Epilepsy pharmacology - Soton Brain Hub

In this video Andrew explains the pharmacology of epilepsy - we hope you enjoy and find it useful! Subscribe to see our latest videos as they come out!

[@deepakkabilan]

After 3yrs i finally understood seizuresssa...hurrah....!! Thank you.. i am happiest man...

[@grandlordrobert4728]

Earlier Last year I was diagnosed with CANCER in 2019 and I have tried everything I could to heal myself, but it was all to no avail, until I saw a post on a health forum about a herbalist preparing herbal medicines to cure everything type of diseases. including CANCER, at first I doubted it was real, but decided to give it a try, when I contacted this herbalist through his email and he prepared me a herbal cure for CANCER and sent it to me via the delivery service of UPS from the company, when I received this herbal cure. They gave me step by step instructions on how to apply it, when I applied it according to the instructions I was totally cured of this deadly disease within 5 months of use, I am now CANCER free, all thanks to Dr. PETER You can also contact this great herbalist for help by email: [e-mail] or contact Dr. PETER through his whatsapp number: [phone] He is also specialize in treating all kinds of diseases, VIRUS HERPES , HEPATITIS B, CANCER, BRAIN DISEASE, INFERTILITY, DIABETES EPILEPSY AND MORE ...... He will also be of help to you.

[@user-dq7uj2lj3g]

a brief and strong explanation.

[@moosen34]

Thank you so much! This is the best explanation of epilepsy pharmacology I have seen

[@SotonbrainhubUk1]

+moosen34 Thank you for the feedback, glad you found it useful! Please share with friends

[@peterturner345]

Yeah I needed this, I feel like my neurologist dsnt even understand this that well.

[@anonymous-kd6td]

I will always come back to this video every time. Greatly summarizing everything! thank you May God bless u

[@ingeluttig9557]

Best explanation I have come across

[@diptisorate6746]

This was an impeccable explanation related to epilepsy thankyou !!

[@bornonmoon4222]

nicest video of drugs mechanism ever seen. Good job.

[@kasahunbentimerga3006]

Wow, you summarized and presented it very well! Thank you so much!!!

[@khamikos1]

perfect presentation... great .... so easy tounderstand...great job..thanks

[@raghusl7692]

Can’t thank enough. Tough topic explained in the easiest way. Thanks again.

[@JohnDKParker]

Thank you so much you explained what my drs, neurologist, or any epilepsy site couldn't. Ive take valpirate, klonopin (benzodiazepine), and currently take topiramate (topamax) ... I never understood how they actually worked until now 😎

[@doug_1489]

I take topiramate, valproate and urbanol and now I understand it all a bit better...thanks! bike accident 1996

[@connorzakin279]

Thank you so much, great review for a pharmacist returning to work after long hiatus!

[@drewgabriel8446]

I was born with epilepsy and cerebral palsy. I have a twin brother, i was born first. My brother was born with no problems. I take phenytoin for my epilepsy, as a child I was on phenabarbatone, then at 14 i was put on Epilim 500mg. Which caused me to gain lots of weight. I went to live in Canada for a few years where I was taken off eperlim & switched to phenytoin. Which I still take today. As a child I had grand mal seizures, which doctors said I would grow out of. Which I did, but I now have petit mal. It' feels weird when I have it, i can hear all thats going on around me, but ppl and any noise, sound much louder, plus it feels like I'm floating on water. Before the seizure I get the smell like burnt toast. I can have a seizure at any time, night or day. Unpredictable. I feel a little confused when I come round, which lasts for a couple of minutes, then I'm back with you again. Usually a cup of tea helps me recover. I read a lot of blogs where people who shared their testimonies kept mentioning Anti-seizure Herbal medication. I searched for a website I just followed the email address of Doctor Patrick that was shared on these testimonies; I got lucky when I got a reply from Dr. Patrick. I followed his instruction, used Herbal Medicine in less than 2 months, I was already cure because of the changes I was seeing. Within a period of 5 months, I was cured totally forever. I went back to my neurologist, I was checked up and marked epilepsy free. If you need his help you can Contact this herbal doctor via his email [e-mail] and WhatsApp connection is [phone] for help

[@Pokimoisnotcute]

Most illustrative and informative video for students.

