Fructose Metabolism - High Yield Review

[@snehanarale8732]

All the lectures just superb,full of clean clear intelligent explanations

[@cargo4741]

Great job. Can you provide me with any citations documenting the preferential tendency for fructose to enter the lipogenic pathway while avoiding the glycolytic pathway? Thank you

[@DrMungli]

Sure, specially when fructose is consumed along with glucose, fructose metabolism is unregulated and floods into DHAP and glyceraldehyde which eventually get into glycerol 3-phosphate formation to provide backbone for TAG, and they are diverted into acetyl CoA formation which eventually get into fatty acid synthesis in the cytoplasm. You should get this from biochemistry reference books like Devlin's textbook of biochemistry but when I get time surely I will provide you the citation.

[@chibaby0306]

Dr Mungli just like all your work , this was awesome! thank you sir!

[@DrMungli]

Thank you Chinenye.. Best wishes.

[@cargo4741]

Can't fructose be diverted from forming DHAP and glyceraldehyde by hexokinase to favor F6P production. This molecule would enter the glycolytic pathway ahead of the well-regulated enzyme PFK-1 thus potentially preventing the further metabolism of fructose toward lipogenic precursors while favoring fructose' ultimate diversion to gluconeogenesis. Is there some regulation of hexokinase to down regulate this tendency?

[@DrMungli]

First thing is once fructose is absorbed from the intestine it enters into portal system which carries it to the liver. In the liver most of this fructose is absorbed, liver has glucokinase and fructokinase, it do not express hexokinase. Glucokinase do not use fructose as it is specific to glucose, so fructokinase convert fructose into fructose 1 phosphate. Though little bit of fructose if any in the systemic circulation is taken by peripheral tissues convert fructose to fructose 6 phosphate by hexokinase. This means most of the fructose in the liver is metabolized to DHAP and glyceraldehyde without going through the regulatory step.

[@fatimahaljawi2047]

how much fructose should be consumed to be transferred to any form of fat? as a fuel resource and as we break our fast first in the morning or after a long fasting state, it fructose still converted to fat?

[@snehanarale8732]

Ur videos are awesome sir One question regarding fructose does having fruit on empty stomach will be beneficial..?how many serving of fruits one can safely choose ?is it useful in treating insulin resistance?

[@giridv7300]

Dear doctor, this is what I have come across in other videos and blogs. (E.g. Dr. Jason Fung). But why many doctors still recommend tho eat fruits? Thanks.

[@hebaaly9146]

thank you sir but I have a question why these stages done immediately in muscles ? why especially in liver?

[@DrMungli]

Liver gets most fructose through first pass metabolism

[@jadhavaniket100]

Amazing explanation sir. Thank You so much.

[@chandankumarsethy5902]

Thanks. As acetyl coA formed it can undergo TCA cycle also but why it divert to Fatty acids synthesis

[@DrMungli]

That happens when TCA cycle is saturated like during fed condition.

[@jindrabartonec5259]

Thank you for explanation! And what about fruit ? I have read one page and they said, that those studyies about fructose are only with industrial made fructose or corn syrup. And that fructose in fruit is somehow connected with fiber and other things which provent rising insulin levels. What is your opinion abot fruit fructose?

[@DrMungli]

You are right, fructose in the fruit is absorbed more slowly than the fructose present in corn syrup.

[@jindrabartonec5259]

Thank you!

[@snehanarale8732]

It’s insulin independent ,how about incretinins?

[@dynamicapproachbyamogh69]

I wanted to learn more about how fructose metabolism leads to uricacid production?

[@DrMungli]

I have a video on this topic. search why sugar is bad for you in my channel. You will see the explanation there

[@seshachary5580]

very nice. thank you for your dedication

[@priyanshimevawala6626]

Thank you sir 😊

[@DrMungli]

You are most welcome.

[@tmk5]

Please improve the sound quality of the videos

[@cargo4741]

Thank you

[@yasirmohammedali]

Hello dr. Mungli

[@alchemist585a]

1. Use the board! 2. Fix your audio. 3. Recent findings indicate that a significant fraction of the ingested fructose is metabolized by the small intestine. However, the liver remains the main site of fructose metabolism.

[@darshanmore8032]

Doesn't fructose come from fruits

[@DrMungli]

Yes, fructose can come from fruits too.