Dave Feldman presentation: ApoB, Cholesterol and the Lean Mass Hyper-Responders Research Update

[@mulv1976]

THIS is how studies should be run and funded. No funding from the organisations with pure profit and self interest as their priority. Well done Dave Feldman and team!

[@realDaveFeldman]

Thank you -- it was really meant to be end-to-end for this very reason. If the results turn out as many of us hope, it will understandably get scrutinized for funding, and I can say plainly it's been funded by individuals (either directly or through their charitable intermediary). It's a big part of why I put in all that time and money to set this up as a 501(c)(3) even before trying to raise a single dime.

[@shellderp]

ideally it would be through grants as well, which is sort of the same thing (tax dollars)

[@tamashumi7961]

Very true, yet working people should not be taxed into oblivion so we could actually have more funds at our disposal to donate to such causes

[@cormchm2853]

@@tamashumi7961 You managed to turn this into a "Me tax dollers!" rant. Well done.

[@ronnapierson7178]

I am so thankful for honesty! Honesty and removing politics from science and medicine and health! I m a senior citizen and will be 78 in November starting my 79th year and I can’t tell you how angry I am that I’m only now in the past year and a half or so Learning that not only can I overcome my obesity and my Hashimoto’s and my high blood pressure and my bladder spasms and my brain, fog and my depression, and I am so angry that we have been lied to, for so many years, and for the majority of my life that I was paying attention, really, really believing I was doing the right thing. I will be passing this information on to my general practitioner. Who is, thank God, a woman who is willing to listen and learn. So grateful! Thank you Lord, for honest people!!!!!

[@paulaelliott47]

I just want you to know Ronna you just said everything that I think and you said it beautifully. I am 78 as of last month I’ve been carnivore for six months I too am angry I never knew this before. I think we carnivore seniors need our own KZbin channel. I hope someone comes up with one soon.

[@lynnwilliams5432]

Yes yes and deal with osteoporosis in seniors too. Every advise they gave for strong bones I have done and still have it . Carnivore for six years now 81 years. Get a DEXA scan.

[@realDaveFeldman]

Wow -- thanks for all the thoughtful comments to my talk! 🙏 -- I'm going to try and answer a bunch of them here for the next week or two. But please bear in mind these important developments since this talk happened (6 months ago): - A portion of the data presented is out of date, but that’s actually a good thing. The more updated prelim data is a bit more interesting. - Obviously, we haven’t yet published, but this too is a good thing. You’ll know why when it’s out, which should be in a few months. - I haven’t started actually campaigning for the “companion study” yet, I’ll be doing so once our prelim paper is published.

[@jeff911rn99]

Thanks Dave for all you are doing!❤

[@떡볶이나리]

Thank you a lot for your work, Dave!!

[@johnhogue9402]

I believe I heard from you in the past that there is a subgroup of people with FH that don’t have higher than average rates of heart attack. Is that correct? If so, can you point me to the data on that?

[@runemartinguldberg9056]

Question to Dave. What is a FMGR. Fat Mass Glycation Responder.

[@alexaad1712]

Even though my LDL is very high with high HDL and low triglycerides, it does’nt quite fit into the numbers that you give to define LMHR. Could I still be a LMHR though?

[@thehoteldeveloper]

This is beyond EPIC. Crazy high LDL. Over 4 years keto. Over age 50. A third have a family history of heart disease. And zero have any plaque buildup. I cannot wait for the results to get published. We need more studies like this to be done asap.

[@thehoteldeveloper]

The study that really needs to be done is to see how quickly it can clear plaque buildup from someone that already has it......

[@clyde9803]

Same here. LC/keto for years, always high LDL, everything else always comes back fine.

[@clyde9803]

And 0% on arterial calcium scan.

[@themuleify]

What do you mean by "...history of heart disease and zero have plaque buildup"? Did those third of your family do the scan that showed 0 buildup? So based on what definition do they have heart disease?

[@nic7100]

Since it's unlikely that these ppl had such low CAC scores to begin with, the keto diet over the years, must have helped reduce their CAC.

[@hlits6310]

Dave, Feldman for Nobel prize in medicine. Simple as that.

[@TheMumseyOne]

Watching this made my day. Canadian 68 yr old female; keto 2.5 years Total Cholesterol 387, LDL 283, HDL 84, TG 101 - [coffee ..I know...] family doctor just about had a heart attack and sent me off to the Lipid Clinic in a panic...Lipid Dr was cool ,understood my explanation of hyper responder and sent me off for a Coronary CT Scan which showed mild to moderate plaque burden but no stenosis in excess of 25% [cover your ass talk]. What is there is most likely accumulated from 66 years of being a Carb lover. Haven't felt this good since I was a kid, brain fog totally gone, and so much energy. Thank you Dave Feldman for your dedication and exploration of this fascinating new knowledge stream!

[@jeffreycooper6482]

What lipid clinic did you attend? I’m also Canadian and want to delve deeper into my lipid profile

[@zhuancaowumaoman1184]

Do you have any CAC?

