Do Antidepressants Work Part I

[@JIMKATSANIDIS]

Very helpful video! Treating your anxiety disorder and depression will improve your life so much. Get help. It's not your fault. Don't feel guilty. It's an illness like any other. Depression is a heartbreaking mental illness and it can destroy the person and the people around way more than we imagine. Thanks for the useful video Dr. Garrett! ❤👍

[@minepolz320]

Thank you, this topic is really important now

[@emaaaanon]

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[@minepolz320]

Can you please talk about PFS/PSSD/PAS It's really important now

[@emaaaanon]

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[@melancholicInsane]

Hello Dr. Rossi; greetings from India. What happened to part 2 where you discuss true efficiency of antidepressants and what constitutes a clinically meaningful improvement in depressive symptoms? We're all eagerly waiting to see your analysis of it

[@SwenPohjola]

In my opinion, based on trial-and-error selection of medicine for myself and other patients I communicate with, the concept of "silver bullet" is very important here. The particular AD may work for me but may not work or even make things worse for other individuals. That's because of our poor understanding of psychophysiological processes as a whole, and symptomatical treatment based on patient's subjective experience, instead of conducting tests and analyses. Plus we all have different lifestyle, diet, external factors, accompanying conditions etc etc.

[@minepolz320]

Maoi is More effective than SSRI in treating depression, i have 3 m remission

[@emaaaanon]

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[@Dave-if5qj]

MAOI can be vary risky

[@minepolz320]

@@Dave-if5qj not really this all overblown, by SSRI monopoly MAOI not risky if you know you are using MAOI

[@Korag4]

@@Dave-if5qj ssri are fcking 1000x risk than maoi... lot of people destroyed life

[@gmo9993]

Have tried a ton of them over the last 15 years and NONE of them have "worked" for my anxiety. It frustrates me when I see people swearing they "work" because that hasn't been my experience at all. Makes me wonder if my symptoms are even "anxiety." Benzos work amazingly well but I drank on them so my doctor won't give them to me.

[@minepolz320]

Did you consider trying maoi like Nardil (Phenelzine)? for example you can do a bit of research on this

[@Dave-if5qj]

After more then 40 year on being on countless ones I Agree That have a place but there not a Cure or happy pill, psychiatry Is far better then it used to be But there is still a long ways to go Benzos help tremendously But it comes at the cost of addiction

[@TonyRentschler]

Where's part II? Really looking forward to it. Thanks!

[@googlereviews7700]

Please don't stop making videos.

[@StevenInCornwall]

Is there a Part 2 to this?

[@BeautyCare248]

I took Sertraline for 5 months but nothing changed, now I'm starting escitalopram I hope it work

[@Mohammadmarketer]

hey really nice video i was wandering if i could help you edit highly engaging videos and also make some shorts out of them.

[@arthurv4401]

They do work but you cannot rely on them for full. You have to work on other parameters also like diet and listening to signals of body and mind

[@Hgtp2_Hat]

I agree publication bias is huge problem in evidence base for antidepressants. I think there are also issues concerning the validity of depressive disorder as a diagnosis. Also anxiety disorders. As there is huge overlap with neurodevelopmental disorders and bipolar disorder. I don’t think starD considered co-morbidities & misdiagnosis in treatment resistance depression. I am a U.K. psychiatrist and also a patient & carer to child with mental health problems. I have diagnoses of anxiety, OCD, depression, ADHD/autism. I’ve taken several SSRIs, mirtazapine, quetiapine for treatment resistant depression. They all worked to some extent, I was better taking them than not. However lisdexamfetamine for ADHD has been the most effective for me by far, in treating all my symptoms, including low mood, tiredness, anxiety, obsessions, intrusive thoughts, fatigue, binge eating & alcohol problems. I am also finding adhd medication the most effective in clinical practice, for ADHD symptoms and also wider anxiety and mood symptoms. Just in case that’s interesting to you. I am enjoying your videos, thanks for stimulating debate.

[@melancholicInsane]

Still waiting for part 2

[@perfectlyundonecustoms]

How is Divalproex affected by consuming antidepressants, combined with anxiety meds?

[@benzapp1]

Looking forward to it!

[@karentitone]

Hello Doctor Rossi, Ive been on Effexor XR for many years. My doctor has just added Prozac 20mg. to cross taper. About 2 weeks ago before starting Prozac, i decreased the Effexor from 225 mg. to currently 187.5 mg. In your opinion, what are your thoughts about doing this. TIA

[@janisjansons5707]

I self medicate whit low dose Mementine as agmutation for my SSRI!!!Mementine has helped alot for my OCD!!!!!😊😊😊

[@reddbendd]

yeah they work but in order tto reach an effective dose there will be side effects, also it will take quite some time for the medication to build up in your system. alternatively you can combine them which works faster but again there will be lots of side effects like akathisia and hypertension

[@bpggg]

Antidepressants for Bipolar 2 patients as versus Bipolar 1. Could you comment from your clinical experience not just the literature or official dogma. I'm biased by my experience. I have had a marked improvement in coping with the stress of working in a forensic psych hospital. I am not on monotherapy. My trigger into hypomania is poor or inadequate sleep.

[@Cap683]

The topic of whether antidepressants work or don't work has been an issue for as long as I can remember. I saw your KZbin segment of roughy four types of depression. If I remember correctly, severe depression is more apt to respond to medication verses neurotic depression i.e. depressed mood with anxiety linked to external stressors did not fare as well with medication. Correct me on the details. My experience ,working as an RN regarding patients receiving ECT, was that the most likely to show marked improvement were those with very severe depression i.e. "endogenous" depression and were vegetative with mood congruent delusions and the patients with less severe depression, although chronic, showed a less marked benefit. This may be anecdotal.

[@melancholicInsane]

Waiting for part 2 😑

[@bpggg]

Outliers. Outliers. Outliers. I'm not saying in every clinical trial but in the larger population. Some people respond quite well and continue to do so even if they are in the minority. It might seem statistically trivial but to those individuals they have to live that life 24/7. I can speak as one. Bipolar 2, very much helped by escitalopram especially my anxiety. I am able to cope with a very stressful job that i was barely coping with before. Perhaps it's its anxiolytic properties for me that counts the most. I also take a bevy of mood stabilizing agents which likely blunts any cycling. There are exceptions and they do matter for those who are them.

[@Dave-if5qj]

They work but often it's not relised till you stop using them They kinda build up so slowly You don't notice as the positive effects right away

[@jonharry6293]

No they do not work

[@saharnavah7244]

Dr.Rossi how can i contact you?may i ask for your email?!i will appreciate your reply

[@callmate9102]

They do work, but act more as mini benzos instead of actual antidepressants

[@minepolz320]

Bezos at least doesn't cause apathy and emotional blunting, but Yes SSRI is not antidepressants just anxiety meds, with bad side effects when using long term

[@reddbendd]

@@minepolz320 they actually do depending on which one you are taking. typically not the pharmaceutical ones, more so the research chemicals.