REVERSE AGING: What To Eat & When To Eat To INCREASE LONGEVITY | Dr. David Sinclair

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Age is not the definitive factor it’s made out to be when it comes to our health. We can use our age as a baseline for tracking our health and longevity, but it isn’t stagnant. For example, certain types of testing can help us compare our biological age to our calendar age in order to tinker with our wellness routine and achieve the milestones we’re after. With the right steps, we can slow down and even sometimes reverse the aging process.
When it comes to our biological age, or the measure of how well our body is actually functioning for whatever life stage we are in, there are many things that impact it. Diet, lifestyle patterns like exercise and sleep, and stress are all involved in forming our biological age, along with many other factors like blood sugar, inflammation, and genetics. This week on The Doctor’s Farmacy, I’m joined by Dr. David Sinclair to explore the topic of longevity and anti-aging and how he reduced his own internal age by more than 20 years. Dr. Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, where he and his colleagues study longevity, aging, and how to slow its effects.

[@user-ux7er9mv5e]

eat one meal a day and not after 7 pm. I've done this for 7 months now. I have eliminated heartburn and healed all of my gastric ulcers.

[@svalerie98]

Wow amazing! 😊

[@-JD56]

Doing that now, and I don't get that tired feeling during afternoon, interesting.

[@terid7996]

My great grandmother was 102 years old when she passed away in her sleep; no diseases, no medication and was sharp as a tack! I don't believe diseases are inevitable.

[@martinworkens6130]

I remember Jack LaLane the 1950s , 60s exercise guru always said “sugar is poison for your body” nobody took him seriously at the time.

[@harborgirl8877]

I remember my mom exercising everyday with Jack! :).

[@user-zy7on4kl9w]

​@@harborgirl8877 ❤❤

[@Iker66M]

"If it tastes great, don't eat it." -JL.

[@InUrGirl]

@@harborgirl8877She got banged nice n good you prolly have a brother you don’t know about

[@InUrGirl]

@@Iker66MFast for 3 days and have any type of food and it tastes like the best in the world so that just about debunks that retarded statement

[@veryberry5138]

The best thing to do is to stop eating all of the time ! Years ago , when I was 198 pounds and sick 😷 with everything , my doctor told me I ate to much . Now I’m 127 pounds nearly 50 and don’t look a day over 28 , with excellent blood work all organic without crazy effort ! ! I eat two meals a day , sometimes , three if I’m really hungry 😋 The bottom line is ….I listen to my body and I only eat when I’m hungry 😋 people are so possessed by food 😩😡

[@rvboondocker2559]

Agreed! My “doctor” could use my advice too!🙄🙄

[@lucyhutchinson2361]

+l

[@almacaoili5448]

Not so much a concern... I wish to eat what people usually buy from the supermarkets or from restaurants but with limited income I'm contented to eat those crops from the farm..now getting aged but no health issues..

[@rvboondocker2559]

@@almacaoili5448 Exactly! Congratulations! All we have is our health.

[@GreaterGoals]

Truth.

[@carolwong9279]

I’m a plant based nephrologist and try to promote diet and lifestyle to my patients. Many have stabilized their kidney function and avoid dialysis. Sadly, many of my colleagues don’t believe in this approach.

[@anakamhi7097]

Wow what a great surprise! Thank you Dr. Hyman ! 🙏🏼

[@alliseeisW]

Amazing content from these leaders making an impact.

[@LefterisAn]

I totally rely on that a patient may know much more about his disease than an expert doctor. I'm 28, have crohn's disease for 13 years and treating it with diet. If it weren't for crohn's i dont know if i would ever get on board on the marvellous ship of wellness and long living. I think that i might start feeling lucky about my disease because of all the doors to science and biochemistry that it opened for me! I'm loving it!!

[@lauradoctorf6415]

Great attitude! 😉 That's the way!

[@LefterisAn]

Thank you so much!! Its so rare to find someone with the same beliefs to interact with!

[@xoxoJassiexoxo]

I totally agree! These hardships have opened up more doors of understanding and willingness to do better with my overall health.

[@user-bw4xw3yt1z]

An injury to my knees was the “end” for me in my mind until I started doing anything I could, eating healthy, fasting, that lead to more energy… now my knees are as strong as ever and I’m junk food free 😁

[@lindahoffa4653]

I learned more from my dna health gene test from “The DNA company” and improved my health from their recommendations. Dr’s were very lil help with IBS since a child. Now at 68 much healthier. Many things I intuitively had been doing but test was a confirmation. Lactose intolerance, (probably why going vegan 6 yrs ago helped so much) gluten sensitivity and poor methylation pathway.s so many more things you learn about yourself. It’s like finally getting your own owners manual. Google the company the ceo has a lot of great videos about.