[@beautifulgirl219]

DAVE IS A GREAT HUMAN BEING! I'm happy to say I HAVE NOW DONATED TO BOTH STUDIES. If you feel similarly disposed, I can't think of any reason not to. Blessings Dave and all the LMHR and Low Carb community. Now back to my steak. :)

[@realDaveFeldman]

Thank you kindly for your support of our research, @beautifulgirl219 🙏

[@Quaerite.Intellectum]

​@@realDaveFeldmanHow do I donate to the second study? Also, is there a way to sign up for it yet?

[@BeefNEggs057]

Mmmm I’m gonna have a pound of Chuck steak for lunch. Thrifty man’s ribeye.

[@dillardsiji]

My Total Cholesterol: 287, LDL: 196, TC: 116, HDL: 66. I'm a 60-year-old woman, active, exercise daily, BMI: 20.5. I've been on intermittent fasting for five years and went on a low carb diet one year ago. My family physician wanted to put me on statin drug because of the high LDL level. I have no high blood pressure and no other metabolic syndrome. I declined to take the drug. Thank you so much Dr. Feldman for the kind of work you do! It gives me confidence to continue to refuse taking statin drugs.

[@ML-yf2dl]

I was putting off watching this video because I was nervous about the content… but this just INCREDIBLE!!

[@auxiliary4023]

I've been keto for 3yrs and my doctor has been insisting I take statins to reduce my LDL which is extremely high, I've gone with my gut feeling and refused and literally just finding this video has made my day!

[@auxiliary4023]

@Feed_Bleed_Read Hmm, the word "Knob" springs to mind..

[@hillsofwi]

No need to look at sport stars, musicians, actors, etc. for heroes when people like Dave Feldman exist.

[@CynCopeland-TheAnswerIsMeat]

I headed down the rabbit hole that is 'high cholesterol' in 2019 while living in Japan. Thankfully, my GP there, and my GP once I returned to Australia, are not on the Pfizer payroll. My ldl was high, but in every single test since then, my TG have been low, HDL high. No push for statins. I pushed for a CAC for my OWN benefit (as the lab always adds their 'notes' to the result and of course the number was outside the range). CAC=0 in 2022. 61 yo female, BMI 21, good waist. LCHF for over a year, whole foods / no UPF for decades. It's great to see there are enough 'folks like me' who can help the medical profession modify their approach to working with similar people.

[@justinmontgomery9526]

Oh wow, I'm so glad you mentioned that! I'm going to Japan next year and I was worried about the pressure I might face about my high cholesterol. Been switching between carnivore and animal based for about 2 years now, and my lipids last week were HDL: 95, LDL: 308, Trig: 46. What was their response? Just keep doing what you're doing?

[@zhuancaowumaoman1184]

Do you have any atherosclerosis?

[@justinmontgomery9526]

@@zhuancaowumaoman1184 No idea unfortunately. Haven’t had a CAC or anything.

[@kenadams5504]

How much does a cac test cost ?.(I'm lmhr), ldl 220 .

[@CynCopeland-TheAnswerIsMeat]

@@kenadams5504 Here in Oz, about $250

[@ElizabethMillerTX]

I'm LMHR and using diet to manage connective tissue/autoimmune/neuro disease to great effect (despite resistance) and am so very geeked. Dave and the Citizens' Science Foundation will save lives. I'm so appreciate to everyone involved.

[@powerpawsmary]

A true scientist and a trail blazer! I’m optimistic that our high LDL’s will be a good thing and it will be proven. Drug companies will hate you. 😅 I was impressed by you at the Keto Orlando Summit. Thanks for your time, sacrifices and for ownyourlabs.

[@realDaveFeldman]

Thank you for the support. I'm hopeful we'll have more news to share soon.

[@monilaistorz]

OMG! As a social scientist, I am so moved by this guy !

[@CClikesIT]

You are a rockstar, @realDaveFeldman! Thank you for removing the middleman from scientific research and for all that you are doing to move our understanding of this fascinating topic forward. I am in awe of your tenacity. It moves me to see your face light up as you relay these wonderful updates to the rest of us. We appreciate you, Dave. Thank you for all that you do :)

[@realDaveFeldman]

Appreciate the kind words. I've always had an advantage in that this isn't really my career (okay, it's a disadvantage in some ways as well). But in short, it allows me to find out what the answer really is -- and thus at any point I can drop what I'm doing and return to platform development (though starting over to some extent, of course).

[@BeefNEggs057]

You left out corrupt before middleman

[@CClikesIT]

@@BeefNEggs057 - It was implied (:

[@sheshechic]

He really does deserve a Nobel.

[@drironmom6815]

Wow. Just amazing. As a doctor who’s refused to prescribe statins I’m thrilled

[@carnigoth]

^Protect this doctor at all cost!

[@mariaberry6874]

Congratulations. Thanks for this amazing undertaking. Applauding you from Australia

[@michaelhegarty788]

Excellent news Dave, can't wait until February next year..watching & following closely from Ireland and Portugal.

