Dr. David Sinclair: The Biology of Slowing & Reversing Aging

In this episode, I am joined by Dr. David Sinclair, tenured Professor of Genetics at Harvard Medical School and an expert researcher in the field of longevity. Dr. Sinclair is also the author of the book Lifespan: Why We Age & Why We Don't Have To, and the host of the Lifespan Podcast, which launches January 5, 2022.
In this interview, we discuss the cellular and molecular mechanisms of aging and what we all can do to slow or reverse the aging process. We discuss fasting and supplementation with resveratrol, NAD, metformin, and NMN. We also discuss the use of caffeine, exercise, cold exposure, and why excessive iron load is bad for us. We discuss food choices for offsetting aging and promoting autophagy (clearance of dead cells). And we discuss the key blood markers everyone should monitor to determine your biological versus chronological age. We also discuss the future of longevity research and technology. This episode includes lots of basic science and specific, actionable protocols, right down to the details of what to do and when. By the end, you will have in-depth knowledge of the biology of aging and how to offset it.
#HubermanLab #DavidSinclair #Longevity
Thank you to our sponsors:
ROKA - www.roka.com/huberman
InsideTracker - www.insidetracker.com/huberman
Magic Spoon - www.magicspoon.com/huberman
Dr. David Sinclair Links:
Lifespan Podcast: lifespanpodcast.com
Twitter: / davidasinclair
Instagram: / davidsinclairphd
KZbin: / davidsinclairpodcast
Lifespan (book): amzn.to/47MLimC
Aging Test Waitlist: www.tallyhealth.com
Harvard Lab Website: sinclair.hms.harvard.edu
Our Patreon page:
/ andrewhuberman
Supplements from Thorne:
www.thorne.com/u/huberman
Social:
Instagram - / hubermanlab
Twitter - / hubermanlab
Facebook - / hubermanlab
Website - hubermanlab.com
Newsletter - hubermanlab.com/neural-network
Timestamps:
00:00:00 Dr. David Sinclair, Harvard Medical School
00:03:30 ROKA, InsideTracker, Magic Spoon
00:07:45 “Aging as a Disease” vs. Longevity & Anti-Aging
00:10:23 What Causes Aging? The Epigenome
00:15:53 Cosmetic Aging
00:17:15 Development Never Stops, Horvath Clock
00:20:12 Puberty Rate as a Determinant of Aging Rate
00:23:00 Fasting, Hunger & Food Choices
00:32:44 Fasting Schedules, Long Fasts, (Macro)Autophagy
00:34:50 Caffeine, Electrolytes
00:35:56 Blood Glucose & the Sirtuins; mTOR
00:37:55 Amino Acids: Leucine, “Pulsing”
00:44:35 Metformin, Berberine
00:50:29 Resveratrol, Wine
00:53:20 What Breaks a Fast?
00:56:45 Resveratrol, NAD, NMN, NR; Dosage, Timing
01:09:10 Are Artificial Sweeteners Bad for Us?
01:12:04 Iron Load & Aging
01:15:05 Blood Work Analysis
01:19:37 C-Reactive Protein, Cholesterol: Serum & Dietary
01:26:02 Amino Acids, Plants, Antioxidants
01:33:45 Behaviors That Extend Lifespan, Testosterone, Estrogen
01:40:35 Neuroplasticity & Neural Repair
01:46:19 Ice Baths, Cold Showers, “Metabolic Winter”
01:48:07 Obesity & How It Accelerates Aging, GnRH
01:52:10 Methylation, Methylene Blue, Cigarettes
01:56:17 X-Rays
01:59:00 Public Science Education, Personal Health
02:05:40 The Sinclair Test You Can Take: www.doctorsinclair.com
02:08:13 Zero-Cost Support & Resources, Sponsors, Patreon, Supplements, Instagram
The Huberman Lab Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user’s own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions.
Title Card Photo Credit: Mike Blabac - www.blabacphoto.com
Audio Engineering: Joel Hatstat at High Jump Media

[@hubermanlab]

The first episode of Dr. David Sinclair's new podcast launches Wednesday, January 5, 2022. You can subscribe now to that podcast, "Lifespan with Dr. David Sinclair", on all podcast platforms ( lifespanpodcast.com ) and here on KZbin: kzbin.info. Thank you for your interest in science!

[@memastarful]

What a beneficial opportunity to learn and grow more. Thank you for this

[@memastarful]

P.S.= Oh and happy almost New Year

[@BS-lc5cd]

Type 1 diabetic here. Lots of Type 2 talk regarding longevity. I have no insulin in me, does that help me? How screwed am I

[@memastarful]

@@BS-lc5cd my 12 year old daughter has type 1 diabetes. 8m so grateful for your question.

[@rubyblu21]

Great interview Andrew! Thank you so much for bringing David on and asking the questions that you did, you've out done yourself yet again.

[@AboodCohen]

Welcome to the Future everyone, where golden information like this is free and available instantly.

[@sauravsingh8534]

We are the Future

[@JC_inc]

. . KZbin is more than 15 yrs old.

[@RichieIsRight]

The future is getting this info directly chipped into your brain and available immediately

[@ronnieradke9240]

@Brett M I think you missed the point

[@ronnieradke9240]

@@JC_inc Jesus Christ zero common sense

[@kcmaxwell1509]

My father is 97 years old. He is a WWII vet and has survived double pneumonia, sepsis and Covid in the last two years. And he rides his recumbent bicycle 30 minutes daily. His longevity, in my opinion, is directly related to his low caloric intake (and great caretaking). He’s eaten once or twice per day for his entire life. Super interesting science. Thank you.