[@heetsees]

2 of my favourite doctors!! Can't wait until Dr.Sinclair does this format with Dr. Gregor!

[@fionanicolson7642]

I love David Sinclair. Great video ❤❤

[@t.t.8878]

My mother had cholesterol near 300 all her life. She ate whatever she wanted, including about a pound of chocolate every week. She never exercised either. Died in her bed age 89. I think she did very good. ( no medication either)

[@winnieloh4279]

But I bet she was physically more active than today average.

[@Asduyr]

Yeah did she consume loads of poisonous seed oil ? 🤓 I thought not!😜

[@jessecollins2453]

She was positive and slept well.?she was like my mom and she won't eat right.but if she would change she can make it to over 100

[@truthserum1931]

Statins are poison anyway. And who wants to live long only to be bedridden & have dementia??

[@jafrasar1]

Was it dark Chocalate she ate?

[@gaminghall-xr7mw]

You are the best by far of making Dr. Sinclair yse orwcise language.

[@sketchur]

Oooh, Dr. Mark Hyman and Dr. David Sinclair in the same video! 💕

[@SilverFan21k]

Ty Dr. Hyman for having on David Sinclair. ❤ didnt see this video until now

[@animishasomayajula4155]

My two most fav people(health experts ) in one video!

[@Mimi-vegi2go]

your program I have your amazing book love it 😍 my question is what’s your thoughts on Microlingual resveratrol-100-mg dose it work? Hope to get answers thx ☺️

[@metodokcsnaturalfitness]

Hi, First of all, thank you for inspiring us all with the work you do on Functional Medicine! We need more doctors talking about these stuff!!! I would love to have access to the paper mentioned by Dr. David Sinclair on the effects of NR on patients with Parkinson's Disease. Is it possible to send me the link? I even got the AI to look for it, and it couldn't find it! I appreciate it.

[@jafrasar1]

What a surprise-AI cannot find everything.

[@thomassit4972]

Very interesting talk and just by listening to your talk Dr Haymann, it is the most cost effective way for better health

[@WhereNerdyisCool]

I like this Dr Sinclair has the same battle with inherited high cholesterol I do. So many of the supplements he's mentioned I'm taking (yay to that Dr Oz Major Ager book!) I just wish I could get my hair back too (clarify...on my head!)

[@AFSMG]

Excellent channel. What is the health surveillance ring you use? Greetings from Spain

[@getmesomefries]

Six months ago I got some blood numbers that leaned toward an autoimmune disorder. I freaked out. Went gluten-free and stopped eating sugar, processed foods. Introduced live probiotic sauerkraut and got my gut healthy. Now six months later, I've lost 20 pounds which is tough for females at age 65. I hadn't been able to lose more than 5 lbs for years. I eat twice a day with the first one being ten cups of fruits and veggies along with chia and flaxseed in a smoothie. Dinner is normal, whatever I want in my boundaries. On occasion, went for 16- 20 hr fasting. Lost weight with not much exercise, but mild walking. Rheumatologist said he saw nothing of concern now.

[@jonassantos4037]

did u take any biologics and dmards?

[@getmesomefries]

@@jonassantos4037 I had to look that up. I took zero meds and am currently off blood pressure meds as well.

[@Bronte866]

2 great experts on one show - what a treat😀. Most interested in your wife’s after-exercise improvement with the mitochondrial cocktail. I have this issue due to fibromyalgia w CFS. I once made a mediocre effort with this but only addressed 1 pathway (the current knowledge at the time) I will be taking your suggestion.

[@corindusfanjoyz6301]

Ok to the end friend. Thank you for completing proper diligence for us all! I appreciate your time and effort! Kudos!

[@MsMelissa216]

What’s best type of ALA should one take. Be nice if he would’ve mentioned name brands

[@user-sz9pz2bt4f]

Yes, when we shift back to an ancestral-type lifestyle, meaning less of a garbage that’s being sold as a food because we’re finding more and more that it’s a toxic product, and exercise. Back in the day, we had to work for our food physically and then we were outside all the time!. We were in the extremes, the cold, and the heat, so that makes so much sense! Love this discussion. When we snap out of the pleasure principle, we find the true pleasure, the true living !!! Health and Vitality. And more focus. Our brains are so much healthier too, which means more power in our senses, and that is be on the five senses! Look around we are having a crisis of the brains in the world right now. Madness appears to be setting in. Berberine is a great supplement that lowers the effect of carbohydrates on a person’s insulin. It also kills parasites! I believe parasites are also causing a lot of illness and death. Dr. Alan Macdonald proved that in his speech called MS as a paracytosis.

