Drug Addiction and the Brain

[@Guidus125]

A drug is defined as "any substance that has a physiological effect". Whats interesting about this definition is that it also includes foods. For example, consuming chocolate increases tryptophan and subsequently serotonin. Even vitamines in food have a subsequent neuropharmacological effect. This is why in pharmacology the definition I was taught was "any substance that has a physiological effect BUT has NO nutritional value". I like that definition better because it gets a picture that resembles more what we think of when we say drugs.

[@Guidus125]

​@Xaviar 77versus99 Well, both can induce placebo (after all, literally anything can induce placebo) and both can have real physiological influence. In terms of the second part of what you're saying, it strikes me that you're phrasing it from the perspective of 'reduction' and 'destruction'. It is equally valid to talk about drugs as substances that increase and repair functioning of the brain and the blood-brain barrier. It's not a black or white kindve matter

[@Guidus125]

@Xaviar 77versus99me too

[@broenodusfr]

Added sugar is a drug by this définition

[@michaelm4725]

So chocolate can't be a drug because it does in fact have nutritional value. Right? Logic is logic. The rational conclusion is that chocolate has both nutritional value and physiological effects on the body. Possibly a more precise definition is required. I read Principle of Neural Science. I know they were really precise about their wording. If one thing only, I remembered that shit. It was mind-blowing writing. No ambiguity whatsoever. That shit is hard. Another thing to consider is the patently clear fact that mere thoughts have an effect on physiology. So, thoughts are a drug now? Okay, I admit it, I'm an iconoclast, a gadfly of sorts. And don't say thoughts are not a substance. If you know anything about Neurology, you know how thoughts are embodied in the nervous system. Many eminent Neuroscientists propose freewill doesn't even exist. Have you made it that far yet? It's hard to conceive of that, but when you move into Physics, it's sort of the only rational conclusion. Nothing moves on it's own accord. Even the concept of "energy" was redefined as "momentum" in modern Physics.

[@frankp8535]

I'm an engineering student whos been using your maths playlist to help me with my upcoming exams and I can't thank you enough, my girlfriend is doing physiotherapy and your anatomy playlist is amazing.

[@Memewmiao]

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[@CM-ng1ef]

I've literally never been more pumped for anything more than a pharmacology series from prof. dave.

[@andrewmunz1639]

yeh me too,

[@RUDEBOYY2K80]

Me too. I can’t🏴󠁧󠁢󠁥󠁮󠁧󠁿🇬🇧👍🏻🇺🇸

[@prahar26]

Ll

[@ayoubsbai6339]

Man let me tell you , you are highly talented covering almost everything...Hats off to you sir. And yes , happy new year

[@JacksonPhixesPhones]

EXTREMELY well done intro on the biophysical mechanics of addiction. I'm a C.A.C. I (Certified Addiction Counselor) in Georgia, and am gonna email you about maybe using this video in a group and/or lecture, so please keep an eye out. THANKS MUCH PROFESSOR!!

[@JacksonPhixesPhones]

@@Pobodies_Nerfect That's the riddle my friend . . you can't keep this thing unless you give it away. It's as if you strike gold,and the ONLY way you get to keep ANY of what you've found, paradoxically, is to give it ALL away. That's the HOW, but I REALLY want to know the WHY of this riddle. I'm so tired of going to funerals. Normally, I'm a heroin junkie with a methamphetamine "issue" who drinks FAR TOO MUCH, but for some reason, if I insist on giving it ALL away, I get to wake up every day without wanting to get loaded, PERIOD. It's been almost 5 years. I am recovered, and I would give ANYTHING to find a way to bottle this solution and save those who are suffering as I once did. But I can't forget this simple fact: A person can RECOVER from cancer, but if they decide to ignore their doctors, and don't take care of themselves, their chances of a RELAPSE out of remission is exponentially higher than if they maintain a healthy lifestyle and take care of themselves. I apply the same principle to being an addict/alcoholic. Hope that made sense. :-)

[@skullmonkey6566]

Am 46 and still learning...... dave you're a legend mate and am looking forward to learning more in 2020 happy new year buddy 😁😁

[@rowdy1003]

You keep learning your entire life

[@harm3825]

Never stop learning 👍

[@jonathanmichaud8484]

Dave all your video are awesome👍👍. The only critism i can tell is sometimes the begining is too much about things we view in previous video, its useful but i little bit long. Keep the good work, i studied psychology and toxicology (im also an ex opioid/cocaïn addict) and you tell everything so accuratly its awesome! The only thing you missed is that alot of addict specialy in opioid addiction are people with PTSD, dépression, anxiety and are automedicating

[@davidsweeney111]

Great video - can't wait for the Pharmacology Series!

[@drvir]

I'm waiting for 2 things : 1. Pharmacology series 2. 1 million subscribers

[@ProfessorDaveExplains]

both coming very soon!

