Do Antidepressants Work or What?

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A huge meta-analysis came out recently looking at how effective antidepressants actually are. It turns out, the results are complicated, and we had a hard time reducing all the stuff in this study to a headline. So, the title's a question, and that's the way it is.
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[@gadflycuisine6754]

If I may paraphrase a joke from Craig Ferguson: "Yes, these pills are a crutch... Who cares?! You don't kick a crutch out from under a one legged person and tell him to hop!"

[@regierse]

gadfly cuisine I feel this.

[@rolandkristo141]

Cool hypothesis, could be tested.

[@penguinbobber]

There's other treatment options

[@rollinthunder1000]

@@penguinbobber like?

[@TheSgtwilly]

@@rollinthunder1000 grass

[@ZeeZeeZeeZeeZeeZeeZeeZee]

After being depressed and anxious since I was a kid, that eventually progressed into me not being able to leave my house for almost a year, I started an antidepressant and antianxiety 6 months ago. Already I am able to leave my house every single day and interact with people without sweating, my heart racing, and scratching myself to the point of bleeding. Other methods have helped but not this much. Though obviously this is not the case for everyone (I had a horrible reaction to prozac) it does work for some people, and for those people it can 100% change their life. I finally have the ability to seek out and try other treatments. This medication may just be an aid to get to a slightly better place, just enough to be able to go from there.

[@ev1ilfreak]

Name of medicament.

[@romannavarro1178]

How long did it take for it to take effect bro I'm on day 4 on antdepress

[@allergiccookies6735]

@@romannavarro1178 well you should have seen effects by 2 years lol, but generally 4-8 weeks is when you see most ssri effects. if you still feel awful after several months, it's time to change / add something

[@romannavarro1178]

@@allergiccookies6735 it make me angry so I stop taking them

[@allergiccookies6735]

@@romannavarro1178 dang, it sure is hard to find what's useful for you

[@somenerdyblonde]

I really appreciate the emphasis on clinical research fundamentals that you included. The inclusion of statistical vs clinical significance is a big indicator that news outlets often overstate the meaning of a meta-analysis. Thanks!

[@missiworld]

This is what I love about the channel, too. It makes his videos super helpful for my pre-med research methods students when teaching them statistics.

[@johnheller7670]

As an Epidemiologist, and in this case a patient, I super-appreciate this video. Thanks, Healthcare Triage!

[@Sherubiiii]

As someone who's been in and out of psych hospitals for the past few years, I can say with certainty that antidepressants work. Just not for everyone. Unfortunately I've been unable to find a medication that works for me, but that doesn't mean that they shouldn't be tried by people. A modest amount of relief from symptoms is better than no relief at all.

[@ARKSYN]

Only if that relief isn't paired with nasty side effects which seems to be the case with every antidepressant I've tried

[@karlinchina]

How do you know they work better than a placebo?

[@feralbluee]

Sherubii yup! well said. . . i’d like to someone with s bery bad case of poison ivy not put anything on it. yeah, sure, they’d scratch themselves to death. or - don’t take the right med for that migraine - just be sick there’s no difference. if one has anxiety or depression - all i can say is - YEEAAA!!!!! as you said, even if it only helps, just give to me. hope you find the right meds for yourself - sometimes our brains like to play jokes on us. :) 🌷🎭🧚🏻‍♂️

[@feralbluee]

karlinchina you could try it and see. take a test for incredible pain - placebo or med. however, brain chemistry is incredibly tricky and your mind is incredibly complex. what works for some doesn’t work for others. people are effected differently as far as side effects go also. 🌷😒😏

[@feralbluee]

JAKE RIEGER jake, hope you do find help. side effects can be quite bad, but sometimes some meds ate better than nothing - and new ones are always coming along. good luck and take care. :) 💐

[@SarahDarkhand]

For me personally, antidepressants make it so I can function. They don’t make it so I don’t have off days, but they make it so I can make more progress in my mental health.

[@assassin7250]

Do u still recommand taking it?

[@romannavarro1178]

@@assassin7250 I'm taking it ut been 4 days

[@tiana5395]

I'm so glad for your channel! The more I see fads appear on headlines the more thankful I am for being exposed to 1) the levels of rigor in research 2) an example of interpreting research (rather than exaggerating it) AND 3) specific explanations regarding common misconceptions Keep up the incredible work, folks of Healthcare Triage!

[@tingtingli9431]

I fell into a major depression few years ago. At one point i couldn't eat solid food for months, weighed less than 80 lbs, and had panic attacks all day. Stigma (especially in asian families) of mental health aid being "crutches" prevented me from seeking help. It got worse and worse until I realized I might not make it out alive unless i sought out medical help. Doctors put me on anti-depressants (tried a few to find the right one) and very low dose of xanax and I was able to slowly have a functional life again. I'm almost fully recovered now and have not needed any medication for almost a year. Antidepressants work and they save lives.

