Diuretic (Part 08 Final) Potassium Sparing Diuretics Mechanism of Action | Potassium Sparing

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A diuretic is any substance that promotes diuresis, the increased production of urine. This includes forced diuresis. There are several categories of diuretics. All diuretics increase the excretion of water from bodies, although each class does so in a distinct way. Alternatively, an antidiuretic, such as vasopressin (antidiuretic hormone), is an agent or drug which reduces the excretion of water in urine.
Diuretic drugs increase urine output by the kidney (i.e., promote diuresis). This is accomplished by altering how the kidney handles sodium. If the kidney excretes more sodium, then water excretion will also increase. Most diuretics produce diuresis by inhibiting the reabsorption of sodium at different segments of the renal tubular system. Sometimes a combination of two diuretics is given because this can be significantly more effective than either compound alone (synergistic effect).
Types and Examples of Diuretics-
(1) Examples of thiazide diuretics include:
Chlorothiazide (Diuril), Chlorthalidone, Hydrochlorothiazide (Microzide)
Indapamide, Metolazone
(2) Examples of loop diuretics include: Bumetanide (Bumex), Ethacrynic acid (Edecrin), Furosemide (Lasix), Torsemide (Demadex)
(3) Examples of potassium-sparing diuretics include:
Amiloride, Eplerenone (Inspra), Spironolactone (Aldactone), Triamterene (Dyrenium)
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Sir up jo transportater ko sympoter bola o actually Na-K antiporter hoga.....keu ki symporter ne 2 ion ko ek hi disa main transport korta hai.......lekin yha pe Na body ke andar ja raha hai.....or K body se bahar......so opposite actions show kor raha hai.....so i think it is Na-K antipodter

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Sir, I am one of your follower. Sorry i cant understand the MOA of K+ Sparing diuretics. I understand how the sodium reabsorbed but i didn't understand how k+ reabsorbed. Can you help me...?

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Sreenath Eravimangalam They prevent the formation of mediator protein which act to exchange Na and K. So there will be lack of medicator protein and Ma teabsorption get affected. This Na absorption affect K and H secretion

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Please explain why it is said spironolactone acts as diuretics as well as an antihypertensive drug

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Diuretic is drugs for hypertension

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Sir spironolactone regulate krega sodium reabsorption apne esa mention kia h blki vo inhibit krega

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Sir when spironolactone is not showing similar effect like aldosterone then why they are said structurally similar & what is the use of replacing them.

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Sir 2nd point me aapne Kaha aldosterone control karta hai sodium ke reabsorption ko... Fir starting me aapne bataya tha ki aldosterone ki wajah sodium ka reabsorption initiate hota hai

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