De-resuscitation & De-treatment in Sepsis and Septic Shock

Sepsis is associated with generalized endothelial injury and capillary leak and has traditionally been treated with large volume fluid resuscitation. Some patients with sepsis will accumulate bodily fluids. What is the association between a positive fluid balance/fluid overload and outcomes in critically ill adults, and do interventions aimed at reducing fluid balance lead to improved outcomes? What does the literature say?
Dr. Mazen Kherallah will explore in details the fluid accumulation syndrome and fluid stewardship in the ICU and will review the available evidence supporting de-resuscitation in septic patients.

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I think all options are reasonable