[@PhilipposACosta]

That is a biased title for the video. He puts a title to induce people to think that the conclusion is that “antidepressant don’t work” but he merely concludes that they work but not “as good as people think”. But doing so, he is misleading people to think that antidepressant “don’t work”, potentially causing harm. There is a guy in the comments already trying to take his wife out of antidepressants (that could even make her situation worse). The way you present information is important and I don’t agree with his approach in this one...

[@roflex2]

How do you know the anti depressants cured you though? You didn't have an identical twin not take them for the same period, hence you cannot be completely sure they were the cause of your improvement. This isn't to say they didn't help, but you can't say they work and save lives from your experience as there is nothing to compare it against.

[@Vezerai]

Antidepressants worked for you* Dont make general conclusions on one case study...

[@syph5646]

Wouldn't say it's a biased title since it is clear that the vast majority think that they work way more than they really do. It's a title that targets those people more.

[@moonkenzie]

I'm very happy that you're doing so much better and that you found the right drug

[@nikkiburt8468]

Love the pop ups with journal information for the citations!

[@TheShadowPhoenix]

I previously had very serious depression and anxiety and took medication for years. I did eventually begin to feel better and am now able to manage my symptoms and mindset, but I should note that I spent a lot of time in therapy and that the majority of the things that permit me to control my reactions now and helped me cope with things then were breakthroughs in therapy sessions. I am now off of medication entirely and, although I still have some issues, they are far from as bad as they used to be. I didn’t really notice any differences while I was on the medication alone (before going to therapy) but I can definitely say I noticed a difference when I was decreasing dosage and when they were no longer present. Thank you for bringing this information to light. It helps me think about my previous use and how, althought it seemed to work with me (in conjunction to other forms of treatment), it mat not work well with others

[@wednesdayschild3627]

Depression is multifactorial. Years ago a doctor told me pills don't do much. They maybe help a little. That was way back in the 80s. This has been known. He also told me the drugs are difficult to come off of. He was not impressed by the drugs, even though companies market drugs and make unfounded claims.

[@hmrobert7016]

The problem is that psychiatry is on the whole is still at “humour” levels of understanding. The four main neurotransmitters (dopamine, serotonin, norepinephrine, and GABA interact in ways that aren’t well understood and while manipulating them is effective for some people they aren’t reliable predictors of who will get better and who won’t

[@HansJSchroeder]

Thank you for covering this complicated topic.

[@saizai]

For some reason, this video entirely omits long-term severe depression. It mentions long-term mild, and acute major, but those aren't exclusive.

[@thirdeye7632]

I can tell from my own case: they are completely useless for severe, chronic depression. Turning someone into a retarded vegetable doesn't "fix" anything. Antidepressants are todays lobotomy. Pointless and barbaric.

[@hmrobert7016]

It’s because those are the DSM diagnostic categories, and researchers almost always use those criteria.

[@saizai]

@@hmrobert7016 Acute vs chronic is a DSM categorization. So is severity rating. The two are orthogonal, though. The DSM permits eg mild acute and severe chronic. This video fails to deal with severe chronic.

[@hmrobert7016]

@@saizai Thanks for clarifying. I kinda assumed (yes, I know) that they were using PDD vs MDD criteria. Perhaps the reason for the chronic severe exclusion is that the chronically severely depressed are likely not treatment naive? I of course am not sure, and it is an important research issue

[@saizai]

@@hmrobert7016 No problem. Interesting question re whether there's more treatment awareness among chronic severe depressives than among chronic moderate; I've no idea actually, and wouldn't assume so. What I can say is that there's a major lack of support for it, especially treatment resistant. Suicide hotlines are for acute only. Meds get tiresome and disheartening to keep trying when they don't work; it takes about 6 months to try one, including the titration. And the "it gets better" sloganeering is a kind of erasure of those for whom it doesn't. In short, there really isn't much for long term *living with* severe depression with no realistic hope of it "getting better".

[@ktomatchu]

so medications that are indicated for major depression are likely not clinically effective when people don't have major depression... go figure?

[@theotherway1639]

The book "30 Days to Reduce Depression" by Harper Daniels is recommended. Gives good daily mindfulness exercises. Worth a try.

[@naminova]

I noticed this effect with Zoloft anecdotally myself. When I was so depressed I couldn’t get out of bed, it was like a stepping stool that made it possible for me to make it to therapy appointments and get out of my house, and all the other things that I needed to do to get better. But once I had my life back on track, even though I still suffered from moderate depression, the Zoloft felt like it did nothing. I switched to Prozac, which helped a lot, but I’ve since learned that it’s treating another disorder I have.

