From Castration to Cure: How Scientists Discovered Hormones With Brutal Experimentation | Spark

Hormones shape each and every one of us, affecting almost every aspect of our lives - our height, our weight, our appetites, how we grow and reproduce, and even how we behave and feel.
This documentary tells the wonderful and often weird story of how hormones were discovered.
Presenter John Wass, one the country's leading experts on hormones, relates some amazing stories - how as recently as the 19th century boys were castrated to keep their pure soprano voice, how juices were extracted from testicles in the hope they would rejuvenate old men and how true medical heroes like Frederick Banting discovered a way to make insulin, thus saving the lives of countless diabetes sufferers.
And hormones remain at the cutting edge of medicine as we try and deal with modern scourges like obesity.
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#John Wass #Hormones #biology #evolution #genetics #science #technology #education #puberty #originoflife #documentary

[@jimbanks206]

My kids woke up at 3 am and I ended up watching this its a fascinating watch.

[@justinbullock681]

As a suffer of Graves Disease endocrinologists saved my life.

[@quinktap]

And don't forget the Gut's microbiome. The "whole" conversation is deeper than one gives credit.

[@ag-gz1wk]

imagine all the things we don't know 🤯

[@joshuajensen5868]

We know nothing is the true reality of it.

[@bullyhomestead7232]

I literally screamed ‘yooooooo’ when he said it. This is next level

[@rinad2345]

We dont know what we don’t know

[@JenniferCocker]

The more you learn the more you realize you don't know

[@stephaniep1761]

Yes, like our diet is causing many modern disorders.

[@dganet]

Bloody fascinating! My husband screamed out with a severe headache & had stroke like symptoms 2.5yrs ago....we thought the worst! Turned out he had a congenital pituitary tumour that burst! Doctors decided to treat it by steroids & other tablets, other than an operation......so far it's better.......my PCOS unfortunately still leaves me infertile & it looks like I've gone into early menopause.... endocrinology sometimes works but it doesn't always! Great documentary however ❤️xxx

[@honeybunch5765]

Wow that is scary, glad he is ok. I also have PCOS, horrible syndrome that only those with it understands, it has such a debilitating effect on our bodies as well as our minds. To the world we do not seem sick and when you suffer with weight gain they just think you are lazy and don't take care of yourself. The whole infertility part of it is heart breaking on its own. I'm 50 now had invitro at 35 but my husband died a few days before I was supposed to go in for extraction of my eggs. It's a painful acceptance not to have a child of your own, my heart goes out to you.❤

[@paulcunnane4]

Thanks.

[@zonderbaar]

PCOS seems to subside with low carb diets like paleo or carnivore. It worked for a friend of mine, she's give birth to a healthy boy

[@zonderbaar]

​@@honeybunch5765PCOS seems to subside with low carb diets like paleo or carnivore. It worked for a friend of mine, she's give birth to a healthy boy

[@wolfpants]

Utterly eye-opening documentary. Not only did this do a great job of educating me about the amazing functioning of this system, but it also filled me with some awe about the passion and determination of the medical research community across the years -- just relentless in their pursuit of the missing pieces of the puzzle we need to understand how our bodies actually work.

[@lotusalivelight24]

Not quite 'relentless,' but a little-bit... Words can hardly do this docu. any justice really, b/c it's 'jaw-dropping'... 😮😊

[@mehmetchiarifriend510]

Hormones always mesmerized me! Some hormones cause you behave like an angel, some make you an evil.

[@shelleyg1995]

Amazing and fascinating documentary, much better to watch something like this, presented by someone that is clearly in awe of the subject despite being a renowned professor on the subject. Not boring at all- should use it in high schools for biology lessons!!

[@ashleelarsen5002]

👍🏻 33:33

[@kenjido69]

​@@ashleelarsen5002❤fa 628

[@Moonstorms]

My dogs just been diagnosed with Cushing’s. Really sad to watch very expensive at the vets to. This has really been great this video. Thanks for putting it up

[@maryamabdi7241]

I enjoyed this 😍😍😍 Endocrinology is astonishing!

