Depression, I was wrong

Depression and serotonin
(UK, July 2022)
www.nature.com/articles/s4138...
Moncrieff, J., Cooper, R.E., Stockmann, T. et al. The serotonin theory of depression: a systematic umbrella review of the evidence. Mol Psychiatry (2022). doi.org/10.1038/s41380-022-01...
The serotonin theory of depression: a systematic umbrella review of the evidence
We aimed to synthesise and evaluate evidence,
whether depression is associated with lowered serotonin
Studies included
17 studies, 12 systematic reviews and meta-analyses, 5 other relevant studies
Serotonin metabolite, 5-HIAA levels unchanged
www.ncbi.nlm.nih.gov/pmc/arti...
Serotonin (neurotransmitter), quickly metabolized
Serotonin ---- MAO ----- 5-hydroxy indole acetic acid (5HIAA)
(5-hydroxyindoleacetic acid)
Plasma 5-HIAA, showed no association with depression
Cerebrospinal fluid 5-HIAA, showed no association with depression
Plasma serotonin
Showed no relationship with depression
Several studies of post-menopausal women,
revealed lower levels of plasma 5-HT in women with depression,
(p more than 0.05)
Serotonin receptors
5-HT1A post synaptic receptor
In depression (caused by reduced serotonin) expected to show increased activity of 5-HT1A receptors
Studies found either no difference in 5-HT1A receptors
(between people with depression and controls),
or a lower level of these receptors
Tryptophan depletion
Studies found no effect in healthy volunteers,
but weak evidence of an effect in those with a family history of depression
Studies of the Serotonin transporter (SERT) gene
www.frontiersin.org/articles/...
Serotonin transporter (SERT) is the molecular target of selective serotonin reuptake inhibitors
As expected, antidepressant treatment reduces SERT
Amount or activity of SERT would be expected to be higher in people with depression
No evidence of an association with depression,
or of an interaction between genotype, stress and depression.
Effects of SSRIs on plasma serotonin
Lowered serotonin concentration was associated with antidepressant use
Sensitivity analyses revealed that antidepressants were strongly associated with lower serotonin levels independently of depression.
Discussion
This review suggests that the huge research effort based on the serotonin hypothesis has not produced convincing evidence of a biochemical basis to depression.
This is consistent with research on many other biological markers
We suggest it is time to acknowledge that the serotonin theory of depression is not empirically substantiated
Some evidence was consistent with the possibility that long-term antidepressant use reduces serotonin concentration.

[@Tzimiskes3506]

Dr. Campbell has the humility and honesty to admit that he was wrong about certain things. And that quality in this world, deserves utmost respect.

[@jenjoy3215]

Moreover, the entire medical community!

[@movdqa]

In the engineering world, it becomes fairly obvious when you are wrong. Something breaks. Eventually. Or someone just proves you wrong. It's a lot harder in other areas because we don't have certainty in them.

[@stefvangelderen8701]

This should be normal, but to day, this is the exeption.

[@ireallydontthinkso]

Absolutely. Which makes him trustworthy, sadly also lacking in this world.

[@ares106]

It’s not that hard to admit the “medical/scientific community” (you belong to) was wrong. A lot harder to admit you personally were wrong about something.

[@zumamaya2396]

After struggling with anxiety and depression for 15 years I was prescribed prozac, I felt so bad the Doctor changed it to Citalopram. Aftter 3 years there was no change in mood but there were side effects. So I stopped the drugs, started at the gym, spent more time outdoors, stopped watching TV and reading news. I haven't had a depressive period for the last 10 years. I strongly believe our environment is the major cause. Look at the state of our society - lack of community, meaningful work, good nutritious food etc. It's no wonder people are responding negatively. But it's harder to fix society, much easier and more profitable to sell a drug to mask the symptoms. Also, at 66, I've lost count of the times medical treatments have been revised in light of new evidence. I suspect in 5-10 years the same will be true of recent mrna injections. I appreciate Dr Campbell's open mind, a rare thing in the medical profession these days.

[@andreaerling7614]

Zuma Maya. I was also prescribed Citalopram. I did nothing for me.( I got out of my depression when my circumstances changed) Stop the drugs, exercise, surround yourself with like minded people, stop watching TV, eat well, look after yourself. No antidepressants needed, no covid vaccine needed, either.

[@stewartmeetball3417]

Diazapam .. anyone prescribed it ?

[@richardfowler9901]

Tyson done it

[@christiancilia7332]

@@andreaerling7614 yes yes yes and we must fight back against these elites trying to destroy us

[@johnl5316]

@@stewartmeetball3417 it is a very addictive anti anxiety agent

[@Robertgriffinne]

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[@marianparker7502]

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[@PhilipMurray251]

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[@marianparker7502]

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[@PhilipMurray251]

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[@Pincer88]

Just a layman's hypothesis here... Working in an elderly care home, I have noticed that depressed elderly (and who wouldn't be, having arrived in the last phase of their lives and in most cases having lost their life long spouses) remarkably respond well to regular personal attention, genuine listening and conversation that adresses their feelings. After a while of intensified frequency in doing so, most of them take up an interest of going out again, participating in social activities in the care home and their mood and general health improves considerably. Even among people who have suffered from bipolar depression for years. I'm not a neuro scientist, only a social worker. But I have always had the notion that it isn't some chemical imbalance that is the root cause of depression, but rather a combination of other and enduring factors that result in emotional distress, such as grief, loneliness, financial worries, etc. I was wondering, wether enduring stress, combined with lack of apetite for healthy food, (moderate) exercise , a regular sleep pattern and so on lead to A. an increase in stress hormones (cortisol, is it? ) on the one hand and B. a lack of the the reward/pleasure- (can't remember which ones those were) and bonding hormone (oxytoxine if remember correctly) on the other, which in turn lead to a detorioration of brain activity altogether. As someone who has dealt with severe depression myself, I've always found that no SSRI or any other drug substantially improved my situation, but social activities, exercise, sattisfying work with fine collegues and a structural, yet inevitably temporary lack of stressful life events worked wonders. Yet somehow contemporate society leaves less and less room for that and on the relational level, it seems many people are more on the edge or downright cynical nowadays. My own life and that of many of my brethren and friends has become increasingly busy with things, that we didn't have to deal with years ago. And they are all stress inducing. I would love to see how socioeconomic en political tensions influence the way we interact among ourselves and what that does to individuals on a neurlogical, microscopic level. My hypothesis would be: the pleasure/reward hormone and the bonding hormone are like oxygen to our entire body; essential conditae sine qua non for proper functioning. And they come from 'normal' and relatively carefree living standards and social relationships. The lack of which drugs could only remedy to a certain level imho. Or is that too outrageous an idea?

[@nonzensy1554]

Free hugs is a good thing. Lifting people out of poverty is a good thing. i think you are on to something.

[@GuardianGamerable]

Regardless of what causes depression, the basic things in life that make you healthy are always going to make you healthy. Eventually we might figure out exactly what chemical balances cause depression and we can imitate “health” with a bunch of chemicals. But until then, doing healthy activities and living in a healthy environment is going to work to some degree.

[@glenwelsh402]

I love your hypothesis bro! A very widespread overview and realistic look at reality! It's people like you we need for restructuring our society!

[@Pincer88]

@@GuardianGamerable Agreed, but it's not the answer to everything. Everyone will testify that being physically fit makes one more resistant against depression. However, fitness is not a guarantee on how people will deal with traumatic experiences - thousands upon thousands of combat veterans with severe PTSS (with among other symptoms, depression) are a stark reminder of that. The death of a loved one (I've literally see people die because of heartbreak after 60+ years of marriage), divorce or just social awkwardness and resulting loneliness can be spirit killers, regardless how much one works out or how healthy one eats. Poverty (i.e. not being able to afford living in a healthy envrionment) and physical or mental disability are also a strong indicators. Exercise helps, but... Good company, someone who's genuinely having and showing interest and who makes you feel you matter, is by far the most effective tool in our kit when dealing with depressed elderly. No amount of diet or exercise, even no anti depressant comes close. It may not be 'professional,' but who cares? We've rationalized and outsourced so much of our basic care for eachother with the sole result as far as I can see that we have material wealth but emotional poverty. Coming from a miltary background, it's the same mevhanism that keeps units fighting under the heaviest of combat: the tightest the interpersonal relations and shared experiences are, the better the unit cohesion, its prowess and the pride its members take in being a part of it. Individualism and the emphasis on personal achievements have killed that in civilian life imho. Leaving the Army and coming back to society, I was and sometimes still am disgusted about how self centered and nasty people can be. Something we would not tolerate in our company; the perpetrator would have been 'corrected' in a way that left nothing to misinterpretation. Yet in civy street it's seemingly normal or even desirable at times. In business for example I've met quite a few predatory types that were the CEO no less. Never met such big A-holes in my life, but when adressed about it, 'they cried all the way to the bank' and simply fired the person who spoke out (among which I was one).

[@Pincer88]

@@glenwelsh402 Thanks man, much appreciated! I certainly hope you'll be on board as well!

[@oneplus7125]

Focus on gut health, lift weights, fresh air, sun light, drop social media. Purpose.

[@bobsaturday4273]

my "depression" over the years was not caused by lack of serotonin , it was always caused by lack of money .

[@dwaynechalmers9478]

100%

[@LDMTX6]

Funny, but I have known several wealthy people who were quite depressed.

[@punxiegeddings2711]

Welcome to 2022 where most of the population forgot what a joke was.

[@elizabethwade9615]

Love it Bob 😃

[@blueseptember2174]

I think there is depression from outside circumstances(i.e no money, abandonment, some cheated on you etc.) And then there's depression from hormonal imbalance(pmdd, postpartum, insulin resistance, menopause, men's low testosterone, men's aging hormone imbalance, puberty for teens etc.)

[@iwillroam]

Nobody I've ever known who is depressed just happened to become depressed one day. They were depressed after a long string of hardships and not having any resources or support. Over time they couldn't "fake it" anymore and "happy pills" got prescribed. Now we all keep going to work, but everything feels like sleeping while you're awake.

[@therookeryvanlife5612]

I’ve never seen a medical professional ever admit to being wrong about anything. This was very informative. Thank you!

[@Tamarahope77]

I don't understand why he said that we have been wrong for 25 years. The chemical imbalance theory was debunked 25 years ago, and top psychiatrists have not believed it for years. There have been quite a few studies and papers written about it over many years.

[@mlmcnew6761]

My god, everyone in the comments have Stockholm syndromes. This man has convinced you to jump out a 10-story window and die of a heartatack on the way down

[@chonsly]

You just believe everything on the internet huh

[@man_at_the_end_of_time]

I recall in the early 1960's that Howard Spiro (Yale School of Medicine) warned students and newly minted physicians that much of what they learned was wrong and would need to be relearned. And he repeated this warning a generation later in his writings. RIP

[@trucid2]

Even more true today than it was back then.

[@man_at_the_end_of_time]

Carlos Vega@UCo3GgYRSWAXivURriKldKig He has a PhD in nursing so what? It is not like the little tin deities (MDs) are so special. Further, in this era many of the primary providers are ARNP or APRN. I read and listen, I try to take my own measure of the available knowledge.