[@dimitrioschatzipetris4674]

God bless you!!!! I finally understand many things about pharmacology!!!!!!!!!!!!!!!!!!! THANK YOUUUUUUUUU

[@SotonbrainhubUk1]

+Dimitrios Chatzis Thanks you Dimitrios, glad you enjoyed the video!

[@roxanneroxanne876]

this is the first video ive s3en that showed me the root of the matter. well done.

[@SotonbrainhubUk1]

+Roxanne Taffe Thanks Roxanne glad you enjoyed the video!

[@oracular7065]

Comprehensive,cool and complete.......Way to go... I guess its d only video on anti epileptics that brushes ur basics.....Thanku!!!

[@SotonbrainhubUk1]

Samir Brandon Thanks for your feedback, check out our other videos!

[@jnaziri2]

GOLD for medical students. Thank you!

[@SotonbrainhubUk1]

+Eloquent Thanks for the feedback, glad you're finding the videos useful

[@rajanthnelu2460]

supppper sirrrr...great ji

[@sarvenazkarimi8720]

It helped me understanding the mechanisms of epilepsy medications pretty much better, thanks alot

[@sarahc.1998]

Wonderful! Thank you 🙏

[@cristirabaza5051]

Thank you for this video. It was really really REALLY helpful in making sense of all these medications.

[@SotonbrainhubUk1]

Cristi Rabaza Hi Cristi, thanks for your feedback! We have new videos coming out all the time so subscribe to be notified! And if there are any videos you would like us to make drop us a comment and we'll do it!

[@maromakeen9218]

Great video

[@Muuip]

Great concise presentation, thank you for uploading it. 1 Question: Does Phenytoin have an effect the "ball on a chain" sodium channel deactivation system in the presynaptic and postsynaptic neuron? And thanks to all participating in pharmaceutical research , Phenytoin saved my life.

[@korayapaydin]

I slept on that class but now i learned that. Thanks for this hope you will keep it up. I will share it with my sleepy friends :)

[@SotonbrainhubUk1]

+Koray Apaydın Thanks for the feedback Koray, have a look at our other pharmacology vids, we also have lots on neuroanatomy and physiology!

[@euphorialeclipsed]

This guy is good. Thank you.

[@Ahmad-vu8uj]

Thank you for this Helpful video and explanation, I hope you post more stuff like this on neuroscience.

[@SotonbrainhubUk1]

+Ahmad ALMulla Thanks for the positive feedback - make sure you subscribe for more of our new videos - a new one posted here every Sunday!

[@Ahmad-vu8uj]

yeah I already did that and I'll be waiting for the great work

[@drk.sharmila6315]

Ur videos r too easy to understand thank u.

[@pfokreniruphre1329]

Clearly explained & well Understood. Thank you

[@Baharaakbari]

Perfect explanation ever i saw everything is clearly understandable 👏🏾👍🏾

[@davidhersey1577]

Wow.....well done!

[@happydaydreamer2533]

It's all crystal clear now... Thank you very much, kind sir! Gbu :)

[@Muuip]

3 Question : Endocannabinoid neurotransmitters from postsynaptic neuron to receptors on presynaptic neuron (to modulate Calcium entry and therefore modulate neurotransmitter release) are gaining popularity these days, are there new FDA approved drugs to activate Endocannabinoid receptors ? Many thanks.

[@maaaaayyy159]

This is just amazing amazing amazing! THANK YOU!!!

[@SotonbrainhubUk1]

+mxmz Hey thank you for your feedback! Share with your friends/colleagues and remember to subscribe for more videos!

[@natasqi]

Thanks, really helpful. I liked the repetition in the video as well.

[@SotonbrainhubUk1]

Nat Mack Thanks for the feedback! We release a new video every Sunday so subscribe for more!

[@annamoore3129]

Really interesting video. Lovely to know how the lamotrigine I take helps stop my fits. Just wish it didn't make me so tired!

[@peterturner345]

Anna Moore I wish it didn't make me so angry :( I have keppra rage. Cannabis helps so much I can't even say

[@DanielLienata]

The only epilepsy drugs video mentioned about epileptogenic neuron

[@eb5857]

Great job.

[@SotonbrainhubUk1]

Thanks!

[@esragbilir]

thank you very much what a great and simple video to understand such a complex concept:)

[@charicehsu1264]

Does Valproate inhibit SSAD dehydrogenase instead of GABA-T?