[@NoelleMar]

I'm so glad this is a source I can go to that looks at medication critically without throwing it all under the "big pharma" and "natural resources are better" bus. (Not saying big pharma doesn't exist, but as someone who grew up with no medicine whatsoever, I have no trust in those who say all, or even most, medication is bad.)

[@gyozakeynsianism]

Another great video, Dr. Carroll.

[@nurmihusa7780]

I have been battling depression and out of control anxiety for decades - let me repeat that word “decades”. In my particular case, the medical “experts“ have either been utterly useless, or have actively made my condition worse. I’m not alone. I know far too many people who have had a similar pile of “unsatisfactory results” to put it politely. Let me tell you what I have learned - because I am constantly researching anything to do with my own condition. What I have learned is that depression and anxiety arise from a variety of causes. No one thing can ever be blamed. In many cases, perhaps even in most cases, and certainly in my case, the word is comorbidity. People like me suffer from several things that are seriously wrong. And medical “science“ is determined to treat people like me as if only one thing were wrong. And medicate accordingly. And if those meds kale your other conditions worse? Oh well, never mind. I won’t put up with that shit anymore. If you say depression to a doctor they will throw an SSRI at you whether or not that’s appropriate in your particular situation. They just throw pills at you and say check back weeks later. And if after a couple months you’re not better, they throw different pills at you. They believe that only low seratonin can be the problem. But low dopamine also results in what can be diagnosed as “depression”. When serotonin meds were thrown at me I didn’t get better I got worse. I had terrible side effects. Which is perfectly understandable since I didn’t have low serotonin I had low dopamine. They medicated the wrong thing. (A cast on your right leg is great if your right leg is broken. Not so successful of it’s your left leg that needs one.) Now I supplement for dopamine and it makes a huge difference. I have recently come to understand that I also suffer from low GABA. That’s harder to supplement for. But I do and that helps some. If you have depression, anxiety - or to be honest almost any chronic condition - Do not rely on your doctor to solve your problem. You must actively be involved in researching what’s out there and what could be wrong with you. Doctors have 10-15 minutes with you to solve your issues and if you have more than one they’re overwhelmed and they’re simply not able to do the job. Also, most of them assume you know nothing about your problems, and talk down to you. They do not understand that you could teach them mountains about coping skills - if they were open to learning anything. Diet, exercise, probiotics, supplements, meditation, acupuncture, breathing exercises, neurobiofeedback, oh God the list just goes on and on - thing is, you just keep trying things because what works today will not work tomorrow or next week. Might work again in a few weeks, months or years...or never again. You just can’t predict anything but constant change with certainty. And you have to do that all on your own because doctors just don’t have the time or training or willingness to listen. Yes, that’s changing. Younger doctors are more open to new ideas, but the battle is ongoing.

[@Sherubiiii]

have you tried an MAOI? The diet required can be quite restrictive, but it limits the degradation of all monoamines (dopamine, serotonin, NE etc). It's also been shown to increase GABA levels in rats, but I'm not sure if that's been replicated in humans. They're pretty old drugs and can be dangerous in OD which is why they're not as popular as SSRIs.

[@nurmihusa7780]

Sherubii E Thank you! I’ve looked in MAOIs but they aren’t appropriate for me. I looked at the formal and informal pharma that has given me relief and all of them boost GABA significantly. So I went looking for something non pharmaceutical that might do the same. That search lead me to L-theanine, a supplement that the Japanese have been using for fifty years. They pulled it out of green tea. I was very skeptical (I have been disappointed over and over) but it really does seem to make a difference. FOR ME. Not necessarily for everyone. Okay, it’s gentle. A preventative. It’s not strong enough to shut down a meltdown, but if I keep enough in my system full meltdowns are fewer and less devastating.

[@roflex2]

Maybe you suffer from your lifestyle. I don't know what yours is but most depressed people lack a truely loving family and sense of purpose and self worth. If you live alone, do not have kids, do not have a fulfilling job, have low self esteem due to being weak and overweight then you will be depressed. Humans live so differently from how we did 20,000 years ago, it is no wonder so many of us are depressed. I tried many anti depressants, I tried opiates, nothing helped. What helped was getting a job that is a challenge that I enjoy with good workmates, getting a solid girlfriend and moving in together into a house that is ours. I am no longer living alone doing things I dont enjoy. I still get down/anxious but a huge improvement from what i did previously.