[@dexterdog2257]

35:58 Greetings from Canada from a 5 year post menopausal LMHR woman. Thank you for your work. IT is much appreciated. I took note that the study cohort was 60/40 men/women. Great data for insights into the general populace. A study delineating gender differences would be extremely useful & much needed for post menopausal women. The loss of estrogen completely changes our bodies, metabolism & our response to most dietary inputs. Usually for the worse. & different from males in many ways. Menopause is an independent risk factor for a negatively altered lipid panel. Would you be interested in designing a study with the aid of the North American menopause society to guide study design ? I am sure you could successfully crowd fund for such a study! Just putting it out there…Cheers !

[@HEARTANDSOULOFMINE]

We need this study!

[@elizabethwatson8063]

Yes! I never had high cholesterol until I began menopause. My theory is that I was estrogen dominant all my life and that estrogen is what protected my arteries. Once menopause came and I lost the estrogen, the cholesterol rose to take the place of it. Our miraculous body is responding as it should.😊

[@떡볶이나리]

As someone who has been an LMHR for a while now (as long as I am strict VLCD) this is a great video to see!! Looking forward to the final results when the study ends.

[@deepuls545]

One man relentless in his questions and pursuit of answers attracts other scientists with the same intellectual curiosity and integrity. This is excellent scientific discovery/review in action. Thank you for the transparency, and continuing to include more in your cohorts. We owe you/ researchers/collaborators/donors a debt of gratitude!

[@karenrotzler1661]

430 LDL, LDL particle number 3191, LDL pattern A, CAC of 0, FH test negative, Triglycerides 90, APOB 230, HDL 82, LP(a) 14, CRP .6, Insulin 4.8, no heart symptoms, no hypertension, active and lean for a 68 yr old woman. But my primary still questions my Keto nutrition (and would prefer me to be on statins). This research is of upmost importance. Where can we donate?

[@ronnapierson7178]

Perhaps your doctor would be interested in research? If you can, print research out and take it in with you and give it to your doctor. That’s what I did, over 2 inches thick, all on cholesterol. If you go to Dr. peter a Tia’s website, that’s a really good start, he has a whole 12 presentation series on cholesterol alone. Remember, our doctor works for us, and it’s about time we started demanding accountability, and that accountability won’t be there, unless our doctors know that they are being bamboozled. I guess it’s us, with the people if you will,that need to teach them.

[@karenrotzler1661]

@@ronnapierson7178 in reference to the literature you shared with your physician…. Any chance you could put together a shareable link to a “viewable only” Googledrive folder with links to the papers, research, data, etc you shared with your physician? That would be a great resource for all of us that would like to share that with our physicians in hopes that they are at least considering other research as they make decisions about the best way to manage our healthcare.

[@nubbinz3048]

I would leave that doctor and find one who specializes in Keto like I eventually did. I tried to present research studies to mine as well but some doctors are old dogs who are too ignorant to learn new tricks due to $, ego, or both. They are also generally obese themselves.. and I refuse to go to someone who doesn't actually practice a healthy lifestyle or what they preach. My old GP fear mongered me due to a 330 total just to push a statin. All my other blood work ranges were normal. I'm a 40 y/o male and had been on Keto for the better part of 2-3 years. My father and uncle almost died from statins due to a muscle wasting disease because they trusted the medical cartel's misinformation. No thanks.. I'll fix my issues with what I put into my mouth.

[@karenrotzler1661]

@@nubbinz3048 Thanks for the info. My Primary is a fresh out of med school nice young lady that was recruited to work within a large medical group here in San Antonio - and I am hopeful that given some updated research and literature, that she might be motivated to read it. I realize that most groups run a very standard protocol, but the only low carb or Keto primary physicians that I can find in San Antonio are concierge doctors who do not accept insurance (& it would be difficult for us to budget the concierge annual fees in the thousands when we don’t currently have issues). So, if anyone has a collection of research links they think a physician could learn from - I’d be interested to share with my young primary physician.

[@luchiayoung]

Fill it. Dont take it.

[@roccosakai8206]

DAVE! KEEP IT UP! YOU ARE THE MAN! :) all the best from LMHR guy! :)

[@SGBULLSVEN]

Please protect this human being at all costs

[@robyn3349]

Thank you, Dave Feldman!!!

[@dchildr360diurnalnutrition]

I’m a little behind the release of this information, however, better late than never. I’ve been keto for better than a year now. I’ve been eating non processed foods for better than 4 years as well. I’m 58 and am about to go for a four mile run with, push ups, pull ups and sit ups at the midpoint of my run. I have energy that I couldn’t imagine four years ago. Every day I’m amazed at how much energy I have. Another amazing realization is that, if I choose to, I could not eat for the next three to five days and be just fine at the end of that fasting period.

[@ultramiddle4991]

Light bearer to the masses

[@ronnapierson7178]

And, we the masses can take that light to our doctors! We need to start demanding accountability, and that’s gonna have to come through a Sharing with our doctors and waking them up.

[@ultramiddle4991]

@@ronnapierson7178 Fascinating visual

[@ronnapierson7178]

@@ultramiddle4991 that’s Michael the bell, at the seminary in Nashotah, Wisconsin.

