Embryo Grading in IVF Explained | What do embryo grades mean? | FertilitySpace

The Complete Guide to Embryo Grading
Wondering whether your embryo has a good grade and what it means?
What is a good blastocyst grade? Is a 4AA embryo good? What is a grade 5 embryo?
In this video, we learn from embryologist, Jessica Manns, all about understanding embryo grades, from the criteria embryologists use to grade an embryo, what is a good embryo grade, what is a poor embryo grade, and how embryo grades affect IVF success rates.
What is embryo grading?
During an IVF cycle, embryos are graded by embryologists in order to help your fertility doctor assess which embryos are developing normally.
This information can assist in selecting an embryo to transfer that is most likely to lead to a successful pregnancy.
"Embryo grading is a way to describe the way an embryo looks based on certain characteristics", embryologist, Jessica Manns, explains. The way an embryo looks is often referred to as embryo morphology.
Grading embryos based on their morphology helps embryologists understand whether your embryo is developing normally and at the expected speed.
This can give you and your fertility doctor some insight into which embryos may be better quality than others and which are most likely to result in success and lead to a baby.
Embryo grading is important for:
* predicting IVF success
* identifying which embryos are suitable for:
* embryo biopsy (PGT/genetic testing)
* embryo freezing
* embryo transfer
* choosing the best embryo for a frozen embryo transfer (FET) cycle
If the embryo looks how it should on a certain day of development, then it is more likely to be viable compared to embryos that may be developing slower or have poor morphology.
Embryos are graded usually on Day 3 and on Day 5 of development.
On Day 3 embryos are graded based on:
-number of cells
-equal sizing of cells
-cell fragmentation
An ideal Day 3 embryo grade would be an embryo that has 8 cells that are all equal in size and no sign of fragmentation.
On Day 5, an embryo should be at the blastocyst stage. This is where embryo grading becomes more complicated. This is the time when most patients start to pay attention to embryo grading. Once embryos have reached the blastocyst stage, embryos are graded on a scale known as the Gardner Scale.
Blastocyst stage embryos are graded on the quality of their:
-development/expansion
-inner cell mass
-trophectoderm
The quality of the embryo's development is graded on a scale of 1-5 with 5 being the best. The inner cell mass is graded on s scale of A-C with A being the best. Finally, the trophectoderm is graded on a scale of A-C with A being the best.
The best embryo grade you can have is 5AA.
Day 5 blastocyst embryo grading scale:
Good (Any embryo grade that has all A's)
Fair (Any embryo grade that has a B)
Poor (Any embryo grade that has a C)
In this video, we cover:
- what is embryo grading
- how are embryos graded
- embryo development timeline
- embryo grading chart
- comparing blastocyst grades
- best embryo grade?
- worst embryo grade?
- how embryo grades affect IVF success
- can the embryo grade tell you an embryo's gender?
- embryo grade follower Q&A
TIMESTAMPS
0:00 Meet the embryologist!
0:19 What is embryo grading?
0:57 Embryo Development Timeline
2:50 Day 3 Embryo Grading
5:36 Day 5 Embryo Grading | Blastocyst Stage
9:05 Best Embryo Grade on Day 5
9:39 4AB vs 4BA embryo grade
10:09 4AA vs 5AA embryo grade
10:30 Day 5 vs Day 6 blastocyst
11:07 Embryo Grading and IVF Success
11:31 Follower Questions on Embryo Grading
11:35 Is a hatched blastocyst good or bad?
13:37 3BB Embryo - what does 3 mean?
14:12 Can a frozen embryo grade change?
14:45 What does fair mean in embryo grading?
15:43 Can embryo grade tell me the gender?
16:01 Embryo Grading vs PGT
16:29 4BB embryo success rate?
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[@Michelle-vq1zg]

Embryology is fascinating. My day 5 embryo was 4AA and I’m due my 13 week scan next week ❤

[@fertilityspace]

Aw congratulations! That’s so great to hear! Hope all goes well with the scan 💕🎉🤗

[@mariacarolinazimara6095]

this is the most informative video I've seen on the topic. Thank you!

[@norikamiu3734]

What an amazing video, so clear and easy to understand. Thank you so much… 🙏🏻

[@thesadboxman]

This is such a great video. So much information packed in a short amount of time, but easily understandable

[@jesusg407]

Thank you for the information! Clears up a lot of questions!!