[@macawism]

At 77 and having had to experience being told I only had months to live, during which I went through the saga of grieving in an almost continuous lock-down in Melbourne Australia. which turned out to be a misdiagnosis, i would welcome some discussion on the role of losing fear of death, simply as a part of ‘resetting’ for well-being. Of course the downside of all this is that the people likely to be in a position to benefit and maybe privatise longevity research are the very same, who won’t allow free basic health care for millions of people. Apart from ethical concerns, I don’t think I’m intelligent enough to sort through the issues of ‘suffering and death’ being at the core of what makes us ‘human’, so I’m just left wondering what it might be like to have my body reset from 60 to 30, when we’re told that our brains change as we go… an old mind in hormone driven, young body…traumas and thrills, a new horizon for therapy?

[@bohd3]

I do Berberine instead of metformin. It has similar clinical results but is a vitamin so doesn’t need a prescription in the states.

[@user-vt4jc9vm7g]

Just when I’m about to get a great point of the whole bit of conversation he interrupts him .😢 but in general its was a great talk . Thanks

[@sandraelder1101]

So there’s real wisdom in the old saying, “Breakfast like a king, lunch like a prince, dinner like a pauper.”

[@thegreatestmantoevrwlkthep9986]

No you dummy

[@Asduyr]

Nah Genghis Khan did intermittent fasting, ate goat sheep & horse, sheep cheese & kefir ! Now what did he do? Apart from conquer abt 1/2 the World😂😂😂😂

[@alvisepersegato8681]

interesting to see the different approaches, at least that's my takeaway Sinclair: studies are important but sometimes taken as valid in a vacuum; some detail on diet; no strict rules; behavior is important but goal is to have a drug- Eventually, there is a drug for everything; take pills as a way of thinking Longo: go back to first principles and see underlying mechanisms; design around it; change lifestyle permanently; find what's naturally encoded and activate it with lifestyle way of thinking. Both solid science but the approach is to find a common denominator in one, and add up all "reasonably good enough evidence" for the other I think is precious that both are working on it from different perspectives; the intersection of the 2 will lead everyone on the correct path Ndr: Not a fan of pills and definetely the least I can take, the better

[@elenabenjamin9980]

Hello And Thank you! What is the difference between R-Alpha Lipoic acid and Alpha Lipoic Acid? Thank you!

[@commitdubs]

the R

[@elenabenjamin9980]

@@commitdubs 😃😃 ? So it same function?

[@schwocky7]

Please recommend to your guest the work of Dr. Stephanie Seneff regarding statins. Her work is amazing and it may help your guest understand the alternatives.

[@planetmuskvlog3047]

What do you think of these sugar enriched gummies to help people sleep?

[@MusicSasho]

Dr. David Sinclair is such a great person he just wanna humanity

[@orion9k]

He wants $$$ but you cant blame him, wealth = health

[@lisengel2498]

Eat less, be hungry once in a while, exercise, get your proteins mostly from plants, carbohydrates are good but avoid processed food, go for hot-cold shower and winther bathing ( good for building Brown fat - keep you slim and fit)

[@EmotionalFelizNavidad]

Get your protein from meat

[@ibtissemgarram4886]

@@EmotionalFelizNavidad No from plants

[@EmotionalFelizNavidad]

@@ibtissemgarram4886 no . From meat

[@wendywitchner6790]

@@ibtissemgarram4886carnivore cult- let’s see how many are still around in 20 yrs🤔 🌱🌱💪🏼for decades 🧐

[@emilyknowlton8602]

Dr. Hyman laughs for no reason, I love it.

[@anilkumarhalimani3204]

I searched someone may comment like this. Because I am also noticed his laugh

[@williamhenry3337]

I am an Apoe2/3 also. There is VERY LITTLE information on E2. Please do a FULL PODCAST on Apoe2 and foxo3 variations.

[@diane1504]

Did i hear correct, that it is possible to take glycolic acid orally? Which form it should be, how to find it? Anyone could clarify? :) Thank you so much!

[@squirt3179]

What do women do about losing estrogen? There's no way to replace it naturally and definitely has effects on aging, dementia etc. There is a lot of talk about testosterone, but very little about estrogen and menopause. I loved this Podcast and follw Dr. Sinclair. I'm very healthy and well tuned to my nutrition and blood work. Just hoping this gets addressed more thoroughly and is top of mind.