[@sarahscottageholidaylet.5071]

Wow! Your Dad sounds awesome! Good for him!

[@big_chungus73]

When someone tells a story like this, a lot of people will say or think, "That's just anecdotal." But when there are so many anecdotes pointing one direction... where there's smoke, there's fire. Love hearing stories like your Dad's, and it's inspiring for those of us half his age to continue to prioritize health and self improvement, and maybe even help others on that journey.

[@luciozanela7069]

Dr Sinclair is an absolute genius and I am great full for his amazing work to change mankind mindset regarding aging

[@gabrielkvarnberg8656]

low caloric intake = looking like a emaciated soyboy with no muscles.

[@Zoltar1811]

Legend

[@mss_tanja]

Dr. Huberman is really creating an amazing legacy of information. The only problem I have with him is that I get lost in those eyes and forget to listen.

[@sfardales]

I so AGREE!

[@tadasturonis]

i am a man, but i totally agree, lol

[@drironmom6815]

Definitely! 😅

[@squamish4244]

I think he's spreading himself too thin, though. He's been firing off these podcasts so rapidly, and I just want to say, dude, slooooow down. You're going to burn through all your best potential guests quickly, and it's too much for a lot of us to absorb anyway.

[@555SwissMiss]

😂❤

[@Niceonthefrenchriviera]

The video starts at 8:00 (for those who want to avoid the advertising and marketing) 😉

[@jeanettewight6365]

I skipped it too!

[@akashprathod]

Two scientists that I follow all the time, now on one podcast. This is a Christmas gift.

[@ballapalleballe]

Yeah! By Far the best Christmas Gift!

[@paulaneves2548]

So true!! Same feeling here!

[@newpixelsapp]

same here!

[@lynnnestor7985]

Yep top Christmas inspiration from my two fav scientists. Very proud of our Aussie Sinclair🙏👌

[@alok3129]

Bhai very nicely put!

[@Livingwithadog]

Imagine how the internet has changed the world. You can now easily prolong your life for free because of technology and intelligent people like Andrew

[@andybaldman]

Live-longer fads (and people making money off of them) have existed for decades.

[@shealdedmon7027]

Just think of all the people that will live an extra week or two because of this video.

[@AstroMartine]

resveratrol and nmn are not free though :>

[@phoenixjoe5520]

People are gullible nowadays, a sad fact...

[@orbifold4387]

Unfortunately it only works if you are not worried or thinking about living longer.

[@peterellis4262]

I have to say that the obvious enthusiasm and excitement you both show as you discuss these topics is absolutely wonderful.

[@KipIngram]

Absolutely LOVE how Dr. Huberman handles this - he carefully brings out all the right things. Fantastic interview!

[@katewenzell]

One thing I question is the exposure to cold. I was homeless for 6 years and it wrecked my health. I have to say right here that I don't do drugs, that was never my problem, because a lot of people on the streets self-medicate, but I never liked drugs, not even pot. The main contributing factors for my health deterioration were were chronic stress (bordering on PTSD), especially due to constant police and societal harassment, and poor diet, due to being poor, eating old, cold and cheap foods. However, one other thing started really messing my hormones up, and that was living through winters and snow without heating. I lived in my van, so I would get under the feather comforter and sleeping bag at night and shiver for about an hour until my own body heat would heat up the space. I was able to get warm during the days at a cafe or library, but there was no refuge at night from the cold. The last couple winters, my body started having trouble self-regulating its heat. I would be so cold, and then I would suddenly overheat and be sweating. I have gone into early menopause in my early 40's. I am totally traumatized by the cold now. I feel like Scarlet O'Hara in "Gone With the Wind," except I would say, "As God is my witness, I will never go cold again!" Dr. Sinclair saying he wears a T-shirt in winter gives me shivers. So I respect deprivation of our ancestors (and the current indigent) as something that can be absolutely damaging. The homeless have a much lower lifespan than the rest of society. Controlled deprivation is still privileged deprivation. That being said, we do live in a society of sickening over-abundance. And I do notice that wealthier people often seem less happy than the homeless, where the smallest thing is appreciated. I watched your video on dopamine, and it finally made sense to me why that is. Now that I am housed, I am able to rest and heal and have some peace, but I'm also in a slump. Being alive in this world is a difficult balance between security and thrill.

[@sarabutt3428]

Thank you for sharing your incredible story of resilience with us. I am so sorry for the trauma that you experienced and very grateful that you are housed and recovering now. My best wishes and prayers for you.

[@katewenzell]

@@sarabutt3428 Thank you for your kind wishes

[@anagroszek7743]

thank you for sharing your story .

[@EmiKimura88]

I've just had an urgent desire to help homeless people

[@katewenzell]

@@EmiKimura88 The homeless survive with the help of kind strangers, but the best way to help in the long-run is supporting the push for democratic socialism, for much stronger social safety nets, and social investment in mental health, addiction support and housing, instead of policing and criminalization of the homeless. The phenomenon of homelessness is absolutely connected to society at large and politics.

[@vickihughes9476]

I am a practicing physician assistant and went into medicine because my family has always been on the wholistic/ natural path. We grew our own veggies, bought farm fresh eggs and grass fed local beef, had fruit trees and grape arbors. We ate fruits and veggies all day. We were physically active all day. My father is 93 and not on any meds. My mom is 89. They do not smoke and rarely drink alcohol. They have never had cancer, diabetes, dementia, heart disease. I have been telling patients for years that it is not rocket science and the best treatment I can give them is to eat only to live and keep moving. I could talk for hours about this! Our food production and lifestyles are killing us. It is that simple!! I would love to help get more of this information out there! And I would love to meet you both! Thank you and Keep up the great work!