[@fertilityspace]

You're very welcome! Glad it was helpful!

[@bunkerhillguy2542]

This is a great video! Amazing explanation and I am getting my test results for my embryos in one week and now we understand the grading better. Thank you.

[@skyblueflowergrass]

Wow, really comprehensive, easy to understand explanation. Brilliant, thank you!

[@Savsabio]

Thank you for the detailed info! My embryo was graded 6AA and I was scared that it being hatched was a bad thing.

[@swatikamra9301]

very well explained, so helpful.

[@fertilityspace]

Glad it helped! 💕

[@saraha.1422]

Thank you so much, this is so helpful.

[@fertilityspace]

You're very welcome! 💕

[@pikauchu5469]

I’m about to do retrieval. This is so helpful

[@dodooxnard]

This was so helpful! I have 5 Day 5 4AA embryos and 5 Day 6 4AA embryos. I'm wondering which will be better to send for genetic testing.

[@rojayelamanchili3006]

Very informative, understood very well. Thank u. God bless u

[@fertilityspace]

So glad to hear it was helpful! 💕

[@ljvandir6554]

Very informative👍👍👍

[@fertilityspace]

So glad you found the info helpful! 💕🫶

[@bebeautiful3915]

Nice explanation

[@fertilityspace]

Glad it was helpful!

[@AlanaVacca]

I had two transferred about seven weeks ago. 4AA and 4AB. On my first ultrasound one had no yolk and the other had no heartbeat. Both equally bad. I’m hoping the second ultrasound I have Tuesday has better news.

[@Roxana11270]

I have 1 blastocyst 5CC on day 6, my clinic chose to freeze it. Do you think it will have any chanse to implant?

[@kanthanathanamutha620]

Thank you for your information, I have 5embroys on day 4/ grade 1, please explain me about the success rate because I am going trasfer on this month.

[@stephlegros9757]

Hello, this is a great video. I have a day 5, grade 4BC expanded blast embryo. It’s also euploid. What do you think I can still have a successful pregnancy?

[@shahnawazali9654]

Hi dr. I got one 3AB Blastocyst ane one early blastocyst. Are they good. Is there any chance. Dr do early blastocyst change some good blastocyst after transfer. Plz

[@bellakhan9184]

Can some some guide me what's collapse expanded embryo what about its success implantation rate

[@swara4318]

2 days before done my embreyo transfer grade 5AA 2embreyo day 6 embryo transfer how % much possible implant and what I taken precautions to implant embryo

[@rabiaadam]

I was informed of 8 embryos on day 3, then on 5th day 4 expanded and 2 blastocyst. Don't understand which one are better

[@Theslowestmarathoner]

This was awesome! Thank you! I have a day 7 5CC. It was my only egg and only embryo. I don’t have much hope, but…. This helped.

[@fertilityspace]

So glad you found this helpful! You have an embryo to transfer, so that's amazing! Sending good thoughts your way for the transfer! 💕

[@Lifewiththekings828]

Praying for an successful transfer!!! ❤❤❤

[@Lifeisprecious9]

Worked?

[@nicole4779]

Hey I’m also a CSU alumni 👩🏾‍🎓😊😊

[@lydiamugoli2002]

If they freeze embryos on day 3 do they continue to develop?

[@monamari5652]

My day 3embryo was not good and waiting for 5 day embryo.. Hope for the best..

[@HelloHello-fy6vy]

I have one 6AA I do pGT-A and it comes back normal, i am just praying for everything to go good when I want to use it,

[@fertilityspace]

So glad to hear your embryo came back normal! Sounds like you have a great grade! Wishing you the best of luck on your future transfer!! 💕🤞😊

[@HelloHello-fy6vy]

@@fertilityspace thank so much 🙏🏼

[@deepanarvekar4535]

Results??