[@Barnardrab]

The nice thing about being a new subscriber is that these "Upcoming" videos are already available.

[@Zetsuke4]

my favorite youtube channel ever!

[@7ele5crivente]

I'd find interesting to understand how addiction works in the brain. I'm talking about the reward system mediated by dopamine. I don't know how to explain... I'd like a more neurological and less physiological sight of how different parts of the brain communicate when it comes to associative learning, and then how drug abuse effects this circuit.

[@michelangelope830]

Addiction is the tormented psychology of a liar, only liars get hooked and only honesty gets freedom. The tragedy of addiction is children who revenge a childhood hurt or trauma against their parents learning from example. I think therefore i exist, therefore i was created or always existed and the creator was created or always existed, therefore an impossibility possible, a miracle, an uncaused cause, God exist. Life and death always existed and science cannot explain the origin because defies reason. God is eternal and mortal, perfect justice, ourselves for eternity til endless death when all life die. I find my argumentation solid but gullible humanity that swallow the addiction is a brain disease lie without questioning have incredible difficulties and objections to accept the obvious truth. Still no parent of addict has said ‘thank you’ to me for discovering the cure to addiction, what confirms my theory that addiction comes from bad households, ungrateful and unforgiving. I don't have a voice in any news media in the world.

[@kylegoff3527]

Wrong. There is no cure. That’s your opinion not facts. Addiction is a chronic and progressive brain disease.

[@Zetsuke4]

FIRST! always notification on so I can learn as soon as video is posted.

[@marioedrozo1589]

The homie professor Dave can’t wait for the new series

[@brandcack4117]

I’m about to do a presentation in Biopsych on the biological underpinnings of addiction, this was very helpful thanks so much!

[@yirehmiyahmagsayo2458]

Hello professor dave how we can we stop drug addiction and how dangerous specially illegal drugs ..specially in any addiction like gaming ,alcohol and cigarittes...thank you for this...many people could be save...

[@srilekkha3736]

Nice topic.interesting to listen as chemistry student

[@mahmoudkhattab4445]

waiting for more pharmacology stuff !

[@ProfessorDaveExplains]

a whole playlist will be coming soon!

[@mahmoudkhattab4445]

@@ProfessorDaveExplains COOL ! Thank you so much

[@peterlustig2048]

How on earth are you able to produce outstanding videos about such divers topics? What did he study? Does he have a doctor in universal knowledge? I envy you and hope i can tip my hat from one legend to another one day.

[@ectopicortex]

At minute 7:50 you mention an isolated rat only using drugged water. I wish you had mentioned Rat Park by researcher Bruce Alexander in 70's which added real world variables to the isolated rat experiment. Rat Park is also mentioned in TED Talk at minute 4:12 Everything you know about Addiction is wrong by Johann Hari also mentions real life Rat Park of Vietnam War and returning home.

[@itskemely7017]

This video was so informative. It explains a lot in a small amount of time very much needed for my class.

[@azulbebey]

You are so cool! Saved me hours of reading to understand these concepts! Thank you!

[@EdilinDeLaCruz]

The video was very educational he covered almost everything I know I am going to use everything I learned in class.

[@KillerAntx]

I want to become a nursing student hopefully these videos keep me educated. Better to watch this on my non-study time then fornite or something of that nature lol

[@蔡小宣-l8e]

Thank you for your video . Keep up the good work. 感谢你制作的视频，再接再厉！

[@yirehmiyahmagsayo2458]

Professor dave can you make s series video of this of how we can stop for this for the solution of this killing addiction in life...woild be meaningful and save many life

[@janeramos9472]

I really liked your video. It was really helpful and interesting to watch. Keep posting.

[@zhivago9286]

Wow that was so well done and interesting.

[@saurabh3228]

Great job professor 👌

[@joiemccumbeesr126]

Thanks for video. Just started a course on the medical aspects of chemical dependency and your video content mirrors the same material found in textbook. Will be looking for more as I move through the course.

[@waynegagas4731]

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[@williampai8333]

can you do a MCAT study list ? thank you !

[@Misserbi]

What I believe will eventually happen is social media and other areas of life such as work and school will assign a health number either coded by a color or a scan that will indicate the person's ability to exchange communication based on his/her health and well being. This will give others who happen upon this individual a chance to understand his/her background by being informed first so as not to blame him or her for everything wrong in the world. That is what happens when random people think they are being subjected to greed and must uphold their honor in circumstance. You don't change the world by cursing it through the first victim you encounter who is unaware of your situation and circle of trust.

[@IntelligenceOfPlants]

Subscribed just for the intro 🎩

[@sid6554]

Heroine isn't most addictive. Fentanyl is many times more addictive, being 10x more potent than heroin with a much quicker come up. And Carfentanyl is many times more addicting than that, being 100x more potent than heroin.