[@nurmihusa7780]

roflex2 Maybe you suffer from ignorance. I don’t know about your lifestyle but most people who blame depressed people lack a truly loving spirit and their sense of purpose is based on diminishing the self worth of others. No wonder so many of us are depressed. When we have to deal with ignorance from people who make assumptions based on their own lack of understanding or compassion.

[@roflex2]

I suffered from major depression for 10 years, I no longer suffer from it. I have compassion, one of my best friends committed suicide due to depression. I honestly meant what I said and didn't mean offence by it. Do you have those things I mentioned? If not, then you are living a life style that will cause even the strongest of us to become worn down and depressed over time. BTW be careful of green tea extract, some of the green tea is grown in bulk in Chinese areas with poor air quality, some of the green tea powders (not necessarily L-theanine which is normally purified) have concentrations high lead and other pollutants.

[@TheSpinningLily]

Hi Aaron. Love the series. However do feel like you could have mentioned the Lancet study published in February 2018 comparing efficacy of antidepressants. It was another paper that got a lot of coverage, here in the UK and I felt like it would have been relevant. Also mentioning how researchers distinguish between 'limited' or 'small' efficacy would have been interesting Regards Lily

[@ooooneeee]

TheSpinningLily thanks for mentioning it! I found it at www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)32802-7/fulltext

[@jynxkizs]

Further Research List: (I keep thinking dysthymia) 1) How well do antidepressants work for milder symptoms that fall short of major depression? 2) How well do antidepressants work longer than 2 months, especially for mild symptoms? 3) Does long term antidepressant use outperform placebo?

[@Roserae16]

Would you consider doing a video on bipolar depression, and how it's different from major/minor depression? I've only been able to gather vague and/or limited info so far on the topic and I really want to understand it better

[@TeamProU]

this is so helpful. thank you!!

[@deanspeer1]

This is an eye opener.

[@tuanz8009]

I used to have anxiety disorder. Ever since taking antidepressant medication I feels like I just came back to life

[@izzylok6857]

What medication you took?? I'm iffy about taking antidepressants.

[@AC-ej2yv]

Hello,what med did you take?

[@cinnie63]

Since the 90s I've been on nearly all the available anti-depressants at one time or another (except tricyclics, not a good idea for someone with major depressive disorder too easy to use to commit suicide with) they all have side affects and some work better than others. But, and this is a big but, they help me function but they don't "fix" me. Drugs may dampen the blackness but talk therapy brings back the sunlight and gives me the tools to deal deal with the cloudy days.

[@OrganicGreens]

you should do a similar video for for anxiety, ADD, ADHD, and anti psychotic medications

[@me-dt5ov]

So how would we/the patients demand the research themselves in a meaningful way?

[@danielturner1891]

Hey! The source for the second study was unchanged, thought you should know! 😄 edit: I mean the recent one that was covering literature including 2016 info and it says the study for 2008 as the source still :)

[@xmatez]

I believe this should get you there: www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(17)32802-7.pdf

[@pvrunner8]

I'd love to see a video about bipolar depression and antidepressants!

[@hmrobert7016]

kzbin.info/www/bejne/enu4Y6mfnNZ_ra8

[@philophos]

You guys should put up non-auto generated English captions on the vids.

[@somedude172]

Antidepressants work very well for me(ive been on the same one for almost two years. The only negative side effect ive had is a lowered metabolism, and therefore weight gain. And I have severe major depression, anxiety, and anorexia nervosa as a result of ASD. I've recovered from all 3 too

[@pavanpyda]

most research studies use Hamilton depression rating scale to observe effectiveness of antidepressants. The scale is imperfect and includes many items that are directly influenced by side effects of meds...so even if pts improve, studies can inaccurately conclude they were not getting better

[@i.ehrenfest349]

Yes, they work, though more for people with serious depression and anxiety than for more moderately affected persons - and probably not because they increase serotonin. They work, and they also have very serious drawbacks. It is hard to say in general whether they’re worth it - depends on a person to person basis.

[@rockinmoshin]

Also, there's very minimal research on withdrawal from many of these drugs, take Effexor for instance. Its withdrawal is extremely strong and hits just like PCP. I've seen a close relative go only a day and a half without it a couple times, and they become a completely different person. it's about the worst thing I have seen them go through.

[@sandizz]

Shane F i have been on this drug for almost 14 years, and just in the early days i had this problem With feeling a little sick if i was not on Them for more days. Beeing a Completely different person while not on Them? I think thats absolutely bullshit! Yes people can be more depressed and appear more sad, but that does not mean They Are a Completely different person. YOU may see The person that way because You maybe never see him/her sad. And as The horrible withdrawal syndrom that everyone talk about With this drug too, i think its Completely bullshit, well i am on relatively low dose, but If i forgot to take medicine one day i Did not feel any different

[@charliec965]

Yes, they work. The problem is some work great for some people and do absolutely nothing for others (or sometimes bad things). It's frustrating. I have crippling OCD and it took 31 different medications to find one that worked. Once I got on a good dose it changed my life. I without a doubt still have OCD and some days are better than others but the drug gave me my life back.