[@sumabk2186]

​@@HelloHello-fy6vy what is the result

[@rosalinpanda1773]

❤ Expecting frozen embryo transfer of 2AB . So what will be it's success rate .how much should be ET for frozen embryo transfer

[@hunnae25]

I had a 5 day 6BB PGT tested embryo that did not implant 😔Recently transferred my one and only euploid that was graded a CC after thaw (it was a B- prior to thaw) and AB graded low level monosomy 7 mosaic. The doctor said the chance of euploid implanting is 20% and mosaic is 30%...Currently in tww but cant help feel hopeless

[@sweetsriniman1291]

Ur result

[@moneyoonmymind]

I had four 4AA embryos and 2 4AB ones.. just transferred one 4AA 3 days ago ♥️

[@fertilityspace]

So exciting!! Sending good thoughts your way! 💕🤞🤗

[@gowthami8688]

Good news? 😊

[@moneyoonmymind]

@@gowthami8688 I was almost 7 weeks and had a miscarriage 🥺

[@rabiaadam]

That's sad, what's the reason​@@moneyoonmymind

[@M87user]

In our country (national healthcare) they don't test embryos for genetical abnormalities, they only do morphology. How would you gauge our chances for a kid with down or turners syndrome. We are 37/36. No history of problems in family. But our friend had hers tested in another country and out of 8 extracted cells, 2 died, 2 had low grade, 3 had down syndrome, only 1 embryo was worthy of transfer. Would you say no to procedure at a clinic that does not test genetical material?

[@cuisineallfuntravelnetwork8615]

Nice from ours colorado

[@sharktv1924]

we got 2 Full Blastocyst one is grade A and the other one is grade D. but they both ready for transfer. is there any reason for Grade D full blastocyst to not live in the uterus for a week?

[@tracey6999]

I have a 4AA that did not work now I have a 4AB Remaining BUT GOD😍😍🥰🥰❤️❤️❤️

[@fertilityspace]

Ah best of luck with your 4AB!! Still a great grade! Sending good thoughts your way 💕🤗

[@lincas8976]

I just had my transfer 2 today that is 4AA and this is day 5. The embryologists said it was perfect. I did invocell where I incubated my eggs for 5 days and then had the transfer.

[@giovyincella507]

​@@lincas8976may I ask how did it go?

[@sabagul8636]

What about day 5 morula stage

[@sabagul8636]

Fresh day 5 morula transfer in ivf what are the chances ? Of success

[@SowjanyaDanda]

Thank you for the info.. I had 4BB day 5 blasocyst Grade embryo transferred 4 days back...my endomterium size was 8.5mm..please let me know whether embryo grade was good to implant

[@anythingsmartview5840]

Are u pregnant?

[@ThePendergrafts330]

I'm also about to transfer a 4BB, was your transfer successful???

[@gavinnoahzion8196]

How was your transfer?

[@NeetuSingh-sz8xf]

How is 2AA and 3AA frozen embryo for transfer in 38 years

[@drdipanwitabiswas4124]

Good

[@dominiquetaylor-jones9484]

I have 5 embryos that are 5 day 4AC, is that considered good, fair or poor?

[@fertilityspace]

Great question! We followed up with Jessica and she shared, “SART considers any embryo with a C grade as poor, even if there is an A in it. So technically, it’s a poor quality embryo based on SART.” But that doesn’t mean that you can’t have success with these embryos. Poor grade embryos can lead to a healthy baby. If you choose to have them tested by PGT-A, that can also give you more information on your chance of success. Hope that’s helpful!

[@RachelBrandt-fj4gj]

What is the success rate percentage for 4AC?

[@MalamateniaTzimpoukaki]

❤

[@sweetsriniman1291]

Mam I have day 3 embryo which contains 6 cell doctor told that grade c ..that c grade 6 cell embryo has frezed for transfer..next month my transfer will come..just tel me that 6 cell day 3 embryo will success?

[@anishabhujbal4457]

What a result plz tell me

[@sweetsriniman1291]

@@anishabhujbal4457 not yet transferred we are trying naturally...that embryo has freserzed.

[@anishabhujbal4457]

Tx for reply

[@sweetsriniman1291]

@@anishabhujbal4457 no issue what is your results

[@anishabhujbal4457]

I have 2 day 3 embroy but next month transfer

[@myvarisu]

3ab 3ab embroyo does it ok or not

[@Soumyareddy23_]

Same here what about result

[@drdipanwitabiswas4124]

Good

[@sumitankalkote9488]

​@@Soumyareddy23_apka success hua kya as mine is same

[@peacebalance8067]

All this is good info. But really only time will tell. Its really up to God.

[@BDTIG3R]

Chances of a 4BC?? 🥚