[@healingjourneys4241]

Where do you practice?

[@vickihughes926]

@@healingjourneys4241 Illinois

[@healingjourneys4241]

@@vickihughes926 wish I was closer because you sound like a perfect physician for me.

[@CollegeWebMag]

Hi Vicki, I couldn't agree with you more. I once had an older bodybuilder (72 yrs old) tell me to stay away from processed food, and you will be ok, Rudy. Thanks for your reply. Cheers! Rudy

[@ey8648]

Have fun making no cash. All the money is in the meds.

[@Jbsa1998]

I felt like I was sitting in on a lecture and I was engaged the whole time! Super informative and insightful! Thank you so much!

[@hobbyfarmer1452]

When I first listened to this podcast, it was about one year ago. Since then, I had listened to many other similar podcasts. I learned so much from all of them. This time listening to this one, I understood the subject so much better.

[@jaynanewbold8263]

In addition to the generosity and vast knowledge provided, can we all agree that this podcast is most enjoyable due to the fact that these two gentlemen utilize the art of conversation very well? No interrupting, grandstanding, one upmanship, talking over one another. A lost art, indeed. Well-directed by Dr .Huberman and cooperative responses by Dr. Sinclair. Riveting!! Thank you both!

[@cindysmallwood2695]

Except that Huberman really likes to hear himself talk. Questions could be summed up in half the time.

[@alsin1597]

@@cindysmallwood2695 he obviously wants to make questions as clear as possible and, in my opinion, very much succeeds. You mam, I assume, just jealous.

[@thomasbeaumont8884]

@@cindysmallwood2695 He knows he's a specimen

[@thomasbeaumont8884]

@@alsin1597 you offended on his behalf. He's a lecturer. It's undeniable he talks a lot

[@alsin1597]

@@thomasbeaumont8884 what... I am actually stand for him

[@TheInterwebzMan]

I’m 35 now and starting to see and feel it. I swear I was 22 just yesterday. Time flies!

[@54Rockit]

Funny, I'm 68 and 22 lives on inside, believe me and hope it never fades. Music is a great way of hold on to that time of your life.

[@clarisaojedaleon3653]

same here bro but I look amazing xd

[@skdjirrrdjdm3926]

Tell me about it...not only did I just turn 34 but now I look just like my mom.

[@christianzwaga9434]

@chevalier577 tell us more

[@templeray5692]

I'll be 37 next month time does go way to fast but at the same time I believe aging will be cured by 2035.

[@germandaria]

The best what I like about how Andrew is handling an interview is that he really does not interrupt. In this case its even more important than saying things.

[@wasimkmob1586]

Dear Andrew, I want to give you a huge shoutout and express my gratitude for all the awesome info you're putting out there hosting such great minds and the incredible work you're doing to make education accessible. On top of all the cool science stuff, your subtle sense of humor really adds to the experience. Watching your videos is a blast! Thanks a ton!

[@rubyblu21]

I knew it was only a matter of time until Dr David Sinclair made his way onto your show. Thank you Andrew!

[@AgendaInMind]

Most of the more severe illnesses happen to people because an upsetting event occurs in their lives taking them by surprise, unexpectedly, impacting first in the brain, then in the corresponding organ which that part of the brain controls. The end of WWI had absolutely everything to do with the Flu and lung TB outbreak that occurred killing millions. In nature, the biological conflict linked with a territorial fear (just what it means-a fear in your territory, your home, your community, etc.) is a widening of the bronchia (tissue loss). Your body attempts to widen your bronchia in order to allow more air into your lungs to give you more strength and energy to fight to keep your territory safe. Stay with me.......The biological conflict linked with a death fright impacts the lungs. The lungs attempt to grow larger in order to allow more air in because breath equals life, as we all know. No breath equals death. While you are in the fear or death fright conflict, you notice no symptoms of “disease”, except you have cold hands, cold feet, you can’t sleep, you awaken at 3 AM every night, you have little appetite. During the war, millions of people were in fear of the bombing of their homes and cities where the war was most active. Fearing for their lives, their loved ones in the war, their ability to survive. The food in the stores was sparse due to shortages. This lasted for 4 long years! The longer the conflict, the worse the healing phase. Within 2 weeks of the German Chancellor announcing the end of WWI, these millions of people ALL went into the healing phase all at the same time. It is during the healing phase that you experience symptoms of illness! What is the healing phase of the bronchia widening? Severe bronchitis, pneumonia. The body attempts to refill this lost tissue and you experience inflammation, fever, coughing, body aches, fatigue, etc. What is the healing phase of the extra lung tissue that grew? Decomposing of the tissue by TB bacteria and fungi. The symptoms of this healing phase are: severe coughing up of blood and tissue, fever, inflammation, severe mucous, body aches, fatigue. During this decomposing of the extra tissue (tumor), the body expels a lot of protein, and without replenishment, severe protein loss can result in death. Antibiotics did not exist yet. If TB bacteria does not exist in a person or they have been vaccinated against TB (big mistake), then the tumor will simply encapsulate and become dormant and not harm you. Who died during the Spanish Flu? Mainly the poor who could not afford to buy meat and proper nourishment, and the people who were directly impacted by the bombings and destruction of their homes. Millions of people suffered fear and death frights during the fighting of WWI, and millions of people all went into healing at the end of it. Not everyone was affected because not everyone suffered the same way. It’s not a “flu”, it’s not something you “catch”. It’s biological, meaningful, and unavoidable. One hundred years later, a Fear Campaign begins, using the media to spread it......

