Cytotoxic T cells | Immune system physiology | NCLEX-RN | Khan Academy

[@themexiranian]

i just like that you are drawing things out and explaining them, rather than pointing to an unmoving ppt presentation thats been molding around for years and years

[@dulee101]

This is absolutely amazing! you saved another medical student trying to connect the dots of the immune system! Good luck with everything, these videos are so so helpful :)

[@andrewmontoya8511]

you doctor yet

[@in2ennui]

Your teaching skills are AMAZING!! Very unlike my own professor... I seriously learn better from you than from sitting in class where a teacher reads slides! Step by Step drawings and words are an enormously effective technique!

[@devidrsr]

THIS IS THE BEST WAY OF TEACHING AS MY HEART SAYS

[@shaynabourgeois7241]

" I am a virus, I am a virus making maching, you better kill me!" This is great! If only my instructor made her lectures like this! Thanks for being a lifesaver!!

[@Akmarvel1995]

Been 10 yrs since you commented

[@scramblesk8]

Love your videos. great idea using different colors and breaking it down with imagines. So much easier than reading a definition. Thanks!

[@cherrytehhladyy]

i'm so slow at understanding processes like this, thank you ! it was so easy for me to connect with this .

[@nappingracez]

"So the big picture is, if you want to just take 20000 feet." HAHAHAHAHAHAHAHAHAHA gotta love this guy! He always makes me day studying MCAT less shitty

[@Ddelke]

Thank you so much!!!! You helped me to get ready for the exam, keep the good work! Greetings from Serbia!! Pozdrav iz Srbije!

[@x3baybeee]

i think i learn better watching these videos at 2x the speed lol

[@tonyakriba6836]

Same

[@pickle_256]

Keeps you focused.

[@boonlorify]

Extreamly helpful!!!! I'm in med school and he explains it better than the book and/or the professors!!!!

[@Pangjunmin]

i can finally understand! my group spent so many hours trying to understand what the heck was going on, this simplifies it so much that i can teach it to them now :D

[@zuay9016]

so these are what i've been learning in my lectures all this while!!thank you! u make my revision more enjoyable :))

[@lloplop]

I second the grammar video! I really really love these videos. they help me tremendously.

[@PurposefulPawn]

dude you have the best video about the lymphocytes on youtube! thanks!

[@Nirvana87]

How can someone possibly dislike this?? Awesome teacher!

[@CRUZifyre]

Incredible videos on cytotoxic and helper t cells, B cells.... These helped me understand more than the college classroom! Thank you!!!

[@mizmoe81]

I am SUCH a visual learner! Thank you thank you thank you!!!

[@khansafi5583]

Hi how are you dear

[@qteshorty634]

sweet!!! this helped a lot for my microbiology class I wish all the teachers were like you !

[@pranabnirmal5597]

After 20 years into medicine.. I start understanding immunity after watching your videos

[@mustafaal-ghezi1757]

I feel sorry for your patients

[@xinahicks13]

@@mustafaal-ghezi1757 😳

[@YaMahaWorld]

Mr. Salman I wish if you were my teacher, i'm currently in basic immunity course at collage and the doc make it boring and not understandable I'm glad that i found your channel, you helped me a lot and made it more interesting to study :) Thank you so much for your efforts

[@MrPyrhana25]

Best life sciences videos on you tube. Great logic of sequence!

[@xenon8117]

4:58 In my immunology test tomorrow.

[@04imran]

was never so clear about this before... thank u osm videao to learn

[@n3r0z3r0]

This is better then Science Fiction!!!! Amazing! Thank you so much!

[@ShimmyMD]

I have a question...when you say the DNA gets shuffled around...do you refer to the post transcriptional modifications of pre-mRNA (exon splicing combination's)? Because I don't think DNA can do that. THANKS Great video btw!!

[@msthekissable]

Thanks so much

[@jimsperlakis5634]

Great audio presentation! Best I've watched. But, You should start with a page that already has the cells drawn. Then, as you describe or define, you can label that specific cell and draw the specific receptor involved.

[@ninjanerdstudent6937]

Lesson learned: Shady characters need to die.

[@DisKeda]

What this guy does can't be done better. Unbelievable videos. The best! Thank you so much!

[@lamishaahmed6094]

I have been following your videos for a while, and omg every time I am in a topic, I am so amazed by you detailing and explaining skills. Khan academy is undoubtedly doing a great job of teaching people the basics of science.

