Diabetes insipidus (DI) Internal medicine

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Diabetes insipidus (DI) Internal medicine
Diabetes insipidus (DI) is a condition related to water balance and fluid regulation in the body. It is not to be confused with diabetes mellitus (the more common form of diabetes), which is related to blood sugar regulation. Diabetes insipidus is a disorder of the posterior pituitary gland or the hypothalamus, both of which play a crucial role in maintaining the body's water balance.
There are two main types of diabetes insipidus: central diabetes insipidus and nephrogenic diabetes insipidus.
Central Diabetes Insipidus (Neurogenic DI):
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This type is caused by a deficiency of the hormone vasopressin (also known as antidiuretic hormone or ADH) produced by the hypothalamus or released from the posterior pituitary gland. Vasopressin helps regulate the body's water balance by controlling the reabsorption of water in the kidneys.
A problem in the production, release, or function of vasopressin leads to excessive urination and an inability to concentrate urine, resulting in the excretion of large amounts of diluted urine.
Central DI can be caused by various factors, including head injuries, tumors, infections, autoimmune diseases affecting the hypothalamus or pituitary, and sometimes it can be idiopathic (unknown cause).
Nephrogenic Diabetes Insipidus:
__________________________________________
This type is characterized by the kidneys' inability to respond to normal levels of vasopressin, even when the hormone is present in adequate amounts.
The kidney tubules do not properly reabsorb water, leading to the excretion of large volumes of dilute urine.
Nephrogenic DI can be caused by genetic factors, certain medications (e.g., lithium), kidney diseases, and electrolyte imbalances.
Diagnosis and management of diabetes insipidus are typically handled by internal medicine specialists or endocrinologists. The diagnosis involves a series of tests to measure urine output, concentration, and blood levels of vasopressin and other related hormones. Imaging studies like MRI may be used to identify structural issues in the brain or pituitary gland.
The treatment of diabetes insipidus depends on the type and underlying cause. For central DI, synthetic vasopressin or desmopressin (a synthetic ADH analogue) can be prescribed to replace the deficient hormone. In nephrogenic DI, treatment focuses on addressing the underlying cause and managing symptoms, often with dietary adjustments and certain medications to enhance kidney responsiveness to vasopressin.
Diabetes insipidus (DI) is a disorder in which polyuria due to decreased collecting tubule water reabsorption is induced by either decreased secretion of antidiuretic hormone (ADH) (central DI) or resistance to its renal effects (nephrogenic DI). In most patients, the degree of polyuria is primarily determined by the degree of ADH deficiency or resistance . Thus, the urine output may range from 2 L/day with mild partial DI to over 10 to 15 L/day in patients with severe disease.
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[@tiffanybrown1715]

Since technology has taken over every aspect of our lives, sadly the art of teaching is nearly nonexistent. You sir are an amazing teacher. Thank you for posting this lecture!

[@doctorbhanuprakash]

Wow, thank you

[@aamirkhan-ut6mq]

But sadly there is no cure...

[@drchandanisingj9527]

Such a delight to watch such a good lecture really a masterpiece by dr Rajesh gubba sir

[@ciyabenoy]

Respected dr Rajesh , sir I was doing endocrinology and was feeling bored reading slides of my ppt , came to KZbin for some visuals and I just love this video . Each and every concept is clear and perfect . Please upload full video of endocrine disorders . Thank you so much !

[@doctorbhanuprakash]

It's my pleasure

[@MG-hj3bw]

Very clear explanation. Understandable also to a non-medical person. Excellent!

[@doctorbhanuprakash]

Thank you kindly!

[@mahnoorkhan4399]

Waa sir mashallah your way of delivering lecture is so clear stay blessed

[@94SantoshKumar]

Great explanation...this is called teaching...even I am not related to medical or medicine field but got complete knowledge...👌👌

[@AnuGrewal-k8p]

Thx sir given knowledge about this 😊

[@doctorbhanuprakash]

Most welcome

[@meerathomas2280]

Thank you Doctor. Wonderful lecture! God Bless.!

[@doctorbhanuprakash]

You are very welcome

[@chandanrathod7525]

Tq sir your teaching is really awesome...

[@muthummm6675]

Nice To See You. It is pleasure For Me To Comment Here!. Very Honest And Good!

[@kazan0013]

Lot of respect which don't make study a business

[@dr.praveenkumar9392]

Very nice lecturr sir..... Thanks for detail knowedledge about DI....

[@saniyakfgh1709]

Amazing lecture excellent iam suffering with diabetic insipid

[@mohamedahmed-xu8nr]

i am appreciate your excellence explanation

[@nsas955]

Thank you very much for such a clear and concise presentation .

