Full User Guide: CUROSURF® (poractant alfa)

Please see full ISI below, at the end of the above video, and on the website: curosurf.com/
Learn about CUROSURF® (poractant alfa), Rescue Treatment of RDS in Premature Infants, including ISI, composition, storage & preparation, dosing & administration, adverse events and more.
For premature infants, recognizing the earliest signs and symptoms of RDS is important. Respiratory support within the first few hours of birth may include CPAP and early rescue.
Early rescue INSURE strategy may help avoid potential for respiratory insufficiency and the need for subsequent mechanical ventilation (MV).
(Stevens TP, Blennow M, Meyers EH, et al. 2007)
It is important to note that the INSURE strategy may not be appropriate for all infants. Infants with RDS may vary markedly in the severity of respiratory disease, maturity, and presence of other complications, and thus it is neces­sary to individualize patient care.
CPAP=continuous positive airway pressure; RDS=respiratory distress syndrome.
IMPORTANT SAFETY INFORMATION
CUROSURF® (poractant alfa) is intended for intratracheal use only. The administration of exogenous surfactants, including CUROSURF, can rapidly affect oxygenation and lung compliance. Therefore, infants receiving CUROSURF should receive frequent clinical and laboratory assessments so that oxygen and ventilatory support can be modified to respond to respiratory changes.
CUROSURF should only be administered by those trained and experienced in the care, resuscitation, and stabilization of preterm infants.
Transient adverse reactions associated with administration of CUROSURF include bradycardia, hypotension, endotracheal tube blockage, and oxygen desaturation. These events require stopping CUROSURF administration and taking appropriate measures to alleviate the condition. After the patient is stable, dosing may proceed with appropriate monitoring.
Pulmonary hemorrhage, a known complication of premature birth and very low birth-weight, has been reported with CUROSURF. The rates of common complications of prematurity observed in a multicenter single-dose study that enrolled infants 700-2000 g birth weight with RDS requiring mechanical ventilation and FiO2 greater than or equal to 0.60 are as follows for CUROSURF 2.5 mL/kg (200 mg/kg) (n=78) and control (n=66; no surfactant) respectively: acquired pneumonia (17% vs. 21%), acquired septicemia (14% vs. 18%), bronchopulmonary dysplasia (18% vs. 22%), intracranial hemorrhage (51% vs. 64%), patent ductus arteriosus (60% vs. 48%), pneumothorax (21% vs. 36%) and pulmonary interstitial emphysema (21% vs. 38%).
INDICATION
CUROSURF® (poractant alfa) Intratracheal Suspension is indicated for the rescue treatment of Respiratory Distress Syndrome (RDS) in premature infants. CUROSURF reduces mortality and pneumothoraces associated with RDS.
Please see full prescribing information: resources.chie...
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CUROSURF® is a registered trademark of Chiesi Farmaceutici, S.p.A.
PP-C-0635 V1.0