[@esraaassu4361]

Thanx alot doctor. Its really helpful Great job! Just keep it up 🌹🌹🌹God bless you

[@Muuip]

2 Question: Do NMDA , AMPA and GABA receptors coexist on one same postsynaptic neuron? Or do they exist separately on various neurons? Than you.

[@begoval4104]

Please, add anaesthetics. Your videos are so informative! Thank so much

[@thefartydoctor]

I've been searching for hours for a video like this. I'm not a scientist at all but when it comes to human biology, I have to know how everything works, and with epilepsy more so, since I have it. I'm moving onto a drug called Episenta at the moment. I don't suppose you know what that does to these receptors? Apparently it's the best drug around. Maybe it does multiples of these at once? That could be why they're slowly taking me off Lamotrigine and Levetiracetam.

[@davidsidebottom1037]

+thefartydoctor Episenta is the branded name of sodium valproate, the salt of valproate as described in this video.

[@addhoc256]

How to know what medication is the right one? Are there specific types of seizures that go with specific medication?

[@chicken-hb9zg]

I was diagnosed a little over a month ago, and was prescribed Lamotrigine. My neurologist told me they usually try Lamotrigine first as it has the least side effects. I'm on an online epilepsy group, most people seem to have Keppra and Lamotrigine is a close runner up, some people take both Lamotrigine and keppra. It doesn't seem to matter the type of seizure, the people in the group who report using Lamotrigine have all different types of seizures. I hope this helps answer your question.

[@addhoc256]

@@chicken-hb9zg thanks for your answer! Diagnosed a month ago? Was it a shock or not? How did you find this online epilepsy forum? I was diagnosed a week ago and i slowly build up medication, they gave me an equivalent of Keppra i think. But only in a very low dosage that they know will not make a difference but they said if I build it up this slow then after 2 weeks i can double the dasage and i will have less side effects. But the neurologist only has 10 minutes and doesnt have time to discuss all my questions in detail to Im looking for a platform to discuss experiences in detail. I only have absenses and not always visually obvious seizures. So I have a lot of micro absenses and i was very surprized that was also called epilepsy. So now I have a lot of questions. What is daydreaming what is epilepsy. I have tons of mental diagnosis like add, daydreaming, dissociation, and an asymetric developped brain and emotional neglect (CEN). So now im wondering what is really neurological and what is mental. I dont expect all my mental health issues to be solved with a pill but we will see what happens next week after the pills kick in. If I know more about absenses and sideffects I can make the puzzle: what is what.These days are an emotional rollercoaster for me because everything i thought i knew is now maybe not true. I wish I had heard of absense epilepsy before. I'm now 50 and probably had it since i was 5. People dont know how to react when i tell them. They laughed at my clumsyness and absent mindedness and thought tiredness is what everyone has. If someone asked: how was your day? And I said: well i was unconsious this morning for hours and i have no idea why: people didnt react at all and just changed the subject. They thought I was exaggerating. Now they say: how can you have epilepsy all of a sudden why didnt you ever notice it? I just dont know what to say to people anymore i just avoid friends now im too angry. I cannot help but think: i told you ten times its just only now it has an official medical name you take me serious.

[@geegeesalsabila4203]

Wonderful!

[@SotonbrainhubUk1]

Thank you! Make sure to subscribe for more videos!

[@sarahcunniffe4678]

Thank you! I wonder if my neurologist can explain it that well.

[@SotonbrainhubUk1]

Lovely comment. Thank you.

[@taniatheboss]

OMG! This was so helpful! Thank you !!!!!!

[@vicnpamrodriguez]

This was very helpful. Thank you!

[@pateln18]

Thank You so much....Really helped a lot !! :)) 👍👍👍

[@paulmorgan6376]

Is keppra the same drug. As the same drug your talking about on here

[@deboo117]

excellent video!

[@enasrizk3584]

thanks alot it is very useful video

[@megumiyamamoto3822]

i'm taking Valpros (Valproic acid) is this good for my situation - epilepsy?

[@highihigh]

Thanks for the upload! Very informative :)

[@girishgaur4908]

COULD U PLEASE LET ME KNOW HOW FRISIUM CONTROLS EPILEPTIC SEIZURE

[@deeptirai5813]

thank you.... it's the best

[@navid14navid]

Wooow! Thanks a bunch.