[@Psartz]

I did have ocd.for example my right always had further than left when I take them off, touching things twice,stepping in boxes and list goes on..for a decade.but I broke them off . on purpose I started exactly opposite after a while I stopped caring.

[@declup]

May I request that you discuss the diagnosis and treatment of avoidant personality disorder (and/or related anxiety disorders)?

[@NotHPotter]

This is purely speculative, but if people are prescribed a drug that's been on the market long enough to start picking up detractors and anecdata saying it doesn't work or has some strong negative side effects, a newly released medication wouldn't have that same history to overcome as far as a negative bias possibly influencing perceived patient benefit. An established but possibly negatively "reviewed" drug would bias patients against it while a new one would not yet have those expected weaknesses or questioned (not questionable) efficacy. Just a thought. The brain is weird like that.

[@thatjillgirl]

I had a similar thought. A previous video on this channel mentioned that patients experience a placebo effect more often/more strongly when they are told that their placebo is an expensive or brand name drug than when they are told that their placebo is a generic. New drugs would be brand name only and may trick the brain into a larger perceived benefit compared to older drugs available in generic.

[@Verhoefswords]

Wayne Gale The solution to bad psychiatry is better psychiatry, not throwing it out completely. Look up some of the research on Ketamine in the treatment of depression. It's likely that Ketamine sessions will replace traditional anti-depressants in the future and these sessions will have to be prescribed by a psychiatrist or physician.

[@shayla4777]

My experience on sertraline/Zoloft is that I no longer have racing thoughts, irritability, and dissociation. But I do have lack of empathy, lack of general satisfaction, very fatigued, brain fog, poor concentration. I used to be an A+ student, and now I'm struggling to get out of bed to even start assignments.

[@ems7623]

Well, they saved my life. That's for certain. I seriously doubt that the list efficiency is "novelty bias.". One of the problems with many antidepressants is that, in a patient taking it for a long while, they seem to lose efficacy. When a drug is new, all patiebts are taking it for the first time so. .... F

[@rosarioadrianacandelerorue3710]

I really believe antidepressants work, but how to fix dying communities, loss of social interaction, alienation at work and hopelessness?? You could mitigate the feelings, but you will need more to forget.

[@gilfhunter42069]

They usually go hand in hand. What causes you to withdraw from social interactions? Usually Self-Doubts, lack of motivation, feeling worthless. Antidepressants help you with that. They don't take over your legs, but they make you able to move your legs by your own will. Hopelessness is usually fixed by antidepressants. Basically gives you a chance to reboot and have a chance to live life again.

[@guilhermejung98]

It would be nice if you list the articles in the description.

[@snappleandcats2209]

Could you please make a video covering the PACE trial that falsely claimed GET and CBT are effective treatments for Myalgic Encephalomyelitis?

[@falwk]

When you say "depression" are you just referring to clinical depression or are other diagnosis included in that spectrum? Like anxiety disorders and panic disorders?

[@greenfire61]

Was there an editing issue? You said recent study but the graphic referred to one from 2008?

[@ebreen2012]

The source card for the main study is incorrect. The card looks to be recycled from the first Ioannidis paper, not updated for the more recent network meta-analysis. Would it be possible to add a link to the meta-analysis in the description? I got really excited and was hoping to read it.

[@ebreen2012]

Nevermind, found it. Here's the MLA citation: Cipriani, Andrea, et al. "Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis." The Lancet (2018). And here is a link to the paper: goo.gl/QJkmJY Still might be a good idea to add this to the description

[@Suph373]

Depression/the need for antidepressant use should be reassessed at least every 2 years, and that assessment can involve trying lower doses or tapering off of the medications. This is recommended in the guidelines, but is rarely actually done. Why risk your patient falling back into depression when they are now used to taking the drug? There's a benefit to taking fewer medications, but doctors are reluctant to take the risk.

[@hippopajamas]

I understand that an individual instance does NOT represent a trend, but- I have depression ans have tried a bunch of kinds of medications over the years. I am on one and seem to be doing SO much better, and I can assure you my life situation has not improved. It makes it far more manageable. I am pretty sure I would be dead without them. (I am a strong advocate for using them along side therapy, though!!! It isn't some miracle pill and I understand that.)