[@cherrycoke8464]

Thank you so much for these videos Sal, you made me just a little bit smarter today. And you didn't bore me in the process. Big ups for that!! :D

[@jahu198]

Thank you so so so much! I didn't understand a word of what they talked about at uni and now I get it. Well, at least the basics, but that's more than I ever thought I'd understand. (Especially with a teacher with a strong accent). Thank you! You're awesome! :)

[@trustjess]

You are the best thing that has ever happened to me! Maybe now I'll pas A+P II

[@LadyD0113]

I just learned everything I need to know in an hour....than in 5 lectures...Thank you! Now to answer the professors ridiculous reaching questions!

[@kareemapollo]

great job khan sahad kindly expand u r area of teaching by including medical sciences

[@backstreetfan2887]

thank you so much Khan Academy

[@illumineat_nutritionist]

This guy explains stuff SO well

[@Arilaynne]

Your vids are truly great. But i'd like to add that thrombocytes are also not nucleated

[@MrPeperonio]

amazing video thank you so much!

[@AznsrAwesome]

10 minutes before my test and I finally understand this material

[@alimukhtar4759]

Thank u so much for such helpful content

[@ghoshsurajit85]

This is an amazing video and exactly what i wanted to know regarding the T cells. so thanks a lot for the pleasent lecture.

[@tombiddles]

I have exams coming up, You have saved my ass!! (a grateful medical student)

[@paulhetherington3854]

Sphere--XL or KL-- for cell. SIDZPHERO= Sip this, carried drink-- cells and receptors-- nodes-- arteries-- vents-- caps. Rapido-- shaped organelles.

[@chadsmith7203]

Entire semester of microbiology and came nowhere close to grasping it like I just did. Thank you

[@andrewmontoya8511]

lol

[@Bodyskillz2011]

thank you very much man its really easy and important better than our books

[@ajiboyewilliam]

You really solved my problem with mhc1 and mhc11. Thanks.

[@BloxyFliks]

i dream of becoming a doctor one day this helps so much and also i just saw this video

[@pokuneff]

You are a gifted and brilliant teacher. thank you so much!!

[@toriroe8401]

ah thankyou so much, so helpful you explain things so well! you're amazing :)

[@DavidTSaad]

7:29 Doesn't the T- cytotoxic cell need some kind of a second signal as the T-Helper cells do? The CD28 with B7? My point is: is it normal for T-cytotoxic cells to be activated from normal cells, or do they have to be activated from professional antigen presenting cells?

[@kareemapollo]

great job khan sahad

[@cynthiad_]

This Video helped me So So Much 💯💯🙏I love your Videos because I always learn so much!!! Thank You🤗❤

[@mcatpdf2248]

this is extremely helpful for MCAT

[@iamchill702]

WOW. Great explanation. Now to time to youtube other things completely not about my final tomorrow.

[@bl3owns3all]

Seriously, good stuff. Now i have more hope for my finals. :)

[@xforestberryx]

this is so brilliant! ty for the upload!

[@agarwalsurbhi221]

thank u so much u have made my problem in mhc1 simpler.

[@babyshamblez]

@addycastro @addycastro B cells display both MHC 1 and MHC 2. the antigens are presented on MHC 2 because the antibodies coating the membrane of the Bcell have attached to a foreign particle. this particle is then engulfed, lysed and some of the protein debris is presented on the MHC2 on the outside of the cell so the Helper T cells can come and help produce antibodies. MHC1 complexes only have antigens presented on them when a foreign body enters the cell without being engulfed...

[@EvelynNLB]

your the best!!

[@Elnora4ka]

Thank you very much for your helpful lessons! God bless you!

[@abdullahyusuf190]

This guy knows everything, he's the voice for organic chemistry and differential equations

[@Nicole-em7iv]

this is pretty basic undergrad stuff. almost everyone with a bachelor's degree knows as much..

[@basicallydelpan8768]

yes probably really simple stuff. Studying it in yr 11

[@ShimmyMD]

@Zturn RBCs don't have nuclei nor any organelles like ER or mitochondria. So they don't have an MHC I. But they get degraded in the spleen every ~120 days

[@ghost2me]

hey shady guy!! love these videos so much!! thanx a lot!! :D

[@abdulandschool2266]

Shot, this is on the MCAT, I have to study good, I might need it later.

[@jessicasingh1286]

you have made my life so much easier.. thank you. You are a legend!

[@joshgilbo]

fantastic video, finally understand, you're a legend

[@DomedOutBullyz]

Man !!!You are tha MAN!!!!

[@xwhiterabbitx420]

excellent! thank you!

[@nystagmus]

Along with MHC IIs, Dendritic cells also have MHC I Same with macrophages and B cells

[@wonkeyleggs]

I totally agree, there needs to be a Khan-uni degree

[@khanacademy]

KZbin just started doing that. It should be off now.

