Estrogen Effect on Muscle

Welcome to an insightful video exploring the multifaceted role of estrogen in musculoskeletal function. Delving into recent developments and controversies, we investigate both direct and indirect effects of estrogen on tissues such as bone, muscle, and connective tissues. Notably, research from McMaster University highlights estrogen's impact on muscle, tendons, and ligaments, emphasizing the potential for hormonal manipulation to optimize performance and active lifestyles across ages. The review covers Estrogen's Role in Muscle Metabolism, Estrogen Replacement Therapy, and its role in muscle repair. Despite progress, challenges persist, including hormonal variability in women and uncertainties surrounding hormonal contraceptives. The video concludes by addressing unknowns, such as the impact of monthly variations and the role of other hormones, urging further exploration, especially in understanding estrogen's impact on men. The presentation underscores the need for tailored strategies in training and nutrition, considering individual responses and hormonal fluctuations, to optimize athletic performance and well-being in the active population.
This video was made my McMaster University students Asha Mundi, Esha Bhutkar, Iman Malik, and Palvir Nagra in collaboration with the Demystifying Medicine McMaster Program.
We would also like to thank Dr.Takuma Isshiki, Brooke D’Mello, and Safaa Naiel for providing feedback and reviewing the contents of this video.
Copyright McMaster University 2024.
References:
Chidi-Ogbolu, N., & Baar, K. (2019). Effect of Estrogen on Musculoskeletal Performance and Injury Risk. Frontiers in physiology, 9, 1834. doi.org/10.338...
Adachi, N., Nawata, K., Maeta, M., & Kurozawa, Y. (2008). Relationship of the menstrual cycle phase to anterior cruciate ligament injuries in teenaged female athletes. Archives of orthopaedic and trauma surgery, 128(5), 473-478. doi.org/10.100...
Delgado BJ, Lopez-Ojeda W. Estrogen. [Updated 2023 Jun 26]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: www.ncbi.nlm.n...
Lobo RA, Pickar JH, Stevenson JC, Mack WJ, Hodis HN. Back to the future: Hormone replacement therapy as part of a prevention strategy for women at the onset of menopause. Atherosclerosis. 2016 Nov;254:282-290. 
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Shumaker SA, Legault C, Rapp SR, Thal L, Wallace RB, Ockene JK, Hendrix SL, Jones BN, Assaf AR, Jackson RD, Kotchen JM, Wassertheil-Smoller S, Wactawski-Wende J., WHIMS Investigators. Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial. JAMA. 2003 May 28;289(20):2651-62.

[@krissp8712]

Great research, thanks for sharing, very useful!

[@mavr1215]

I’m hoping oestrogen hrt will strengthen my ligaments, tendons and muscles. Just discovered the progesterone has made my muscles sore and made my joints hyper mobile.