[@senetrasen618]

Very helpful sir thankyou 🙂

[@PriyankaKumari-md3vp]

Thank uh sir for such type of useful video ..nd ur way of teaching is too good

[@kaushallata5378]

rajesh is the best teacher i ever know he is currently teaching us in DR. BHATIYA CLASSES

[@rajeshgubbadr]

Kaushal Lata thank u for all the love

[@Cass_i]

Perfectly taught. I understood this lesson very well and was able to do my practice Mcqs. Thank you😌👏👏👏

[@kyngkyng908]

i know it is kind of off topic but do anyone know a good place to stream new series online?

[@graysonibrahim9078]

@Kyng Kyng try Flixzone. You can find it on google :)

[@tobiasmyles5375]

@Grayson Ibrahim yup, have been using FlixZone for months myself :)

[@imranpaxton6538]

@Grayson Ibrahim Yup, I've been watching on flixzone for months myself :D

[@matteobrayden3276]

@Grayson Ibrahim thank you, signed up and it seems like they got a lot of movies there =) I appreciate it !!

[@sharingcare3058]

Great lecture sir...thank u...

[@jigarnayak22]

Miss u sir....and feeling happy to see ur lectures😊😀👌

[@DreamWithQueen]

Thnq for the video sir. It really helped me

[@doctorbhanuprakash]

Glad to hear that

[@rohitnautiyal881]

Beautiful Explaination 💓

[@doctorbhanuprakash]

Glad you liked it

[@rohitnautiyal881]

@@doctorbhanuprakash its our pleasure to watch ur highly knowledgeable view

[@doc1780]

Nice explanation more helpful if treatment dose aslo included

[@nishabainsla9063]

What is trauma Sir

[@siddiquimariyam2561]

Awesome explanation 👏 👌

[@doctorbhanuprakash]

Glad you liked it

[@shivamdubey3993]

Thank you sir for detailed explanation of ADH

[@II-tc7of]

Sir Please upload video on knee joint and hip joint

[@WildBloomChronicles]

Superb sy b upper 👍

[@swapna2289]

Great lecture Sir...Thank you

[@dr_mirzanimmatbaig7995]

Great sir

[@annasunny7239]

Thank you sir for this good explanation🙏🙏🙏

[@nishantpatel3144]

Absolutely loved the way you teach and cover all the points ❤👏

[@doctorbhanuprakash]

Thanks a lot 😊

[@Shan0025]

👍🏻 awesome sir....thankyou

[@doctorbhanuprakash]

Most welcome

[@muhammadusama6524]

This is one of the most precise explanation of diabetes insipidus disorder, thanks alot sir,keep move on and make further videos to serve the people most with your knowledge...!!

[@vishnumohanan2296]

Thank you🎉

[@doctorbhanuprakash]

You’re welcome 😊

[@deepamvyas2984]

Very nice explanation sir..thankyou😊

[@lyanlaith8448]

Where can i get more videos about another subjects for this doctor?

[@drikahmwanga2999]

Thank you Dr. Very helpful explanation 👍

[@jaldipchaudhary]

Easy to understand 🤩👌

[@doctorbhanuprakash]

Tysm

[@devashishvishwakarma3507]

its really helpful..thanks a lot sir .this makes this topic easy to understand for me. and also it coveres every information related to topic . again thankyou well explained!!!!

[@rishabhashok9299]

sir really very helpful and your explanation is tremendous plzzzzssir i insist one video upload on diabetes mellitus

[@ramsdoc2395]

Thank you so much sir

[@doctorbhanuprakash]

Most welcome

[@mukeshSharma-dd8nn]

Tnq so much sir... U teach very well

[@kritikathegreat6781]

Very well explained sir .... thank you😃

[@bipinpatel5608]

Thank you sir your video is very help ful for me

[@Vishalstu]

Very nicely explained

[@Jingles522]

Really helpful

[@santoshkoppula4124]

Do more videos sir. I'm ur student From mist Hyderabad.

[@gowrigowri1465]

Very excellent explanation sir thank you so much

[@sajadahanger3087]

Very good lecture

[@rimsharani17]

Great teacher 👌👌

[@anjithreddy3891]

Thanks sir......👌👌👌

[@mariajose7960]

Really good

[@doctorbhanuprakash]

Thanks!

[@altushaikh7929]

Thankyou soo much sir.....

[@apoorvasingh8470]

great.. thank you

[@priya9130]

Sir how sickle cell anemia can be the cause for nephrotic diabetic incipidus Please explain 🙏

[@zinnatali4122]

Sir I want to know about diabetes started from which point OR bomber pls sir possible answer me, next 6.8 are any diabetes chance OR fear pls answer me, sir if you answer this things that is very big help me also, Thanks. pls take care. have a nice day.

[@pratikbarvaliya2344]

very good presentation. thanks for explaining it in such easy way 😊

[@ricky240z]

May I ask what kind of medicine you had that solve this issue?

[@srirambhardwaj2343]

Thank.you.very.much.sir.