[@LTPottenger]

50% of all we know is wrong, but we don't know which 50%, or something tot hat effect. Medicines are needed sometimes but often have terrible side effects and cost, but fasting is free and often very effective. Some of the many benefits of fasting and a lower carb whole food diet on the immune system, blood pressure, blood sugar and anti-aging, all backed up by clinical data: Fribrosis/scarring is reversed. Reflexes and short term memory are increased. The hunger hormone ghrelin lowers with extended fasting and rises from dieting Thymus stem cells are regenerated, which suppresses aging and renews the immune system. Fasting stimulates phagocytosis, the ingestion of bacteria and viruses by the immune system. Blood pressure is quickly and dramatically lowered, which is very important for a good outcome with the current pandemic. Fasting increases nitric oxide, which has manifold postive effects like reducing arterial plaque. Weight loss from fasting only loses10% lean tissue and 90% fat compared to the typical 25% lean tissue and 75% fat lost when calorically restricting for long periods. Blood clotting is reduced and blood clots and arterial plaque are reabsorbed into the body. Vitamin D plasma levels are increased, and vitamin D in turn increases autophagy! Blood sugar and insulin are lowered, allowing white blood cells to move more freely throughout the body and do their job. Ideal blood sugar is around 80. Some viruses activate glycolosis (the release of sugar in the body) and clinically it has been shown that decreasing glucose metabolism in the body weakens the influenza virus. Is fasting just the same as caloric restriction? No! Dieting increases the hunger hormone ghrelin while fasting decreases it and has many other health benefits! kzbin.info/www/bejne/qYfPXqGfoc2KgsU What breaks a fast? kzbin.info/www/bejne/bZK1faZ5pd2sadE When you move out of MTOR your body shuts down the building blocks of the cell which are used to produce organelles and proteins. This means the mechanisms needed by viruses to replicate are by and large unavailable when you are in a deeply fasted state. Does fasting lower testosterone? No, it raises it and builds muscle! kzbin.info/www/bejne/nHu4daiZd7ypatU Fasts of several days will not affect short term female fertility and may increase long term fertility especially in women with PCOS. Fasts from 36-96 h actually INCREASE metabolic rate! kzbin.info/www/bejne/eJamkJp_h5eNZ5Y The hormone Leptin is an immunomodulator that keeps the body from attacking itself and obesity causes leptin resistance. Fasting very quickly reduces leptin resistance and leptin levels and one day of fasting can cut your leptin levels in half and gets your immune system working properly again! Does the body preferentially prefer glucose as a fuel? No, it never uses mainly glucose for fuel and using glucose for fuel is very biochemically damaging! kzbin.info/www/bejne/hJeUm6qDl9uBrtk Fasting stimulates the AMPK complex and activates autophagy. Autophagy (literally self eating) will cause cells to recycle foreign matter such as viruses and kill cancerous and senescent cells. AMPK does many helpful things in the body including activating the body's antioxidant defenses. Fasting can make you gain muscle faster: kzbin.info/www/bejne/a4OwaXqIr9h8f8k Deep ketosis virtually eliminates chronic inflammation in the body. This can offset the life threatening symptoms of viral pneumonia which effectively kills you through inflammation. This also creates BHB ketones in your body, which also help your immune system and anti-oxidative system, especially in the brain. Ketones also provide an additional energy source during infection, which is critical when trying to fight off a bug. In fact you can have as much as three times the total energy available in your blood when you are in deep ketosis, or even more. It increases mitochondrial function and repairs mitichondrial DNA, leading to improved ATP production and oxygen efficiency and thereby making cells better able to fight off infection. Increased mitochondrial function also has the added benefit of increasing your metabolism and cancer prevention! Your body releases interferon which is also triggered by the body during viral attacks to shut down the replication ability of the surrounding cells and stop infections. After 72 hours or more fasted, your body actually recycles large numbers of immune bodies and creates new ones, rejuvenating your entire system. When you fast, this stimulates apoptosis in senescent or genetically damaged cells. This kills these cells off completely. Senescent cells are responsible for the effects of aging and are the root cause of the development of cancer. If it were possible to destroy them all it would completely stop aging and cancer. That is not possible but fasting can help limit these effects by killing off many of the affected cells and limiting the future effects of aging. Fasting also releases BDNF and NGF in the blood which stimulates new nerve and brain cell growth, helping a great deal with diseases like MS, peripheral neuropathy and Alzheimers. In fact, the biochemical regulator of BDNF production is beta-hydroxybutyrate, which is the same ketone the body produces to nourish the brain while fasting. Autophagy induced by fasting even helps hair regrow. Dieters losing weight through intermittent fasting show greater reduction in waist size and increase in insulin sensitivity for the same weight lost and alternate day fasters were shown to lose fat while gaining muscle at the same time over a six month period. Fasting reverses metabolic syndrome, which is tightly correlated to Chronic Fatiguque Syndrome, high blood pressurecancer and many other chronic diseases. Fasting has been shown to increase bone marrow volume by 10% and levels of carnosine in the body in as little as a few weeks. Fasting also increases telomere length, negating some of the effects of aging at a cellular level. Eating one meal a day can bring most of these benefits to a lesser degree, and adding a few entire days off from eating per week will have even more effect especially when starting to feel poorly. Exogenous ketones can aid with fasting, making it easier in healthy people and allowing some people with specific issues to fast in spite of them without worrying as much about hypoglycemia. Children, pregnant or nursing women should not fast for periods longer than 16 hours. People with pancreatic tumors or certain forms of hypoglycemia generally cannot fast at all. Type 1 diabetics can also fast but it is more complicated and should be approached with caution as it could lead to ketoacidosis. Those with Addison's disease may also be unable to fast without liberal use of exogenous ketones, depending on severity. If you experience extreme symptoms of some kind, especially dizziness then simply break the fast and seek advice. Resources: pubmed.ncbi.nlm.nih.gov/7714088/ pubmed.ncbi.nlm.nih.gov/6859089/ www.ncbi.nlm.nih.gov/pubmed/23876457 repository.upenn.edu/cgi/viewcontent.cgi?article=1537&context=edissertations www.cell.com/cell/fulltext/S0092-8674(19)30849-9 www.ncbi.nlm.nih.gov/pubmed/25686106 www.ncbi.nlm.nih.gov/pubmed/24905167 www.ncbi.nlm.nih.gov/pubmed/10859646 www.sciencedirect.com/science/article/pii/S0005272806000223 www.ncbi.nlm.nih.gov/pmc/articles/PMC1413655/ www.ncbi.nlm.nih.gov/pmc/articles/PMC2815756/ www.cell.com/cell-metabolism/abstract/S1550-4131(15)00224-7 www.ncbi.nlm.nih.gov/gene/25712 www.ncbi.nlm.nih.gov/pmc/articles/PMC1779438/ www.ncbi.nlm.nih.gov/pubmed/10232622 academic.oup.com/ajcn/article/81/1/69/4607679 www.ncbi.nlm.nih.gov/pmc/articles/PMC3017674/ www.sciencedirect.com/science/article/pii/S1931312809002832 www.ncbi.nlm.nih.gov/pmc/articles/PMC5895342/ www.ncbi.nlm.nih.gov/pmc/articles/PMC6526871/ www.nejm.org/doi/full/10.1056/NEJMc2001176 pubmed.ncbi.nlm.nih.gov/23408502/ pubmed.ncbi.nlm.nih.gov/27569118/ pubmed.ncbi.nlm.nih.gov/21410865/ www.ncbi.nlm.nih.gov/pmc/articles/PMC6407435/ www.arcjournals.org/pdfs/ijrsb/v3-i11/7.pdf www.amjmedsci.org/article/S0002-9629%2815%2900027-0/fulltext pubmed.ncbi.nlm.nih.gov/20921964/ www.ncbi.nlm.nih.gov/pmc/articles/PMC6141719/ faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.2019.33.1_supplement.819.10 www.biorxiv.org/node/93305.full pubmed.ncbi.nlm.nih.gov/25909219/ www.nejm.org/doi/full/10.1056/NEJMoa012908 pubmed.ncbi.nlm.nih.gov/15522942/ clinical.diabetesjournals.org/content/36/3/217 europepmc.org/article/MED/22402737?javascript_support=no onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2265.2005.02288.x www.collective-evolution.com/2017/05/16/study-shows-how-fasting-for-3-days-can-regenerate-your-entire-immune-system/ www.health.harvard.edu/heart-health/abundance-of-fructose-not-good-for-the-liver-heart holistickenko.com/vitamin-d-kidney-liver-disease/ pubmed.ncbi.nlm.nih.gov/20102774/ n.neurology.org/content/88/16_Supplement/P3.090 www.nia.nih.gov/news/research-intermittent-fasting-shows-health-benefits pubmed.ncbi.nlm.nih.gov/23707514/ pubmed.ncbi.nlm.nih.gov/31877297/ This list compiled over years of research by the user known as Pottenger's Human on youtube but feel free to copy and paste this anywhere you like, no accreditation needed! My channel which will always contain an updated list of fasting benefits on the community tab. I also have playlists on fasting and health and wellness and make a little commentary on health and fitness as well.

[@trucid2]

@It’s OK but Given that more and more studies that are coming out today are downright fraudulent, it's more likely than you think.

[@joshburrell5621]

@It’s OK but yes and no, they may know more (or atleast think they do) but there's also more going on in current times which asks more questions of them that they don't have answers too. So it kinda evens out to be fair.

[@jess3591]

I was first put on antidepressant medication when I was 13 years old. My symptoms worsened to the point of needing hospitalization. The solution was more or different medications. I'm in my 40s now and the "more/different medication" strategy really sums up my psychiatric treatment throughout the majority of my troubled life... About 2 years ago, I tapered all of my meds and eventually stopped them all together. It was not easy at first, but I was receiving excellent talk therapy and am blessedly living in a very stable, supportive situation. Now, I'm more emotionally stable than I can remember. Very few doctors have been able to answer my questions about how the drugs they claimed would help me work. The best I got was a relatively intelligent argument regarding anecdotal data and statistics. But after learning that the statistics can be skewed by cherry picking data, then learning how much cherry-picked data actually drives treatment recommendations by public health authorities, his argument no longer holds weight for me. I can't say I feel great. I have a deep understanding of what is going on around me and I value my ability to feel empathy for the pain I see. However, I'm able to see that pain in perspective now and it doesn't shadow every aspect of my life anymore. I will not go into detail about how I awakened to the insights which helped me come to that place, but I will say medications had very little if not absolutely NOTHING to do with it. Thank you Dr Campbell. Something about your coverage of this topic feels like the genuine apology I feel I deserve for being part of a failed experiment for most of my life.

[@robosborne5527]

Jess, thank you for sharing. I totally get your experience.

[@readyorknot2344]

Sounds like your a very empathic person in a crazy crazy world.

[@cwnoxid1966]

Hi Jess I have had a simular experience with anti depressants and it wasn't until I went to a naturopath that I realised that nature has far better medicines to gently help you without the side effects incurred from the chemicals in pharmaceutical products.

[@susanmarada3089]

Kudos to you! Couldn't have said it better myself. Drs force this crap on you and it doesn't help. Tired of trembling and having nightmares from side effects. Depression still there anyway. So why take the crap? I know some people it helps, but not all of us.

[@suzannemcgregor6089]

I just want to send some support your way.

[@hewehawi]

I remember the doctor recommending I take some anti-depressants. I respectfully declined saying “No, I want to get out of my shitty situation, not feel better about it”. And if we were to be honest I think a lot of people around me needed to change but they were not willing to do the work. I was just a person they chose to externalise it on, because they didn’t want to do any work on themselves.

[@Varocka]

For many people with major depressive disorder they can feel so poorly about everything that they simply cannot change their situation without some kind of outside intervention, that's why they wish they could stop existing.