[@rachellouisejoyce8482]

Thankyou so much for your video's they are amazing and really helping me revise:) Keep it up x

[@sameenaz2006]

@stardanny33 He is referring to alternative splicing. Different ways to splice out introns creating different sets of mature mRNA to be translated, thus giving off different proteins. Also, it gains more variance through post-translation modification, such as different forms of sorting and glycosylation at the golgi before being presented on the surface. Hope that helps.

[@theprophetez1357]

Thanks Kahn you do a great job and have a new sub here. I need a break after watching two of your videos, but I certainly look forward to coming back and learning more. Thanks again.

[@kendramartin6103]

You do an amazing job explaining this system! When I'm looking at my lecture notes it's harder to make these connections. Now I have a question... My professor has on his notes that the dendritic cells are the only cells that carry both MHC II and MHC I. You are also saying B cells have this quality?

[@joszaynka]

+Kendra Martin All nucleated cells (essentially all cells minus erytrocites) have MHC I proteins; while only APCs have MHC II proteins, however since they are also nucleated cells they carry MHC I as well.

[@rajkaur17]

Reason why Tcyto cell binds to MHC1 is beacuse Tcyto has cd8+ signal that has its complementary receptor on Mhc1 only, plus Cd8 cells binds only to the peptide having length 9-12 A.a, So the chances of binding Tcyto to Mhc2 is not possible, but Tcyto can recognize Mhc1 which is even present on the lympho cells as they are nucleated one ,and can kill them .

[@GoodTunesFtw]

I've never seen ads on his videos.

[@amenamahmood6402]

awesomeeeee...i learn alot.

[@rosecook7110]

I love his enthusiasm on all subjects 😂 teaching is his calling

[@andrewmontoya8511]

im actually gonna have to agree ngl

[@maram5102]

Science legend .

[@iamanubertuber]

In the case of HIV infection, where CD4 T helper cell is infected with virus, do the MHC I of CD4 present HIV fragments, and consequently get destroyed by CD8 cytotoxic effector cells?

[@MsRsclips]

i'm doing still fine with lung cancer :) sometimes pain in the chest and can't breath really great but :D

[@Donau005]

Thanks alot...This is great :) Although.. Neurons (Nerve cells) doesn't have MHC-I receptors on them. (?) Isn't that correct? But except for that one type of cells, all nucleated cells DO have MHC-I receptors..

[@BMTaher]

Is there anyway we can thank you enough?

[@lronbutters5688]

Love the T cells!!!

[@woloabel]

At the cruising Altitude of 40k Feet, the one challenging aspect of Anaplasia (So-called Cancer) is the Involvement of the Immune System MHC I (The Failure of Perforins to Rupture Cell Membrane or Create/Induce Apoptosis) or the Entire System itself. Actually, when contemplating or proactively tackling the Medical Phenomenon of Cancer, Oncology is Deficient because such Challenge should really be an Immunological Objective when trying to Research (Mechanism of Pathology or else Morphology of Malignancy), Treat (Diagnosis, Prognosis or Therapy if not Currently merely the Management) and/or Cure (Chemotherapies or Bone Marrow Transplants as only some examples) Francoanaplasia, Mankind's Second Most Challenging Pathology--the First being Autoimmune Proliferation Pathologies.

[@JoseHernandez-zh5tu]

LOVE IT! GOD BLESS YOU!

[@rajkaur17]

Also, Thelper cell only recognize 12-18 peptide and has complemenatry receptor for Mhc2 only and they can't bind to Mhc 1 unless and untill there is a mutatio

[@kcmanurse81]

You are awesome! I feel like I should be paying you $363 a credit hour! Thanks for breaking it down for me!

[@akmi1717]

good video.

[@TheHishamable]

thank you so much !!!!

[@adhamhamadneh4134]

Thanks a lot , actually this is the only source I completely understood the process from .Thank you again . I have a question , please . Why Tc doesn't kill B or dintritic cells while B and dintitic cells have an MHC1 proteins , like other nucleated cells ?

[@diby1555]

I think B and Dendritic cells have MHC II

[@wlsgh50]

Thanks alot ^^

[@jerryliao5299]

much nice visuals, many help. so thank you

[@wendyQR]

thank you so much～now I manage to understand the whole process~~

[@ronzaarraf]

God bless u

[@lotteboyhk]

thanks for all of your teaching but it is hard to know which is which and their orders it will be nice if u put numbers in so people knw which one to watch first it's like in the video when u say, ' ok following from the last video' I do not know which one u mean by 'LAST' thanks!

[@saskiakuik99]

really helpful! thanks :)