David Sinclair Is Extending Human Lifespan | Rich Roll Podcast

David Sinclair PhD is a biologist and Professor of Genetics at Harvard Medical School, co-director of the Paul F. Glenn Center for the Biological Mechanisms of Aging and author of the forthcoming book "Lifespan: The Revolutionary Science of Why We Age -- and Why We Don't Have To".
This conversation is about the science behind aging and David's research on the biology of lifespan extension, treating diseases of aging and extending human lifespan.
Note - this is AUDIO ONLY (we didn't film this podcast)
Enjoy!
✌🏼🌱 - Rich
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Hi I'm Rich Roll. I'm a vegan ultra-endurance athlete, author, podcaster, public speaker & wellness evangelist at large. But mainly I'm a dad of four. If you want to know more, the NY Times wrote some nice things.
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[@dalekirkendall5283]

I am 86 , retired, healthy also have some aches and pains, mostly from a bad auto accident .I am finding out that I am tired of being retired, it is boring, I want to start a new adventure , a new carrier, I am starting to do what Dr. Sinclair is talking about , I think there are a lot of people out there who would be bored and want to help to make the world a better place , to feel useful again, if they could reverse their aging and be young again.

[@jamestowey1183]

Do you take any NMN or Resveratrol?

[@jamestowey1183]

@Wuotans Krieger oooh what a prick

[@lightning4457]

@Wuotans Krieger Ironic that a useless amoeba like you says that. I contribute more to society in a single month than you will in a lifetime. Judging by the fact that you spend time trolling people instead of trying to make discussion, you are a loser and a nobody.

[@xino_z]

Dale Kirkendall best wishes in your pursuit!! 😘👏

[@jonanderson6882]

Set a goal and make it happen. Our elders are invaluable.

[@yamishogun6501]

4:45 why Sinclair went into anti-aging field 12:30 university and M.I.T. with Leonard Guarante 20:00 longevity sirtuin genes in the 1990s 25:00 the epigenome 32:23 NAD+ and NMN 39:53 what are Sinclair's anti-aging drugs goals? 45:23 NMN's effects on old mice and humans, blood flow 49:23 effects of boosting on the mitochondria 55:05 resveratrol 1:03:20 going out to 100 1:05:05 intermittent fasting and exercise 1:18:54 mtor and rapamycin 1:21:05 mimicking exercise 1:35:30 people will be living into their 100s 1:53:00 how humanity might change with 150+ year lifespans 2:01:50 Sinclair's advice for better health; NR and NMN supplements that raise NAD+

[@kiim81]

,

[@kiim81]

Jzja

[@OfftoShambala]

Thanks for the list!

[@jamestowey1183]

Great job bro. Well done x

[@melaniel7263]

yamishogun Enormous thank you 🙏

[@nternalPractice]

I've seen dozens of interviews with David Sinclair and this is by far the best one. Virtually every question I have got asked and answered in the interview. Bravo Rich!!!!

[@dcole7092]

The Area of how inflammation effects longevity was not discussed enough.

[@soulsurfer639]

@@dcole7092 also, would be great to know which Resveratrol to buy...

[@dianibutchart5824]

I am 70 and have practiced only eating when your hungry missing meals drinking apple cider vinegar etc I am also a long time meditator so I look in my 50s that’s others perception. So it works!

[@StarCoded]

For information of readers -- ONLY drink apple cider vinegar AFTER you dilute heavily with water.

[@soulsurfer639]

@@StarCoded Yes!!! I thought you were supposed to drink it straight and it burns your lungs lol.

[@dalekirkendall5283]

David, God Bless you and your kind heart, Keep up the great work. Thank you! I am 86 and I have always planned to live past 150, I am watching your podcasts everyday, and starting to do what you talk about.

[@jaypepito8176]

It seems you did not listen to the podcast. People have the tendency of having fewer children as population grows so no overpopulation will happen

[@aaliyahlee1265]

I have been watching Dr. Sinclair's interview and this is the best so far. Very informative conversation. His book is also very educative. I love that book. In there, there's no point increasing lifespan without healthspan. The goal should be to live longer while staying young and healthy. Sinclair believes that in the foreseeable future, it's possible for humans to live beyond 120 or even 150, without the frailty, diseases and disability we now associate with old age. I hate aging and the illnesses it brings over time. This is why I am now taking NMN supplement by Vitruvin constantly.