[@hewehawi]

@@Varocka and that’s why I stated it was MY experience. Not everyone’s, not ‘some people’s’, but mine. I know how some people feel- I know how most doctors treat most people. But maybe we should try to fix the shitty situations sometimes, and that was what I needed in MY experience.

[@dickJohnsonpeter]

But that's the totally wrong way of looking at depression. Not only do outside events have nothing to do with depression you also don't have the ability to change outside events if you are depressed. Depression is can't be caused by events happening in your life, they can trigger the depression you already have but they can't cause it. If you actually have depression you know this because you could win the lottery and still have depression. You still would have to force yourself to do everything. Whatever is necessary to make yourself able to deal with events in life is necessary and the pros and cons need to be weighed logically when you're dealing with medication. If a medication might have a few side effects but makes you feel motivated and not anxious then the pros far outweigh the cons. But you were right to not take medication since you didn't have depression and were just having a normal reaction to stress and bad things.

[@bosmer3836]

@@dickJohnsonpeter source? lol

[@swegatron2859]

I think a harsh reality is not everyone is capable of making changes to improve their situation. It’s kind of a social natural selection. Some people will just remain perpetually miserable and not have the capacity to make changes. If anti-depressants can get them through the day it’s better than nothing ig

[@user-yx3yt6kk3n]

Those of us in the psych med reaction groups have been screaming this for years. Thank you for bringing light to this important finding and discussion.

[@cherylgreene6686]

I have late stage Lyme turned Lupus. When I have intestinal troubles, I also have depression and anxiety. Heal your gut and you heal your brain.

[@cindlou7335]

Best probiotics??

[@Kthomasritchie]

@@cindlou7335 Probiotic are BS. The carnivore diet is the best way to heal your gut.

[@jasonuren3479]

Healthy gut, healthy body/mind

[@moonhunter9993]

yes, gluten-intolerance was at the basisof it all.

[@revcrussell]

I have intestinal troubles too, and noticed anxiety when my gut is having issues. I just figured that because most (~80%) of serotonin in the body exists in the gut because the brain and gut started evolving at the same time. The brain and the gut operate on the same chemistry!

[@allenortega9672]

I have corrected most of my depression without medication. What helped me the most? Diet. What I eat is what affects my mental health the most. Then it's my interests and surroundings. Medications always made things worse for me.

[@moonhunter9993]

with me, gluten-intolerance was the main cause of it all.

[@iamthatiam363]

Yeah look into the gut health, kimchi, natto, sauerkraut etc. I'm the same if I eat inflammatory causing foods such as dairy, wheat, sugar, white rice, breads of any kind, alcohol. It doesn't leave much😄

[@rahn45]

Mine was a vitamin D deficiency. Supplements helped more than any anti-depressant, change in diet, or exercise.

[@terrynash-ie9lz]

what did you change in your diet?

[@TheKitchenerLeslie]

Much of it is the cognitive dissonance caused by societal mind-viruses installed by people who really know what they're doing. Depressed people are easier to control. You'll always be happier if you shut off the tv and mainstream media.

[@johntnguyen9917]

Psychedelics helped me deal with my addiction. Having suffered anxiety and depression as well. I must say taking them turned my life around. I started micro dosing and just in a couple days I noticed major changes in my stress levels, depression, and everything else. It’s been really great. After battling with these for years little did I know that shrooms will save me.

[@clairepala3094]

I’ve heard so much and I really want to try them too. I put so much on my plate and it definitely affects my stress and anxiety levels

[@claire.morales9884]

I was having this constant and unbearable anxiety because of university stress. Not until I came across dr.coxx, a very intelligent mycologist. He saved my life honestly

[@johntolliver8940]

He’s on insta?

[@ronaldcarter1541]

yeah mate.. @ dr.coxx

[@realisticlife647]

The trips I've been having has helped me a lot, I finally feel in control of my emotions and my future and things that used to be mundane to me now seem incredible and full of nuance on top of that I'm way less driven by my ego and I have a lot more empathy as well

[@coloradoskilife4793]

I know it's something we've all heard, but sleep was so essential and in my case saved me. I way underestimated how much of a role it played. I'm not perfect with my health by any means , but has significantly improved since getting more sleep.

[@F4CTZV]

Sleep is actually bad for depression and makes it worse. Everyone who stayed up for 48 hours for example who suffers from depression experienced the vanishing off the depression once sleep deprived.

[@tjx982]

I noticed winding down for the night earlier and eliminating blue light 2 hours before sleeping has made me wake up much happier

[@DickMullen41]

@@F4CTZV This is nonsense. The proper amount of sleep is essential to combat depression and be in good mental an physical health in general. Sleeping too much can indeed worsen depression though, that much is true. The reason sleep deprivation may have gotten rid of depression in these people is because of the short term euphoric effect that sleep deprivation causes. This doesn't last and is obviously not a viable long term solution. It's like arguing consuming alcohol is good for depression cause the depression vanishes while being drunk.

[@jordandesmet6593]

Depressed = deep rest. Boom.

[@Sinoochka]

Too bad a major symptom of depression is inability to fall asleep

[@robertm2608]

I was taught about the Serotonin Depression connection in medical school in the 1990's. This is exactly what I have learned over the past few decades of practice. Whenever someone in supposed authority tells you that the science is settled, do not accept that as a fact. it could be anything but settled until the next discovery comes along.

[@joannbozeman2014]

No pm hi g GG

[@joannbozeman2014]

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[@joannbozeman2014]

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[@joannbozeman2014]

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[@joannbozeman2014]

Ml k

[@ohlookitsasquirrel]

absolute respect for admitting you were wrong....if only politicians and scientists did the same....oh look it's a squirrel!

[@picksalot1]

So, the "Experts" are wrong again. What a surprise. 😂

[@RunPJs]

Not that special. Politicians are just generally human trash

[@kristinpiechotta9000]

So who do you think did the research? The scientific process leads to new findings all the time

[@somebodyelse4786]

He's a scientist, too!

[@ohlookitsasquirrel]

@@kristinpiechotta9000 lol..i didnt say all did i...so fast to get things wrong eh! Am talking about the ones that are wrong, i thought that was clear by the subject matter.

[@Tindre]

I was on SSRIs for anxiety/depression and my own experience was that they removed my physical responses to anxiety and removed a lot of my nuanced feelings. I still haven't gotten most of them back yet. I used to be able to enjoy rain and feel cozy, and I used to have very nuanced feelings of love and sadness. Now these feelings don't appear or last very short time. I feel flatter overall and I have shit memory, but without them I don't think I could have survived since my anxiety made me stop eating and lasted from waking up until going to bed. It feels like they removed a lot of my personality/brain and I guess it's permanent. I didn't feel happier on them, or well I had the period of super highs and lows when taking them at first, then I just felt blank but able to work on my anxiety patterns without anxiety attacks. I was a mess for years. I feel better overall but different. I wish I had proper psychriatric help instead because I understand why I felt anxious and horrible in the first place,. and those issues are still unresolved. as soon as I have more money I will get proper therapy. But I will never take medicine again. The brain zaps when quitting them and sleep paralysis I got on them was horrible.

[@399THUNDER399]

Man what you said about nuanced feelings is very relatable, down to the coziness of rain, I feel exactly the same. I only took them for about 4 months and even though I have stopped I still feel less sharp. I find myself caring less about things I observe so I end up forgetting important details at times. For me it was worth it, I would rather deal with this than the constant pain and insecurity, but sometimes I do feel that a fundamental part of me is missing.

[@sealslayer]

I’ve not been on SSRI’s but was on mirtazapine, I know exactly what you mean, I can’t feel cosy or relaxed, can’t tell what season it is or the time of day but I do believe the feelings are still there but the depression has locked them away. I think we have to learn to feel them again

[@OcedarMopzar]

Heavily blunted anxiety was the biggest noticeable improvement from SNRI as well. It killed that shit dead, I haven't had anything even resembling the panic attacks I used to get before taking it. My depression got better but never disappeared, though I wonder if that was a side effect of me being less anxious about things. Still got low moments but they weren't as bad. I never noticed the general emotional blunting a lot of people talk about. I still love a rainy day, and when I asked my family whether they noticed any differences personality wise after several months, the only thing they noticed was that I was more outgoing and social. So, YMMV. Worth noting I was on a fairly low dose of venlafaxine, 75mg, and took it alongside therapy for ~2 months. Definitely noticed when my junk stopped working for a few days after I started. That was concerning but went away over time.

[@girlbuu9403]

Got put on SSRIs and... nuanced feelings yeah you could say that. It was more like I just stopped caring. Not in a "I think I will lay down and die sort of way" but in a "Huh my eggs are cold, oh well." "Ow I stepped on a board with a nail on it ha ha maybe I'll get tetanus" "This person is kind of annoying okay I can just punch them in the throat" That last one happened. Yeah, no nuance. I wasn't even like furious and screaming. They just annoyed me so I punched them. I felt no remorse for it either. Things even darker than that happened, and when certain thoughts entered my head... read; increased risk of suicide is a side effect of a lot of these. When before dying was terrifying given my uncertainty of the after life, when that thought never entered my head even in my darkest depression until I was put on this drug, when I was annoyed at a bunch of people and thought "Well I might as well take them with me", when I actually started thinking about how I could pull that off... ... I quit cold turkey before I hurt myself or others. Horrific withdrawals. Thought I was going to die. Worse bit? I was a teenage lesbian who was raised in a fundamentalist house hold. I was depressed and anxious because I thought I was going to hell. Also other things, things I'd rather not go into detail about, but that was the thing that was really eating me at the time. But sure, chemical imbalance in the brain. PS: Not a word about my family being evil. When they did find out they were upset, disapproved, but didn't disown me or anything. It is weird how used to I was more concerned about people attacking me for being a homosexual and now I am more worried about people attacking them for not 100% accepting me for it but here we are. Or maybe this is the worst bit. I hate to tell all of you this... but I am in my late 30s. This was in my mid teens. The dullness never goes away. It aged me mentally by forty years, I am suffering memory loss early and constantly am doing stuff like walk into a room and forget why I came in, space out for no reason, pace around, where are my keys oh they're in my hand... Sure everyone does stuff like that but such behavior was rare before Paxil. I think the damage is permanent. Between this and a few other incidents I will never trust doctors again.

[@Mimi-lo2gi]

​@@girlbuu9403

[@richardjones7984]

So refreshing to meet a doctor who admits his mistakes thereby allowing correction and improvement. This approach is called science.

[@noreenalbright2245]

He is awesome. Enjoy his sense of humor and honesty.

[@hoxtondave9619]

@Richard Jones - he is NOT a doctor, although he's happy for everyone to lazily assume that he is. Has he admitted he was wrong to shill the Covid injections yet? Has he apologised? No. Why do you think that is?

[@noamto]

He's not "a doctor" in the way you mean. He has a PhD not an MD.

[@oopalonga]

agreed. he's amazing. it's also scary there are so many with medical degrees who still believe SSRIs work

[@hoxtondave9619]

@@oopalonga It's amazing how many people still think that the Covid injections work as well.

[@m2hmghb]

This is why I keep coming back Doctor John. You don't say follow the science, you actually follow the science. You also admit when you're wrong. Much respect Doctor Campbell.

[@zazzyz4558]

HE wasn’t wrong. He was just promoting what science was saying at the time. I reckon that’s his job. And now he’s bringing us up to date. Bravo Dr. John!

[@m2hmghb]

@@zazzyz4558 When you say something that is factually incorrect you are wrong. It doesn't matter if you know it or not. It doesn't matter if years later you are corrected. Everyone is wrong about things, it's just people tend to shy away from admitting it.