[@StoicAurelius1]

Me too, I knew it was gonna happen before the end of 2021

[@RoscoeDaMule]

it was recorded in mid summer so it already happend a while ago

[@Darnabymom]

I just turned 60 and am the caregiver for my mom who this week turns 100!!!! For her age she is doing amazingly well. As I see her quality of health, it spurs me on to increase my health span not just my life span.

[@jelizabethpetrie6656]

Same here, 60 with 92 yo mom & 14 yo border collie. Learned applicable lessons for us all! Most appreciative 🧘‍♀️🚴‍♀️🧗‍♀️🚣‍♂️

[@nebber1234]

Your mom had you at 40? That's amazing by itself.

[@CB-ln2eb]

Could you share with us what they say their "secrets" are to living a long life? 🙏

[@randdiamond8090]

@@nebber1234 In the first place, the “infertile by 36” data comes from a really high-mortality time and place 😂

[@Darnabymom]

@@nebber1234 Actually my grandmother, who was born in 1884, had my aunt at 36 and my mom at 38. I had my daughter at 40 and our son at 43.

[@alisontomsett5248]

Angina completely gone since taking reservatrol and NMN. Also doing intermittent fasting. Amazing info thank you. Life changing literally.

[@carolfairfieldmua9040]

Currently watching this. Only recently discovered Dr David Sincalir and Huberman this morning. An absolute pleasure to listen to these 2 gentlemen. I'm defo going down this rabbit hole lol

[@oliround]

This channel/show is a gift to mankind and we should be forever grateful to this man

[@sovereign775]

100% feel you. I am blown away when I share this podcast with others and they don't tune in

[@markkash]

Thanking you very much for your brilliant work on genetic influences attaining fountain back to youth so to speak .people close to me are astonished at the bullet proof genetics I was blessed with I just turned,60 don't look day over 40 literally lived the life of a rockstar rarely ate and when I wasn't obliterated it was all about adrenaline surf snow skydiving racing motorcycles cars . never seen a depressed person dropping into 20ft wave wondering if adrenaline has benefits slowing deterioration of are meat suites

[@Kitten_Stomper]

For someone who's 52 yrs old and looking like that, Dr. Sinclair's an excellent ambassador for anti-aging science.

[@jonluis2647]

He's done botox tho

[@lionemporor]

@@jonluis2647 are you sure?

[@joelcruz811]

@@jonluis2647 He said on Joe Rogan that he hasn’t done Botox

[@TheSweetvyc]

He looks every bit of 52.. However, maybe if he wasn't taking all of his anti-aging supplements and taking care of himself, he would look older than that

[@amoghdurgam5621]

@@TheSweetvyc bruh have u seen most 50 year olds?

[@tijen_]

My father lived to be 90 years old; my mother is a healthy 93 year old. In my opinion, their longevity is based on good genes, a healthy vegetable heavy; meat light diet and, a physically active and social life style. We have a citrus orchard & they ate a lot of citrus fruits. Perhaps, vitamin C can take some credit too. Most of their senior years they lived in a Blue Zone, south-western corner of Turkiye where the seas Aegean and Mediterranean meet. There are four seasons and only summers are hot. I have been told by a doctor that continuously living in a hot climate tends to result in shorter life spans.

[@BloomByCC]

Menopause is brutal. It led me to David Sinclair and life changes... i feel so much better but still not the same as before. We desperately need more research to address this bro real issue affecting over half the population.

[@xxlegitfailxx]

Was on the borderline of checking myself into drug treatment this month until i started reading Why We Sleep by Matthew Walker, watched a few of the podcasts in this series followed by a responsible psychedelic experience...can't explain how grateful I am for resources like yours, Dr Wakers, Dr Sinclairs etc. People don't talk enough about how diet, exercise and proper rest enable making the right decisions in other areas of your life so much easier. Normally i shitpost and troll in the comments but with 100% of my sincere-ness thank you.

[@nikos4641]

You should probably look at "Why We Sleep" by Alexey Guzey. KZbin doesn't allow links but he implicates that the book is riddled with errors.

[@sweetsue4204]

It’s always nice to come across someone else that this podcast is helping. Thanks for sharing, and good luck going forward. I feel pretty certain stories like yours are what they hoped to create when they kicked the podcast off. 👍🏻

[@burnttoast6397]

@@nikos4641 what’re alexey’s certifications? Is he even qualified to try and discredit Dr. Walkers book? I highly doubt it

[@nikos4641]

Burnt Toast I’m confused why qualifications matter; he just cites the relevant literature that goes against his claims.

[@ES-ex5it]

Congratulations on your progress. Two books that I'd recommend: Spark by John J. Ratey, MD and Dopamine Nation by Dr. Anna Lembke. Godspeed!

[@ronandheather3079]

2 humble geniuses genuinely appreciating each other’s genius. No competition. No agenda. (Except to share) wow! What a gift indeed. Everybody loves this

[@szymonbaranowski8184]

Sinclair promotes the greatest global experiment on human beings... so not so much agendaless... not mentioning nr of pharma businesses involved...

[@Michael-gi5th]

@@szymonbaranowski8184 yeah I'm not so sure about NMN cause there's so much contradiction involved, some say no it doesn't get into the mitochondria of the cell so can't increase lifespan as it does in mice

[@brandonbarnes6493]

Why I love Dr. Sinclair. He always answers so honestly. “We don’t know, but I’ll give you my best answer.” I appreciate you both for taking the time to educate us!

[@TatooedDoc]

LMAO!

[@susanhenley8844]

I am so happy to have stumbled upon this podcast and will be listening to more. Thank you!

