Diagnosis of Syphilis EXPLAINED | Non-treponemal and Treponemal

Learn all about the diagnosis of syphilis. We'll cover non-treponemal (RPR and VDRL) and treponemal tests (FTA-ABS and TP-PA) and how to interpret these results depending on the order in which you do them.
#syphilis #nontreponemal #treponemal
We'll also walk through a practice question at the end so that you can answer those pesky test questions easily.
I hope you find this video helpful. If you do, please make sure to like and subscribe.
Check out our other video where we discuss the different stages of syphilis.
• Stages of Syphilis EXP...
Video Content
00:00 Intro
00:24 Non-treponemal
01:06 Treponemal
01:26 Non-serologic tests
01:52 Diagnostic approach
03:14 Case 1
03:45 Case 2
04:23 Case 3
05:19 Case 4
06:05 Test names
06:37 Practice question

[@samuelyosef8114]

This one is much more helpful than those videos i hv seen abt syphilitic test so far...appreciate it!

[@medstudyplaylist9295]

what a wonderful explanation - THANK YOU

[@mareortiz7207]

Thank you so much for this video. I tested positive for RPR but Non reactive for FTA but the doctor just went with the positive RPR and gave me antibiotics didn’t explain the FTA part at all.

[@yousefhussin7946]

great explanation.

[@armughankhalid9692]

Excellent Bravo superb quality 👌👍

[@fredShr]

thx

[@Karthikeyan-vw6yz]

2021 i haven take test for all STD i got syphilis only positive and i treated FTA ABS VALVE is 18.2 , after now i take again test but this time again showing postive , FTA abs value is 22.23

[@gracetogonon6693]

Hi doc. What does RPR reactive mean? Is it consider it is syphilis?

[@quickmed]

Hello! A reactive test means a positive result. The test result is just one data point. You have to always consider the patient’s history and physical exam findings as well when considering a diagnosis of syphilis. Hope this helps!

[@sudarshanthapa7597]

Hlo madam which test is best and more accurate for late latent stages after the infection of 8to 9 years syphilis plz reply

[@quickmed]

There are two types of diagnostic studies for syphilis: your treponemal and non-treponemal. The use of each one, as well as their results, depends on the clinical situation. For that reason, we recommend that you reach out to your physician for management that is catered to your specific situation. Hope this helps!

[@sudarshanthapa7597]

@@quickmed thank u madam

[@jgr0797]

So if I tested negative for my RPR test, should I take a treponemal test? Thank you!

[@quickmed]

Hello! It really depends on your overall risk. I recommend reaching out to your physician for further guidance.

[@Jdoe560]

I tested + for non-T then + for the Treponemal. But a week later I tested - for the non T right after getting the injection the same day

[@Jdoe560]

Is that normal?

[@ashantisanderson887]

Hi, what does non reactive vdrl mean?

[@quickmed]

Hello! A non-reactive VDRL means that the result was negative.

[@backslash75]

What about an equivocal result? I just had one.

[@quickmed]

An equivocal result can be one of two things. It could indicate an early primary syphilis infection or a false positive result. A repeat test would need to be done in that case if there is a strong suspicion for infection.

[@backslash75]

@@quickmed the lab told my doctor they couldnt tell anything from my blood test & couldnt even tell her if there was any kind of positive or antibodies. Would a lab mess up cause that?

[@quickmed]

@@backslash75 It is definitely possible. I would check with your doctor to consider repeating the test.

[@adahmsphilogene2629]

If it remains positive for life dose that mean I can still spread it ?

[@quickmed]

This depends on what is remaining positive. For any personal health questions, we recommend that you contact your physician.

[@louieramos1265]

I already finished my 4 shots of benzathine penicillin. Do you think it's cured ?

[@quickmed]

Please seek all personal medical advice from a medical provider.

[@krisnicolemasunong1356]

Gumaling kana

[@melindaleuterio21]

Nagkaroon po ba kayo ng rashes non at sores po?

[@user-th1px3vk3z]

Test after 10 month of exposure is negative. But I have faint rash 5 spot on sole feet. Then I have syphilis or not? Please comment on this

[@LONEWOLF-kb4iw]

Do you have any ulcer on genitalia

[@neshawnbarney6584]

retest

[@caioduarte8299]

Why the treponemal are positive for life?

[@quickmed]

The treponemal tests detect antibodies specific to syphilis. They usually appear earlier than the non-treponemal antibodies with acute infection and they usually will remain in the body for life, even after successful treatment.

[@caioduarte8299]

@@quickmed I know that, I was wondering if you knew why they don't decay since they're not protective against the bacteria. I didn't find anything in my search. :(

[@quickmed]

@@caioduarte8299 I believe you're asking how a person can get re-infected by syphilis even with treponemal antibodies present? Look like the exact mechanism of immune evasion is unclear...but a current hypothesis is that it is due to antigenic diversity of Treponema pallidum repeat protein K (TprK). This protein is found on the surface of the bacterium. Hope this helps!

[@caioduarte8299]

@@quickmed No, I was asking why the antibodies don't decay. Why they are on the individual for life. Never found anything. Thanks anyway!

[@nafeesaanjum421]

​@@caioduarte8299 What is the treatment of tpha positive