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In this lesson we describe:
The structure, function, and activation mechanism of the G-Protein-Coupled Receptor (GPCR) receptor.
G-protein characteristics.
Overview of GPCR signaling mechanisms.
• Ionic channel activation associated to GPCR activation.
• Adenylate Cyclase activation mechanism.
• Phospholipase C activation mechanism.
Second messengers production:
• Cyclic AMP (Cyclic adenosine monophosphate) .
• Diacylglycerol (DAG).
• Inositol triohospate (IP3).
Examples of physiological functions associated with GPCR activation.
GPCR-signaling regulation:
• Inactivation of GPCRs signaling.
• Desensitization of GPCRs receptors.
Three-dimensional structure of the G Protein-Coupled Receptor.