[@riccsan1884]

Can someone tell me what over the counter drugs i can take. I've been suffering from anxiety worse than usual, my chest feels heavier than usual and i often get nauseous.

[@hmrobert7016]

kzbin.info/www/bejne/b3Oanq2wfNZ8m8k

[@roguecodes]

Yes. Love, someone who is alive right now because of my dopamine reuptake meds.

[@jessemunson1352]

dopamine reuptake is real?

[@laurap4415]

Clinical best practice indicates that people have best outcomes with combined pharmaceutical and psychotherapeutic support. Could you review this evidence as well?

[@monicanguyen6891]

Out of curiosity, I absolutely love HT since I'm in the medical field myself, but is Dr. Carroll an MD or DO?

[@leonthebleh]

MD, with a masters in health services research.

[@CarolineGarland]

So what does this mean for people with chronic depression? I am unclear whether the data says anything conclusive. If not, other than non-pharmacological treatments such as talk therapy, are there treatment recommendations?

[@Mythicalmage]

I would love to have a psychiatrist on the HCT Podcast. ^.^

[@XIIchiron78]

Why *don't* we have a patreon for research...?

[@firefox5926]

pharmac thanks you :)

[@natalieramsey4727]

Please please do an episode on the new FDA approved migraine medicine coming out soon! It’s the first time in over 20 years a migraine medicine was put on the market and all us chronic migraine suffers are kinda freaking out about it! 😃

[@Psartz]

What's the name of the medication please?

[@markeric1337]

I think that if antidepressants worked, the outcomes of studies would be very clear. And you could do these studies with patients living in a facility, closely monitored (because it shouldn't take too long right? they .. work.. right?). My suspicions are that, people may be negatively reacting to the pills so much so, that they might, for example, go out and buy a new wardrobe of cloths to wear, self medicating secretly, start running, start walking, eating better etc..... In other words, they fell so bad, they start treating the symptoms of the pill, rather than the depression or anxiety. Then returning to the study saying, um... well, I guess there is a little improvement. Why do I say this? because this has been me, for 20 years now.

[@bijoubaybee]

Having studies on people living in monitored facilities has already been done and lean more in favor for the anti depressants. However, there is a huge problem - - when you're in a facility, you are getting more care than you would be at home, more attention, a stable living situation, and a more consistent sleep schedule. So even if they started feeling better it may not be the medicine but just a change in environment and finally getting the care and attention and safety they've been missing.

[@Mary-li1rm]

What resources did you use to create this video

[@sorrelknight]

What about the other disorders like OCD that SSRIs are prescribed for?

[@lifanonline]

about the last point of the pharmaceutical companies not having much incentive to get more data, wouldn't competitive advantage over other potential therapies be one reason for them to gather this sort of higher quality data? Or is the competition between different drugs not yet high enough to impact companies' decisions in this way?

[@bshay513]

Do you teach any CE course? You should... I'd sign up.

[@abbottabbott1120]

Link to paper?

[@starghost09]

This video generated more questions than answers.

[@SugaryPhoenixxx]

That is the point.

[@michellealtman4844]

Why do doctors prescribed antidepressants for people with fibromyalgia and other chronic pain conditions as the first medicines to try even when depression isn't a big factor in the diagnosis at the time?

[@DandyParrott]

Michelle Altman my guess is some numbing effect as far as widespread pain. I take a tricyclic for CFS. It doesn't change my mood, but it helps me sleep at night as well as keeps me from feeling sleepy during the day. Before starting it, I couldn't get out of bed most days, not because I felt sad, but because I had very severe fatigue.

[@penguinbobber]

Can you do a video on TMS... Trans-cranial Magnetic Stimulation?

[@jarnaildhindsa4531]

Sir secondary amine tricyclic aur tertiary amine different

[@soulshinobi]

How and why are there no links to this meta-analysis in the description??? Cite your sources!!

[@nickb9237]

Been researching this for 15 years, for me antidepressants actually do more harm than good. Ssris and snris feel like a shitty version of amphetamine. Ssris narrow your emotional “bandwidth” so you don’t get sad but you dont get giddy or joyful either

[@nel7441]

My doctors suggest anti depressant pills for me, since therapy hasnt helped me at all. I just dont know if I wanna take them because I feel like im slowly starting to feel a bit better somedays.

[@jmddetecting5503]

Hi, hope your feeling better and yes if u was you I really wouldn't start them because it's slippery slope once started

[@nel7441]

@@jmddetecting5503 hey. I started on anti depressants 4 months ago because i got diagnosed with depression and panic disorder. Last week i got a new diagnoses for BPD, borderline personality disorder so the doctors are thinking that i should stop with the antodepressants.

