hello, can you also talk about: Nanoxidil vs. Minoxidil: What’s the difference? if i am not wrong, Minoxidil has been around as a hair loss treatment for nearly 40 years, but it’s certainly not perfect. There are those for whom it doesn’t work, as well as those who experience some mild but unpleasant side effects like scalp irritation. Nanoxidil, by comparison, is virtually brand new. It doesn’t have the same amount of research behind it, but early studies indicate a similar level of effectiveness and, potentially, a lower side effect profile.