[@SotonbrainhubUk1]

M Navid Glad you enjoyed the video!

[@romeolhk1008]

Clear AF, awesome!

[@dr.chiranjeevis2944]

thanks a lot. ..

[@SotonbrainhubUk1]

+#Dr.CHIRANJEEVI. S Thank you for giving feedback, we have new videos released every week- hope you find them useful!

[@Anastasia-fp2kv]

Outstandiiiinnnggggg...

[@SotonbrainhubUk1]

+Red Angel Thanks for the feedback - subscribe to our channel for more!

[@davidvick3800]

Really clear, thanks! Could be improved if the narration was a little more energetic/upbeat though. See khan academy videos for comparison...

[@MR-xi7yy]

Awesome, thanks

[@almalikyhaider8425]

I think there's a mistake!!!! Lamotrigine acts on Na and Ca channel blocker not as glutamenergic neurotransmitter blocking

[@SotonbrainhubUk1]

+Almaliky Haider The video doesn't say that - it states that lamotrigine stops glutamate from being released, not that it is a direct anti-glutaminergic drug. By blocking voltage gated Na and Ca receptors on the pre-synaptic membrane lamotrigine stops glutamate from being released from the pre-synaptic terminal, thus the anti-epileptic action is ultimately to stop glutamate being released. Hope this helps

[@almalikyhaider8425]

+Soton Brain Hub well.. That's what I'm confused with ... Thank you VERY MUCH for replying ... And you are awesome I have an exam tomorrow wish me luck

[@SotonbrainhubUk1]

+Almaliky Haider Best of luck for the exam! Hope you find the videos useful!

[@yam-vv6re]

Thank you!!!!!

[@crystalcollins3741]

I have sezuiers I've been five sezuiers now pills what bother me can not driver

[@grandlordrobert4728]

Earlier Last year I was diagnosed with CANCER in 2019 and I have tried everything I could to heal myself, but it was all to no avail, until I saw a post on a health forum about a herbalist preparing herbal medicines to cure everything type of diseases. including CANCER, at first I doubted it was real, but decided to give it a try, when I contacted this herbalist through his email and he prepared me a herbal cure for CANCER and sent it to me via the delivery service of UPS from the company, when I received this herbal cure. They gave me step by step instructions on how to apply it, when I applied it according to the instructions I was totally cured of this deadly disease within 5 months of use, I am now CANCER free, all thanks to Dr. PETER You can also contact this great herbalist for help by email: [e-mail] or contact Dr. PETER through his whatsapp number: [phone] He is also specialize in treating all kinds of diseases, VIRUS HERPES , HEPATITIS B, CANCER, BRAIN DISEASE, INFERTILITY, DIABETES EPILEPSY AND MORE ...... He will also be of help to you..

[@azemo90]

scots eh

[@drewgabriel8446]

I was born with epilepsy and cerebral palsy. I have a twin brother, i was born first. My brother was born with no problems. I take phenytoin for my epilepsy, as a child I was on phenabarbatone, then at 14 i was put on Epilim 500mg. Which caused me to gain lots of weight. I went to live in Canada for a few years where I was taken off eperlim & switched to phenytoin. Which I still take today. As a child I had grand mal seizures, which doctors said I would grow out of. Which I did, but I now have petit mal. It' feels weird when I have it, i can hear all thats going on around me, but ppl and any noise, sound much louder, plus it feels like I'm floating on water. Before the seizure I get the smell like burnt toast. I can have a seizure at any time, night or day. Unpredictable. I feel a little confused when I come round, which lasts for a couple of minutes, then I'm back with you again. Usually a cup of tea helps me recover. I read a lot of blogs where people who shared their testimonies kept mentioning Anti-seizure Herbal medication. I searched for a website I just followed the email address of Doctor Patrick that was shared on these testimonies; I got lucky when I got a reply from Dr. Patrick. I followed his instruction, used Herbal Medicine in less than 2 months, I was already cure because of the changes I was seeing. Within a period of 5 months, I was cured totally forever. I went back to my neurologist, I was checked up and marked epilepsy free. If you need his help you can Contact this herbal doctor via his email [e-mail] and WhatsApp connection is [phone] for help.

[@pfokreniruphre1329]

Clearly explained & well Understood. Thank you