[@jmddetecting5503]

Hi can I ask which antidepressants they have given you and have they made you feel any better?

[@nel7441]

@@jmddetecting5503 of course❤ Im on an anti depressant called "sentralin orion". The doctors wanted me to try that one first since it helps for all depression, panic disorders and anxiety. The first weeks of adjusting to a anti depressant is usually very hard and doctors always warn you and say ur depression and anxiety will probably get a lot worse at first. For me the first two weeks were terrible, barely made it out of bed, wasnt able to eat, bad anxiety and felt like throwing up a lot. But once my body & mind adjusted it was worth it. Since i have BPD Im probably quitting my antidepressants since its not the right medicin for BPD. But if u struggle with depression I suggest u to give it a try because it can definetly be life changing❤

[@jmddetecting5503]

OK glad thay have worked for you, maybe if they have lifted your mood you should stay on them for a while 👍

[@MadeagoestoNam]

I understand the usuuefulness of meta analysis studies and other forms of data collection and examination for professionals who know what they are doing to be better at their job, but considering how often and how easily studies can be manipulated to show certain results they didn't receive. 11 major studies on anti depressants repackaged to give conflicting outcomes? If someone says "here's some data and research" nowadays are they really saying anything at all?

[@hunterellis9848]

At the end of the day. If it's banned from all sports (highly stigmatized) "IT WORKS"!!!

[@jordanwiser9011]

It’s banned from sports because it can kill you and is very very bad for your brain, they just want to give you pills to make the pharma money but don’t want to give you the good ones cause the dea will show up to their office if they give anything besides Prozac and abilify

[@nerdwriterfighter212]

The effectiveness of anti-depressants has to do with the person. Everyone is different. I have dealt with major depressicw depression for a long time and anti-depressants has helped me cope and control it. For me, most of my medications worked while I was on them one in particular did not. Just because it is not effective for one person, it doesn't mean that it works for everyone. And for some people, medications don't help, which is also fine. We need to stop looking at it as a one size fits all and look at it more individually

[@catherinemcintosh3793]

Mine dont work! And the fact that we are just test rabbits puts me off taking them! I will sort myself out and in my own time!

[@squarekolt]

What about all the other indications for antidepressants? They are not just used for depression!

[@Yurinsm]

The baseline here is that Psychiatry is an art of trial and error.

[@Amir-ez2qh]

Have been on prozac.. xanax.. effexor.. all dont work on me.. ON ME atleast.. im sure it works on other..

[@jaxfax8064]

Whaaat xans dont work

[@hippopotamusanonymous1580]

This tells me my thoughts is stronger than antidepressants.

[@elsagrace3893]

Why would they mix the old drugs in with the new types? That just seems wrong. The old type and the new type are very different.

[@LaielShepherd]

Even as a person with severe chronic depression, antidepressants are risky and their effects highly variable. I've been prescribed some that have made my symptoms much worse, caused me great pain, and the like. Finding the right balance of psychiatric medication is a moving target--my needs change over the years, as do the effects I experience from some medications or combinations. I do wish psychiatric medicine had more of a grounding in science than it currently does.

[@leotrimpira9301]

Tablets cure depr.or no?

[@1MNUTZ]

Doctors and psychiatrists get bonuses for filling out prescriptions for psych medd

[@codediporpal]

My sisters CAT is on antidepressants.

[@iexposehackers1048]

They only work for one thing, i graduated hs last year and there are alot of kids taking antidepressents , mostly getting them illegally and i live in a suburban neighborhood, kids forget who they are when theyre on those, and most act out when they forgot to take the pill that day (withdrawls)not to mention none of the kids that take them all the time even know what day it is, 80’s had crack, 2000’s are the years of benzos and opiates

[@blakejohnson8639]

Please research Robert Whitaker before taking any antidepressant medication. He was nominated for a Pulitzer Prize in his work on the subject. Antidepressants can work up to three or four years and then you’re worse off than you were and dependent on medication and now with side effects. His evidence based medicine research is world renowned and published. He has two books. ‘Anatomy of an epidemic’, and ‘mad in America’. Please read and be informed before doing this to your brain and body.

[@korikafez]

4:36

[@dosetaimagnus7427]

Pharma hands them out like sweets...

[@kewlmark72]

is it clinical depression or Loneliness....Why have humans done this to the earth? They ruined it...

[@davidabad469]

"Short length"? Aaron, you know better than that.

[@MrThatGuyYouForgot]

I'm fully convinced that the drug that saved me from my depression was not an antidepressant. It was a mood stabilizer. I'm on it and an atypical antidepressant now. The antidepressant seems help some but the mood stabilizer does the heavy lifting. I'd really like to know why that is. Also I'd like to note that what we know about neuroscience suggests that all psychoactive medications wear off eventually. Neuroadaptation is really wonderful. Someone should look into getting them to last longer.