[@EyesOnCarnivore]

Just found out that I am LMHR and super curious. Thank you Dave Feldman, legend

[@JMK-vo8pv]

After Dave Feldman, et. al., totally shatter the Lipid-Heart hypothesis, I wonder how many American cardiologists will admit they have been giving the wrong advice for over 50 years, contributing to the CAD "pandemic" we are now experiencing.

[@OrionFyre]

0

[@BeefNEggs057]

I bet ZERO. Arrogant asses will discount the study since Feldman is a lowly Engineer (who is doing more for heart disease than the entire medical scammunity.

[@tamashumi7961]

Doctors used to advise smoking tobacco for good health. Let that sink in...

[@davidgrimes4726]

I'm coming late to this party, but as a LMHR concerned about my health I'm definitely going to be contributing for the second study! A mountain of thanks @realDaveFeldman! 🙏👏

[@waisssss123]

I have finally found a video that very likely answers my question

[@MrPixifan]

How can I donate to the funding of the next study? I don't have much, but I want to contribute. This is about improving the lives of billions of people. There is no more worthy cause!

[@sarahb.6475]

Congratulations Dave! You must have been so happy + excited at the news! And another new study as well!! ❤❤❤

[@swingtag1041]

I like how he's an engineer and not a doctor. Doctors are well-behaved little boys and girls who don't ask questions.

[@tomunderwood4283]

It’s almost like doctors have too much to lose if they step out of line. Also they have a mental superiority complex that they honestly don’t believe anyone else unless it comes from their medical board approved sources. They even see nutrition knowledge as beneath them.

[@ketolomics]

It makes me sad to read this. Sure, a lot of practitioners simply go by the book. But think of all of the practitioners whose curiosity has led them to new learning, like all of the nurses and physicians and dieticians whose experience led them to learn about and practice with ketogenic nutrition. I agree that I think having an engineer in the biochemistry research space is great. But that's in no way to take away from the accomplishments and contributions of the Eric Westmans, David Unwins, and so many more physicians who have shone new light on the many gaps between clinical guidelines and actual clinical results. As a statistician/research methodologist, my experience with students is that just about anyone with motivation can build the necessary foundations in chemistry, experimental design, and statistical analysis to navigate the content. Equipped with those skills, choosing an area of interest and then digging into the research literature in that area, as Dave has obviously done in lipid metabolism, virtually guarantees that you are going to identify substantive questions for new research. Maybe not something as profoundly impactful as Dave's project, but not every hit has to be a home run. While getting in is not prohibitively difficult (assuming you enjoy math and dissecting the methods and analyses of lots and lots of research studies), it's not what practitioners are paid to do. They are paid to test and treat. If they aren't scientists, it's not honestly their fault: they went into practice, not research. And of the practitioners who do pursue research, they are wise enough to recognize that some topics are much more likely to receive funding than others. This is where I think Dave has made his most monumental contribution: learn your way into the field and then choose a project that is not fundable by any institution, foundation, or company... but is so important to a specific collection of patients, practitioners and researchers that THEY fund the project. Wait, you did WHAT?! In the eternal debate over funding priorities at the NIH and NSF, not to mention all of the university funds, Dave gave us a clever alternative. In essence, if your research proposal looks interesting enough and useful enough and important enough to enough people, they'll fund it. It's staggering. And delicious at the same time. But remember: a lot of practitioners along the way are the ones who wrote the research literature that Dave is building on and adding to. Not to mention so many of the key members of his team. So let's give them a shout out, too!

[@rmgpdoc]

Totally agree. Conformists at the very best.

[@tamashumi7961]

​@@rmgpdocwell, the medical education and licensing system puts in place a filter that ensures other kinds of people wouldn't pass through. So no surprises we don't see them in the profession.

[@dbzgtcrazy]

Feldman 2024!

[@bigalharris]

Thanks for taking us on this journey with you. Such a wild adventure.

[@realDaveFeldman]

Indeed, it has been.

[@fbrhawk]

Wow! What a wonderful example of unbiased science. As an Alzheimer’s survivor, I am one of those who must stay ketogenic and should not take statins. Because it is only preliminary, this cannot be described as the last nail in the coffin for the lipid-heart hypothesis, but it is the FIRST nail😅 Thank you Dave for all of your hard work.

[@BeefNEggs057]

Wow this is great - my Mom recently died of Alzheimer’s which sent me down the keto rabbit hole. Do you watch Dr. Boz? She has some great methods for brain repair. Basically lots of fasting and almost no/low carb. Less than 20 total carbs (no net carb nonsense). I got off the nuts and feel much clearer in the brain - mostly meat/eggs and dairy.

[@mariawilliams2996]

Look up dale bredesan. Survivors of Alzheimer's is actually a thing. @@Feed_Bleed_Read

[@cyberfunk3793]

His own example described a little kid with high LDL and 0 other risk factors yet heart attack at 6. I would say the lipid hypothesis is very much alive and nothing in this study even begins to refute it. If these are 1 in 1000 genetics, how could the study ever answer anything about the general population? The study didn't even tell us if these people ever had any plaque or if they had had a 0 score all their life due to their genetics.