[@vinayakpatil9562]

very helpfull sir ty

[@ayushikhajuria3365]

well understood

[@murlygovin5011]

Wonder ful sir

[@kishorekumaraindala1587]

Thank you sir.

[@mujammeljewel1696]

thanks a lot

[@tuniyabeemroth1140]

nyc sir......👍👌

[@naveen3962]

thank you sir

[@souravnath1652]

Thanks a lot sir

[@rajendrabalara2539]

Osm yaar

[@arvinddr4543]

Good mornig sir pls about diabetes melitus

[@kernakoni5210]

This has been a challenging time, I appreciate you so much Dr igho, because you restored back my health, with your Herbal, i got from your KZbin channel, thank you so much for curing my Disease naturally, You are a Godsent

[@sanesapiens88]

Sir, isn't Thiazide Diuretic has the exact opposite effect? Isn't it actually used to clear water from the body? Here, we want to re-absorb the water to prevent excess water loss in the form of urine.

[@AhmadRaza-ye9qg]

How to measure urine osmolality?whats the formula?@Dr.G.bhanu parkash

[@tekkhatri8596]

dr.what is the treatement available for Central dibeties inspidus for cured.

[@drjavedhussain8311]

hi sir, just read that despite of pressure effect and resultant damange to posterior pitutary, hypothalamus still can secrete ADH direct to circulation.. whats your take on this

[@zahidmustafaunknown8045]

Good sir

[@tejaramnaidu868]

Nice 👍

[@onlineeducation3673]

Awsome video I have been using 40 iu vials (using 6mm BD syringes) for insulin for the last one month but I want to shift to insulin pen since it has 4mm needle size ,but the pen has cartridges of 100iu , how to convert the 40 iu doses to 100 iu ? For instance I take 35 units of insulin from the 40 iu vial how much should I take from the 100iu ,that would be equivalent thanks

[@fidauddinsiddique1971]

Sir how to fully control this Disease

[@gowrigowri1465]

I want to detail about hypothyroidism

[@tekkhatri8596]

dr please can u explain by hindi plz I am from nepal m suffered from this problem.

[@nishabainsla9063]

Sir ADH hormone ki synthesis body m kha pa hoti h

[@shivamdubey3993]

Hypothalamus ke supra optic nuclei Ke magnocellular neurons me, 9 amino acid hote hai isme

[@shivamdubey3993]

Ok

[@uniquemedicalstudy8878]

nice

[@ssulochanassulochana3696]

👌👌👌👍

[@ashishkumar-ks4bm]

Sir please upload cvs lecture

[@mansiruhela3868]

👍🙏🙏

[@shitijhkumar9146]

where i can met u

[@alfaxs738]

sir good day my brother suffering now diabetes insipidus please help me get a medicine for him. please thank you

[@mrsimranjeetsingh2601]

You are father ok yes or no

[@doctor.kaushee4845]

👍🏻👌🏻

[@poojajaidka1784]

I am suffering from Diabetes Insipidus .I took desmopressin medicine for a year but it didn't work.

[@plantlove4619]

How are u now? Even I suffer from this disease

[@hamzajarrral9044]

Take chlorpropamide or carbamazepine

[@hamzajarrral9044]

With desmopressin

[@nijabudeenmohammedn5354]

@@hamzajarrral9044 which medicine you are taking ? is their any betterment for di?

[@sahabazkhan1243]

I have diabetes insipidus? i was admitted CCU NRS medical college season on August 23 2020,

[@thakuryuvrajsingh6401]

Ab kaisa hai

[@MDJahangiralam-dg2jk]

বাংলায় অনুবাদ চাই।Please translate to bengoly.

[@poojaaryal8852]

How hypernatremia occurs in patiens with diabetes insipidus?

[@rajeshgubbadr]

pooja aryal There is free water excretion in Diabetes insipidus so there is hypernatremia

[@shitijhkumar9146]

which doctor cure this I have this diseas pls help me

[@rajeshgubbadr]

Endocrinologist

[@poojajaidka1784]

There is no cure for this one . I have been suffering from the last 16 years.

[@SomNath-cm3jn]

@@poojajaidka1784 Really?

[@shitijhkumar9146]

@@poojajaidka1784 im suffering from 8 years

[@poojajaidka1784]

@@SomNath-cm3jn yes

[@drnishukumari5292]

very slow rate of teaching kindly improve it

[@muthummm6675]

.

[@chandanrathod7525]

Tq sir your teaching is really awesome...

[@muthummm6675]

Nice To See You. It is pleasure For Me To Comment Here!. Very Honest And Good!

[@muthummm6675]

Nice To See You. It is pleasure For Me To Comment Here!. Very Honest And Good!

[@Jingles522]

Thank you sir

[@muthummm6675]

Nice To See You. It is pleasure For Me To Comment Here!. Very Honest And Good!

[@muthummm6675]

Nice To See You. It is pleasure For Me To Comment Here!. Very Honest And Good!