[@Nightowl1947]

What a gift for us, your audience. I do the fasting at 74 and feel great. Implementing new ways to maintain good health, never felt so good! Thank you both for you kindness and willingness to share .

[@susanwoodward7485]

I do the same at 70, convinced I can beat the chronic kidney disease I have had since 2005, for which modern medicine offers nothing but ineffective drugs with powerful negative side effects. Never once has the concept of fasting, sirtuin pathway activation, mTOR inhibition, autophagy, NMN supplementation to increase NAD+, or stem cell regeneration crossed any of my MD's lips - criminal.

[@jackparker6472]

Fasting is easy if you place yourself in a location where there is no food and you don't leave that location. Drink some water and get over it. It's not like being cold and getting colder. When you are hungry, you don't get more hungry. You're just hungry, and if you eat, you'll probably be hungry again in a few hours. So cowboy up.

[@jessikalove4788]

I feel like Professor Huberman is my friend on the inside at this point, lol. I look forward to these weekly podcasts. Such a wealth of information. Also, he seems to have such a positive aura. Keep up the great work, Professor! ♥️

[@walkerusmc07]

I couldnt agree more!

[@CertainExposures]

Lol, it really does feel that way. Tossing my multivitamin today. Too much iron!

[@jessikalove4788]

@@CertainExposures Me too!

[@funtimes8296]

Oh girl don't lie, you wish he was more than just a friend.

[@keng7758]

Hey Jessika, I gotta say…you are simply gorgeous! Nothing creepy…just a compliment!

[@bio_vet]

That was a mindblow. What a conversation to shake everything we heard before about diets and health. Thank you for doing this podcast!

[@franciscochacon5542]

Thank Andrew and David. This is the best video I've ever seen about aging so far. Thank you for sharing all the good knowledge 💯

[@1234highman]

I'm extremely impressed with Dr. Sinclair's insights on aging - it's incredible how much progress is being made in understanding our biology! I recently heard about a study that showed certain dietary modifications could extend lifespan and I'm excited to see what other discoveries we uncover on this fascinating topic!

[@rarebird_82]

Me too, stop shouting! 😘

[@mermaid5948]

What were the dietary modifications? Thanks 😊

[@chuckleezodiac24]

@@mermaid5948 according to Sinclair: Metformin, Botox, Spermidine, yogurt & plants.

[@ifnotnowthenwhen9063]

We Are being lied for many years.He actually pointed it out that living longer is connected to eating less which was ignored by the medic world no wonder why

[@lauralockie]

After viewing this podcast, I grabbed a copy of "Lifespan" by David Sinclair, and I was completely unprepared for what a well written, intriguing theory of life itself on our planet it would contain. Everyone should read this book to gain an understanding of the science of themselves and how to live a better life. Thank you so much for introducing us to his work!

[@breadinthesesticks]

Just ordered mine now!

[@joeanna1100]

are you going to take metaformin

[@THEWIZARDDK2]

nice advertisement. did they pay you to write it ? because that also just happens to be a fact in commment with this type of weird doctors

[@xxcorrosive]

Is it a tough read? And how long did it take you to finish it?

[@lauralockie]

@@xxcorrosive Not a tough read, in fact there are illustrations and Dr. Sinclair isn't pompous or evangelical, in fact he's pretty humorous at times. I'm still reading it, because I skip around a lot of books at once, and even within the book.

[@jonahalldors5488]

Thank you both for a fantastic podcast, I can’t thank you enough for your great work and for sharing this with us ❤

[@erwin_888]

Comment on the first minute (before watching it all): For over 3.500 years Chinese culture knows about longevity and slowing down the aging proces by prevention, medicine and health-care. Think (but not alone) QiGong, Tai Chi, Tai Yin (Chinese Yoga), Kung Fu, acupuncture, Tui Na (massage and manual therapy), cupping, plants and herbs, and so on. Based on YinYang and or 5 Elements, An integral and holistic approach for health including reversing / slowing down aging. Just start with what resonates with you, get some intel and go from there. You won't regret it. Having said that, iam gonna watch the vid now ;-) And many thanks for Andrew Huberman for his -free- series on health. I've learned a lot 🙏

[@laurenwinters6897]

What a difference it makes to have well practiced professors explain these ideas! This is such a gift.

[@JeffNixonComedy]

Just finished reading Lifespan last night and now waking up to this podcast. Pretty sure this means I’ll never die. Hell ya, time to get into hobbyist sky-diving!

[@MMyL7]

😂 😂 😂

[@avaidn7451]

🤔🤔🤔

[@zorabw8948]

You should really do a parachute tandem jump. It is an unforgettable experience.

[@lisabrown3015]

This is gold… I am 48 and started taking AG1 and NMN and I got pregnant…. Nothing else had changed except those two things! … I did lose the baby at 3 months but I understand the body will do what the body wants… the key is consistency!

[@roxypedro100]

Awesome!!! Gives me hope, I'm all about supplementation, may I please ask- What BRAND/TYPE of NMN??

[@lisabrown3015]

@@roxypedro100 Renue By Science

[@roxypedro100]

@@lisabrown3015 THANK YOU LISA 🥰 i'm going to try that one!!

[@scotchbarrel4429]

Your line of questioning, and thought process is on another level here. It maybe the dynamic between the two of you, or maybe the time period. A solid four days of intermittent listening/digesting, thanks Docs 👊😎

[@AB-zq4fw]

Thank you Dr. Sinclair and Dr. Huberman for all you've done and do! We appreciate you 🙏

[@digitaldeepak21]

Going to buy the book. Insane podcast. I didn't take him seriously until I knew he was 52.

[@RunOfTheTrill]

Botox tends to have that effect.