[@andrewditton7226]

What about the people who were right about it, while being treated like they were wrong? Are we going to extend them the same praise and compassion?

[@m2hmghb]

@@andrewditton7226 I hope we do. Do unto others as you would like done to you.

[@lechatel]

Science isn't something that is 'followed'. Science is something that is constantly challenged, tested, and reviewed. One 'follows' a cult. Not science.

[@lb1798]

In the light of NEW EVIDENCE....OH MY GOODNESS...A DR. THAT CHANGES His MIND!!!👍🏾👏🏾👏🏾🥰

[@tawnywol2009]

This is actually progress in the study of depression, it’s quite exciting. And very clearly explained, thank you for sharing Dr C.

[@seedsman02]

Fascinating. I can give you a reason to consider, something I’ve noticed. Ever since the mobile phone appeared we have suffered from depression more. Even children have become depressed more so than ever before in my lifetime and I’m 66. Or perhaps we have reached that utopia we wanted and the results are very similar to the rat utopia study. So many similarities. As to why the brain reacts in the way it does is from the vibrations, and we all know the energy fields in our lives. Love your stuff and thank you.

[@nockianlifter661]

As a longtime sufferer of depression and severe anxiety attacks for no apparent reason, I found that it was entirely caused by a mass of conflicting concepts which prevented me making clear decisions and destroyed confidence. Once I’d sorted these conflicts out the depression disappeared and never returned.

[@CHX_37]

Glad to hear that. I remember listening to a man who did rock climbing say that it was an activity that forced a person to focus on one thing and how good that was for overcoming stress.

[@nathansurendran2602]

What did you to to sort the conflicts?

[@kkpaine]

Did you talk to someone?

[@bigfletch8]

Poor breathing techniques cause so many physiological problems, which are then linked to the mental process. For example, " normal" day to day stresses cause extreme breathing restrictions; already poor. Wim Hof has created a simple breathing sequence which increases the breathing capacity dramatically, so next time the obstacle appears, your breathing handles it easily. Restricted breathing is the worst cause of panic attacks. Think of having difficulty carrying a moderate load then building up your strength. The load becomes easy. Dont be put off by the ice part. Try it by all means , but the breathing is the key. The cold therapy just demonstrates how yiur capacity has improved. It truly is amazing how many conditions this cures...but sadly, no profit for big pharma lol...

[@nockianlifter661]

@@nathansurendran2602 If I could pick one single thing it would be taking an online course ‘An Introduction to Logic’ by Leonard Peikoff. I had taken the course on a recommendation as part of studying The Trivium. I found it really tough, but I worked really hard at it to answer all the set questions. It took me over 6 months. A few weeks after completing the course I said to my wife that it felt like physical changes were occurring in my brain-a really odd sensation as if rusty gears were beginning to turn. After a few days of this process I was aware of a mental clarity that I’d never had-I suddenly knew things and I had no idea exactly how I knew them. My low moods cleared up at the same time, the anxiety attacks ended. Since then I also began serious weight training three times a week - this seemed to be the perfect and natural physical compliment to the work I’d done on my mind, so I cannot rule out that this is also a factor, but it was at least a year after the logic course.

[@uselesshero]

I came for the covid news, stayed for the respect for science. Dr Campbell you are awesome. Thank you.

[@mrangelino]

Same here ☺️

[@alejandrinahs]

Absolutely! His professional and ethical insight is beneficial to the general public.

[@Jadeserphant]

I just love that you always post links to the studies. Thank you, Dr Campbell.

[@Pandoradan]

This has been discussed for quite some time, and in my studies it was clear that we didn't know exactly how these SSRIs were working, and it wasn't a given that this was all due to serotonin levels. There's a lot we don't yet know about the brain. Honestly, being able to discount something in the face of new evidence is just good science. 👍🏽

[@dannyjensen2123]

Actually ssri inhibitors May not work at all. Science is fraudulent.

[@Pandoradan]

@@dannyjensen2123 I'm just gonna point out that, with respect, you're using the gains of science to even post in KZbin. So the blanket statement is a bit dramatic, not too mention inaccurate. Do you have any references to support this statement or are you just trying to start an argument?

[@dannyjensen2123]

@@Pandoradan i would suggest Reading “deadly psychiatry” by the former head and co-founder of the nordic Cochrane institute peter c goetzche or dr David Healy who has spoken openly about this problem for years or Ben goldacre who wrote a bestseller about why medical science is broken (bad pharma)- this is not new - sadly

[@chonsly]

Your studies? Who tf are you? What studies?????

[@Pandoradan]

@@chonsly I'm sorry, does education trigger you?

[@emmettturner9452]

“No stream Tap to retry”

[@Harlow_fan_page_]

Yeah me too I can’t play the video

[@club4ghz]

The only way to survive this deadly double pandemic of covid and smallpox is to lock down economy for next 20 years. We can do it !

[@emmettturner9452]

@@Harlow_fan_page_ Seems to be working for me now. You?

[@Harlow_fan_page_]

@@emmettturner9452 yea it’s fine now thank you!

[@mamaalaska]

Your entire demeanor, humility and ability to say we just don’t know, is why I trust you so very much. I truly wish I lived near you and you were my healthcare professional.

[@anna-rosarosa7947]

The problem is, if you would have had him as your healthcare professional at the time he was beliving the serotonin theory(he was teaching it), then you would have had with great certainty an antidepressant.

[@kellyberry4173]

@@anna-rosarosa7947 Like EVERY OTHER doctor. Doesn't mean he was wrong...nobody knew.

[@catherinenelson4162]

You'll see this sooner or later, so I'll explain it to you. In England, medical doctor's tend to be called "Mr ", as opposed to the U.S. way of calling them Doctor. If you are a professor in a University, however, then in England, you would be called Doctor. In the U.S. a few with PHD's want to be called Doctor, but most don't, as it's viewed in our universities as putting on airs. John Campbell has a PHD and taught nurses in a large, British University. He also did some training of nurses in foreign countries. As appropriate for England, he is called "Doctor". That being said, he knows his stuff and is very good at research. He isn't a phony or a pretender, and with his PHD is is as capable of reading and interpreting medical literature as any M.D.

[@mikewallace8087]

State of the Art is parlance best intended treatment . Then change may come later. What seems certain is if you drop a rock onto your foot the sensation will not be pleasure.

[@cmdreltonpoole6303]

@@anna-rosarosa7947 They still work, you know, they didn't just magically stop. There's no reason to stop prescribing them.

[@chazprivate]

I was put on SSRI'S 23 years ago for postnatal depression... I had 4 children and recently came off them 9 months ago after the birth of my last child. Throughout my time on these meds, I felt numb and finally came to a conclusion.... My theory is that depression is both a genetic and environmental issue. I also feel that dopamine base levels have a lot to answer for in this mystery. The same way that certain people are predisposed to addiction etc. Many still think addiction is a mind over matter issue and a symptom of being weak willed. 😔 I am certain that in 20 yrs (ish) We will look back on our ignorance towards addiction with a huge amount of shame and sadness. The same way that we now look back on our attitudes to mental illnesses and asylums. We have so much to learn. Until we get to the truth, I ask that people be compassionate, loving and empathetic towards those struggling with depression, anxiety, addiction etc.

[@Vousie]

The thing is, while some people may well have a predisposition to addiction, which would make it much harder to break an addiction, in the end, they still need to put in that effort to say "no", to decide that they want to make something of their lives. They're not a slave to their own desires. Mostly I think addiction is more of a mental health issue once again - that people don't feel unhappy with their lives in the first place, which is why they turn to drugs to make themselves feel better. Thus why so many keep relapsing even when they've had "help" to force them off the drugs: The root cause, their mental health was never dealt with, so it just drives them straight back to drugs. This has been shown by Dr. Bruce Alexander in the study where they had rats in a cage with morphine available. When the rats were kept alone, they would use more and more morphine until they overdosed. When they were together & had lots of others to play with, they barely used any of it. (serenityatsummit.com/news/overview-rat-park-addiction-study/)

[@rundogrun297]

I have been depressed for many many years. I have been on and off a buffet of ssri's They have NEVER helped me EVER. So I agree we do not know squat about the cause of depression at all. I'll just keep moving on with my life.

[@MrMarbles0Xecution]

I was diagnosed with depression and anxiety based on some stupid mood questionnaire. I took antidepressants for about a week and realized it only got me high, I still felt the same underneath a fake smile, i immediately stopped taking the antidepressants. Not until 10 years later when im in the hospital in serious condition do doctors realize i have an immunological disease. I literally had to diagnose myself (with no biology or chemical understanding) and i told them i had Crohns Disease. They ran all their tests over like 8 months and turns out I was right.

[@rundogrun297]

That is why I highly recommend NOT going to docs at all unless medically necessary

[@SrNavi155]

When I was depressed in my college years, I took venlafaxin and it was great, it totally changed my mood from one day to the other, I was on the brink of suicide and took a massive amount of 150 mg. I have never feel more alive and full of meaning and goals. However, I returned to the normal dose and eventually started to feel the "good" mood I was in as artificial or fake. Eventually I started to change my lifestyle and life started to improve. Antidepressants in my opinion are good as a 'tactical' method for boositng the mood when the situation is almost suicidal, however, for me, the right solution for depression, is the holistic one, changing the environment you're in, your diet, performing excercise, working towards set goals and trying to bond with people.

[@cindy6101]

I’ve been taking two doses of Venlafaxin (150mg + 75mg) daily for twelve years now ( I’m 61) I didn’t realize this was a large amount My depression was situational and my life is full of joy now But I’m afraid to go off my medication and would never do so without my doctor’s guidance That said, I’m still afraid to change anything because I don’t want to fall into that deep dark hole of depression again

[@vivvpprof]

I'm in therapy and I can just say the same - I have periods of feeling like living the most meaningful life on earth. Yet, I've never taken any antidepressants. Conclusion is I think obvious. Best wishes to you and congratulations.

[@timtripp4222]

Please read the book 'the medicated child" by Peter ??? That will give ya a good background & help ya understand things.

[@DJWESG1]

I've taken everything for depression, even had a few experimental treatments.. Two things work for my depression one is ibuprofen the other is weed. Dr looked into my 'issue' and agreed, ibuprofen and weed were far superior when combating my personal condition. If ur ever feeling super low and confused, take some ibuprofen see what happens.

[@adararelgnel2695]

Same for me. My situation seemed good and normal but it was not right for me at all. I think, if you can answer to yourself "why" you are depressed, then you don't need medication. You need to deal with the "why"

[@donm5354]

Much depends on WHY a person is Depressed - sometimes there is a real reason - like a botched surgery or job loss or loss of spouse or someones life is generally going downhill ...... it is different than someone whose life objectively going well. Doctors have too much of a tendency to say "Here take this pill and you will feel great again!"

[@troywalkertheprogressivean8433]

Circumstantial depression. It's perfectly logical, reasonable, and rational to be depressed if one is bothering to perceive the truth/reality. And some of us can't unsee it.

[@MrOlleyOlley]

Gets worse when you know that between 60 to 80% of the benefits of antidepressants is a placebo effect

[@SpaceTravel1776]

People experience the same event, yet some people suffer clinical depression for most of their life and some people don't get "depression" in the clinical sense. It has nothing to do with the "Why" something happened, or more accurately, the "What" that triggered the depression.