[@amberskies5287]

I'm happy to come across to a Vitruvin user like you... I hope to hear the same results in the long run. 😇

[@vegains]

just listened to it because you recommend it in your recent part 2 podcast and I learned so much. Thank you! Gonna read his book for sure

[@kmichalene]

This is such an interesting and intelligent conversation. Thank you so much!

[@tejaK]

What an amazing interview, thank you, Rich,, thank you, Dr. David Sinclair, you rock! xx

[@derektheodore3032]

Fascinating research & fascinating discussion. Good job Rich!

[@Libertas_P77]

Really interesting from 1hr 30 onwards when you got onto challenges around the philosophical and practical challenges of population increase and so on. David Sinclair more impresses with his fully rounded perspective on the work he is doing and likely impact.

[@NikWeber.]

No matter how long you live it's trained mindfulness which really makes each moment come alive and more enjoyable. For that Thich Nhat Hanh is the master to learn from. My takeaway is to up my lvl of exercise and to keep improving my 8-year experience with a healthy and fresh, highly varied plant based diet. Other than that I will try to get more hungry more often. I will keep going with my cold showers and my intermittent fasting regimen and will try more regular sauna.

[@RogerioRios]

Great talk! Thanks for uploading.

[@jaywallcreeper]

Im listening to all the podcasts with dr Sinclair. Now I think Ive become addicted to his soothing voice apart from being fascinated with his work :)

[@MightyKern]

this was a fascinating podcast. thanks!

[@idrennelim-alparaque7174]

Wow ! Such an awesome conversation ! Dr. David Sinclair and Rich Roll you are the best interviewer --- thanks for asking the " layman's" question and " translating " for peeps like me the highly complex scientific terminology --- breakinf it down to practical lay person's language.

[@flornitacobile9808]

Brilliant Ideas; God Bless You Dr. David Sinclair

[@karim111]

great interview, fantastic topic!

[@MyLongevityExperiment]

Thank you for taking the time to meet with David Sinclair and sharing it with the world too.

[@silvio.r8443]

So good! Loved this.

[@rachelstark8002]

I love every interview of Dr. David ever since he started discussing longevity. I have also acquired his book "Why We Age and Why We Don't Have To." That book is eye-opening and educative. In there, there's no point increasing lifespan without health span. The goal should be to live longer while staying young and healthy. Sinclair believes that in the foreseeable future, it's possible for humans to live beyond 120 or even 150, without the frailty, diseases and disability we now associate with old age. This is when I found my NMN supplement, Vitruvin Nutrition 500mg/day. I want the world to know that we only live once, let's live a little longer.

[@firehorse_44alpha-omega]

There you have it people. Right from the pioneer of aging reversal. What you put in your mouth and getting active is key to longevity. Take personal accountability and make your life all it can be. Omit high fructose corn syrup... A great start ...... Thank you for your life long dedication to helping our children Mr. Sinclair.... Cheers

[@MyLongevityExperiment]

Eat clean, exercise regularly and supplement what you can't get from whole food.

[@sheripalmer3192]

Wonderful and informative as always!

[@akimexgreen5841]

David is a lovely man, and what he is trying to do for humanity is just amazing 👏

[@rl7012]

If you think doling out misinformation is helpful, then you need to raise your bar.

[@LP-lm3by]

A wonderful podcast with a wonderful man.

[@MyLongevityExperiment]

A great subject to cover.

[@LP-lm3by]

Just unfortunate that he mentions eating a steak is the worst thing you could do..ONLY on a vegans podcast. He never mentioned it on Joe Rogan's podcast or others I have heard even when he is specifically asked what they should do to stay looking young.

[@lisengel2498]

I love the optimistic vision you discuss in the end of this very interesting podcast. I am deeply convinced that people with a vision Will continue to be active and that wisdom can change the Way we understand and interprete life and possibilities 🎵🍀🎶💚🦋🙏

[@Liberty309]

Next 10 years is going to be amazing 😀

[@kevn99]

Liberty309 I doubt it. Probably 25 years before age reversal is available to the masses if we are lucky. Ill be 77 😖.

[@Liberty309]

@@kevn99 Eat healthy, and exercise and we'll make it. 😆😆😆

[@dream1430]

Kevin that’s cutting it close , good luck man

[@squamish4244]

I'll be 65....hmmm... We'll first start to see weirdly young-looking billionaires that just seem to keep going.

[@kshonkinite]

It will be amazing. because its already amazing. .