[@rhshrimpton]

​@@cyberfunk3793You've entirely missed his point. The "1 in 1000" are those with high LDL due to genetic FH. His study is of lean mass adults with high LDL due to intentional low carb dietary choices. The hypothesis is that high LDL in that circumstance is NOT atherogenic. Please keep up.

[@cyberfunk3793]

@@rhshrimpton What are you talking about?The LMHR is exactly the rare exception and with all the other criteria for the study group even the doctor doing the recruitment has admitted it was very hard to even get 70 subjects while they had screened lots of people.

[@ultramiddle4991]

I’m eating as a carnivore and thinking as a vegan doctor who would say (and has been said to me), “It takes 10-15 years for blockages to appear, this study is LESS THAN TEN YEARS. That’s when I told him that I had been a low fat starchavore vegan, eating meat and fat only when the pain was so bad I couldn’t work. I am thrilled at this prospect even though I am not a hyper responder; my total cholesterol has been 280s. I suppose that will give my doc a reason to say these findings do not apply to me. Ah, you would think finding a keto/carnivore doctor in Texas would be easy. ❤

[@karenrotzler1661]

We travel for hours to Houston (Webster), Texas to have checkups with Dr Nadir Ali. Well worth the peace of mind to work with a knowledgeable physician who continues to research even while continuing to hold down a practice. He is pretty amazing.

[@ultramiddle4991]

@@karenrotzler1661 Thank you so much. I’ll look him up

[@aztonyusa]

Dr. Ken Berry video on finding a keto friendly doctor in your area: kzbin.info/www/bejne/fnuUeJtnitt_b9ksi=FkM0P3EstRnCyKnM

[@realDaveFeldman]

A big reason for my drawing attention to Monogenetic FH vs LMHR is that the former show plaque development very rapidly. The girl mentioned in my talk was symptomatic at age 3 (not just appearance of plaque -- but appearance of symptoms, which would happen at very advanced stages of plaque). This is why the baseline data were so compelling given we had a 4.4 year at that LDL magnitude.

[@ultramiddle4991]

@@realDaveFeldman Gratitutde and support with my dollars 🖖

[@scoobtoober2975]

Dave is the steve jobs of the low carb community. The regular joe discussing high level matters in a way everyone can understand. Like apple, changing lives for ever. But with out that anti-right to repair non-sense. To say high fat isn't bad for you and why. to go agains the grain of fake science. You and may others inspired me to change my life one year ago and it has never been better. Thank you. Your talks about what happened with you and a few others was monumental to change the mind set. It's all of these regular joes getting problems and saying this isn't what the Dr said. It's finding the info for you on your own then telling the other joe's here's what my " " problem was. Thanks

[@w4rsh1p]

Fantastic! Also check the amount of n6 linoleic acid being consumed in their keto diets. It’s something we often forget about.

[@shellderp]

Amazing work Dave, this has the potential to be one of the biggest learnings for the lipid hypothesis in recent times. Crazy that this has to be crowdfunded and not paid through grants..

[@4bennybear]

Great news, can't wait.

[@reneebaker3749]

Mind blown, thank you!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!

[@AnitaCorbett]

Fantastic work ❤ And to the team and their families who I am sure sacrifice much too , a very sincere thank you

[@franklinbruce7121]

AWESOME

[@DJM8910]

Dave is a legend!

[@TheAstonGuy]

That is similar to my case! I am not on keto, but I eat healthy (usually low carb, no soft drinks, no sugar and processed food, lots of meat, fish, avocado) and my doctor when he saw my LDL-C told me to go on statins as my risk is severe. Now I am not against modern medicine but would like to make an informed decision. I am 46, 187cm, 80 kg, BMI 23, never smoked, always active (gym 2x a week, running 2x a week), blood pressure 120/80 (+-10), no health problems so far. My LDL-C was always on the higher side (runs in the family). Grandpa died at 86 (natural causes), Dad is 79 and still going strong, so no genetic disadvantages, no heart problems. These are some of my results: TC 271 , HDL-C 72, LDL-C 187, non-HDL 199, TG 60 apoA1 179, apoB 110, LP(a) 39, Homocysteine 9.49 umol/l, HbA1c 5.2% (34 mmol/mol), Insulin 3.38 mU/l, hsCRP 1.0 mg/L apoB/apoA1 0.615, TG/HDL 0.83 I 've recently had my carotid arteries checked and was told there is no plaque, no calcification, no narrowings. Maybe small dose of statins and see if I tolerate them? I am looking forward to see the results of this research, I am just worried that one year is not enough. Would like to see results after 10-20 years.

[@MrKanti-yy5ux]

True enough, but keep in mind this first study people were already on keto for 2-4 years (presuming consistency). So to come out with a CAC score of 0, especially for the older members of the study, is already pretty intriguing. If the risk of high LDL is really as severe as conventional wisdom claims, you'd think there'd be SOME evidence of endothelial damage.

[@sarahb.6475]

Well what is your resting heart rate? If its low it also shows no signs of heart problems.

[@TheAstonGuy]

@@sarahb.6475 my WHOOP tells me, that my average RHR for the last 6 months was 55 bpm.