[@arianeingham6699]

@SpaceTravel1776: Precisely. Brain chemistry is in perpetual fluctuations and the elusive “consciousness”, is the master chemist… or, in the undisciplined, the apprentice chemist. But we are each on our own journey to self mastery. We all deserve patience, from ourselves and each other.

[@ciscokid0110]

When I was young, people were just sad for short periods of time. It almost seems like a club to join anymore.

[@nargly8208]

This man is great at explaining complex things in simple terms. I very much appreciate that.

[@vonphysikbismetaphysik]

OMG, the way that he presents this new insight is so real and down to earth. No crying about the past, just honesty. This is how you do it. Damn good. This is grown up science, ready to allow for new perspectives when there is proof. Thanks, I needed to see this! Gives me back a little trust in humanity. As a scientist myself, I met sooo many people claiming to be scientists and then hanging on for fear life to their old beliefs instead of allowing for new truths to be unveiled. Thanks so much!

[@kaitlinwilson]

The fact that depression and chronic pain can be treated by the same medication tells me that it's not a deficiency it's a symptom.

[@wyattfamily8997]

I'm a 73 year old Australian male who was diagnosed with fibromyalgia ( a catchall term for undiagnosed cause of pains ) many years ago. Recently I've also been diagnosed with Ulcerative Colitis and found the chemical prescribed by my specialist didn't agree with me. My G.P. suggested I try Curcumin, which is widely used in South Africa as an anti inflammatory and for gastric problems. It is a derivitive of Tumeric. I found it not only effective for the Ulcerative Colitis but many of my other "fibromyalgia" pains also vanished. The added advantage of course that it is not a manufactured chemical either. The chronic pain did also cause some depressive symptoms also which have ceased.

[@chrisstevens8431]

I get the feeling that so many thinking that big pharma has a solution to ALL of their problems, is a symptom of mass formation...............

[@4TIMESAYEAR]

Actually, psych meds don't work for chronic pain. Been there done that.

[@itsjudystube7439]

Correlation isn’t causation. Just because two things can be treated the same way doesn’t mean they have the same cause. If you have a pain in your knee because you twisted it you can take a pain killer. If you have a headache you can take a painkiller but you haven’t twisted your head. 😀

[@itsmewayne428]

Totally agree...I suffer with chronic pain & Tinnitus..

[@nancya8262]

The medical community could use a million clones of you Dr. Campbell. What a blessing you are. Be well and thank you for all the hard work, it is much appreciated and valued.

[@darrenthomson1930]

get me a bucket

[@chrisstevens8431]

It would be like the return of Nazi German medical experimentation on a far wider scale.................

[@heizensperg]

Where’s your appreciation for the scientists who have been speaking out against this bullshit for years and called cranks for it? Campbell is late to the party. And he didn’t do anything btw

[@chrisstevens8431]

@@heizensperg Worth bearing in mind campbell spent 2 years cheerleading for tea, which has proved to be deadly.............

[@littlemissgroove]

@@chrisstevens8431 what? tea is deadly ???

[@anarchocompactdick]

Thank you for taking the time to explain this issue clearly for us layman. Im very glad i found this video!

[@joannalewis5279]

Thank you for stepping up and talking about this topic. So much harm is done via SSRIs and SNRIs, even though they benefit some. We have to find new ways.

[@melaniemurphyofficial]

Highly recommend the book ‘Lost Connections’ on depression and anxiety. It outlines many different causes of depression … fascinating read! When I experienced severe depression 14 years ago I did take antidepressants but it was only when my situation changed and when I addressed things like how I was choosing to spend my time, who I was close to, the lack of ‘meaningful work’ in my life etc that my depression actually went away! And I can only see that now when I look back. Many people do find that antidepressants help but they don’t help everyone and that’s why this new research is so important. There’s definitely been an attitude of ‘well if you are still depressed on antidepressants then it’s obviously not REAL depression’ which is awful. So many areas of life can be focused on and changed in order to alleviate depression symptoms.

[@garyschollmeier779]

Oh man, I forgot I bought this book on Kindle a couple of years ago. I need to read through it again.

[@boomtao]

Author? Found several books with that title. I suspect it must be: Johann Hari?

[@garyschollmeier779]

@@boomtao I believe it's Johann Hari but best wait for OP to respond to double check.

[@andytalks7898]

I second this recommendation, it was a bedrock foundation for my recovery with mental health issues and addiction. I am almost 1,000 days sober and life has been an incredible journey. I wish you all the best.

[@richardcarnell2551]

Doctors aren't trained to know about the endocannabinoid system because it was discovered because of cannabis, it isn't there because of Cannabis but the Omega 6 and 3, omega 6 toxicity and omega 3 deficiency is the cause of depression and anxiety and also bipolar and schizophrenia, the Cannabinoid system regulates serotonin and dopamine - our natural thc (made from omega 6) is called Anandamide - this is from an old BBC horizon documentary and shows a scan of a human brain and torso for CB1 Cannabiniod receptors, as you can see there are throughout the brain wherever there are cells - this is the biggest medical discovery ever made and again doctors aren't trained to know... www.dailymotion.com/video/x2u9q58

[@Captain_MonsterFart]

When I was a teenager in the 90s I was sent to the doctor because I had fallen into a pretty bad depression. She, who has no psychiatric training, diagnosed me within five minutes as having a "chemical imbalance" and sent me home with free samples of one of those SSRI drugs. Nasty business, that was. No question about what I was eating, who I was spending time with, was I doing recreational drugs, do I exercise, nothing! What a journey to find one that didn't mess me up completely! Never again!

[@timefortee]

I've experienced the exact same thing when I accompanied a teen to his pointless appointment. Until the very end was waiting for the moment she'll finally ask at least _one_ question about the kid's family or school life... That moment never came and I was utterly appalled and in disbelief. Fraudsters.

[@finwilliams4550]

The owners of pharmaceutical companies fund all medical schools and control the curriculum. They are not teaching anybody to make people healthy. Those companies were created by the monopolisers of the oil industry to sell the waste from their oil and they have made fotrunes from sick people over the past century.

[@sn0wchyld]

partner had a similar experience but with cholesterol. No questions re stress, diet, lifestyle etc, not even a 2nd test after a few weeks, just a immediate prescription for statins, because its the national health authorities policy. This is for a woman.... where despite statins having no benefit for women (in fact all cause mortality studies suggest negative outcomes) and being in her mid 30's who'd just been through some very stressful times & events, was overweight, poor diet, and doing little exersize... but why address the causative issue when we can just give a pill and call it a day? SMH

[@baldmichaelresoluteprotect1206]

I was misdiagnosed with cancer when in fact it was sodium nitrite poisoning (E250) in food I ate. Ignorant doctors should have known about this as the toxicity of sodium nitrite has been known about for over 100 years. I now believe the immuno-therapy I was given has caused my symptoms to be worsened as my pituitary gland is not functioning correctly after I terminated the treatment having worked out what was going on, no thanks to the NHS.

[@mikecheq45]

They couldn’t get me on sssri’s quick enough. Horrible things. My head has never felt right since.

[@stevenkramer1975]

How many Drs will actively and wholeheartedly come out and admit when they are mistaken? Ty Dr. Campbell for your continued pursuit of truth and informative discussions on the various medical problems afflicting our world today. 👍

[@CincyKat]

Fascinating. I have Major Depressive Disorder and have been under treatment for 20 years. Thank you for this information and keep us posted if you learn something new!

[@glenwelsh402]

The book Lost connections by british-swiss journalist Johan hari, who had suffered on antidepressants for 15 years, beautifully explores the outdated belief that depression comes from a lack of serotonin and offers 9 actual causes for depression that are taken from studies from around the world. I urge everyone to read it.

[@chrisberry9017]

Thank you for your recommendation Glen

[@dh00mketu]

Care you mention these reasons?

[@JanCarol11]

Katinka Blackford Newman, a BBC journalist, has also written about her harrowing journey into antidepressants and psych-diag-nonsense in "The Pill That Steals Lives," turns out she had a liver enzyme that made these drugs exactly wrong for her. It's a very accessible read - the science & studies interspersed with her own compelling story.

[@NS-xt5wv]

I was never buying the whole serotonin theory. Depression may be stemming from physiological reasons, but these reasons probably will be found elsewhere in the body, like nutrients/macro elements/hormonal misbalance, but in most of the cases, my personal belief is that depression is an existential issue, or an issue caused by trauma.

[@glenwelsh402]

@@dh00mketu the causes? Well the book is called lost connections because it says that when we lose certain connections to things it can cause harmful effects. Some that I remember are A connection to nature, A connection to a hopeful future A connection to meaningful work A connection to others, to name a few. I guess the idea in the book is to find balance across all the different needs we have as humans (somewhat relating to Maslow's heirarchy of needs) as opposed to ignoring the emotional signals we have that tell us something is wrong and overwriting them with pharmaceutical products.

[@VikinGingerGiant]

“That makes perfect sense, except that it’s wrong”. You my friend are a remarkable man/Doctor.

[@heizensperg]

It always made 0 sense and it's crazy it has taken this long for them to realise. We all know why $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$

[@s.a565]

That's not how common sense works. Famous words from Judge Judy: if it doesn't makes sense it's BS!

[@timblock3483]

@@heizensperg Yep, gotta sell that poison.

[@JamesOKeefe-US]

Dr. Campbell is our generations primary care physician. Love his teaching acumen. He is truly the best. Thanks from the US!

[@lesliekok2328]

Thank you Dr John. How wonderful to get some new insight on depression. Interesting updates

[@robyn3349]

I am so happy to hear that there are doctors and scientists out there who are continuing to advance knowledge, who are not sitting pretty on thrones of settled science. Thank you, Dr. Campbell, there is so much we do not yet know. ( I have taken SSRIs for depression. They may have helped, but I think it was changing stressful circumstances and rest that really helped me.)

[@thedave7760]

No such thing as settled science, if you can't question it then it is dogma not science.

[@mp7161]

Sitting pretty on the mountains of money obtained by creating drugs and profits on fake assumptions. Almost identical with the kovit vaksin. Maybe the anti-depressants work because of the placebo effect.

[@kimparke6653]

Even changing the way we think about things helps. I feel trauma causes anger, if that anger isn't processed ,it goes underground and turns into a depression.

[@AlexM-jd2ro]

It could be placebo effect....

[@tiredoftheworld4834]

@@thedave7760 people don’t allow you to question it…

[@TH4Peace]

So much respect for this gentleman! His knowledge & explanations are delivered with kindness & humility. An international gift to us all.

[@milktobo7418]

He missed how physical activity seems to cure depression. To bad he didn't tie it in.

[@baseballmomof8]

He certainly is.

[@thomasphilip8916]

@@milktobo7418 depression mainly caused by dietary issues

[@Miss_Numerous]

Dear Sir Campbell, thank you for having investigated and sharing this. But now I'm very interested in psychosis, dopamine levels and the effect of anti-psychotic drugs.

[@natsully]

Thank you for being open to admitting that we aren't always right and we can learn and grow our knowledge. If it means that something we previously believed wasn't right, then it opens us up to possibilities!

[@davidk6269]

Fascinating. Finding out that what one has been teaching for decades is not correct must be distressing. I applaud your ability to not let your personal pride or ego hinder your goal of providing accurate, up-to-date information about the latest medical findings.

[@jasonrattue]

But isn't this the fundamental principal of Science - that there is no right answer; that 'the answer' evolves due to the latest research. Which is why the "I am the science" comment caused such disgust in everyone except the MSM.

[@69birdboy]

This has been asserted in alt medicine for decades. Pharmaceuticals did this initially in Japan I believe as a selling point.

