Determining SN1, SN2, E1, and E2 Reactions: Crash Course Organic Chemistry #23

Organic chemistry isn’t that different from an adventure game, with substrates as characters, nucleophiles as magic potions, and reaction conditions as different magical kingdoms. In this episode of Crash Course Organic Chemistry, we’ll learn the tricks to this game so that we can figure out which transformation, or mechanism, will occur when we combine any substrate with any nucleophile. Let’s go on an adventure!
Music Used:
Truth of the Legend by Kevin MacLeod
Link: incompetech.filmmusic.io/song/4551-truth-of-the-legend
License: filmmusic.io/standard-license
Series Sources:
Brown, W. H., Iverson, B. L., Ansyln, E. V., Foote, C., Organic Chemistry; 8th ed.; Cengage Learning, Boston, 2018.
Bruice, P. Y., Organic Chemistry, 7th ed.; Pearson Education, Inc., United States, 2014.
Clayden, J., Greeves, N., Warren., S., Organic Chemistry, 2nd ed.; Oxford University Press, New York, 2012.
Jones Jr., M.; Fleming, S. A., Organic Chemistry, 5th ed.; W. W. Norton & Company, New York, 2014.
Klein., D., Organic Chemistry; 1st ed.; John Wiley & Sons, United States, 2012.
Louden M., Organic Chemistry; 5th ed.; Roberts and Company Publishers, Colorado, 2009.
McMurry, J., Organic Chemistry, 9th ed.; Cengage Learning, Boston, 2016.
Smith, J. G., Organic chemistry; 6th ed.; McGraw-Hill Education, New York, 2020.
Wade., L. G., Organic Chemistry; 8th ed.; Pearson Education, Inc., United States, 2013.
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[@charlesbwilliams]

I love this series, organic chemistry can be so much fun when you don't have to learn all of it in one semester with a deep emphasis on grades

[@ashnovahmada499]

Well, can't wait for a new DnD sourcebook called "Chakravarti's Guide to Chemistry"

[@fionaruss1401]

Why would problem 4 react through SN2 if the nucleophile is weak? I though weak nucleophiles were for SN1 only.

[@Peace_And_Love42]

Most of the organic chemistry episodes have gone over my head, so I skip them, but putting it into D&D terms made it palatable. (I'm probably an outlier, but I wanted to say how much I appreciate the extra effort)

[@Peace_And_Love42]

Follow up, I found "we might expect A, but B actually occurs" derailed me a few times when I knew the answer, but then doubted it when you brought up a wrong answer as a contrast. Since this is information I'm trying to memorize, talking about the right answer first (or only mentioning the right one) may be more helpful. Thank you! #NeverNotLearning

[@jneal1347]

Same!

[@radagastwiz]

Cameo appearance by Craig Benzine as the Primary Benzylic. Nicely done.

[@SuperAndrewlove]

Hehe thank you glad you appreciated that 😉

[@ironpenguin42]

I’m in Orgo 2 right now learning ethers and epoxides this is helpful

[@kummarikrishna9608]

Any JEE and NEET students from INDIA here....

[@21centuryg]

What a great way to teach this subject!

[@nilishabharadwaj]

This was bloody needed!

[@Cremebrulee.7]

IDK WHAT ID DO WITHOUT U CRASH COURSE. My teacher is a good teacher but the ampunt of time they out into their own doodle video examples is insane... i usually watch all of them and these but it was 5 hrs long this week and tbh, your videos sum it up way better PLUS PICTURES. I NEEEEED PICTURES AND RELATABLE EXAMPLES TYY

[@soco2020]

Nice timing with this video. Thanks!

[@odainicdenis1060]

It's all fun and games until chemichals get an upgrade

[@pvtpain66k]

Fun Fact: That "Benzene" is modeled on Craig Benzine, AKA Weezey Waiter. He was the host of Crash Course U.S. Government & Politics.

[@SuperAndrewlove]

Well done good eye! 😉

[@Randomthingsandchick]

Learning this in orgo perfect timing

[@bestsynth4102]

I clicked for the D&D, stayed for Deboki's TF into a dragonborn. We need more dragonborns in this day and age

[@aniketkedare8]

Best video and innovative, creative creation

[@trlanhuseyn741]

Crash course is the best. #thankyoucrashcourse

[@yashvangala]

First! and thank you so much for helping me get through O chem!

[@jerrystokvis5857]

I just want to say a massive thank you on behalf of 147 THOUSAND people who are learning with your help!

[@jannethasmr]

even though she put it nicely into D&D terms, I am just plain stupid because I STILL cannot understand it.

[@BullPavl]

How does one know which direction a reaction goes? Like, in the example 3 at 12:52, the result is counterintuitive to me: we start with stable methanol, and the reaction goes in the direction of formation of a strong acid (which is quite unstable). Why doesn't the reaction go the opposite way? How do we decide which direction it is supposed to go?

[@mohitgohil4650]

WHY LATENT HEAT OF VAPORIZATION DECREASE WHEN INCREASE IN PRESSURE OF WATER PLS EXPLAIN.

[@tanmaykhamankar]

Hi there love ur videos

[@Roltt]

Never thought chemistry will be a game

[@twokidsmovies]

D&D for life

Haha just before my exams, waiting for epoxy ether etc

[@ethanbonafede]

Smart words...

[@ellenmurphree4927]

oh thank god, my exam is tomorrow

[@mdsifat8900]

Nice🤟🤙🙄

[@smoopydoopy7745]

Yayyy

[@abhijeetsharma8966]

leaning this for my jee exam

[@awesomezilla]

Chem tree

[@Emi-tc5ju]

the video is too fast

[@SamiKankaristo]

The kind of game you're describing sounds more like an RPG (role-playing game). You go for an adventure in RPGs, too, but an "adventure game" usually means either: - a (point-and-click) puzzle-solving adventure game (e.g. Grim Fandango or The Secret of Monkey Island) - an action-adventure game (e.g. Tomb Raider or The Legend of Zelda series).

[@katday5928]

We fact-checked this episode so carefully, too ;-)

[@jewett425]

25 likes but 1 view and 1 dislike, how is it possible

[@ahmedgxr8213]

First comments اول تعليق

[@childofgod9219]

Rere

[@barthelemygarceau157]

What are you even talking about

[@childofgod9219]

Eeeeeeeeee

[@henryelicker2403]

Mfw you think it's one E1 but you get multiple products with E1, SN1 and who even knows what

[@childofgod9219]

First!

[@prestoncassell4461]

First

[@cgsplendor9745]

first

[@jiabarrett]

what about cash course kids:(