[@saurabhchaudhary7342]

Wow kinda surprised to see you here. Make a post on FB about this too and even this might trigger a few lol.

[@diamoo8021]

Keep in mind that he has access to high level professional tests any time he wants to optimize how he interacts the world. This is not available to most.

[@aaronsilva5784]

@@RunOfTheTrill what makes you think he's had injections?

[@michelles2299]

Really I think he looks in his 50s

[@supremecanine6848]

Dr. Huberman, thanks for making the world a better and healthier place.

[@adrianbalteanu6095]

Andrew, fantastic job! You've placed all the right questions in order to complete the image of what Dr. David's explained, great work!

[@roadrunna.]

This is still better than any movie released since this episode. Such a high repeat value I can watch it for fun sadly not with popcorns, two of my most fav scientists today

[@shabuqazi86]

maybe do it with yoghurt + resveratrol

[@abigailthomas6971]

Yessss

[@aminakhan4199]

​@@shabuqazi86 p

[@loverofthewordofgod4156]

I have been completely ignoring movies since I found this channel.

[@johnulcer]

I took resveratrol for a while because of Sinclair's recommendation on Joe Rogan, but I began to feel emotionally reactive and moody and tried to isolate my supplements to figure out what could be causing it. While researching resveratrol I found out it's a phytoestrogen. I am not a scientist or doctor so I don't know if that literally means it converts to estrogen in the body, but I personally stopped as I didn't want to risk it impacting my hormone levels. Kinda wish they'd delved into that aspect during this discussion as it's something I don't think Sinclair has ever addressed. I also seem to recall he was president of a company that went bankrupt at one point and their whole focus was resveratrol drugs so it makes me question his biases. Edit: I just double checked and I was pretty close with my recollection. Go to his wiki page and scroll down to the career section and there's a paragraph about his pharma company that went under. They were focused on resveratrol according to Wikipedia. Not implying he isn't credible, but honestly just made me a little more skeptical of some of his claims.

[@yourone]

well he is not biased now

[@Samson-yl1jx]

This needs to be bumped up. Wrong or not.

[@undergrace1808]

Phytoestrogens are “plant estrogens,” they are not the same as “mammillary estrogens,” that are found in dairy products. Phytoestrogens actually protect us against cancer, while mammalian estrogens disrupt our estrogens.

[@amruthasrinivasan3875]

Phytoestrogens actually have (weakly) anti-estrogenic effects, as they compete with and can displace mammalian/human estrogen at its receptor sites, thereby preventing mammalian estrogen from exerting its effects. This is one of the reasons their intake is associated with decreased risk for breast cancer (which is fueled by actual estrogen).

[@deniseunknown4576]

I could listen to Dr. Sinclair for eternity. Great interview. I rarely stick around for 30 minutes much less 2 hours. So great job Andrew & David. Thank you for such amazing information. Enlightening to those of us that aren’t on that biological level of information. Eye opening. Truly appreciated.

[@marywakely5550]

Great info Tks So much

[@marywakely5550]

Q

[@gabrielledavis7491]

Thank you SO MUCH to both of you for allowing us to listen to this spectacularly insightful conversation. Us viewers are sincerely appreciative.

[@stevegreen65]

I love Dave. He is such a smart guy, has a great sense of humor and he is able to break down complicated subjects in easy to understand pieces.

[@lotfibouhedjeur]

Both of my favorite professors get together! This was so exciting I could listen to them all day. I love how they treat anyone who gets close enough as a potential science experiment 😂 Thank you both for making this happen.

[@andreaslynen6113]

So great. Dr. Sinclair and you changed my live. I read his book. Great interview. Thanks so much🙏🙏🙏

[@kathy8389]

Wow, even from the first question posed by Huberman and then Sinclair's answer to that, it's a paradigm shift. Now, will continue listening to the rest of the podcast.

[@hariprasanth2727]

This was the collab I was eagerly waiting for. I am a researcher in robotics and I am very excited to learn about a topic that is completely out of my research interest all because of you how interesting you guys made this. Thanks for all this work

[@motherofcrows5911]

Every time I hear Sinclair talk I learn something new. Your interview here was just perfect and covered a wide range of actionable longevity strategies.

[@MB-my5kc]

Thank you both for this most informative share. Health is wealth and knowing how to achieve that is key. Thank you for your transparency, so very refreshing!

[@Susan-L193]

I freaking love this conversation! Wow, the iron levels. When I was pregnant with my first child I was advised strongly by my doctor to take iron. I did so, and when my daughter was born, I could smell the iron in her/our blood! That frightened me and have only ever taken it in moderation and rarely since then. Fast forward two years, the same daughter was pale in skin tone as she inherited her father's celtic skin, and a different doctor was concerned but at least didn't go hard on advising supplements and I knew her diet was good. Fast forward a few decades and when I started donating blood, noticed my iron level was lower each time I donated, so I limited my donations to annually despite being told that it is 'safe' to do this every 6 weeks. It is so refreshing to hear the science with acknowledgements that everyone is different, as is our upbringing.

[@shaktirising3854]

Only trust yourself... YOU are the expert on your body, if it feels off, it is.

[@paduraruovidiu201]

I believe this is the 7th episode I'm listening to, in the past 4 days. Thank you again, Mr Huberman!

[@potbellygoblin2495]

thanks for putting education stuff out there for everyone. I never adapted well to the standard educational system and didn't do well at college, but I still love learning. Thanks to this kind of content I can still feel like I am learning and broadening my horizons.

[@roljicb]

Thank you Andrew for all informations! I will try to do so as much as posible. I wish to look young as Dr.Sinclair who is 52!!! Awesome!