[@wmp3346]

Thanks for your time Mr Sinclair - very informative - also a nice job by the host Rich

[@premierbike4268]

I have been on NMN and Resp. with vegan diet and B12, D3, PQQ supplementation for about 15 months. I cut out alcohol for that 15 months and exercise a lot. My wife and I did the Dr. Longo fast once back in April 2019. Last year was the best year of my life for training and general health. All my markers are good for a 60 year old. I went off everything for one month (Dec 2019) after completing Ironman Cozumel and felt like (I used to). Now back on the program and look forward to getting back to training.

[@jonash226]

What’s nmn and resp

[@user-qu9hn5su5j]

so enriching thanks a lot

[@dennisfink2619]

Great work Dr. Sinclair! I was very interested to hear you are working on iPSCs like the Belmonte group. If selling a house were not so expensive I would apply to the PhD program there and come help! My MS in biochem. is pretty rusty (1988) but I've been thinking of helping out on the aging/health-span work as my 5th career (20 yrs. USAF/pilot, taught chemistry/biology many years) before I hit age 76 next summer! I'm 6 hrs. SW in Reading, Pa. w/ no comparable school in the area.

[@michellegrantvaughn1561]

Loved this conversation.

[@palecompass3598]

Great podcast!

[@EddyTritten]

This podcast is my only food, I'm gonna life for ever !

[@glennrobinson7193]

Doing hard PHYSICAL work(I'm 65, a window cleaner), not playing with a computer mousse all day, I believe helps too.

[@brianhickey666]

Imagine your parents are still around, or your grand parents. How amazing would it be to have four generations healthy and around. That maybe in the very near future.

[@albertmarble]

As long as those relatives are decent people, it would be fantastic. If they are a bunch of abusive narcissists, it’ll be a nightmare.

[@71whitey]

@@albertmarble like the dreaded mother in law!!

[@AnkitYadav-td6mg]

@fortnite4201 x 😂😂

[@LC-bn4fo]

yes! lots more people around to fight and argue ;-)

[@jonzerr]

Oh Jesus ... my dad will have time to start his 4th set of children. My children will have their own children plus baby aunts and uncles.

[@matthafer2415]

In Huxley's Brave New World they talked about about shortening the disease phase at the end of Life, something like people don't wilt with old age they snap and die quickly when the time comes

[@Owl-of-Minerva]

In Huxley's "After many a summer dies the swan" a millionaire travels to England to meet a nobleman who figured out how to extend life. When he finds him, the nobleman had turned into an ape.

[@sidilicious11]

What a FANTASTIC interview and discussion! I always thought it was ludicrous that we get to an age where we are wise and experienced, and then body starts to fall apart. Crazy! I had no idea that an aging drugs and research were so close at hand. I'm 64 and looking forward to the drugs, as long as they are safe. Meanwhile I should eat less and exercise more. Also I see that pet lifespan will also be increased, making dog owning a lot less stressful! Maybe when we know we can live a couple hundred years we will be much more careful about preserving and healing our beautiful Earth environment. And also be much more responsible about procreating.

[@MyLongevityExperiment]

The supplements NMN, NAD+ and Resveratrol are now on the market, check out Joe Rogan #1234 where David Sinclair talks about how he takes it.

[@OrasSelection]

Maybe I am 3 years to late listening to this. Maybe not. As I have said before to those who will listen and learn... It's never to late with life as we know it until you are in your grave. Love Words of Wisdom

[@gavmegs]

Thank you good man .🇦🇺

[@aurorasanchez7922]

Wow! You are amazing.

[@toyknitter]

You were going to leave some information about Resveratrol in the show notes but I can't see it. Interested to know what brand and source for what you are taking. Thanks

[@sammcrae8892]

Yeah! Me also!

[@soulsurfer639]

Thanx for mentioning, still don't know which is the best one...

[@Kit-o-matic3000]

Still waiting for the link!

[@ThatMountainMoment]

Thorne Research Labs has one of the better resveratol supplements available. It's very pure. Third party tested and noticeable in its effects after a couple weeks of taking it. It's also combined with the Quercetin that Dr. Sinclair also praised. I'm not sure if he backs this company or not but it's a very reputable company backed by other brilliant minds su h as Dr. Rhonda Patrick who's also been on RR multiple times.