[@nellybelly4388]

Hormone replacement therapy. Something you can do when you get older and go through menopause

[@squirt3179]

@@nellybelly4388 Thank you so much for your reply. I was hoping they can also address this on a holistic point of view and how and if any any of the supplements Dr. Sinclair talks about (NMN etc ) can also possibly affect/help like its seems to help with testosterone . Though maybe the answer Is to only get HRT. It didn't seem to me as though much thought has gone into this. I am currently in menopause so it is top of mind and exploring options

[@j01150126]

Having regular sex also helps to augment the hormones. Can I get your number? 😆

[@eeaotly]

@@squirt3179 I remember that years ago (I think it was in 2017 or 2018) I have found a video on this subject on Dr. Berg's channel (it was long before he became so popular). He was saying something that has attracted my attention because it was unusual and never heard before. Basically, he was saying that all the menopause symptoms wouldn't appear if the suprarenal glands would work correctly. Basically, those glands are supposed to take the function of ovaries after menopause. But if they are already tired, they can't cope and the woman starts feeling all those things and the body looses body mass, etc. I think that the answer to your question is somewhere here. You should check on his channel. I am sure that you xan find something useful there. He usually makes several gideos on the same subject because he keeps himself and his followers updated. Also, you could check on dr. Ekberg's channel. (Yes, their names sound quite similar.) Sorry for my English. I know that I must have butchered the name of those glands.

[@christinewolf1510]

Dr. Andrew Huberman does a whole thing on hormones. He has one episode specifically on women's hormones. Hope you find your answers :)

[@abhijitborah3005]

Please make a video on how to fix low stomach acid level

[@01maggie]

Drink celery juice every am on empty stomach. one whole bunch... Cleans stomach, liver and increases HCL in stomach

[@chadyboutros2899]

Look into Apple Cider Vinegar

[@lisengel2498]

My grandmother told me that nearly 60 years ago - and I still like to wake up with the Sun …. And I always like to eat most early in the day and I even experiemted with the last meal at 2 pm - and thats truly a fine Way of having very high Energy ….But it is off rhytm with the most common culture. 🙃🎵💜🎶

[@TellthetruthAtleastdontlie]

Exactly

[@bluesouth9090]

What is the name of the other scientist appearing in the 2nd part of the video? Thank you.

[@janebautista4273]

The two Greats!

[@GS-rw9og]

excellent

[@dalevandenheuvel3927]

What is the best form of QUERCETIN?

[@coachquick1339]

Jack was the man!

[@JMSsssssss]

I've worked a second shift nursing shift for over 20 years. I currently work until 12:30 am. Can you give us evening and night shift nurses some good news? Should we all quit those shifts for the sake of our health?

[@OperculumAudio]

Im a paramedic and the 24 hour shifts wrecked my body. My face started to look a lot older, especially under the eyes and mid face. I dont work 24s anymore because the chronic stress, and interuption of normal restful sleep is way too much to handle

[@emilyknowlton8602]

Yes, quit those shifts immediately.

[@RogueCylon]

Shifts suit some people. Are you getting quality of sleep, and avoiding processed foods and oils? Are you testing for deficiencies? What you do is invaluable, I have so much respect for our nurses.

[@mscrunchy68]

Hi, I used to be a nurse. Worked just nights for around 6 years - constantly exhausted snd stressed. Since giving up nursing, I haven't looked back. You don't realise quite how ill those shifts can make you until you stop for a good long period and rediscover your natural rhythms. Now I'm self-employed- in bed by 10, up around 6, energised, broke but happy. Take care😊

[@ian7033-qj9wg]

12.30 am isnt that late, thats my personal clock , I worked that for years and was pretty healthy on it. Its all about a good diet, exercise and sunlight.

[@AFSMG]

In what natural foods do we find nad?

[@linaaboudheir3878]

Very Interesting eat before dark , he has a very good point However with people living I. Countries like Sweden or the other side , what do they do

[@janinebarrett5422]

Cholesterol control - dropped mine from around 300mg/dl to 170mg just by taking lecithin capsules - it emulsifiers cholesterol

[@eftsoulpath333]

The differences simple carbs versus complex carbs

[@planetmuskvlog3047]

I was once a “doug man” at our pizza place. Have you heard of “Bigga”? It is a multigenerational yeast lump which can live forever in the correct environment. Some dough men swear the cultivation and utilization of their bigga is the secret to their dough quality. I always used fresh yeast.