[@chrissienewtosupps7733]

Again another information packed interesting interview.. both you Andrew And David are incredibly knowledgeable... extremely enjoy listening to the depth you went to... thankyou for sharing your incredible work :)

[@raquelvidales7568]

Thank you Andrew for this awesome podcast! I’ve read Dr Sinclair’s book, and I’m so grateful that you have covered a lot of open questions that are not so easy to Digest, specially for the non-scientific people (like me). It really helped me and clarified a lot of the Q’s I had myself, and that you have covered them in a very easy going chat with him, by sharing, discussing and doing a deep dive on how the ageing can be reversed and so forth… it was such a great idea on inviting him to your show! I’m looking forward for your next updates and shows!

[@dannypiper383]

Time flew by while I watched this 2 hours and 10-minute video; it was equivalent to watching a great movie. It's refreshing to see the dialog and hear unfiltered information directly from the source instead of through an intermediator. A wide array of subject matter was extrapolated from this podcast. Well done!

[@shay5025]

I took resveratrol because of his research in the 2000s in my early 30s. I had a critically bad response and all of my tendons became really weak and I had massive onset of what felt like arthritis throughout my body. I was on the Imminst/Longecity forums back then and there was a subset of people on resveratrol who had very bad tendon responses. Sometimes they would just get up out of their chair and rip their Achilles tendons. Never touched resveratrol since then and it took years to recover, and I don't think I ever fully did.

[@Adam-M1]

Thank you for this info. It put me off that’s for sure.

[@TheMamaKitty98]

I hope you see this, you could have had a herx reaction because resveratrol is used to treat Lyme disease. 14% of the world population has it you should test for it. Lyme in particular causes the “feel worse” and the symptoms you described are textbook herx symptoms

[@hardasnails1973]

Resveratrol may cause copper deficiency

[@deSeriosa]

Sinclair's reservatrol has come under heavy criticism by the scientists and the positive effects interpreted was considered false. This came out AFTER all the hype and after he sold his reservatrol company for $720M. He bevere apologized or recanted his suggestion

[@annap214]

People really thirst for this type of information!~ thank you for sharing all the amazing and extremely useful information in this channel ❤

[@treyd3433]

Stuff like this is a representation of some of best attributes of our species. Thank you doctors for sharing your knowledge!!

[@abdulsattarali8220]

Truly what these incredible human beings are doing is amazing. People should follow their findings and listen to their advise and try to live healthy life and keep helping others. Together we need to spread this information as much as possible.

[@luiscrespo9902]

Awesome interview, Andrew! Your detailed questioning was superb!

[@mohamadhasanansarizadeh7420]

Super informative, I really enjoyed it as a researcher in the biotech field. this is perfect to share such videos and making them viral instead of superficial medical suggestion on social media

[@samuraiyun219]

I'd love to see a podcast on Discipline and raising conscientiousness.

[@MMyL7]

Such a great idea, after having the 3rd percentil on the Jordan Peterson's personnality test in conscientiousness, I need help 😂

[@BuddhishMusic]

@@MMyL7 lol same here

[@yuliyahrybachova6473]

Yes, yes, yes

[@samuraiyun219]

The advice is essentially to have a long term plan (future authoring can help with this - I got it, it's pretty good), make a schedule (Google calendar is fine to use), try following it alittle more than the day before, start small you will improve. Paraphrasing, he said more but that's all I remember and it's pretty useful imo.

[@MMyL7]

@@samuraiyun219 wow thank you!

[@susanstultzhauss132]

Dr Huberman and Dr Sinclair. Thank you so much for sharing your passion and knowledge, for free, with us!! It is very frustrating that a lot of sources want you to buy their book first or pay for the "secrets". I loved this podcast!!

[@Mohammadali_9999]

I love you Mr.Huberman, I've said it before and say it again, you are my hero. Wish you the best,from Iran.

[@nancyreilly1873]

Please accept an infinite Thank you Dr. David Sinclair and the one and only Huberman.

[@anonona1]

I just watched the "best gratitude practices" episode, where he shows one of the best ways to practice gratitude is to replay a story of someone being genuinely grateful to someone else, and here Andrew himself provides us with that story, such a heartfelt moment. Thank you both for all you've done.

[@ES-ex5it]

I have watched many hours of David Sinclair interviews and I was able to gain new insight thanks to your interviewing skills. You posed certain questions with a clinical edge that other interviewers lacked, and you also relayed questions that "lay people"/non-scientists asked you. It was very well rounded and accesible. The timing of the podcast is great too. As we approach the new year it is refreshing to have scientifically proven ways to improve one's life paired with actionable steps. Thank you for this interview.

[@anyaturker412]

Brilliant ! ❤❤❤ so very impressive to hear about your great grand parents winning the NOBEL PRIZE with critical periods (The apple does not fall far from the tree). Can you PLEASE do a podcast specifically how to reopen critical periods even if briefly due to infants getting ill during a critical period and having long term developmental issues ? PLEASE? This would be incredibly helpful. THANK YOU SO MUCH for sharing all this information with the public, truly brilliant !

[@Sr-yo7cz]

Such an inspiring conversation. Thank you very much!

[@garygreenlaw503]

It's insane to think about how much more medical/life changing information has been discovered/is known around the world but is still not a common part of everyones daily lives... What a wonderful world this could be...

[@chadspro]

I'm not sure humans not ageing would be as fantastic as it sounds. I could think of lots of draw backs in fact.