[@ninjashhh8344]

Were these your questions or questions he told you to ask? You asked great questions, and gave good analogies. So far 1hr it's an awesome interview. I'm hoping there r a bunch of action steps coming. Thanks 🤙😎🤙

[@ninjashhh8344]

@Mike Haydon Yes, I will be scooping it up for sure. I'm always down to support positive people like this guy! Not to mention, there's gotta be some golden nuggets in it.

[@paullemay3218]

Thank you for sharing another great podcast. 🇨🇦😎

[@lilykhan11]

Great Info

[@anamayorga8988]

Thank Dr David Sinclair ALL THE INFORMATION ABOUT THE NMN IS PERFECT BUT IT 'S VERY IMPORTANT TO KNOW HOW AND WHERE WE COULD BUY THE NMN . PLEASE DR SINCLAIR SEND US INFORMACIÓN ABOUT IT. THANKS.

[@ryanwilliams9644]

How is it changing your life?

[@indigopisces]

Diane Williams what brand of nmn did you purchase from Amazon? I was looking at them tonight and not sure which to try. Thank you!

[@normajanedehoag3660]

I am 74 no ache and pain but with asthma under control. My mom is also an ashmatic but her asthma disappeared 98 yesrs old

[@D.Rothchild]

So these supplements he’s mentioning needs to be taken everyday? Or every other day?

[@zzzabi1]

Are they using sound frequencies to turn it off and on? 🤨

[@samantha-kemp-therapy]

fascinating

[@tubevalve8366]

big, big business coming...and Dr.Sinclair pitches the concept.

[@freedomchannel3656]

Wonder what Sinclair's stand on adjusting hormones to optimal levels such as human growth hormone & testosterone to help slow or reverse aging.

[@LL93]

Yes

[@stevelk1329]

Fun fun fun. Thanks for enlightening and uplifting podcast . Sounds like great stuff. Lots of risk. Don't know if David is all he says he is or knows all he says he knows or how much of it is true but it seems to all line up with my own superficial look-see over the past few years. Again, giving I don't know him, I like his attitude and his humility. A little worried he is a little presumptuous. In this case it may be warranted :-) Usually isn't though. For example maybe some people would prefer to live to 60 with lots of muscles than to a hundred without them. Might even be the best thing for them... In this case - in a unique case like this - it seems that philosophical implications can affect humanity not unlike hard science discoveries, and so must be identified and then weighed carefully. Presumption eventually leads down blind paths.

[@kyleganse4978]

He was on Joe rogan and that podcast I believe he explains his background in the science far better then this. Second I agree him explaining the benefit/cost of certain diets and supplements is just opening an avenue for people to choice how they want there life to grow. I imagine a society where many will live longer as this data is harnessed into better information, then they will live longer but we all be different as a species.

[@videosforcatsanddogs214]

I think Aubrey De Grey has a better plan for ending aging actually, but David Sinclair is a much better salesman. That is why the masses listen more to David than Aubrey.

[@JamaaLS]

45:54 "Is this cool?" LOL. I love it!

[@theresarose-ham3350]

Interested in trying some of these pharmaceuticals. What is the cheapest/basic starter kit for this( if there is)?

[@jimyost2585]

My mom lived to be 93 years old. For the last two or three years she would sometimes say "We're living too long." She was in a fair amount of pain and discomfort most of the time from arthritis and allergies.

[@StudioSilver]

The link to the reservatrol you mentioned in the interview? Ty

[@renatewinter8631]

look for resveratrol

[@tabormiston5054]

I remember asking my parents at age elleven, about why are we going to die? It scared me.. im now 59 and about to turn 60 September 7th 2019..wow I cant believe it..

[@MyLongevityExperiment]

Time waits for no Man! Do you feel 60?

[@fergusmoffat8926]

Death is an illusion don't worry

[@fergusmoffat8926]

@Papaya Tasty wow that was such a synchroncity , i was literally thinkng about reincarnation then i saw this message

[@fergusmoffat8926]

Youve probbaly been born and been young and then grown old hundreds of times and youll be young again , give 15-20 years- reincarnation

[@nahidbodiz7053]

Happy birthday

[@smarthalleck3233]

Hello Good Sir, What is the relationship between NMN and Nitric Oxide? Cheers Daniel

[@Venus.actor.singer]

Adam in the bible died at the age of 930 years old and his descendants died at the age of 800 to 700 to 600, etc and Joseph died at the age of 110 years old. We will be lucky to have Dr. Sinclair help us live up to 200 years old with this poluted and processed food world.