[@Fedorevsky]

I went to a psychologist for depression 30 years ago. He was more of a believer in depression being a kind of thought problem. Negative experiences leading to negative thoughts and it bringing mood down naturally by all the negativity becoming too much too handle. After a while once my situation got better my depression slowly let go of me. I never used any medication.

[@bobf5360]

I have in the past taught some of this and I am actually excited when I find that what we have been teaching is wrong. New scientific information is always exciting. It doesn't mean you have wasted time in the past, it means you have an opportunity to be closer to ground truth. To be fair though, a lot of what is in textbooks isn't wrong, its just oversimplified or incomplete. It has to be, otherwise you could never get through even the basic Krebs cycle without spending a semester on how that works in different contexts. Anyway, another great video by Dr. Campbell.

[@bobf5360]

and one more thing- good scientists don't take being wrong personally. If you show a good scientist data on why they are wrong, they are happy to change their mind or adjust their hypothesis- thats how science works. Being wrong doesn't need to bad. CONTINUING to be wrong in the face of solid, multifactorial evidence, that is bad.

[@glendagrant9042]

I moved from another country to take care of my mother. An only child in a place I did not know anyone. I became very depressed. It was quite bad. I started on medication and I pomise within a few weeks my mood improved. It was such crushing weight being lifted. I took them for some months but did not tolerate the side effects well. I got off them but never went into that deep depression again. It gives me shivers to think of ever feeling like that again. After 2 years my mother went in a nursing home late 80s. I found out 1 week later I had breast cancer. I was not nearly as afraid of that illness as I was of depression. I went back to work and moved into an apartment I liked. I got my treatments and surgery and went forward. I now have cancer a second time 6 years later but I am not depressed. Fully retired. Depression is so horrible. Mom lived to almost 91.

[@DL-vw8ku]

🙏🏻

[@bredadonlonalder4643]

I've watched on and off since covid first started and you started videos on it. I just wanted to wish you good health and thank you for the videos.

[@monsirto]

I suffer from GAD but that is to be expected from anyone who has a creative bent. The best therapies I know are exercise, being surrounded by nature and making music. It will be different for everyone but I think exercise is a really effective therapy for most of us who suffer Anxiety or Depression. Thank you, Dr Campbell. Wonderful stuff as usual!

[@superwoman6413]

As a sufferer of depression since my teen years and a scientist, this is a conversation that I had with my psychologist a decade ago when I decided against all doctors to wean of my SSRI after diagnosis in my mid-thirties with a repetitive depression disorder. I was not getting a wow effect from the medication and I pointed that I was diagnosed just by some medical questionnaires without anybody having a look at any physical grounds for my condition (apart from discarding physical illness). My therapist gave me the credit to recognize that there are very little and very contradictory investigation about the grounds of depression and I have not regretted getting off the meds and trying to manage myself with a better lifestyle since then. My educated guess as a scientist is that at the end when they will investigate, we will have a parallel to "cancer" and we are grouping a vast amount of different illness or mechanisms that produced similar symptoms under the "depression" label. For some patients the SSRI works and works well and I do not doubt that this group could really have the mechanism of recapture of serotonin as a main problem. I have also heard of good results by improving the absorption of micronutrients. Anyway I think this is a good thing, as it will bring new research to this area and we may be closer to a real view into the "black beast". Take care

[@thelettuceuk]

Agree strongly too, have found it bizarre/tragic that doctors have dished out anti-depressants to friends/relatives without asking for a food/exercise diary first at least. For some that would doubtless give better answers/treatments.

[@scarred10]

Nobody gets a wow factor from antidepressants and there is no diagnostic physical test for depression, its diagnosed by clinical interview based on DSM criteria which are somewhat arbitrary.There are several hypotheses for depression and serotonin deficiency was just one.

[@nate6511]

I think this theory also fits what I have been told by a former psychiatrist, who told me that I may have to try several antidepressants before I found something that made me feel better. Eventually we realized that SSRI's were making me feel restless and anxious (prozac was the worst for me) and was advised to avoid them altogether; the first SNRI I tried was an immediate hit for the anxiety I experienced... I know it does affect my depression as well because I have increased the dosage a couple of times during difficult periods in the past two years, but once I'm stable again I can decrease the dosage and feel mostly the same--albeit with a clearer mind... Which honestly doesn't seem like an issue of a chemical imbalance, especially because these depressive episodes are generally triggered by life events.

[@nate6511]

@@thelettuceuk I know people (minors even) who received antidepressants before ever visiting a therapist! A lot of the issue here is that it's simply easier/less time consuming/cheaper to offer a "miracle drug" over options that require more work from all parties involved.

[@scarred10]

@@johnandrewcameron1 you mean there are several precipitating factors but they would present with consist symtoms.I remember 33 yrs ago when I was diagnosed with organic depression largely due to family history and absence of onvious stressors they thought only meds would work and I was offered no therapy.The cause was actually BDD but they put that down to the depression also.I would agree that psychiatry is the least evidenced based of all medicine withany docs having very little psycho therapeutic skills at all.

[@ghostbeetle2950]

I cannot say just how refreshing and admirable it is to hear so much epistemic humility from a researcher. The sentence "This makes perfect sense, aside from the fact that it's wrong." is a sure sign of somebody who is worth listening to. That has become so rare to find, especially in the last two years. Thank you!

[@iatsd]

He's not a fvcking researcher. He's an ER nurse. That's all. I wish to god people would stop pretending this guy is anything other than that.

[@eugeniebreida1583]

Who is the researcher to whom you refer? John Campbell didn’t/ doesn’t undertake laboratory research, so far as I know.

[@iatsd]

@@eugeniebreida1583 They won't reply. They don't have the honesty or the intestinal fortitude to reply when their fantasy is threatened.

[@AngelaKSellsHomes]

You are so Awesome, thank you for help we can trust. You are one in a million!

[@livechimera666]

hi john i am very appreciative of all the information you provide andit has helped me no end. i am an autistic adult suffering long term high anxiety and depression. me watching this video is part of me trying to resolve a forward path for my treatment of my depression and whether or not to start trying anti depresents. so thank you for the updated data on this.

[@BiltongJerky]

Speaking of wrong assumptions, amyloid plaque causing Alzheimer's is classic.

[@GailBecker-MSED-CM-Author]

Thank you for correcting that information. We love doctors like you who are not afraid of honesty. Bless you, Dr. Campbell! 🙌

[@andrewditton7226]

"People who are no afraid of honesty" You mean the people who were labeled as crazy for saying exactly this for years? The ones that knew they'd be ridiculed for spealing the truth and did it anyway? Or the ones who are only JUST NOW coming out with it? Now that it is safe for them to do so?

[@carlospoblet8692]

Thank you for your intellectual honesty

[@baileescott401]

Depression is an environmental disfunction, your life has you in this mindset. The way you process your emotions is clearest identifier of mood disorders. What if we provided a Mental Health class, in every elementary school, giving children a foundation to process emotions healthily. It wasn't until 7th grade that I asked an adult to actually explain stress to me, and how do I choose to be happy. Currently Society fails those who have a hard time with emotional awareness. Particularly in rural America, there's no where to truly get help, unless you have TONS of cash to hand out. All of the medications I have tried are band aids to emotional symptoms, which triggered by a dysfunctional environment. The symptoms don't go away, or even become manageable, unless you have the emotional support there as well.

[@nauxsi]

Interesting. It would have helped me as a youngster.

[@nsiebenmor]

Yup. This is pretty much it but “Doctors don’t yet know was causes it”. I believe what always precedes depression is intense or chronic stress and inability to manage it in a healthy way. Also ruminating in the past. This could have a genetic component causing obsessive thinking which when not channeled in a healthy way leads to rumination. Some people are born more sensitive then others into a society that values materialism and competition for resources. If these people and their emotions are not recognized and channeled in a good way by their caregivers during those formative years they develop unhealthy attachment styles, feelings of not belonging, personality disorders, black and white thinking, and other dysfunctional thinking patterns which lead to depression.

[@ReeceS6419]

I felt like I knew so much after I graduated from nursing school. You are in a good place if you are willing to learn things all over again and let the pride go. This is a man that I trust, because of his willingness to admit when he is wrong. 🙂

[@andreawalker2535]

Well, it wasn't his fault that he got it wrong! The science was faulty, and it is a miracle that anybody was helped by these drugs. The drugs were meant to get people back to work and eliminate face to face therapy which is what helps people, IMHO. Insurance limits therapy, and, so, think that through. Retired psych RN here.

[@baseballmomof8]

Yes!

[@ReeceS6419]

@@andreawalker2535 You are so right and I meant no offense. You rarely hear of doctors or scientists saying they got it wrong, is what I meant. Data is constantly changing and we need to be up to date and informed and readily admit when we get it wrong. Especially now with the craziness of the last 2 years in the medical community!

[@leonardmead1425]

I love this guy and I'm going to draw him and put it on my wall, he is just so honest and and wants people to know what they would find hard to hear anywhere else

[@MichaelJohnson-kq7qg]

That's not a reliable arbiter of trustworthiness - it's a bare minimum you should expect of any person. Campbell has been wrong or misinformed on a lot of subjects and is yet to admit he was wrong about those issues - don't put him on a pedestal because he accepts the results of one metastudy.

[@punkynoodle9370]

Thank you for your video. Another issue as well: your gut microbiome. The types of bacteria in your gut, and any dysbiosis, really do affect your overall health and the gut-brain axis.

[@CostaKazistov]

Really good point.

[@bradturner7678]

Sunlight, gut microbiome, and enough nutrients will help most greatly, ive looked a lot at diet and lifestyle and they have a massive impact on depression.

[@thomasrussell4674]

Dr Campbell, I really respect your honesty, all I can say is that it's refreshing to see people acknowledge the need for revising their views.

[@FiatMihiSecundumVerbum]

Thank you Dr, now I know I'm not crazy or broken for still having depression even after increasing my serotonin levels. Let's hope and pray for a cure soon.

[@tcperry66]

I love how you explain things. I think if I had you in school I would have done better with remembering what I was being taught. Thank you for the visual. This helps me understand more.

[@gwenbrowne9900]

For me, the SSRI didn't really make me feel any happier, it just made things look 'not so bad', so I was able to function better.

[@flowerpower3618]

Exactly. I’m on them because I need the boost to be able to practice cognitive behavior therapy and exercise and even pray. I don’t care how they work but I know that for me SSRI ‘s have been a miracle.

[@stadiumarcadium2351]

numbing is not a fix

[@momkatmax]

It took me from the blackness to a level of gray. That was a victory. I could catch my breath and allow myself to function. SSRI didn't have any side effects, and certainly didn't make me happy just removed the abnormal depression. After 30 years I am of normal mood, a person who has contentment with normal occasional changes of mood . You can't be happy all the time, that isn't guaranteed to anyone. You get days that stuff happens!

[@666chapelofblood]

Brain killer tablets.

[@roisinmc7442]

They made me completely blank and emotionless. I'm convinced it created an ahedonia in me from which i've never properly returned even though i'm off them 20 years. I never feel excited or really happy or sad about anything.

[@ms.information8747]

WOW! Takes not only courage but a really high standard of ethics to admit this error, and by doing so right after finding out the truth Dr. Campbell gains even more of our admiration! Can we please get him on an advisory board in the govt.?

[@alexam1848]

I'm a long haul depressed patient under treatment with SSRI since 2005 and it's working.

