From Genes to Therapies for the Hereditary Spastic Paraplegias by Craig D. Blackstone, MD, PhD

[@shanerainey6513]

I have neurological symptoms and just found out via genetic testing I have spg7. My neurologist originally said I just had a functional disorder due to mental health

[@il3mendo]

I have spg4, celiac disease, Chron s and a previous metabolic syndrome. I can say that despite the complicated history, with cerebellar Ataxia/bilateral Babinski, Hoffmann and Romberg test, since I restored my gut (took 10 years) the worse symtoms disappeared. I know that lipidemia is associated with insuline resistence through the Gad 65 antibodies in Spasticity. What about hdl cholesterol with fat soluble vitamins such E, K2, D ? What about cytokines ?