[@sara76201]

I wish my mother lived little longer I am so heart broken.

[@haddynough8402]

Me too.

[@melaniel7263]

Sara singh Sending you love 💖

[@xino_z]

Sara singh I'm so sorry!! 😘❤️😍

[@gracetoglory5020]

Sorry 🌷

[@gracemcalpin271]

Thank you sir david you are awesome, atleast somehow my worries of getting old diminish abit, iam 49 years old I hope and pray for your success,specially on longevity matter.😊😊

[@mikepict9011]

Ascending to infinite enthalpy and energy, perfect balance of energy . Or perfectly controlled imbalance. Or perfectly observed imbalances. Or no observer and just flow

[@ravensheat4life]

r/longevity is a great place to discuss this topic for anyone interested

[@NadinaRama]

Great tip! Thank you.

[@MyLongevityExperiment]

I'll check it out, thanks.

[@rachelaronoff387]

the idea that epigenetic marks are lost upon DNA repair is excellent and the research looks great. One simple way to think about it all is that it's all about dynamic genomic integrity, and who needs NMN (or NR)?? -> if you can get B vitamins (niacin, remember is B3), have enough Magnesium (just the simple salt is fine) and anti-oxidants, and move a bit... just imho! ageing well for all is a great goal (not just looking for new things to market to the masses)! Take care!

[@belikewater7717]

I’ve not yet come across this question .. Has David Sinclair tested himself daily to monitor his level of NAD when using metformin, Resveratrol, and NMN? It would be good to know if one dosage kept his levels up for just only the day or a few days.. obviously everyone’s chemistry is different but it would still be a good measure to know. Thanks!!

[@Frogman214]

From watching previous and newer videos with Dr. Sinclair, he's been taking NR or NMN for ten years now and his 23 and Me test revealed that he biological age was in his late 30's or so if I recall correctly. The $64K dollar question is, how old are those mice now? How long did they live? Especially the treadmill mice!

[@albertorufinomartinez1387]

How do we get into a program of sort to start? GOD Bless Tito. From Las Pinas City, Philippines

[@indigopisces]

How fascinating, and exciting! With Uranus in Taurus for the next approximately 7 years , we will see many many breakthroughs in the field of regenerative health. I think we are on the brink of discovering and understanding many secrets of human life. Hopefully we will make the best of it and use our energy to expand our consciousness and develop the virtues of peace and love as a society.

[@sirt1353]

I don't really understand what I can concrete do to combat aging, or my most important issue to regrowth hair: Will reservatrol help? Fasting and sauna? What else can I do based on this knowledge?

[@StarCoded]

HIIT (easy but most effective exercise). Only pure water (no fluoride and preferably no chlorine) -- buy "cosmic stones" and "prill beads" from Global Light Network online. Also buy their Miracle II 'soap'. Give up wheat and processed sugar. Give up all pharma drugs, they're harmful and not needed.

[@SpyderDobro]

Special interview

[@Anastasia91000]

Please tell us what you ingest or drink on the days of no food....

[@martinsinclair55]

A. We'll have to forget about retiring at 65. Maybe 140. B. Our old age security fund is going to run out of money. C. I'm going to get a lot more motorcycle riding than I had figured.

[@haqk4583]

A. We'll retire earlier due to AI & automation. B. We'll get the UBI. C. You can ride your bike as much as you want.

[@brianhickey666]

B will be saved by less health care need

[@MyLongevityExperiment]

Who needs an old age security fund when you got wheels and years!

[@yamishogun6501]

C. You can ride on an automated motorcycle longer than you thought...

[@DonutAgain]

related?

[@rainrain5593]

Why do you dose with the precursor NAD, which has no studies, rather than NAD which has multiple studies? Thanks. I dose with NAD.

[@Kzombie]

I think about it almost everyday at 30

[@lyfeproof53]

What a fabulous video, very informative

[@laserloui2008]

One interesting thing a friend of mine mentioned when i told him about all that stuff in relations to not only expanding the life-span but the health-span as well is: All the years of struggle we currently have to go through, the period of morbidity, getting hit by one desease after another, getting weaker and weaker and so on actually prepare us for death. At some point we just die out of resignation, no longer able and or willing to keep up the fight and we actually feel relieved of letting go and saying goodbye, knowing its for the best, its time, its all good. As David mentioned, by pushing the tail end of the vitality curve as far out as possible and when you are 130 you get sick for 1 week and you die would most likely result in people not getting confronted with their own mortality that much at all, clinging to life and their vitality and actually getting surprised of things ending so sudden. Not being able to make their peace with it. Our life-span increased by a lot and i guess its fair to say that our health-span couldn't keep up and therefor increased the period of morbidity. So shortening it would be surely a good thing. But shrinking it down to a week seems a bit too much and would result in other problems, as mentioned.