[@DrSpooglemon]

The USA is the only developed nation where antidepressants are advertised on the TV.

[@woofquackm]

Where are the links to the meta-analysis reports? Also please don't wear stripes and checks - It looks terrible in general, but worse in a digital format

[@jurgor8661]

Usually I never comment on videos. But this shirt and tie totally not fitting together just is asking to be pointed out. That being said amazing content. Reminds me a lot of the book missed connections.

[@marioalfaro8988]

Sooo yes or no?

[@AussieAdamJ]

Fun fact: the overall effect size of the 'these things work' study was SMALLER than the effect of the first 'these things don't work study' XD

[@brianpjenkins]

Oh, the plaid and stripes!

[@Gitohandro]

"Ghosts in our blood"

[@OreElect1]

May cause damage to the following organs: liver, central nervous system (CNS). Special Remarks on Chronic Effects on Humans: May cause adverse reproductive effects and birth defects (teratogenic) Special Remarks on other Toxic Effects on Humans: Acute Potential Health Effects: Skin: Causes skin irritation. Eyes: Causes eye irritation. Inhalation: May cause respiratory tract irritation. Ingestion: May cause gastritis, thirst, increased salivation, tongue discoloration, fecal incontinence, stomatitis, dysphagia, eructation, esophagitis, gingivitis, melena, nausea, disturbances in appetite, diarrhea, vomitig, bloody diarrhea, colitis, duodenal or gastric ulcer, salivary gland enlargement, May cause skin rash. Systemic events may develop in individuals with rash. Although these are rare, they may be serious, involving the lung, kidney, or liver. Bronchitis, rhinitis, anaphylactoid events including asthma, bronchspasm, angioedema, and urticaria alone and in combination have been reported. Pulmonary events including inflammatory processes of varying histopathology and/or fibrosis, have been reported rarely. These events have occurred with dyspnea as the only preceding symptom. May affect behavior/central nervous system/nervous system, with symptoms such as anxiety, nervousness,insomnia, abnormal dreams, agitation, fatigue, drowsiness, confusion, delusions, hallucinations, psychosis, paranoid reaction, depersonalization, apathy, emotional lability, euphoria, hostility, amnesia, decreased libido, antisocial reaction, hysteria, suicidal ideation, violent behvavior, hypomania, mania, seizures, dizziness, asthenia and headaches, tremor, lightheadedness, abnormal gait, ataxia, akathisia, buccoglassal symdrome, vertigo, tinnitus, hypesthesia, neuralgia, neuropathy, acute brain syndrome photophobia, incoordination, neck rigidity, extrapyramidal syndrom, stupor, coma, paralysis paresthesia, carpal tunnel syndrome, dyskinesia and other movement disorder, . Hyponatremia, altered platelet function. May also affect the liver and cause abnormal liver function tests, jaundice, hepatitis, liver tenderness. May also affect the endocrine system (pancreatitis, hypoglycemia, (hypothyroidism, gout),and cardiovascular system (chest pain, hypertension, syncope, hypotension (including postural hypotension), angina, pectoris, arrhythmia, tachycardia, bradycardia, ventricualr arrhythmia, myocardial infarction, cerebral ischemia, cerebral vascular accident, thrombophlebitis), blood (anemia, lymphadenopathy, hemorrhage, bleeding time increased, leukocytosis, lymphocytosis, thrombocytopenia, thrombocytopenic purpura, thrombocythemia, petechia, purpura, sedimentation rate increased, aplastic anemia, pancytopenia, immune-related hemolytic anemia), urinary system ( frequent micturation, urinary tract infection, urethal pain, urolithiasis, kidney calculus, urethritis, hematuria, albuminuria," msds link... www.sciencelab.com/msds.php?msdsId=9924084 (above link for msds currently disabled so another link provided below from caymanchem) www.caymanchem.com/msdss/14418m.pdf rtecs link... www.drugfuture.com/toxic/q109-q148.html emc medicines link... www.medicines.org.uk/emc/product/3768#UNDESIRABLE_EFFECTS ebook "Prozac™ - The Ultimate Deception It’s Risks “Far Outweigh” Any Potential Benefits! By Dr. David W. Tanton, Ph.D." www.life-with-confidence.com/support-files/prozac_theultimatedeception_ebook.pdf any copyright infringement is allowed by law for educational purposes.

[@evan-sb9pl]

im 13 and im going on antidepressants :(.

[@JZGreengo]

Well if the drug hurt you then you’re going to be anti drugs like me