Gordon Lithgow, Ph.D. on Protein Aggregation, Iron Overload & the Search for Longevity Compounds

[@FoundMyFitness]

Some of you observant folk have begun sending well wishes and congratulatory statements. So I'll respond all at once... thank you! 😊 On another note... If you found the discussion surrounding the hemochromatosis and transferrin gene polymorphisms interesting and have done 23andme, you can actually run your raw data through the foundmyfitness website to learn about your personal genotype (for informational, non-medical purposes). Learn more about how to do that at foundmyfitness.com/genetics. Additionally, if you just loooove the podcast, videos, newsletter or any of the other various things coming from FoundMyFitness, you can learn how to support the podcast in a variety of different ways, including a pay-what-you-can subscription, by heading over to foundmyfitness.com/crowdsponsor. This includes direct subscription options, patreon, and more. All of that said, one of the very best ways you can support the podcast also happens to be free! Just by passing it along to a friend. Thank you for your consideration!

[@Jack-id6sj]

YAY!

[@iloverumi]

have you done any videos on optimizing diet for fetal/baby health? if not, would be greatly appreciated!

[@atlet1]

Thank you! and congratulations! I hope you will have some time to continue your important work when taking care of your baby.

[@breeve12]

Smartest, healthiest baby of all time!

[@nickspano4709]

mmm molecular chapperones

[@BrandonWyrsch]

OMG I didn't know Rhonda Patrick was pregnant. Congratulations!!!!! I've been watching your podcasts on JRE for years now, completely changed my life. Thank you

[@jodo6329]

Gordon Lithgow is a credit to his institution. What a fantastic interview.

[@craigburkhart1616]

love the channel. Im glad you are specific and dont dumb down the science, there are plenty of simple channels on youtube! congrats on the baby!

[@funny-video-YouTube-channel]

Great suggestion @ 20:20 We take too many metals with vitamin pills. What I do is to cut the pill in 3 parts, so that there is never an overdose of something. A day of fasting can balance out the body and remove the excess. Another great trick is garlic, celery, and wasabi, which helps to remove damaged protein and heavy metals from the body. 41:31 bada bing, bada boom :-)

[@charlesmajcin7780]

one of the best yt Channels by far.

[@BuildingOffGrid]

That's going to be one smart baby!! Congrats!!

[@IvorMektin1701]

Darren Off Grid And super healthy!

[@HeyWelcomeToMyWorld]

Lucky unborn bastard!

[@davidplyler8173]

Yeah but remember Joe Rogan is the daddy.

[@ThomasPH123]

Dr. Rhonda Patrick...my personal health hero...my daily life health habits all are based in her advice...the smartest and sexiest woman and soon to be mother alive, congratulations Dr. Rhonda!

[@artdevany1850]

Great stuff as usual from Rhonda. Now, here is a slight problem: an organism has only so much capacity to respond to stressors. If you respond to many stresses simultaineously you develop what is called allostatic load, that is a load on the stess response triggered by many unresolved stresses. All these pathways seem to go through the integrated stress response which reduces protein synthesis but increases the translation of micro RNA and seems to alter the translation program. If you took every so-called hormetic molecule and engaged every stress response system, you would collapse and die from stress overload. By the way, c. elegans is a good model, but only a few stressed worms live longer and while others die quickly. There is a bit of a statistical problem here.

[@Olehenry]

+Art Devany Your thought has also been my intuition, but I have yet to read the details of so-called "allostatic load". *Do you have a list of favorite writings to share* on this concept (which should have citations to the important scientific pubs)? Most of my "anti-age-ing" colleagues, associates, and a couple friends seem to hope for additive (+) effects by combining: hormesis, supplementation with minerals, anti-oxidants, and other small molecules in combination with a nutrient-dense diet ... on top of intermittent fasting, reduced calorie days, and 1xmo 40-60hr fasts, etc... but I find their arguments to be mostly hope (encouraged by supplement companies and talking heads like Rhonda, de Grey, etc...) that is supported by arguments of hype (due to adding-up the effects from separate research articles). I share (what I consider to be superior) moral & ethical philosophical conclusions that (should) motivate one to live life as though unbounded, but the early adoption/hype of each little interpretation of research by young PhDs (or new-to-the-field, like de Grey was when he wrote his '07 SENS approach) gets annoying, year after year. What do you think, Art?