[@Elayman1]

Most people are probably going to want relief from their own restlessness and vitality after 130 years -- but telling them to just go kill themselves when they have had enough is not going to be an acceptable answer either.

[@noumay]

What are the concerns of increasing NAD and it’s relation to cancer?

[@ubself]

I don’t see the link for resveritrol mis spelled or brand ??????

[@mrugendrapatil4356]

If we stopped taking NMN and resveratrol, will that have reverse effect?

[@halneufmille]

I'm 38 and depressed. When I was happy, this research inspired me. Now I don't care and I don't expect to live very old.

[@haddynough8402]

halneufmille aw😚

[@fionabell1744]

Concentrate on getting over ur depression. Theres alot of research on the net . Good luck

[@ChildofGod124]

Yet somehow through gods grace you ended up here. Coincidence- I think yes ❤

[@Cristoforo80]

So at this point the question is: How do we determine the levels of "healthy" stress (hormesis). If we overdo this, we will do more bad than good.

[@Elayman1]

It is a vital question. To use the example he discussed, fasting decreases fertility in women because hormones that regulate ovulation and probably other functions are incredibly sensitive to energy intake. On the other hand, NMN that is activated by exercise or fasting also has the effect of erasing symptoms of menopause and restoring regular monthly cycles, potentially making it possible for older women to become pregnant again. All we can do for the time being is regular blood testing to track biomarkers that may be thrown out of range by any of these techniques or supplements.

[@betzib8021]

@@Elayman1 well how confusing...can a super skinny person with little muscle fast do you think?

[@lauraholmes9353]

betzi b yes, I do. As long as you ingest healthy fats and nutrition when you do eat, then you should be fine.

[@dcole7092]

Good discussion. One clarification in your Dad's Story on the reason his employment services were requested for so long. It is not because Anchorage or Alaska has an enormous Native population and they value wisdom of elders. Both are true however Alaskans value anyone who has many year experience working in the Alaskan Environment, particularly Engineering and construction. I know first hand. My Grandparents came to Alaska in 52 when it was a Territory. They both African American lived to 99 and 97 as well as all there siblings into there 90s and mother 100. All worked into there 90s. A good friend of the family owned a construction company and buildt perhaps 10% of the city. He is 86 and still is called for advice and work by non native Alaskans who are the majority of the population. I have lived all my life in the state, while travelling to 33 countries and working few years abroad. My family's key to long life. Work, have a purpose and eat clean nothing processed nor excessively.

[@lopezb]

2:20:13 "what I do to sleep better"

[@scottherf]

filter blue light at night and get heathy sunlight, all cells work on clocks.

[@TheCROWXII]

Lol too good

[@richardlazaro6969]

What can David Sinclair say about TA-65? And what is someone cannot afford to buy NMN and Reservatrol? Are their natural ways you can get those supplements.more power to rich roll and David.

[@kkhinson4913]

Dr. Sinclair, you are on the right track as it is the will of our Wonderful Creator to appreciate Creation and His awesomeness. Sir, evolution is NOT scientific, and we ate not animals; that is why we are conscious of death. Medical Science has it's root firmly established in Genesis chapter 2 of the Holy Bible. Our Wonderful Creator put Adam into a deep sleep, opened him up, took a rib to form a woman, Eve, for a wife. Hence, marriage between man and a woman is the foundation for a family!!! I respect the fact that some people feel/prefer to be different. DNA is a complete and the most complex form of program. It contains diverse forms of human beings in accordance with their environmental needs, which is adaptation. Adaptation is NOT evolution! DNA has the ability to repair itself.

[@andreasmaher8749]

I have pretty much lived this way for the last 35 years without really knowing it. Vegetarian, relative caloric restriction with a lot of aerobic exercise in extreme temperatures etc....Id be curious to be tested by Dr. Sinclair to see what if anything this has done for my health.....

[@shejar]

Do you look young for your age?

[@andreasmaher8749]

People always think I am considerably younger than I am.

[@shejar]

@@andreasmaher8749 thats great :) am just 23 but my boyfriend keeps saying I look really old and could u give me some tips maybe ?