[@MrIhatemylife2]

I'm a resident doctor currently. During medical school a few years ago, most of the psychiatrists I worked with didn't believe that increased serotonin levels were the main mechanism by which anti-depressants actually worked. Studies from about 10-20 years ago were pointing in that direction. The psychiatrists, at the time, were under the impression that SSRIs worked through anti-inflammatory properties of the brain, or other vague/complicated pathways not yet understood.

[@alnicospeaker]

reduction of inflamation sounds interesting and would certainly explain why drastic changes in diet also seem to work

[@merg-vh5sx]

So juicing and fasts are probably as effective as anything else. Love it for us. 1x liver detox (but detoxes don't work) annually while we fix our gut microbiomes (hippie nonsense, won't work, leaky gut is a lie). Imagine patients' frustration. Imagine.

[@robinhood4640]

Our current health crisis is inflammation, it's been going on for a while,and it has caused a lot of suffering and death. Coronavirus is a stroll in the park in comparison.

[@monishbiswas1966]

Yeah - as with a lot of things the evidence base and consequently sentiment changed gradually, rather than a single study or paper changing eveyones mind.

[@ysteinberg5084]

Which means, again, that sugar might be the real culprit.. medicine tends to go for the symptoms and not trying to find the root cause..

[@ronelsteenkamp8716]

"I was wrong"...NO, you only taught what you were taught. This is happening in every and all sectors of life. We learn, we teach, we live, we improve (hopefully), we learn some more, we adopt an we start teaching again, only to improve and adopt again. As long as we stay teachable, we will keep on improving. Thank you for being a teachable, adopting teacher!

[@georgyporgy5539]

…It’s not as simple as just saying “I was wrong” the carnage caused to humanity in the meanwhile is unfathomable.

[@dougb70]

the message that doctors can be wrong is a good one though. There is a happy balance where we trust our doctors, that requires both authoritative and prescriptive advice alongside a humility that we are just all just human making educated guesses based on the limited information we have.

[@georgyporgy5539]

@@dougb70 “…doctors can be wrong” and then there is blatant incompetence. I wonder how many times doctors heard their patients telling them their (depression) medication is not helping, and their Doctors ignored their pleads AND gaslighted them into continuing to take them.

[@pmm8621]

Not a squeak from him about being extremely wrong about Ivermectin? Eh?

[@dougb70]

@@georgyporgy5539 the problem is that the do work. But they work with side effects and cycles. Super hard to tune. Most doctors would just change the script and/or dosage until they stumble into something that works better. The suicidal ideation is perplexing though. I think that is novel to some SSRIs. I don't think the science is in really.

[@emmagifford9417]

Excellent and insightfully put. More research definitely needs to be done, I have always been a bit suspicious of antidepressants with all the side effects it can cause and the difficulties with people coming off them.

[@Stormingnj]

Excellent Dr. Campbell. I hope you will follow any progress in this subject and present it.

[@wallsgreebo8352]

The world needs more doctors like you. Clarity, honesty and good communication. Thank you🙏

[@chrisstevens8431]

Campbell is a retired nurse, who for months was cheer leading for the deadly tea, and now when the dangers are undeniable has reversed his earlier position.......lol

[@clavo3352]

Well said in few words !! I sure hope AI gets Dr. Campbell's integrity.

[@iatsd]

He's not a medical doctor. He's an ER nurse. Unless you were intending to say the world needs more doctors that are actually nurses, in which case, carry on.

[@wallsgreebo8352]

Mate i can carry on regardless of whether you give me permission or not 😂 Whether he's a doctor or a nurse, all i care about is he's giving decent information and communicating it in an honest and clear fashion. Now off you piss 🖐

[@cvbabc]

Wouldn't it be funny of they submitted the paper incomplete saying they were just too depressed to finish it...? Thank you Dr. Campbell for everything you do, your lack of fear and unswerving honesty is a Godsend during these dark times we live in.

[@darrenthomson1930]

Get me a bucket.

[@nturner82]

Thank you for your work, John

[@2stayfree11]

So much to learn.... Thanks for standing in your integrity.

[@allanchapman7986]

As a student many years ago I was told that these drugs do not work for everyone. At the the end of the lecture there was the normal "any questions". I asked a simple question " if depression is caused by low levels of serotonin and that is corrected but does not cure the depression in some, surely there must be other causes"? That was 35 years ago! I was told I was over simplifying a very complex area. To me it was a basic observation based on logic which now appears to have been right.

[@squirrelpatrick3670]

Your teachers were repeating a party line which your question exposed as flawed. The party line is now, the drugs work but we don't know how. The truth is that they don't work, but the industry can't admit to just poisoning everyone for pharma profit.

[@squirrelpatrick3670]

Very similar happened with mercury amalgam dental fillings. The party line changed from, the mercury is locked in and doesn't escape. Then when that was disproved, they changed it to well it escapes but not in any significant amount to cause harm. Then when that was disproved, they changed it to well yes it can cause harm but patients are best off not changing anything as removal can be dangerous. The guiding force is to admit as little fault and disruption as possible

[@cowboyjohnsontown]

Exactly! Also if talk therapy and CBT help, why include the meds? Or if the meds work, why do talk therapy? They almost seem like opposite treatments and yet they're usually prescribed together. Are we trying to get to the heart of the issue (talk therapy) or numb the pain (SSRIs)? The truth is that SSRI are emotional pain killers. In certain extreme cases, they can be life-saving. But in reality, they're over-prescribed by doctors with no sustainable long-term treatment plans. The chemical dependency they cause is intense and often not discussed when the pills are prescribed.

[@PoKeKidMPK1]

this doesnt make sense, it would be right to say that would be simplying the problem. you did admit, and present, a simply simplifying question to something really general, and so cant really be answered right then there... it could be multiple things rather than just, serotonin or not serotonin. and even if you single out serotonin, it just takes away a single thing from many many possibilities, rather than giving some or saying everyone of those many many possibilities could work instead... the question seems to want to answer itself, or do whatever that fallacy is where you force the answer you want, thus making a fake question. (as well as ironically, despite wanting and thinking that answer and be it as correct, you consider it incorrect. so you contrarily dont want the response while asking for it and thinking it, and they did give it, but also consider it right and wrong at the same time?) it also seems the question was about something already known, as you stated they said drugs are known not to truly work and shouldnt be relied on, and yet or but making it as if it wasnt known... but then the knowledge which the question was based upon wouldnt exist and so the question as well wouldnt exist if that was the case... it just seems contrarily ironic and redunant all at once... (most especially contrary when considering you want and dont want the response, you both have the response but consider you both dont, and seem to consider both that exact statement right and wrong at the same time?...) its more of an unfinished thought said out loud rather than a well built question to ask.

[@allanchapman7986]

@@PoKeKidMPK1 .In many ways I agree with you but when you are told the answer is down to one element without other elements being discussed in the lecture then it is an obvious question.. At the time I was working on a ward where every patient had had some from of abuse in early life. To me that made more sense to me as a primary cause. Sadly at the time there were differing views on treatment some doctors going for chemical treatment whilst others were in favour of councillors and early forms of CBT.

[@dawnelder9046]

My parents noticed the extreme rise in depression starting in the 70s. About the time they started pushing low fat and fake fat diets. I followed a low fat, high fibre diet for years. Had all sorts of problems. Would not take drugs. Fourteen years ago my husband had 3 strokes and we found out he was diabetic. I put him on the low fat diet they gave me at the hospital. Basically the same diet that had failed me for decades. For 8 months both he and his blood work were worse. I read Good Calories, Bad Calories. Watched The Oiling of America. Changed both of our diets to the old 1950s British diet in the prologue of Good Calories. Removed all seed oils from the house. Two weeks later he had his first improvement in bloodwork. Several months later a stranger understood him. I went from barely fitting a Canadian 18 to a 6/8, all without starving. My depression disappeared. My degenerative bone disease in my right foot healed. My hunger shakes disappeared. Have stuck with the old diet advice and would never return to low fat hell. Interesting history of the Food pyramid, which effected the world. A good Nutritionalist did the research, but she refused to have her name on it. The senator in charge let his vegan buddies change it to the monstrosity that came out. She warned them if they put it out and people followed it that there would be a massive increase in obesity, diabetics, heart attacks, strokes, depression, dementia, autoimmune disease, cancer, etc. She was right. When they saw that it failed people, especially the carb sensitive, they gaslighted them into believing they were the problem, not the bad diet advice. Most people are carb sensitive, and will gain. But just because you do not gain on the death diet, does not mean you are healthy. Breast milk is full of cholesterol for a reason. The brain needs it. Look up the Korean Cholesterol Mortality Study published in 2019. Over 12 million subjects and no money from big pharma. Low cholesterol is the big killer. People between 200 and 240 live the longest. Over that it is barely noticeable and that is likely connected to damaged lipoproteins. Under 200 the death rate increases dramatically for everything, including suicide.

[@dylan3657]

Makes sense were dealing with bond villains they call them selfs our representatives

[@kep8814]

Bingo! you're spot on.... The brain runs off fat. High quality fat is a necessary... limit or avoid seed oils sugar and processed foods.. that's the key. Humans aren't meant to eat the way we eat today. Sweets were limited to raw honey once in a while. If your ancestors didn't eat it 100 years ago... don't eat it.

[@estycki]

My health also drastically changed when I switched to high fat diet. better digestion, skin (nails became stronger), energy levels, even my menstrual cycle was less painful! I still need some carbs I just can’t have the fast absorbing sugars.

[@ellachallas]

Excellent comment! Thank you for sharing!

[@tinaschultz9371]

The food started to get faker yes and the world more controlled, less free.

[@susiecassens879]

My so-called depression was from problems with my thyroid. I believe that tiny little organ is the culprit in most cases. Nice that finally medical establishment is questioning rather than prescribing. I am on a very good regiment now and I feel great.Thyroid tests do not tell the whole story and a good endocrinologist will listen to the patient's symptoms to arrive at a solution. I was fascinated to read how according to history "people were dropping like flies(dying) before the discovery of the thyroid connection". I feel it's connection to mental illness is overlooked to the detriment of society. Tests started in the 70's just aren't accurate and people aren't being diagnosed correctly.There are studies that connect it to addiction, depression and hyperactivity. Iodine is a big factor, too. Thanks for sharing your info.I hate seeing people suffer needlessly as I can totally relate.

[@user-dr350]

👆👆👆he helped me out drastically

[@user-dr350]

He got e'm all and ships discreetly too

[@movienut]

Always enjoy your content, Dr. Campbell. Thanks for sharing. Cheers.

[@francesco5581]

i am with Jim Carrey on this one, depression is your body asking for a change. What happens with neurochemistry is just the phisical reaction to that situation.

[@ChristianBiker777]

Depression is a sickness of the soul. The spirit of heaviness, sent by the devil to kill and destroy. I was healed (delivered from) this spirit and the sickness after suffering for over twenty years. I was saved by the grace of God through faith in Jesus Christ and healed. Depression was taken away - and I was cleansed through the blood of Jesus Christ, my saviour. A sinner, saved and healed by the grace of Almighty God. Only believe! Trust the science? No, Trust Jesus.

[@francesco5581]

@@ChristianBiker777 i think was your body (or soul depend of what you believe) asking to be more spiritual, to make a step above. Science is a way to gather knowledge, scientism however is bad

[@funkyfranx]

@@ChristianBiker777 Please stop. You are not helping anyone.

[@lady-bug939]

Dr Campbell has very effective teaching skills. His teaching is effective because he doesn't treat his audience like a bunch of 8 graders. Love his diagrams.

[@0miy0]

At last, Good on you sir for having the confidence to combat decades of work because of a study, true humility

[@annoates4221]

Thank you John for such a clear explanation.