[@wildlife3083]

Watching this discussion take place with relevant references and definitions popping up on the bottom was an incredibly educational experience. Thank you and congratulations Rhonda.

[@dalekriens1397]

as a regular layman I usually watch your video's all the way through. Even not knowing a thing of the technical aspect. I'm just very interested in health. Thanks!

[@eighttracks]

Ok I finally accept it , I accept that my love is married and having a child .Dr can you please add time stamps to the different topics of discussion?

[@mikefrizzell2532]

And the hits just keep coming... Thank you Dr. Patrick for an interesting and informative discussion with Dr. Lithgow!

[@joeyandres]

Congrats on your baby!

[@MusixPro4u]

God damn, if I can be as happy as Rhonda looks here just once in my life, that's fine with me.

[@Nick-sl3ws]

you and dr Michael Greger should be way more famous. ur value to the everyone on earth is so under appreciated.

[@johnoconnor9343]

Congratulations, Dr. Patrick!

[@IvanBFit]

LOVE your passion and accomplishments. You put out the absolute Best scientific content. Cool stuff. 👍

[@BioStuff415]

So many people are tip toeing on Vitamin intake... Why? because the ignorant MD community has not a clue. The last person I would consult on any vitamin is my MD. Clueless. When I asked the oncologist about vitamin K2, She responded, why are you taking potassium? I shit you not. And I am going to consult with her on vitamin D? Ha ha ha ha ha ha ha. I'll go to the researcher any day and every day.

[@gururajbsavakar7154]

They try to play dumb, and obscure the question, usually They never answer if confronted with facts beyond their confines, all in the name of money minting" licensed practitioners ",

[@brax0789]

Love your work, just hope you can make things fun and simple even though its really complex

[@undeadpresident]

How about rhodiola? I've heard that it extends the lifespan in worms substantially. Any evidence for it fighting aging in humans?

[@ElishaLong]

Keto, Cold Showers, Sauna, Broccoli Sprouts *Everyday Day Crew* Thank you Rhonda. (edit) forgot to mention NoFap #monkmode

[@funny-video-YouTube-channel]

How about contrast showers ?

[@ElishaLong]

epSos.de Are great

[@funny-video-YouTube-channel]

I think so too. The people in sports take the contrast showers professionally. So can we too, for the overall well-being.

[@albertc2373]

Why no fap?

[@funny-video-YouTube-channel]

It's OK in general. The fappening removes the clarity of the mind. The drive goes away. It's like half a day is lost, when the concentration and the drive is gone. Night time fappening is a whole other story. The yogis do say that the clarity is lost, when we fapppen and dive into the self created illusions of that process. Met one anti-fappening yogi who did very well in life, after he found that path in life. Now he got a cute wife, a functioning business, and kids too.

[@DushyantJoshiNewZealand]

Best wishes from New Zealand :)

[@rosiejase]

This was so enlightening. wow!!!! Thanks so much

[@abhishekshah11]

Very enlightening.

[@brandonking1709]

You should definitely have on Dr. Jack Kruse. I would LOVE to hear that discussion

[@sandywatson2189]

I would love to see Dr. Jack Kruse and Rhonda together!!!!

[@maxsterling9908]

Another awesome video! ... thank you!

[@Crazytaru1]

rhonda is an inspiration. a model other health-nuts can follow, just imagine her physical beauty, her knowledge and articulation, and pleasant way of being. Now apply it to yourself, isnt it something like what we had hoped for ourselves? So i realized the sense of admiration I had for her for knowing and applying knowledge related to physical and mental health (against alzheimers or dementia, cognitive decline) is something I had for myself all along. And it makes me want to pursue my goals, i was imagining looking sexy like her and being articulate in my communication, and I was saying to myself "I want that ;o)" thank you rhonda

Congratulations!