[@andreasmaher8749]

There is really no secret as far as what Ive done over the years. I run and cycle up to two hours total most days, sometimes more sometimes less. I typically only eat two meals a day other than say a lowfat yogurt and maybe a piece of fruit for "lunch". Im not vegan, I do have milk products on occasion but never any meat, fish, poultry etc...My breakfast is invariably a large bowl of oatmeal with maybe a few walnuts, some blueberries and brown sugar made with water. Dinner is usually some sort of vegetable concoction and maybe some bread of some sort. I do have a bit of a sweet tooth so I indulge in desert in the evenings. I burn a lot of calories through endurance training so I think the sweets help to fuel that. Not that it makes a difference but Im not a caffeine person so little if any coffee, tea or the like. Mostly only drink mineral water. As Ive gotten older I do take a multivitamin as a precaution.

[@shejar]

@@andreasmaher8749 thnk you :) I'll follow it from tomorrow

[@maciejkubik2198]

To me the only problem with nmn and resveratrol is that i am not sure where to get it. Mean how to know if the supplement that i am buying is what it says it is. If i could get it in pharmacy as a medication and stuff. Like to be sure that it is what it supposed to be.

[@nickbroadhurst2050]

Brilliant!

[@tulanejayasinghe1909]

Hi David, My brother who is 64yrs, who had non Hodgkin's lymphoma in 2011, he is in remission at the moment, after having chemo and radio therapy, after that he got dementia. His eye sight is failing, he had his cataract operation in 2018, and also in 2019. He is having glaucoma, I think he loosing sight, he is a jolly good fellow, I am so sad that I can't do anything about this. David, I am his sister, he lives with me and my mother. David would you be able to help us if possible. We are from Melbourne Australia. If so please. Thank you Tulane.

[@aerotuc]

its very true ,im 60+ and think like a 20 year old and find i prefer to talk to young people over older as older people mostly are so negative and behave old.

[@houndofzoltan]

Can't agree about forgetting about death from 6 onward. As your brain develops as a teen I certainly started to think about all kinds of questions like if there's a god and what happens after you die. Many people just accept there is a heaven which then allows them to stop thinking about death and get on with living which has it's advantages. Now we can hope that we can live an extremely long time and not worry about dying in that way and get on with our lives (although of course doing all the things required to increase your probability of long life, but these things should be habit, not conscious acts)

[@maricarbo]

I ordered The NAD and I started taking it twice a day.

[@Mikolas649]

What brand name and where do you order it?

[@maricarbo]

Mick Nikolas I ordered it, the NAD, on Amazon.com, and I also ordered the NMN. And both are sublingual for better absorption.

[@InSync3912]

Maria, do you feel any benefits?

[@denniskillin9853]

Whilst it is interesting to think about living longer physically we need to think about the emotional and structure of society when will what David Sinclair is doing and how we design the future going to come together so that mankind can cope with potentail consequences. Science as all to often come up with answers to problems before mankind has known what question to ask.

[@robert2real]

Rich you ever read Hilton Hotema's "Man's Higher Consciousness"? Interesting views on mortality

[@rachelaronoff387]

there is an amazing study about DNA repair during sleep (in zebrafish), and I totally agree about avoiding the blue light! best to all!

[@StarCoded]

Do you think, for people who must sleep during the day, they could block all light and achieve the same? (E.g., Dr Joseph Mercola designed his own sleeping mask, which he sells from his website.)

[@jaym9846]

What normally regulates NAD+ levels? Is it energy balance?

[@SquatFull]

I would appreciate a response to Dr. Charles Brenner's Article "Sirtuins are not conserved longevity genes" Life Metabolism, Volume 1, Issue 2, October 2022, Pages 122-133.

[@Manonsilvermountain]

At 46 got my first batch of NMN and Resveratrol last week, and 6 months of exercise at gym. so far so great!

[@jasonlovin3442]

Manonsilvermountain what company did you go with for nmn?

[@Manonsilvermountain]

@@jasonlovin3442 I got it from alivebynature dot com

[@Michael-ug9ge]

@@jasonlovin3442 I've been taking Genex NMN sold on amazon

[@albertorufinomartinez1387]

How do we get NMN? GOD Bless Tito 😊😊😊

[@lazarusblackwell6988]

I would like to live as long as possible so i can make the world a better place I want to experience life beyond this computer and the internet