[@r8chlletters]

I can tell you firsthand that lowered hormones in perimenopause and menopause causes depression and anxiety…and the solution for me was HRT, that is, hormone replacement. Without them I’d be in a spiral. Many doctors shuttle women toward antidepressants which is a huge error if the issue is simply lower levels of hormones (E, P, T).

[@passionatesingle]

I guess it's because so many women are afraid of taking HRT therfore they are put onto anti-depressants to help their symptoms of mood swings etc. Once again it's been misinformation on Hrt studies that have scared women off them. I am on HRT myself. I also take care of my mum who has Alzheimers and I am sure I wouldn't be able to cope without it asmy sleep, hot flushes and night sweats kept me up at night and grumpy in the mornings. Not to mention depression that I could have developed from the situation. But I am great! It is also protection against heart disease, osteoporosis and alzheimer's. I think the benefits are greater than the risks if you are an ideal candidate.

[@Burevestnik9M730]

Not only that but schizophrenia as well

[@blueseptember2174]

I believe it because I get severely depressed the three days before my cycle. But I remind myself that it is coming on and why I'm crying, down, and depressed. It helps to cope when you know your causation. Def hormones for some!

[@prettybirdbeenlpeacock6592]

HRT is not for everyone. I was going to start taking them and have a hysterectomy due to a family history of ovarian cancer. But I put it off for a year. Thank goodness because at 43 I was diagnosed with metastatic breast cancer which would have grown like wild fire had I taken the HRT and then shortly after they discovered that HRT increases the incidence of breast cancer. Funnily enough, I took Effexor for anxiety after the cancer diagnosis. Effexor was noted to have the added benefit of reducing hot flashes - which were horrific due to the early menopause caused by the chemotherapy. But hey, I’m still alive 22 yrs later!

[@giao2380]

I have BIOTE pellet and I’m still depressed.

[@fff5572]

Thank you for making this. The narrative around depression and serotonin never made sense to me. I suddenly developed chronic depression and severe OCD after my daughter was born. While I am predisposed to mental illness it seems strange that I'm mostly okay all my life and then, as if hit by a train, now need to take medication in order to function normally. It's been three years of this now and I don't know why I'm not back to normal

[@puppetken]

This happened to me after my third child. Full blown postpartum and OCD. I take all natural now.

[@ciderodd4278]

Such an important video. I’ve been on the same ssri for 10 years and don’t think I’ll ever be able to come off. I’ve worked very hard to heal myself from anxiety and ocd.such a multifaceted condition

[@adamnottage8642]

It was a great shock for anybody in the medical profession to admit to an error. Unprecedented, in my experience.

[@reginaford8575]

Humility is a gift. The best of mankind is the BESTof mankind. No perfection ! We are finite and there is a Creator greater than us. My Father in heaven in Jesus name says" His thoughts are higher than my thoughts, Gis ways are higher than my ways" Once The Creator is removed by the creation, there will be confusion. Study the Manual-The Bible, believe it and do what it says to do. We have suppressed the truth and the TRUTH !!

[@jujutrini8412]

You must be young.

[@scarred10]

I've been I medicine a long time and never heard a psychologist/ psychiatrist claim low serotonin caused depression, it was only thought to be 1 possible explanation but without evidence.

[@heidid418]

Yes and how many peoples brains have been damaged for the rest of their lives like my spouses.

[@scarred10]

@@heidid418 no evodemce anyones brsin wax was ever damaged by meds

[@KingsClinicGlasgow]

I remember an enthusiastic drug rep, sometime in the 80’s, bringing me (a GP) the news of a new class of drug, the SSRI. Apparently, so the story went, depression was caused by a chemical imbalance in the brain and SSRIs, one of the early ones being Fluoxetine (Prozac), were effective in helping restore a proper balance. I also remember my immediate response: ‘Just a minute! Correlation is not causation. Perhaps the ‘chemical imbalance’ is not the cause of depression but the result of it’. I’m putting it simply. Since then, of course, we have discovered a lot about how the brain works. The brain does, indeed, change in response to our state of mind, not only chemically, but macroscopically too - the changes can be seen on MRI scans. The phenomenon is known as neuroplasticity. (I realise you know these things, Jon!) It seems to me that it we ‘form ourselves’ through the choices we make, not least through the thought processes that we choose to accommodate (or reject). Throughout my professional life I have taken this to be a guiding principle, particularly in the area of mental health. The application of this principle is the foundation for CBT (Cognitive Behavioural Therapy). If you want to change unwanted symptoms it is necessary to change how you think. That’s it, in a nutshell. SSRIs represent inappropriate treatment because, in so far as their mechanism of action is understood at all, they don’t go to the root of the problem. The use of SSRIs was always a case of the ‘cart’, of trying to treat the consequences, being put before the ‘horse’ of managing the causes. And that’s why they don’t work. During my 40+ years of general medical practice I saw many hundreds of patients taking antidepressants. Very few of them unequivocally benefited from them. Many took them for years without knowing whether they made any difference at all, but were reluctant to stop. More often than not, I think, they were prescribed as the default option by hard-pressed GPs for ‘treating’ unhappiness. The evidence for the efficacy of antidepressants is conspicuously absent.

[@jeffkiehne2545]

There seems to be evidence that cover up of use by Mass shooters in the United States as they hide medical records .

[@Ayyeliki]

@Kings, I’m with you on the CBT front- although connecting with a competent therapist can be quite a challenge, sadly! I had the fortune to find one such soul who helped me with an eating disorder after college - and the ability ( a learned skill) to question my thoughts and challenge the rationality of them has helped me on so many levels ( esp. with my nutty teen now). As an aside, Have you ever read The classic “ the Road Less Travelled “ ( 1978 I think) by M.Scott Peck , MD ? He was A practicing psychiatrist, back in the day when they mostly offered psychotherapy before any meds ( slim pickings anyways those days ). After years of experience, he came to the conclusion that “… this tendency to avoid problems ( which he previously states are common and to be expected in life) and “the emotional suffering inherent in them is the primary basis of all human mental illness. Since most of us have this tendency to a greater or lesser degree, most of us are mentally ill to a greater or lesser degree, lacking complete mental health.….”. It’s a very deep, fascinating and thought provoking read- my favorite book after the Bible. I highly recommend , the older stuff (as I call it) is so solid!

[@kimlarso]

👏🏻👏🏻👏🏻

[@jeanwallace9791]

@Running Red Fox Why would you want to change peoples thoughts If they can live with them.?

[@dougb70]

there is a right time and place for each tool. If a patient comes to you starved, you don't take the moment to teach them to fish. You feed them. Then over time you teach them sustainable patterns. I suspect that is the same for mental health. SSRIs can be a good tool to facilitate coping in the immediate term. In the intermediate term, you apply therapeutic methods to mold the development of healthy thought patterns.

[@bonniewood5286]

I am just getting through a five year fight with severe drug resistant depression. Tried many different kinds of anti depressants over that time and for three first four years it was hell. It gave me panic art tracks, high anxiety and agoraphobia. So I think it is something else other than what you are saying. I believe it’s in our DNA, on my mothers side there were four generations of depression suffers, two committed suicide, two tried. At 67 this isn’t my first time, I was hospitalized at 40 for suicide and was there till they found as drug combo that helped (Effexor and Nortriptyline) which I was on till this break. I just wish they could a way to stop it it changes you, you lose memories, get brain dogs etc. I appreciate your explanation of the new findings and look forward to the next information you provide! Thank you, I’ve been following you since Covid started along with Chris Martensen at peak prosperity. You both kept me healthy, no covid, no omicron ,, no flus or even and no jabs. Read to many reports on to put in this old body. Thank you!

[@SarahDale111]

Would you consider trying a carnivore diet? It has helped me (and many others) immensely.

[@robertdancho9671]

Thank you for your dedication

[@trobertw]

I started having seizures in 2020 for the first time in my life. Had to change careers because of it. Almost all I've learned about seizures and the medication since then I learned on my own. The neurologist meetings only lasted for a few minutes, and basically boiled down to: "here's your pills, call us in 6 months for a follow up" ... disappointing. Upon researching the pills, neurologists don't know exactly how they work apparently other than that they "calm" the brain for whatever reason. So in addition to the pills, I've taken it upon myself to try and "calm" my brain in other ways too. I've cut out caffeine and alcohol, and greatly reduced sugar and carbs, started going to sleep earlier, and even meditating and using less electronics at the evening. It's worked for 9 months now, but why did none of my doctors even recommend those things? They seem like obvious beneficial measures to me. They just wrote the prescription and had me on my way.

[@Broken4forever]

Some Dr's aren't there to help you with health, just there to prescribe and get a paycheck unfortunately...

[@lindacox4176]

Our health care system wants us sick, not well. They don’t make any money when we are well!

[@happyguy2k]

@@Broken4forever also look into the endocannabinoid system

[@lisashapiro6737]

I've been seizer free for 20 yrs. Medication caused my few spells ..

[@sandrawalker8839]

Western medicine is pharmaceutical oriented

[@I_Am_SciCurious]

I was taught this in college 35 years ago. It’s disheartening that for decades we haven’t done research into the true cause of depression, working on the false assumption that we already had the answer. I’ve been diagnosed with depression for decades, and no medication ever truly helped. What does help is eating only whole plant foods. it’s a diet that reduces inflammation, including neurological information. That and mild exercise of just getting outside and going for a walk every day or swimming, gardening, etc. A few years ago, I read a paper on depression being caused by inflammation. Inflammation occurs as a symptom of illness, which makes social animals like humans stay away from others in case they infect their entire group with a disease. I think some of us, or even many of us just can’t deal with processed foods and all of the crap in them, along with animal products which contain myriad inflammatory molecules.

[@mrsthatcher9815]

enjoy getting dementia without animal products

[@I_Am_SciCurious]

@@mrsthatcher9815 there is no scientifically demonstrable link between vegans and Alzheimer’s. Population studies show a lower risk of Alzheimer’s for vegans, while others say it makes no difference. Having said that, even if there were a demonstrable link, I would still stick to the whole foods plant diet. Alzheimer’s is hardly the only disease that can afflict humans, and avoiding animal products and processed food demonstrably lowers your risk for countless other diseases including heart disease and type two diabetes.

[@mojopin70]

Yes it's an inflammatory illness I am certain and stress with anxiety / depression causes the inflammation. Sure the gut has something to do with it all too.

[@mrsthatcher9815]

@@I_Am_SciCurious total nonsense, you are confusing processed food with animal products, there is no evidence for your claim but there is evidence for mine - good luck with obtaining all you nutrients from plants, lol

[@I_Am_SciCurious]

@@mrsthatcher9815 No, I’m not confusing the two, which is why I listed them separately. Studies show vegans are deficient in four nutrients vs animal product eaters being deficient in seven nutrients. This will be my final response to you. You’re clearly not interested in learning outside of your biases and bigotry, and I have better things to do than talk to a proverbial brick wall.

[@patriciathemaras3274]

I would trust you as my primary doctor any day! I truly trust you. Medicine and the sciences are always evolving. Thank you for your info and research doctor.

[@lindawesp9846]

Thank you soo much for telling the truth!!!

[@danatowne5498]

Humility like this is what inspires trust - not the (over) confidence you often see. I think that false confidence helps doctors/scientists do what they need to do, which is tinker with the lives of the the people coming to them for help, but the risks of that approach far outweigh the benefits. This sense of humility should be taught to medical students everywhere. Thank you so much, as always!