[@Keithzzzzt]

Why would you want to go on statins if you have a zero Calcium artery score? You will wreck your brain , weaken your muscles and triple your risk of getting type 2 diabetes. The only benefit of statins is that they are mildly antithrombotic and anti inflammatory. Garlic does the same thing as does omega 3s and curcumin.

[@clyde9803]

You publish it. How likely is it the medical establishment can simply choose to ignore it?

[@karolinahudyma1383]

Thank you for all the work you've been doing!

[@larsnystrom6698]

We learn much! Eventually, the medical society will know enough that they will be better aligned with our preconceptions. I admit it. I'm not following my doctors well intended directions, and largely ignoring the measurements they focus so much on. Of those, I only care for low triglycerides and high HDL. Looking forward to see the study published! You, Dave, are doing great work!

[@realDaveFeldman]

This is beautifully said, @larsnystrom6698 -- I likewise feel the vast, vast majority of doctors are very well intentioned, whether the markers being focused on are as relevant as currently assumed. But again, we always needed research like this to help get us here.

[@stanroberts229]

You are always thought provoking! I like that!

[@scoobtoober2975]

I've run into two sky high lean MHR people. They are very high strung and energetic. There's a lot going on with them And man they would make some good distance hunters and endurance athletes. My aunt is one of them. She is an energizer bunny and eats low fat and say's if i eat fat my cholesterol goes sky high. I'll await the data to send to her.

[@watcherworld5873]

My extremely high LDL since I reduced carbs got me really worried. But, I had very high HDL and low triglycerides levels. Last few months, I was eating more carbs, and as expected my LDL went down. What surprised me was that my HDL only decreased a little and my triglycerides increased a little. I will reduce carbs again, but not attempting to get to zero like before.

[@CashMoneyMoore]

I'm a little confused because the reference consortium study appears to be a CAC study and we are looking at non calcified plaque. Guess i'll have to wait for the papers. Still stellar results though!

[@realDaveFeldman]

I don't think I articulated that moment as well as I could have. Budoff was going to show me both CAC and TPS (Total Plaque Score, which includes both calcified and non-calcified). So when he showed me the CAC first and I knew it would be comparable to a "0 Risk Factor"-like group (such as that from the CAC consortium), I then just felt confident the TPS slide he'd show me next would look comparable to the CAC one -- as in, we'd likely have majority with 0 TPS, some with moderate, and a handful with high TPS (such as 4 or 5 with double digits, probably one or two in 20s or higher). But instead the TPS chart had only single digit TPS for all 100 participants, a majority at 0.

[@crimpers5543]

I'm not convinced this study is sufficiently long enough to draw a conclusion. It only shows this group of people do not develop calcified or non-calcified plaqs according to the known rates. It could also be that they are very slowly forming plaques. What were the ApoB/LDL particle counts? Those are the numbers we need to see. If every single participant had low particle counts, then the data just further strengthens the particle model.

[@hugoanderkivi]

@@crimpers5543 The numbers are irrelevant, set by the genes that respond to the environment they are placed in. Bart Kay talks about this in-depth.

[@Mar.Lop.]

Thanks 🙏❤

[@WickedLowCarb]

Dave, can you explain where/how ketones fit into the lipid energy model? Congrats on how your study (soon to be studies) are going. You are tenacious on this subject and many thousands of us appreciate so, so much what you are doing to further our knowledge of our health.

[@bruceprigge5212]

Thank you! :)

[@robertsimpson2177]

Had heart attack June 5 2023.. male 72 …6ft 2…166 pounds…cholesterol 140, ldl 90, hdl 30, triglycerides 300

[@michaelgalloway8786]

Fits the picture, low Hdl/ high triglycerides!

[@RIP5582]

Wow. I am both amazed and humbled. Thank you for your effort; for putting your abilities to (good) work.

[@scott-unretiredcarnivore]

100 thumbs up

[@thecovering]

Absolutely ground breaking stuff here Can't wait to see what's to come Many thanks Dave

[@Edwards87]

The David vs Goliath vibes are amazing. Really excited for this citizen science project and looking forward to it’s findings ❤

[@laural1543]

My money is on you Dave!!

[@leojleoj]

This absolutely sensational and should be headline news everywhere. With CAC that low, keto is not just good for maintaining CAC levels. It seems like it is actually reversing or curing it.

[@cyberfunk3793]

Reversing and curing it? 🤦🏼‍♂ How do you know what it's doing when you have no data on these people? Perhaps they had plaque at some point and the diet actually fixed it, or perhaps the thing that makes these people 1 in a 1000 also caused them to never have any plaque to begin with and they would never get it no matter diet? You obviously need people with plaque first and then monitor them to see and from the heart attacks I'm reading about with people on carnivore, I'm not very optimistic. And if this study tells us about the 1 in 1000, it doesn't tell much of anything about the 99% of the population then.

[@1st2nd43]

​@@cyberfunk3793but the idea is they through conventional medicine is that people with high levels of LDL are at risk for plaque development right? Under that presumption, they are already by default should have developed a higher CAC than most of the population.