[@fabulousdoc]

Rhonda you are epitomising pregnancy glow! and your mood seems positively exuberant!

[@rodmacmillan]

congratulations , great work as well. !,

[@mattm00ey]

brilliant rhonda!

[@daniellebernier6096]

ohhhh!!! Congratulations!!!

[@robert4716]

Powerful Baby

[@ogadlogadl490]

Paul Smith That's a baby bump.. she's expecting! Wonder how long that babies going to live, the ripe old age of 130? Let's start taking bets.

[@musclebrainsmartypants6275]

I hope for a healthy baby :)

[@Lea-mf7sv]

Can't you make a video regarding pregnancy diet and "supplements/superfoods" ? :)

[@icebox_Intruder]

So, in theory, people who grew up in Phoenix should live longer than someone who grew up in Anchorage: higher aggregate heat exposure.

[@bdesilva]

Great video. Do you think that if the sauna available is at 200 deg F that less time will provide the same result in HSP increase?

[@jetski275]

Can someone help me find where they talk about iron.

[@Katana_00]

Can someone summarize the key points of this talk? It's a bit too microscopic for me to follow.

[@kiltedcripple]

congratulations!

[@redzus583]

Does anyone have any info on how good broccoli seeds are opposed to broccoli sprouts? I haven't started sprouting any but have started eating the seeds by just putting them over some salad.

[@jordanrivera576]

If you put say 1/4 tsp. of broccoli seeds in a few ounces of water and blend it - maybe add some lemon and stevia - this would be more beneficial. Otherwise if it's no broken down, it would just go right through.

[@ifoundthistoday]

Rhonda guest talked about that saying the seeds seem to be even better than the sprouts ... try finding the podcast about solfuraphane or however you spell it it's like 3 podcast ago

[@herbboughner3944]

@@ifoundthistoday Look up Dr. Jed Fahey for this review,

[@katiie7]

Are copper levels typically higher in Alzheimer’s cases?

[@terrigelbaum8066]

Have a happy healthy baby. Cute and smart. Congrats.

[@ditchweed2275]

Young people are inflicted with a healthy sex drive. In some ways being almost 50 im a lot more at peace. Would love to reverse ageing without the sex drive. Life is so much fuller/richer/happier without it. Im serious.

[@stuarttanner2175]

Your husband is a lucky lucky man!!

[@PraveenSawh]

congrats :)

[@mustardseedist]

I hope you 2 know Jesus.....And as it is appointed unto men once to die, and after this the judgment. Hebrews 9:27

[@1019jen]

Lucky baby

[@gskohner1]

Congrats ! When you are back in the office I am curious about how this study fits in with your latest findings > neurosciencenews.com/microbes-alzheimers-neurology-3826/

[@mr.johnhan]

Hello, I use a cast iron pan to cook, is that bad then? Because in the cooking process the food probably absorbed some iron from the pan?

[@mattimus13]

P.D. Mangan from Rogue Health And Fitness advises against them: "The amount of iron added to food from a cast-iron pan isn’t negligible, it’s around a couple milligrams."

[@Skiddla]

1:11 "fairly economically" good save, wouldn't want them to cut funding eh wink wink nudge nudge know what i mean eh huh wink wink. good work

[@Michael-4]

Glowing.

[@Charlestonkayakandfishing]

Name him Bruce

[@fantasick8880]

It's so funny how pregnant she is. Her whole personality is different. It's adorable.

[@kelseybrennan3127]

She is so cute omg

[@casperprimdahl456]

Get Dr. Michael Greger on here! :);

[@animalspirit77]

She interviews only scientists as her, dr Gregor is not a scientist, he is a cherry picker vegan crapshottist ...

[@richardmann800]

it's said that women would faint in the presence of albert einstien

[@supercal333]

Triggering endogenous stress responses reminds me of how vaccines work on the immune system. Can we think of this as vaccine against aging?