[@dritanballa6982]

I Started watching this by free will, and finished by hormones :)

[@Light_EnterTainmenT7]

Me too:) but dont worry about the theories of determination people and illusion of free will people they all drag and go too much deep and dont have idea themselves...hormones, free will, genes or whatever it all changes according to environment and circumstances. Thats it.. THE PERSON IS WHAT HE EATS, WHAT HE READ, WHO HE MEETS.

[@retard_activated]

I want Dr. Sapolsky to comment on this comment so hard!! 🤣🤣🤣💖💖💖

[@patrickwinther]

+KZbin's algorithm....

[@NEETmedicalGK]

Awesome. Subscribe

[@ahmedmujtaba1790]

Haha, a genius comment

[@psyclotronxx3083]

One of the best documentaries I've watched in a very long time. 👍

[@woodman9083]

💚

[@rigalaitheseer]

I wish i had access to the internet when I was in school. Very interesting documentary

[@eldonbrown742]

Love it! Thanks for the upload...

[@deonb6106]

Fascinating insights! Kudos to Dr Wass and all involved - past and present - for sharing this knowledge with us in the 21st century.

[@AngelAustin]

I did my Music History term paper on Farinelli and other castrato. I got an A, but I'm sure my professor was a bit perplexed. I just thought his voice was so beautiful and the practice was intriguing. It was also very sad. It was outlawed, but continued for a while.

[@-astrangerontheinternet6687]

Now it’s only done to kids born in the “wrong” bodies.

[@paulcunnane4]

Castrati.

[@Cat-hr9xp]

That's crazy man

[@sharinaross1865]

I find this fascinating.

[@honeybunch5765]

These scientists are true heroes.

[@tiujasmine1601]

Love watching documentaries, so glad that our prof let us watch this

[@alpha5708]

Long but fascinating and worth my 1hr👏🏽👏🏽

[@toni4729]

I'm well aware of the fact that hormones can be seriously effected by medication and that can make you gain weight. It happened to me, and no matter how little I ate it made no difference. At the age of forty my weight went from 48kg to 101kg in a little over a year. It cost me my gallbladder and because of this I remained that weight for twenty years until it was finally put down to my thyroid. Because my gallbladder had been removed it seems I couldn't lose the weight after I'd been taken off the meds.

[@middleofnowhere1313]

My thyroid bit the dust too. Along with this came diabetes. I've got meds and lost the weight but good lord all the problems that still exist for me daily because of this endocrine disruption.

[@buyzjewelry]

Thank you for this presentation. I've learned so much about our glands, hormones, and the effects!

[@danadams6477]

Nice documentary. Good job folks.

[@skinniekinnie1]

I truly believe junk food is messing up the hormone leptin resulting in so much obesity in society today. A very informative documentary. Thank you.

[@elsagrace3893]

Sugar has the same effect on the brain as socializing. I think isolation drives people to eat sugar in place of socializing.

[@lindass5966]

Processed food also

[@blaineedwards8078]

We are purposely being poisoned with the glut of chemicals and toxins in our food supply. The shit is also in the air, water and soil....there is no escaping it. This has been orchestrated by the super-wealthy and elite Illuminati, the world's true power, who have implemented this global poisoning to bring about a severe descalation of the Earth's ever growing population numbers.

[@Centerpieceofmind]

Sugar is one of the main culprits.

[@Centerpieceofmind]

@Sarah Marie Child abuse causes obesity? What? Explain, I'll wait.....

[@charliepearce8767]

32:23 1993 I met a guy in hospital with this condition. I said to him " You so big and tall what's wrong with that ?" Looking down at me he said.." it hurts..hurts bad ! "

[@kbeeharry]

Brilliant documentary. Wish to see more findings on hormones in very near future.