[@kjy05]

Amazing❤God bless you🙏

[@user-sm9zs7sc8u]

I have a question regarding 4:38 : Shouldn’t taking Acetylcholine Supplements have the same effects as taking nicotine? I know this assumption is wrong, I just’d like to know why

[@alexandria4307]

I'm so excited for the Pharmacology series!!! Thank you for existing and for your amazing content

[@matthewshannon7235]

nice hair cut Dave!

[@souravverma1781]

The intro was too cool😂🔥

[@utsavsinghania7534]

Sir can u plzz do some questions on d and f block elements .....it would help a lot

[@copperhead5277]

See how Not worth it IT is !? It does not define "who"you are. But then again, until you are clean and sober, who are you ??

[@PotatoChips-jy9pk]

I suggest looking into rat-park experiment. Very interesting.

[@harjotmann952]

good job man

[@mujib4466]

Thank you

[@ddtt958]

I used to drink a lot before. I've been sober about 7 months. I suspect the alcohol has damaged my brain a bit (gaba receptors etc). I feel better now than I did when I first decided to quit but I still deal with some anxiety and depression though I probably had that to a smaller degree while I was drinker also but I just didn't notice it then. I think my brain is slowly recovering. Would I set my recovery back or damage my brain receptors etc more if I were to use benzodiazepines for example in small amounts maybe once a month?

[@melissasomaya1876]

I'm looking forward to letting it all go,but it lingers. It scares me, cig beer weed. I want it all gone.

[@tarak5446]

Nicotine is the most addictive substance followed by cocaine and then heroine

[@chemt4684]

Very interesting.

[@k4b44l]

4:17 cocaine is not physical addiction it is a dependancy. As the withdrawal symptoms are not physical but mental. You might have ment caffine though.

[@tdhanasekaran3536]

There is another form of addiction that is even more dangerous. Watching too much porn videos and classified as Porn addict. This is because after every sexual orgy (natural or porn) the brain releases dopamine the pleasure molecule and makes one feel good. But too much depletion of Dopamine (lets say 4 to 5 times /day) leads to feeling low and depressed. The effects are similar to drug induced release of Dopamine.

[@iggynosrovlah6355]

Never get addicted it hurts..

[@fbi6893]

Epic

[@harisshah8284]

The best herbal remedies to get rid of drugs are possible so attention needs to be paid to this۔

[@ProfessorDaveExplains]

You should probably watch this whole series.

[@Vivek-qz9br]

tomorrow is my exam what am i doing here

[@TL....]

addiction is the only prison where the key is inside

[@Ronald_ze8k]

The future revealed: exclusive interview with Binance's CEO

[@iliketurtles5180]

I guess you really are sick of flat earthers in your comment section

[@johnhalbe6530]

This isn't my problem it's theirs.

[@jacobsavage8831]

All you really say on the topic is that each release dopamine and ‘neuro-adaption’ I thought it was going to be about how the cells adapt chemically... all you talked about was what different drugs do to the body like getting drunk, disappointed.

[@ProfessorDaveExplains]

"How the cells adapt chemically" doesn't mean anything.

[@dariustaylor6983]

0:10

[@PotatoChips-jy9pk]

6:18

[@LucasMendoza-yn8vm]

This made me high

[@raggedynomo1974]

Heroin is not the most addictive substance; sugar is.

[@ProfessorDaveExplains]

Um, no.

[@melissasomaya1876]

How did i become dependant on alcohol but not cocaine?

[@pacifiquebusiness]

🙏

[@PotatoChips-jy9pk]

I love putting chemical compounds in my body.

[@angelarhodesbellamy661]

CAN YOUR BRAIN HEAL AFTER YEARS OF DRUG ABUSE...SELF MEDICATION...

[@oneearthmerged6855]

💜

[@prahar26]

.

[@juanpedroperaltacota1990]

Not agreed on genetics!!!!

[@michelangelope830]

Addiction is the tormented psychology of a liar, only liars get hooked and only honesty gets freedom. The tragedy of addiction is children who revenge a childhood hurt or trauma against their parents learning from example. I think therefore i exist, therefore i was created or always existed and the creator was created or always existed, therefore an impossibility possible, a miracle, an uncaused cause, God exist. Life and death always existed and science cannot explain the origin because defies reason. God is eternal and mortal, perfect justice, ourselves for eternity til endless death when all life die. I find my argumentation solid but gullible humanity that swallow the addiction is a brain disease lie without questioning have incredible difficulties and objections to accept the obvious truth. Still no parent of addict has said ‘thank you’ to me for discovering the cure to addiction, what confirms my theory that addiction comes from bad households, ungrateful and unforgiving. I don't have a voice in any news media in the world.