[@sandybrazee1916]

What was the supplement the second word was acid? Where fo you buy the mentioned supplements? Ty

[@monetteramirez8795]

Alpha lipoid acid or ALA

[@biancay.michaels5832]

Dr. Sinclair said at one point that he suggests not eating too many carbs. But if you look at the Blue Zone, Italians or Japanese's diet is composed over 50% of carbs. Italians eat so many grain-based foods: bread, pasta, pizza, pastries. Japanese eat rice at every meal, and btw they are widely recommended to make rice 60% of each meal. So I don't know how that adds up.... I wish to know more about the research about how carbs are not beneficial.

[@TheMwegasShow]

I ain't no doctor but I would look at 'level of energy use'. If you are not so active, limit carbs. If you are always active like an athlete or someone whose job requires high energy expenditure like being on your feet and moving around and running around... carbs are needed

[@sonia1082]

Isn’t it primarily a sugar and trans fat problem when they talk about carbs? I think they speak generally about avoiding all carbs because of the bad quality of food in the US. People in Italy and Japan seem to be more lucky with the quality of their products.

[@sonia1082]

Also you could take a look at the research of the „glucose goddess“. She has found out that the order of your food intake has a high influence on your insulin level. I recommend you to listen to the podcast from the Diary of a CEO with the Glucose Goddess. It’s very interesting!

[@83shaunam]

I feel like sugar is more of an issue than just carbs in general. I recently had baked goods from other countries and they are noticeably less sweet than what I'm used to. I can only imagine that Italians are just eating their bread products with far less sugar. And pairing carbs with protein and fat can lessen the blood glucose spike you get with simple carbs. So in the US it's common for people to get a donut or two with some coffee with even more sugar and it's just so much worse than a baked good with much lower sugar paired with some eggs or something. And eating some bread with a protein rich dinner is so much different than eating cookies for a mid afternoon snack.

[@mattiuzzididier8911]

Hello. Japanese people start to be fat because of the modern changes of their diet, and Italian people are very fat, less than Americans, but more than French people. The Mediterranean diet or Okinawa are not followed by most of them ;-)

[@lisengel2498]

The six normals ? Difficult to understand - I heard them as blood pressure, blood sugar, hæmoglobin Ac1, BMI, LDL cholesterol ( no smoking) - 😊

[@benmccarthy2796]

What was that site with recipes on

[@carlav8357]

How can I get help and start today

[@lcm2023]

what’s the yogurt brand!!!!

[@marathapalace]

How long should we consume NMN. For ever

[@maripelayo6438]

Dr. Sinclair is not a medical doctor he’s a researcher so therefore take the information he presents as that vs. Dr. Hyman who is a medical doctor. I’ve personally really enjoyed listening to both their perspectives and then taking what applies to me where I’m at now.

[@shazam314]

And medical doctors don't know much about nutrition, if at all.

[@youremomlol2263]

​@@shazam314 I am studying medicine right now, I can confirm they barely ever teach you anything useful about it. The most semi useful one we had was in biochemistry, but you needed a lot of extra information in order to understand nutrition. Any doctor who tells you you need 3 meals a day is completely ignorant

[@elizabethk3238]

What crap! Researchers have more knowledge than doctors who haven't upgraded what they learnt in medical school 30+ years ago. My very honest doctor gave me her private email, and I send her info that I feel is helpful.

[@BuddyBellTree]

You could never tell me meat is bad. 2 million years of evolution. Far more people were carnivore than vegetarian

[@Mike-20193]

Evolution gets you to reproductive age, Sinclair is working to age much further.

[@GaiaNaVi]

No. Sorry. Evolution points to a 3% meat intake as maximum.

[@robinlabranche6147]

What about lymphatic drainage for getting rid of zombie cells?

[@margaretburnham5683]

I remember my mom watching Jack LaLanne on TV during the week when I was a kid.

[@theresadillon2281]

I'm really enjoying this. Great information. The way this was filmed looks like forced perspective & I can't help but make a LOTR joke_ I'd never expected a hobbit to advocate for intermittent fasting.

[@sherrymiguel7052]

I try to eat the right Foods all organic and stay away from refined Foods but I'm very heavy on the frequencies for health I also use frequencies for anti-aging natural face lifting and skin rejuvenation and nobody can ever guess my age most people guess me twenty years younger than I am

[@gabriellecases6167]

I never use hot water for shower even in the winter

[@lcm2023]

My Dream Team Podcast Series “True Health Care”, Moderated by Dr. Casey Means and including: Hyman, Sinclair, Perlmutter, Fung, Lustig, Gundry, Bikman, Fettke, Huberman and Amen! Then make it mandatory for every politician to watch it and every medical school have a semester of functional medicine using it as a teaching guide!!! Why is this so hard to make happen?!