[@tyvrymch]

Rock on Dave!!!

[@SLPCaires]

WOW!!

[@dillardsiji]

fantastic work!

[@sandyglover736]

This is so encouraging!

[@victorhauk5973]

I am a 71 years old man who has a long history of CVD. Started low carb 7 weeks ago and I’m hoping and praying for a reversal of my disease. Hmmmmm…….

[@johnny7808]

nothing good happens without reducing that waist and crp back to youthful levels. That is the standout feature of this group - their waists and crp are like a teens

[@victorhauk5973]

@@johnny7808 lost 20+ lbs in 6 weeks

[@aztonyusa]

I suggest you follow Dr. Ken Berry, if you don't already. He has lots of videos to help you in your low carb/keto/ketovore/carnivore journey. I'm also 71 and have been doing low carb for 4+ years. Just stick with it, get rid of all the grains, sugars, vegetable oils, and processed foods. Read the ingredient label on everything you buy. The hardest part is changing your thinking from what we were taught about what not to eat, to now eat it. Also, don't eat by the clock. Eat when you are hungry and eat until you're comfortably full so you won't snack. Eat enough fats and p;rotein at your meals. Integrate intermittent fasting into your eating routine. kzbin.info/www/bejne/fWmodpefZr2Ki5osi=JsaCmLx3uiHTrB6y

[@databoy2396]

Yeah, Dave!! 👏 Keep up the amazing work!!

[@Mee0tchy]

Hey Dave, can you please clarify exactly what tests are being done during the "scan" at baseline and then at 1 year? It is my understanding that CAC scores of 0 are fairly common in healthy people so I am hoping the testing takes this into account. Cheers!

[@crimpers5543]

Yeah I was hoping there would be the gold standard measurements of CT angios. CAC are known to be unrealiable, someone with 0 CAC scores can still have problems because there are soft plaques that will not show up in CAC but there still could be diseased arteries.

[@droolian01]

I think he said they were measuring NON CALCIFIED plaque, CAC measures calcified plaque. The expert with Dave (can't remember his name) is a recognised authority on this type of measurement.

[@defdaz]

Holy shit! Congratulations to everyone involved. This will be life-changing.

[@LVQ-so5th]

Another group that might be worth studying in the future are those who had a major heart attack, and then became LMHR afterwards because of adopting a keto diet. This population is known to develop plaques, but can they prevent new formations? Do they have better prevention of secondary events than those who don't adopt a keto diet?

[@PorcupineMusic]

@realdavefeldman you are a damn mensch! Thank you for your hard work. So many of us have been following you for years and have been waiting for data like this to validate our choice of lifestyle. Keep up the great work!

[@wocket42]

Ground breaking

[@teragram50]

How does one get into the study?!!!

[@coreysmith3438]

I just started doing keto, I am a lean 37 year old. BMI 21. TBD if I will end up being a LMHR, I plan on staying with diet as I already feel great, have more energy and simply find it to be a healthier option than the SAD. So far LDL is 178, HDL 44, Tri 74. So don’t quite fit the triad of LMHR, but LDL is high already. This was taken only 9 days into keto. Wish I did blood work before, but will be interesting to see where I’m at in 3 months when I do another lipid test

[@Roberto-cg2gr]

Hope more foundations will support Citizens Science Foundation

[@arthurdinucci]

'kin amazing - where do I sign up?

[@benfmd]

Great work Dave! I was wondering if you could expound a bit on the pathophysiology of the abnormal lipid metabolism in monogenic homozygous FH. Why is it so different from having high ApoB in LMHRs? Thanks

[@sarahb.6475]

A short while ago I watched a video by Dr Berry and he mentioned something called "Fibrinogen Factor VIII" which causes clotting. Maybe that is it???

[@1st2nd43]

​@@Feed_Bleed_Readso what's the proper diet to you and why do you criticize the study? It's a pretty compelling study, even if he cannot link or answer that question (at the moment). The evidence still shows that high levels of LDL is not correlated with plaque builld up.

[@peregrinuslohr5512]

Congratulations!! Great news! Thank you for asking questions and seeking answers!!

[@dkhallal]

How do I get in the next study group?

[@danielrichwine2268]

I wish I had been able to be a part of this study

[@btudrus]

I predict that at the end of the study next year (feb 2024) the big majority of the participants will have the same or lower plaque score... It seems pretty obvious...

[@떡볶이나리]

I wonder what Peter Attia might eventually say as I know he is very much opposed against what Dave is saying, assuming we can get enough research done to actually prove that it is in fact not as deadly as some say.

[@nataliajimenez1870]

Some stuff seems obvious, but when you are battling very entrenched interests (and statins are a trillion dollar industry for Big Pharma), you need to show the results of well-conducted studies to chip away at the dogma

[@btudrus]

@@nataliajimenez1870 I don't argue that...

[@larsnystrom6698]

@btudrus Don't forget that there's a correlation between high LDL and arteriosclerosis. When we are convinced that high LDL isn't the cause, we have to look for the real cause. We aren't finished with this, even if these studies gives us more knowledge. Or perhaps, corrects faulty knowledge.