[@bonbobos]

About vit.D: kzbin.info/www/bejne/hKa6dGWaZdKHmNE

[@adamloepker8057]

Rhonda advocating for sulforaphane? No way..

[@koala8313]

eugenics is the answer

[@koala8313]

Rhonda Patrick is a Race Realist. Good to hear.

[@karas0ne]

congrats 🍼

[@thecasualcitizen492]

Dr. Rhonda is HOT! I have a crush.

[@catalyticcentaur5835]

Meant humorously and really benignly: You felicitous mingle-minx! Good fortune! And also: Thank you for your contributions! You glow so brightly that the pressure of the photons is palpable. Good. (If you don't like this comment, please feel free to delete it. Or I shall on your request.) (From a tscherman cosmopolitan with best regards.)

[@kanableator]

Wedding band being resized?

[@250txc]

Heat shocking worms? god, humans will spend \ waste as much money as possible..

[@ashylarrymp]

Placental stem cells are going to repair your body Rhonda. Congratulations.

[@Trendle222]

love your channel Rhonda but omg they are soo complicated, and ive spent prob 20yrs studying nutrition! although i know a lot (prob 50%) of what you and your guests are saying, i have to rewind constantly and read or whatever tto fully grasp it all, lol maybe im an idiot but this stuff is far too complicated for even somoene that understands nutritiion and longevity and related topics. Most of us havent been to 10yrs of school to know all the super super details.... i guess what im saying is i wish you could do more interviews with people that are more 'down to earth' and that makes sense without the Layperson having to make their brains explode trying to understand lol, but then again maybe im an idiot. So if your trying to get important topics across to average people that havent been to upteen years of schooling about how a mitochondria does Whatever! LOL (you get the point lol ) your most likely going about it wrong =( , most people initially give your channel a chance because one , (just being honest not rude) your a very beutiful woman, two they are interested in Health and longevity. Its kinda like a personal trainer telling their clients about every detail on a microscopic level (books of info) on how the muscle responds and all the client wants to know is how to workout and make it effective hehe. BUT then again maybe your audience is super educated on the microscopic level and thats cool =) this is not meant to be a Rant or Bashing you of any kind, im just rambling and putting my 2cents in i guess. i will Continue to watch all your Vids happily , mainly cause i think your a very beutiful person (inside and out) and i can understand at least half of what you and your guests are talking about =) Sorry for such long post =( And CONGRATS on your Baby! And i hope you are not mad , i respect you a great deal

[@lottiecooper5634]

There are PLENTY of podcasts that explain these topics in a more basic way. I personally LOVE that there is a podcast that micro-explains everything. That is what fascinates me. I understand being frustrated by information that is too hard to follow. However, it doesn't mean Rhonda needs to change her podcasts, it means you should find one more suited to what you are looking for.

[@Metrowhite]

is she vegetarian? what is her view on meat and fish? Couldn't find this info anywhere. Help plz.

[@Trendle222]

i just dont see how she can teach lay people how to get healthier when they are confused to hell and back. i Understand most of what they are talking about but how wil that help people that are looking for Health? Most dont understand 10% of what they are talking about, hence why do this? Most my friends dotn even understand half what im talking about much less these vids, so if the reason is helping people and i hope it is why be overally complicated about health? i dont think thats unreasonable? Unless this is meant to be some nerdfest of only 1% of the world so they can exchange ideas back and forth? SOrry but i love this kind of stuff, dont get me wrong.... but im taking up for all the people that want to learn about longevity and health, if you dont get what im saying then thats ok , u can disagree =)

[@undeadpresident]

She pregnant?

[@kroovyandcal]

Invoking Catholicism

[@250txc]

2:00 -- people fall in luv with worms they are testing? These might small minded people at best ... Sounds totally ridiculous and should not have been uttered.

[@jordanrivera576]

I don't have to wonder if your baby will be getting the right nutrition and no vaccines. I usually cringe when I see a baby thinking I hope they did their research so another baby isn't vaccine injured.

[@deukiray9918]

Congratulations !