[@gambinored81]

Dr. William Li "Eat to beat disease" Dr. Will Cole leading functional medicine expert. Dr. Eric Berg DC. He's not a functional medicine doctor but after years of research and 7 million subs. He is worthy of learning from. He also teaches other Drs.

[@RogueCylon]

It’s hard to find a reliable source for NMN. Most comes from China, and is suspect. Some folks have lab tested the most popular brands and found them to have no NMN?

[@jeannevessard3510]

My uncle talked about passing in his sleep for decades. One day he played golf and had lunch with his friends. He passed in his sleep that night at 73 years old. His wife thought he was still sleeping when she saw him in the morning but soon found out he had passed. He got his wish. Some years later his wife wanted to notified before she passed. Her daughter told me she was holding her mother's hand one morning and her mother told her she had been notified. She asked her daughter if she had paid the bills and the daughter said she had. Right after when she was still holding her mother's hand she felt the energy leave the hand. My cousin said her parents got their wishes. They passed the way they wanted.

[@KJSvitko]

You are what you eat. Your diet impacts your health. Lower stress, reduce obesity and more exercise are key to a healthy life. Obesity in children and adults is rising across the world. Fast food and sugary drinks are contributing to the problem of poor health and obesity. Eat a healthy plant based diet and exercise regularly. Reduce or ELIMINATE cows milk, eggs, cheese and meat. Eat more salad greens, beans, fruit and vegetables. Eliminate fast food, snacks like cookies, cakes, chips, and sugary drinks and juices. Every adult and child should own a bicycle and ride it regularly. Regular exercise will help you sleep better. Yoga is a great stress reducer. Obesity is all too common today. Get off the couch. Get off the phone, ipad or video game. A variety of stretching and other exercises help with increased mobility. Ride to work, ride to school, ride for fun. Every city should be a bicycle city. Speak up for bicycles in your community

[@user-hv8jw1fx7x]

Organic pasture raised eggs and meat is super good for you and has health benefits to the gut. Even raw dairy is actually anti inflammatory due to the beneficial enzymes and bacteria that are there since it hasn’t been pasteurized. Which makes it super easy for the body to break down lactose. But I do agree adding lots of fruits and veggies for the microbiome

[@samarajmohan9101]

Thank u

[@ZacharyTech7]

@Dr.DavidSinclair @Mark I want to live forever. To always see the ever-changing future of technology, science, and health. I eat one meal a day 90% of the time occasionally 2 meals not often. I am 27 and yet people always think I am 18 (without a beard chiseled jaw etc). My grandma lived until 85 with brain cancer the rest of my family 90+ others 80+ with other cancers. None of them ever fasted. I do IF, only eat clean food that I cook. I hate going to stores and fast food thanks to my high functioning Autism which is mostly sensory issues. I also have a repaired heart condition called TOF, and DiGeorge 22Q11, so with my gene mutations will probably live for a long time like dogs that are mixed mutts live forever. Oh, my aorta is also right-sided. I know HTML5, CSS3, JavaScript. I want to see flying cars and again just the future of technology. Maybe there will even be a cure for cancers or other people with disabilities like Autism and TOF or other genetic issues. I personally don't have cancer, just other issues and cancer runs through my family. I walk an hour a day and sleep 8+ hours every day. I also use Oura ring and other devices to track steps and sleep and personal data. I try to always get a minimum of 8000 steps a day which is 4 miles. Also my uncle retired as a sleep doctor so really ironed in our family how important sleep is.

[@ZacharyTech7]

We also have the good FOXO3 and other genes you mentioned. At least I and several others in my family do.

[@ZacharyTech7]

Also if we fix aging and health. We will eventually need to be able to populate planets because Earth will become too crowded populated. So we will ned to populate other planets.

[@mezbhakaziusa7901]

Did women can take this supplement resvitrol and nad booster?

[@linaaboudheir3878]

What type of yogurt ? I am a vegan Would coconut yogurt work ???