[@btudrus]

@@larsnystrom6698 "Don't forget that there's a correlation between high LDL and arteriosclerosis." Correlation is not a causation. And the mechanisms how a defective mitochondrias cause both, high LDL/TG and insulin resistance which in turn causes atherosclerosis. It all comes down to a mitochondria spitting out citrate in large quantities because it is unable to burn the substrate for energy. The citrate gets converted into AcetylCoa in the cytosol and further gets converted into both, triglycerides and cholesterol which got exported out of the liver as VLDL and later converted into LDL. There you have the atherogenic dyslipidaemia. At the same time, citrate activates the Randle cycle which manifests itself as insulin resistance and causes hyperinsulinaemia. High insulin makes the immune system dysregulated and ineffective. This is the root cause of atherosclerosis. Also it seems that mitochondria spitting out citrate contributes likely to the activation of the Warburg effect which not only causes cancer but e.g. also exists in fibroblasts which prevents the resolution of fibrosis.

[@mymomsoldlandcruiser7220]

I'm 56 and would participate in your study.

[@garyroach8624]

I had a CAC score of 110 in December 2020, i have had another Cac score completed recently at 277 so I was a bit shocked, I have been doing Keto for 2 years and I am probably a LMHR 65 years old 170 cm and 67 kg, I have had full blood analysis recently which were perfect low Trig, high HDL, no inflammation but high LDL. My cholesterol HDL ratio is low at 2.5 and states " Low CHD risk". blood pressure is around high normal 140/90. some times over but mostly under so a bit confused ?

[@tomunderwood4283]

Fetuin-A will clear out calcium from arteries. Vitamin D increases Fetuin-A levels in study. Test your Vitamin D. These are also associated with clearing calcification per Partrick Theut. (Search for podcasts with him as guest) Do you get 10-15 minutes of mid-day sun? Do you take magnesium? Do you get vitamin K2 from food or supplement? Do you eat food with retinol (vitamin A). Do you avoid seed oils? Do you manage stress and reduce cortisol by being active?

[@AsdqwdAsfdqw]

What is your Lp(a) score?

[@jeff911rn99]

My understanding is there is a delay between non-calcified plaque and calcified that show on the CAC.

[@garyroach8624]

Lp(a)

[@garyroach8624]

OK I will have that checked, thanks for you input.@@AsdqwdAsfdqw

[@danielbrown8105]

how do we contribute to the next study?

[@davidcottrell1308]

Dude!

[@Roberto-cg2gr]

Have a Mendelian Randomization for insulin resistance on All cause mortality compared with APOB

[@biodivers5294]

Congratulations! Early data, but very nice early data 😃

[@vivianhudacek1556]

Just had an APO-b test,134 “very high”. My other results fall in line with LMHR. Should I disregard the APO-b? Love this video!

[@DK-pr9ny]

From the title I thought there would be more info on ApoB..

[@tms6565]

I've got high ldl, triglycerides 60 , hdl 60 , low hs-crp & insulin sensitive...but my apoB is around 120...should i be worried ?? Oh and 5 years ago my CAC was zero but now it's 7.

[@LowCarbLowDrama]

kzbin.info/www/bejne/g4nOdmuVg8l0r7M

[@MOAB-UT]

HELP NEEDED PLEASE. Can you please help me understand something? My Tri is 48 (scale is 60-150); my HDL is good, 75. My LDL is 127 (high). Ratio Tri to HDL is 0.64. My BP is perfect and BMI is a very low 20. I run a lift a bit (not excessively) but cannot gain ANY weight. I lost a gallbladder a few years back so maybe fat absorption (A,D,E & K) is an issue. I take a Dig. enzyme. I also think I have a fast metabolism after trying IF 18:6 just to try it. Lost 10lbs I did not need to and could never gain it back. I am going to a Cardio and a Gastro doc(s) tomorrow basically for check-ups. Are there any tests that you can please recommend? Also, any thoughts on my health picture would be very much appreciated. I have energy and feel mostly good- just too lean and heart disease ran on my fathers side. He died younger than I am now. Am I a LMHR? Thanks again!

[@mikewagenbach1787]

What would the equivalent of a CAC Agatston score in the 30s (single spot of calcium in one coronary artery) correspond to on the 0-45 scale?

[@realDaveFeldman]

It depends on a number of things even to work out the correlation, such as age, sex, etc. Ideally, one would simply get the CCTA directly to find out.

[@BeefNEggs057]

I’d love to know if anyone in this study was on statins in the past. I’ve seen some research saying statins promote calcified plaques. Stable plaque but still it’s promoting plaque. I was on a very low dose statin for years. Stupid me for listening to my doctor.

[@AsdqwdAsfdqw]

What Lp(a) and apoa does this cohort have? No mention at all - what? Its an essential metric I'd say. Maybe this cohort has zero apoa proteins or high?

[@bomberman21321]

What is essential about it? Most of the cholesterol causing heart disease hypothesis is BS anyways. Correlation is not causations.

[@Aquapumpkin]

Is high protein on low carb diet bad? (I like eating 4lbs of meat a day😢)