system structures?

[@Adaughtersheart-Isa53]

hahah! I was leaving and just noticed a red dot on my alert and guess what I found :)

[@PMHNP101]

Hi Marlana, I'm working on neuroanatomy video. It might be a while before it will be posted. Was that something you were interested in?

[@PMHNP101]

What did you find? (I hope its a video you were looking for)

[@ourfilipinoamericandream6724]

Thank you for this...great explanation!

[@PMHNP101]

Thank you for the feedback. I appreciate it. It’s a great motivation for me.

[@ginaashman8849]

Your teaching is amazing. Thank you

[@PMHNP101]

Thank you! I guess it’s one way to be an educator 😎. KZbin 😇

[@franciscaonunaku2563]

Thank you thank you thank you 😊 🙏

[@PMHNP101]

You are so welcome😉

[@ds97382]

Bless you 😎

[@PMHNP101]

God bless you more!

[@PMHNP101]

Our NEW Patreon Channel is here! Here's the link: www.patreon.com/pmhnp101

[@terriellis28]

This os awesome

[@PMHNP101]

Thank you!

[@reliasell3729]

Nice video amazing improvement!!!

[@PMHNP101]

Thank you so much! I tried. 😀

[@cozyone9862]

To test my own understanding, with Antabuse and tegratol , you would increase the tegratol correct?

[@blessingokpo1780]

does that mean zyprexa and nicotine are both inducers?

[@kittenburger_prime]

TIL the ol' doc has been prescribing me against recommendations and then acting confused when I have weird reactions, labeling me a troublemaker. Thank you.

[@PMHNP101]

Hi Ben, Sorry to hear about your experience. I hope you didn't have severe reactions and were able to find a good provider.

[@kerrycallender5802]

Thanks for the video,! very helpful. Are there any crash courses that you recommend for the psych NP boards? I know Joanna Asia has a course for the FNP, but I can’t seem to find any for the PMHNP. I find those more helpful than the review manual since I’m an audio and visual person.

[@PMHNP101]

Hi Kerry. Glad it's helpful. You can show your love and support by liking the videos and sharing it with your peers. I would greatly appreciate it. I'm trying to make PMHNP review but since video editing and presentation isn't necessarily my forte, it takes a longer time for. Hopefully in a month or so, I can have it ready.

[@PMHNP101]

Let me know if you have any questions or requests for videos. You can email me [e-mail]

[@keedahouston6950]

Hi I have a question: As it pertains to Carbamazepine and Oral Contraceptives; you would decrease the Carbamazepine because the birth control takes priority?

[@PMHNP101]

You would either discontinue, put them or another medication or increase the medication because of what you are treating them for (diagnosis). Even though it decreases the birth control, you can advise them to take precaution. Depends on what the question is asking. Think safety of the patient.

[@corehealthservices1724]

Flonase has steroids that would increase Tegretol level; therefore, Tegretol has to decrease. Increasing Tegretol dosage can lead to agranulocytosis.

[@PMHNP101]

Hi Ashley. Are you saying that you would decrease Tegretol? Its true Flonase has steroids. Yes, its true Tegretol can lead to agranulocytosis in which you will be doing routine blood work to monitor. With that said, Flonase is a PRN medication. It's not a standing medication. Tegretol on the other hand is a standing medication. You wouldn't necessarily be adjusting the standing medication over a PRN medication. In addition, if you are studying from the purple book, note that steroids induces depression or it can induce mania. The question focus isn't about inducers and inhibitors, its based on are you adjusting the medication because it's causing depression or mania. In which, the med is adjusted based on that. If the specialty is psychiatry, I wouldn't be adjusting any other medication that is out of my scope of practice, rather contact the primary.

[@trob6700]

@@PMHNP101 yup understanding the question is the first step in choosing the right answer.