[@garygreenlaw503]

@@chadspro You’re probably talking about resource allocation, over population, increased disease, etc.. and you’re probably right. But I’m a bit of an optimist and believe that there is a Pugh resources to handle quite a bit more people, however, people would need to learn how to be more resourceful, live a life of less waste, learn how to provide for themselves, etc.. Essentially, I believe it’s possible that we could live longer and in a larger population while staying in harmony with the nature.

[@seetheanimal5867]

@@chadspro chad slo the dangerous kind

[@seetheanimal5867]

Lifespan and intelligence engineering are both needed.

[@peteplayz-norskgaming5723]

Chad nah

[@JoyOnTheDaily]

What a gift! Thank you to both of these brilliant scientists, Sinclair & Huberman, for being not only articulate in their thoughts & data, but also entertaining! I’m on my second listen & have shared with many friends & family. Great takeaways for living an optimally healthy, long life! 🤓♥️✨

[@avinashrockstar]

Great job Huber🎉 All your videos should get language subtitles for most of the used languages so that it reaches all over the world.

[@jonathandaniels5825]

This was the best interview of Dr. Sinclair and I've seen a lot of these interviews over the years. Too many times interviewers ask Dr. Sinclair questions that his book or prior podcasts answer. You asked some to unassumingly baseline an understanding and go further to ask questions I would have asked (e.g., dietary cholesterol, iron, finer protocol practices, etc). We got answers we hadn't heard before. Nicely done!

[@allangraham3649]

Thank you to yourself and David for your time and to everyone involved in making these happen as ever !

[@alisonmcintosh937]

This was one of the most exciting things I've listened to in a long time. So interesting. Thank you both!

[@BloomByCC]

100% into following Sinclair's guidance on health. Brilliant.

[@Borromeo377]

My two favourite scientists who I deeply admire 🙌🏼 Thank you Andrew for bringing David to your podcast 🙏🏼 I am grateful to both of you for sharing your precious knowledge and experience with us ❤️❤️❤️

[@ssiddarth]

This conversation is like one of the best Christmas gifts ever, thanks Dr Huberman for having Dr Sinclair on the podcast and asking such great questions

[@vka82055]

Very excited about these facts we can apply to our lives instantly with amazing results❣ Many thanks to you and David Sinclair!

[@ZeepXanf1orp]

Can we please get ATTIA, SINCLAIR and GALPIN in the same room together to parse out a fitness regimen specifically geared to garner every longevity& immediate health adaptation that is possible from the various exercise strategies?

[@cyndijoylee]

This was so very awesome. I’ve watched both of you on other podcast and I’ve learned so much. Thank you so much for the work you are doing and for the lives you are saving and changing.

[@juicebox86]

Huberman Team; You're truly making a positive impact in my life. The information and the way in which it is presented leaves me feeling empowered. Finally caught up to your most recent podcasts after binging all last year to catch up. I look forward to being hooked to the Lifespan Podcast as well!

[@tylerjcranford]

The problem with meat and eggs isn't the cholesterol, it's the saturated fat (among other things - heme iron, neu5gc, TMAO, et cetera). Eating saturated fat raises LDL cholesterol, not eating cholesterol.

[@karenvantuyl901]

What an Amazing pod cast 🎉 Im grateful for the information from scholars in the fields.

[@billkemp9315]

Great podcast! I always love to hear what David has to say and you Andrew ask all the right questions.

[@segfahlt]

This was a phenomenal discussion. Thank you both for your time, your knowledge, and your dream to bring your knowledge to the masses.

[@x83ix]

I am a US MD graduate from a top 20 medical school, soon to be board certified in Internal Medicine. I practice Primary Care in California, and much of my time is spent counseling patients about blood test results. Many patients ask for blood tests that they have no idea how to interpret. For the general public without any science or medicine background, I don’t like to order a panel of blood tests that won’t lead to meaningful changes in their lifestyle or health status. Sure, it can increase a level of health-consciousness if there is an abnormal result, but it just as frequently leads to illness anxiety and increased healthcare utilization that doesn’t make a long-term impact.

[@frederickmatthews4259]

Can you recommend a source to help non physicians interpret bloodwork results?

[@VistasVibrantes]

I was reading his book and it's amazing how I got this interview to see, it is 2 years old. thanks

[@TheSheekeyScienceShow]

I'm intrigued to hear Dr Sinclair's podcast when it comes out! It is great to see scientific research presented in such an engaging manner.

[@Sh0n0]

Same i hope he has lil xan on

[@BarsandNightclubsAU]

Your show is awesome

[@Sh0n0]

@@BarsandNightclubsAU thank you

[@Chrissssk]

same here but i wish we get more clarity on resveratrol because according to Dr brad and multiple others doctors suggesting not to take resveratrol, hopefully we will get more clarity from huberman or sinclair soon

[@BarsandNightclubsAU]

@@Chrissssk if you don't want to take resveratrol, just take olive oil. NMN + olive oil works good for me. I'm 37, I weigh 93kg (admittedly I exercise hard 5 times a week) and my resting heart rate is 47.

[@YEE087]

Thank you Andrew, what a great episode. You've asked the questions that I've been thinking about over the last few years since I first listened to David.

[@TREEfool]

This was an absolute goldmine of knowledge. Thank you guys so much for sharing.

[@leafy6182]

Sir in India Fasting is practised from 1000 of years in Hinduism can you make an podcast.Ancient eastern traditions dating back thousands of years lay much importance on fasting as an adjunct to a full-fledged life. Prominent Hindu scholars believe that the purification of the body at the cellular level happens when the stomach is empty and the systemic functions are allowed to re-synchronize themselves. Most commonly, fasting in Hinduism takes the form of a spiritual sadhana, festival observance or penance.