[@GaiaNaVi]

I came hear to listen to Dav8d Sinclair but that interviewer seriously loves the sound of his own voice 😢

[@basildaoust2821]

I'm going to be 60 next year yet I have been through a bad time sort of. I mean on one side of the coin I am not sad about who and what and where I am except that I am getting less fit all the time and if I can find a reason not to do something that I don't really want to do I do that. This is bad as far as I can tell, like you say exercise and I say no, it hurts too much. OK, obviously that is not the right response but when I try and do something so simple like walk a little ways I can see that I'm a very slow walker when I used to walk much faster, distance basically was not an issue but now I am slow and weak and if I walk out for 30 minutes the walk home will take like 60 minutes and I will not be all happy that I got my walk in, I will just want a drink and to find a bed to take a nap. So I have a simple question. How do I get into a fitness routine that will get me out of my hole and back into life? I guess that if I get in some basic fitness for 8 weeks or maybe more I can do the work without ending up with sore legs for 3 days and feel like I can do it. How?

[@lindajones4849]

I am a retired PT and it sounds like you are very deconditioned and it will take time . First, you are 60 so I think you should see a doctor and see if you are healthy enough to exercise. if he gives the ok then start exercising under supervision of say a personal trainer who can monitor your vital signs. If you are sore for 3 days after exercising yo are doing WAY TO MUCH . If the doctor gives the ok I would probably start with about a 10 minute walk. Walk for 5 minutes outside, then turn around and go back.

[@JakeRichardsong]

Did they say which brands of Resveratrol and NAD they take?

[@C2C.]

Check this out on resveratrol first: kzbin.info/www/bejne/gHKpn3dobMuZp6c

[@miracoli16]

@@C2C. Resveratrol is prooven to cause stress in your cells. Does not work!

[@C2C.]

@@miracoli16 That's my point, as detailed in the video.

[@nightmisterio]

So is the eye regeneration stuff out yet???

[@Spicydoc1]

I’m not sure I completely agree with Dr. Hyman and the organic stressors. I heard something contrary on NPR. I don’t see a difference in the taste between organic and non-organic, frankly. What’s everyone else’s thoughts?

[@JamesMena-ym9vf]

Non Organics and GMO's are the cause of our Bad Health world wide. Toss in Sitting on our Derriere's and Contaminated waters and VOILA!

[@irenadurakic-edwards9577]

So what molecule you gave to mouses and took besides metformine lower your bio age on 31,2?

[@MrYuri1989]

This guys is doing all the things you tell us not to do.

[@bryanspicer90]

Like what?

[@ihealthliving]

Thanks Dr. Mark for all the videos. I am not over weight but I am having Diabetes type 2. I stop eating all the time from what they were telling me to, I am also doing the fasting but my sugar wouldn't want to fall instead keeps rocking! I recently try to taking Metformin in the morning while skipping breakfast because I wear free style I can see that my sugar up as soon as I woke up 8 and get up 10 driving going up 12 13 and even gone up to 14 something after walking in the cold, or while working in fast mood or required a lots of thinking. Anyone please help, I have try many different things, I've learned the only way that keep my sugar low is lying on my bed and play a specific game only my was comes down to the the lowest 6.2. I recently start a job and my sugar levels all over the place and extremely high 😢

[@l-gool_t]

You need to reset your liver with three days of water fasting. Then eat properly and little junk food.

[@wellnesscoachingwithmar]

What do you think about cold showers 🚿 for those who have already high cortisol? I believe they don't need more cortisol and cold showers stimulate it. Fasting is also a catchy thing because it can also increase cortisol from what I've read .

[@joeschmoe5583]

Exercise also increases cortisol. ;) And phytonutrients affect cortisol metabolism negatively! :O

[@j01150126]

Go hot to cold. Hot shower or suana is effective for anti aging as well as cold. The cortisol will be ok if you eat at say 11. If you want to fast 36 to 48 then no exercise.

[@Nasrin782]

On the timeline 35.20, he is mentioning a resveratrol name, which I can't quite catch 😢.. can somebody maybe help me with that? Greatly appreciated ❤

[@sonia1082]

Pterostilbene I think.

[@TheJoaofrancocosta]

What do you have to say about scientific studies showing that metformin does not increase longevity?

[@pespsijackson3958]

dr sinclair is talking about doxycyline in every videos azithromycin and doxycyline reset the age

[@captainpike2468]

The Mister Rogers sweater effect is. Good look for you - call the fashion police !1 ‘ahhhhh ha ha ha ha

[@healerca]

apo E2/E2 is associated with a condition called dysbetalipoproteinemia

[@benjaminbritt7862]

Disagree on the vegetables but David is a great guest

[@vickiwu184]

Concerning fasting, some people like me can't bear hunger due to low blood pressure and can only do natural fasting from 6 pm to 7am. Any suggestions for this kind of group?