[@travelforfun20]

So interesting and educational video. I enjoyed watching this video, thank you for producing it

[@nospaceforsadness816]

I love this documentary..it really fascinates me that every time that i watch it i am capable of understanding more..i never thought it would come a day that i would actually want to watch scientific documentaries I just wanted to point out that as far as i am aware of the subject ,the pacreantic ducts enters in the duodenum of the small intestine and not in the stomach Feel free to correct me if i am wrong 😂 I don't hold grudges

[@FOJO27]

Good catch 🤙🏻

[@naa2083]

great documentry thanks for the upload

[@MissNebulosity]

70 years old even though he had a pituitary tumor with such a delayed removal!!! Ive never heard of such a thing!! This has to be a record, right??

[@Carelmartyn]

This was beautiful! Excited for the future discoveries of hormones and their powers in our bodies. ❤

[@AryanKumar-ch7gu]

Before watching this video, I thought studying bio was a burden and boring. And now I love bio and I'm looking forward to similar documentaries

[@dganet]

Biology is the best science around! We use it every day...yes chemistry & physics also make up our life but YOU, a person is pure biology......study it, you won't regret it x

[@lanaharlow2515]

This is biochemistry

[@ferntheinkling]

@@lanaharlow2515 actually it's endocrinology 🤓

[@artdonovandesign]

A thought enjoyable and informative episode.

[@toni4729]

Very interesting, thank you doctor Wass.

[@2ndhandjoke]

I never paid much attention to the subject until recently after 3 marriages and plenty of gfs in between, I met a good looking woman that, in her presence anyway, I became a complete idiot. I mean, my heartbeat increased, I couldn’t speak correctly because of dry mouth, I literally tripped over my feet, it was fucking pathetic and ridiculous. She had complete control over me and my bank account. When I wasn’t around her I was fine. I never had that problem before with any woman so I was dumbfounded and she knew it. I’m lucky I got away but that is my first encounter with the power of pheromones!

[@jht3fougifh393]

Pheromones aren't the same as hormones, and there's no evidence that humans use them.

[@samsimmonds1079]

Cheers for the free lesson lad!!

[@lilialfaris805]

Very educational video!🥰

[@dukekibuchi8998]

Great content.

[@martinanami880]

wonderful presentation.

[@katiefromcolorado4972]

Lately, I speculate if my colorectal cancer had opportunity to flourish because of my hormones. I have done all genetic testing available, and despite being Ashkenazi Jew, I have no predisposition to have colorectal cancer at 28. Hormones are the most powerful forces inside my body, I feel.

[@paulcunnane4]

Good luck friend.

[@soloster100]

My kind of tv... ty for the lesson professor.

[@chuckeynewkirk199]

So amazing!

[@jouleSansLoi]

I learned a lot. I find this professor to enjoy talking about hormones and I see his excitment.

[@khangphattan6407]

Amazing and knowledgeable kudos!!!!

[@spring1785]

Im grateful for this 57 minutes in my life .... & appreciate alll scientists hard work to make our life much better and understandable ❤️❤️❤️❤️...

[@eemoogee160]

That's a sweet comment

[@shelleysheaves5416]

So strange that anyone would have wanted to sing in a higher range. As a woman, there is no nicer sound to me than the deep timber of the male voice. It's a sound that exudes confidence and makes me feel safe and warm.

[@jasonwiley798]

Supposedly, the young males voice is the purest sound.

[@solaiyre]

took me 8 hours to finish the entire doc bcos im taking down notes and i used 8 pages that is back to back

[@buzzpatch2294]

wow! very well done & i learned a lot thank you

[@missmurrydesign7115]

Fascinating endocrinology...

[@Mikeexteriorcleaning]

Klinefelters syndrome, a man can reach high and lows without being a Castrato. Also look at Dimash kudaibergen for this eras maestro of voice (many including me say "greatest singer in the world" . Boasting over 6 octaves and singing in 13 languages. His newest song is a 13minute movie about the world where he sings for 12 minutes showcasing his amazing talents and vocal agility called "The story of One Sky"

[@IsraaPoetry]

Thank you, I really enjoyed the documentary, and yeah a little bit of knowledge is dangerous. The worst thing is that many people claimed to be very very sure when they are discussing science based on old researches or even new. Science mean doubt and then have a strong clue based on observations and experiments and waiting while there is new discovery . It's a renewable process as we live we know more and new things.