[@rickmcentee9204]

Mike Roizen is the doc on the second clip

[@markveen1373]

13h fast is already good. People are so stuck on numbers like 16h or 18h. More is not necessarily better. Depends alot on the foods you eat, BMI, exercise, etc. Most people these days have around 8-10h fast window with bad diets and sedentary lifestyles. Which is recipe for disease.

[@samanthakiu4055]

eat the right proteins and fats, exercise everyday even just walk for 30 mins, eat leafy greens

[@veggiechick6215]

I have a low blood pressure, never could go without early breakfast and meals every 2-3 hours. Try to increase your fasting gradually. I could easily go 24_30 hours without food and water, if I tried to go longer i hit the wall. I built up a fasting regime slowly. Now I fast easily 16 hours every day. 20 hours once a week, will bring back 36 hours once a month

[@schweizerbergnomadin1054]

I also have a very low blood pressure (100/60) but now I can easily fast for more than one day when taking chicken broth during fasting

[@SamSam-qm1li]

The Internet had freed our mind

[@ilyab.5127]

Getting your body through stress everyday to add few years...sometimes i think what's the point really? Most people enjoy food and love sugar, that makes them feel good. So living to 80-90 and enjoy everyday of your life or add few more years and restrain yourself every single day then die at 95. Will fasting and cold shower make you live to 120? No! With that in mind i am still obssesed with longevity for more than a decade. I do fasting here and there and miss some sugar food here and there. But im not going to "suffer" by fasting several days or doing 22/2 diet and avoid all sugars all my life. What the point in life then? Not eating to extend few years is a poor solution really. Humanity need to come up with something better, like a pill that mimic this fasting mechanisim.

[@mayalacubana1441]

that is what metformin does….

[@user-wu4rk1ls6x]

This is exactly what I think. However problem is that, this scam called David Sinclair spent some years in laboratory researching some substances and at the end came out giving diet advices. You don’t need to have phd in biochemistry to tell don’t consume animal protein which is absolute nonsense because most long living and healthy people on earth had liberal amount of animal products… seems like after selling scam company for 700million usd, he got some shares in fake meat industry

[@clintonfussell7385]

It's not just about longevity, it's also about looking and feeling good, not walking around as a 250-year old sack of wrinkles and crumbling bones.

[@chadyboutros2899]

Best thing I ever did was give up sugar. It is poison. Everyone is different. I am sure your lifestyle choice is good for you, but those of us who fast aren't suffering. We feel amazing, every single day.

[@jc1157]

Life is short dont punish ones self jus to add yrs to your life. Eat n enjoy in moderation. There r ppl who excercise skip meals do all sorts of things just to extend a few more yrs n natural disaster happens n lives gone in a sec its not worth trying n missing out on foods that u crave for. Jus go for it in moderation n stay happy n healthy.

[@nmj2411]

Is stevia okay to use? How much resveratrol?

[@joeybrazda364]

1500 bottles of red wine worth

[@peterazlac1739]

We need quality proteins that supply essential amino acids and it has been known for decades in animal nutrition that plants are not a good sources especially soya and grains which need supplementing with lysine and neither do plants supply vitamin B12 which is a most essential vitamin.

[@yesitsme8702]

Dr. Sinclair sure aged instantly 😂. Jk, who's the second doctor being interviewed?

[@compucentrum]

It happens to all of us. We don't seem to age, and suddenly a particle arrives from outer space that rains a shower of deadly radiation on us and we age by leaps and bounds.

[@SquatFull]

This bio alchemy replaces the old alchemy of transferring base metal into gold by reversing old bodies into young bodies. Dr. David Sinclair advocates eating less animal protein, and skipping breakfast after overnight fasting. He also advocates the use of metformin which blunts muscle hypertrophy in response to progressive exercise training in older adults. Given sarcopenia, the gradual loss of muscle mass due to aging, why would Dr. Sinclair claim his advice to be beneficial for longevity?

[@secondskinfillers8709]

Sweet potatoes ❤. Yes true I eat like this

[@dwightdarin5716]

Odd cut to other Dr. who seems to contradict what Dr. Sinclair does, i.e., eating once a day, later in the day.

[@cristinarossi7367]

Where does he obtain resveratral? Why does he take metformin and other such drugs if he eats well and takes plant sterols?

[@mikaelamathews9790]

I can never get the cold therapy down. I HATE being cold. I want to get the benefits of this but its HARD. Any suggestions?

[@Maximissesable]

You can try putting your face or hands in ice water.

[@mag4926]

At 32:29 At that point it felt like partial censorship..👎 I am very disappointed about that...