[@seanriopel3132]

Brilliant observation. People with just a bit of information can be very dangerous and especially when they try to use statistics or when they "know" their right but can't explain or defend it.

[@jackiedykins4412]

Great...leave it all alone and discover your vast ability ....were to distracted by intelligent information...our true potential lies hidden behind ..if you like...our ego intelligence ...hope we don't loose it to technology and so called knowledge....I'm sad that we don't seem to want to try ....can always come back and try again !!!

[@emilythorne8181]

Excellent documenty

[@212025510]

Amazing documentary film. I love human progress!

[@mariorico440]

I agree humans have made a lots of progress in science and technology but we have many problems to solve like pollution, obesity, junk foods, GMO, global warming ...........

[@bibicu19a]

This is simply incredibil

[@Cmz764]

What a wonderful documentary

[@navyashrees2869]

It was an interesting video, amazing to know about how discoveries where made, even more amazing to know how hormones act on humans

[@robertcronin6603]

Fascinating stuff.

[@user-px2ro6nv7y]

Excellent

[@bluemacaroons]

that was so interesting! I didn't realise how weird hormone history is

[@rafamartinezkhomenko6484]

Nice Video

[@ikpeessien7399]

Nice one

[@himanshusingh-er7dd]

I love molecular biology 😍❤

[@LearnThaiRapidMethod]

Reminds me of a fascinating BBC docu about a young woman wanting to change her sex to a man. A year before the gender reassignment surgery, she started on a course of HRT. The before tests of her cognitive, creative, social and physical skills were diametrically opposite those of the same tests conducted 6 months later. She gained muscular dexterity and improved hand-eye coordination, greater physical strength, better control over her emotions, etc., but key social skills were drastically reduced, as well as her ability to multitask, communicate verbally, and her stamina declined significantly. Her personality changed too. And all (only) because of the hormones!

[@carlosjorgemartinsjorge6551]

Sensacional documentário.

[@markrowland1366]

I'm sure Prada Willi has been looked into. Great presentation.

[@mainbhigamer5564]

They are the real heores of the society❤️

[@jackyblue67same10]

I would love to know what kind of pills he gave her for her thyroids being out of wack cause mine are to & the 3 my doctor gave me neither 1 of them worked at all .

[@middleofnowhere1313]

The synthetic ones did nothing for me. See about one that's extracted from pig thyroid such as Armour thyroid, np thyroid or Naturethroid

[@kenh9508]

Fascinating

[@lawrencealepin1451]

what a great documentay

[@foxyloxy6670]

Thanks for sharing!!!

[@toni4729]

Dr. H. Lustig "Sugar-The Bitter truth" ~ Regarding Obesity is most peoples best hope.

[@openureyes]

Fantastic

[@toni4729]

I fear sometimes, the more we learn, the more damage we tend to do. Look at the the awful things drug companies have done with their thousands of drugs that all have horrific side effects. These people are so proud of them but they never repair anything.

[@MrScipio2011]

Alright, I’m convinced; bring back castrations. Improve music this millennium. 😁

[@jossielrodz]

Corrado like Michael Jackson

[@the486kgman2]

Corrado i bet you don’t have ball’s yourself

[@ejmtv3]

having that voice is not even, for me, worth listening to. Not to mention the other side effects of not having testosterone which results to hormonal imbalances that leads to early death

[@aacc3585]

Obviously I’m extremely biased, but this millennium has by FAR the best music ever made

[@iamjoyt]

😂

[@baraahhamdi8533]

interesting keep going

[@clivejoyd7043]

THIS IS SUPERB CLARIFICATION OF A SUBJECT THAT MOST PEOPLE DON'T EVEN BEGIN TO UNDERSTAND

[@music.button_6191]

I trully beleive in that seems of creativity husefull medically content with everywhere

[@KalibreDubstep]

It is funny how the narrator is laughing hysterically at these old "testicle rejuvenation techniques", while today you can pump old men with exagenous testosterone and increase strength, muscle mass, bones strength, memory, mental focus etc.

[@quinktap]

Yes, Dr. Wass, your last remarks were most profound. Cavendish and Rutherford's observations are still theories.

[@armiesep8710]

Oh goodness me, what craziness.

[@EarlLedden]

Amazing and fascinating documentary. I do quibble with the assertion that leptin, without exception controls your weight as it does not account for the ability to exercise free will and conscientiously eat less and exercise more, thereby influencing body weight. I realize Dr Wass and the leptin presenter are not good examples of the free will argument , but there are many people who have overcome obesity through sheer will power and they should be given their due.

[@iodaspark]

Awesomeness...

[@nicholasashley2172]

So does that mean if we inject leptin will that act as a diet aid, or in the case of body builders a cutting aid.

[@redietgetu3540]

So sad that this has only few views😭 Where are we heading to?

[@sbh_tx]

documentaries are not a popular topic on youtube. I'm also pretty sure this aired somewhere else

[@rohanboswell5408]

What food is recommended for hormone health

[@stevenherrold5955]

at the beginning of this the narrators description of his subject this would be a perfect biological horror movie i would love to see that movie if one reading this knows a movie producer call them and tell them you an idea for there next production do you remember YOUNG FRANKSTIEN ??? i laughed so hard i got a cramp in ribs

[@shaggymcshaggison9751]

If you are obese I highly recommend Psyllium husk it's helps regulate your digestive system and if you drink it in a smoothie it expands to fill your belly. Also stop eating garbage... your body requires a simple regime and has a hard time coping with excessive consumption, you are using more energy to try and digest food than you are taking in and that is why you are tired all the time. Eat three meals a day, drink three litres of water, do 20 mins of yoga and go to bed for eight hours. Do this and you will feel like a new person in six weeks... I promise x You are the universe

[@floriangrc]

Half true: in fact it was Nicolae Paulescu, a Romanian scientist who first discovered insulin! Wiki: “The work published by Banting, Best, Collip and Macleod represented the preparation of purified insulin extract suitable for use on human patients.[115] Although Paulescu discovered the principles of the treatment, his saline extract could not be used on humans; he was not mentioned in the 1923 Nobel Prize. Professor Ian Murray was particularly active in working to correct "the historical wrong" against Nicolae Paulescu. Murray was a professor of physiology at the Anderson College of Medicine in Glasgow, Scotland, the head of the department of Metabolic Diseases at a leading Glasgow hospital, vice-president of the British Association of Diabetes, and a founding member of the International Diabetes Federation. In a private communication, Professor Arne Tiselius, former head of the Nobel Institute, expressed his personal opinion that Paulescu was equally worthy of the award in 1923.

[@elizabethschreiner5151]

Did you just use wiki as a source? Noooo.. common this is a science crowd.

[@laurieeschrich7661]

Just another confirmation that we are fearfully and wonderfully made by a genius Creator!

[@DorothyPotterSnyder]

There is no evidence whatsoever for deities in this science.

[@iamjoyt]

Yes & amen agreed!

[@musicislife863]

I love Science 😊♥️

[@distel360]

Anybody knows the name of the classical intro music?

[@glenliesegang233]

Why robots will never truly match human beings.

[@zazenmed]

Castrated....... to hit the higher notes?. What a sick society 👹

[@ASMRkatz]

Hormones are always the answer and the ones who creates society play with this truth on our shoulders without most people even know …

[@nathanferrarese6363]

this mans cackle is hilarious

[@focus_on_]

Every scientist must acknowledge the fact he is important to the upbringing of scientifique knowledge and grind to become the best in the domain and give us some fucking information about our existence Kudos sir for this documentary

[@Chandler_bagels]

Anybody know the title of music at 14:07 ?

[@tripeeblonde8309]

I have hens /roosters and am extremely curious how you find the testes of a cockerel.

[@kendosa1]

Knowing who am i.

[@Centerpieceofmind]

Testosterone replacement therapy and Thyroid medication has changed my life. 1000% for the better.

[@KG-if2oc]

Far, far too many ads :( Would have been a good show though, if there had been continuity.