GLP-1 and Ketosis: Novel Mental Health Treatments

GLP1 medications like Wegovy and Ozempic can help with weight loss but may also be able to help with psychiatric symptoms from depression, bipolar disorder, anxiety, and more. But are GLP1s safe in psychiatry, and how do they compare to nutritional interventions like a ketogenic diet to treat mental health disorders? Dr. Roger McIntrye, a world-renowned psychiatrist and researcher, joins Metabolic Mind to discuss the potential roles of GLP1 medications and ketogenic therapy, and how clinicians and patients could consider their use.
Expert featured in this video:
Roger McIntyre, MD
psychiatry.uto...
Twitter/X: @rogersmcintyre
About us:
Metabolic Mind™ is a nonprofit initiative incubated by Baszucki Group. Our mission is to provide education and resources in the emerging field of metabolic psychiatry, including ketogenic interventions for mental disorders.
Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.
Timestamps
0:00 Introduction
2:40 The evolution of psychiatry
6:49 The impact of GLP1s on mental health
11:44 Understanding GLP1s as psychiatric medications
15:07 Ketogenic therapy for mental illness
17:51 Considerations before recommending GLP1s or ketogenic therapy for mental illness
26:49 Does diet impact mental health?
27:28 Psychiatry's shifting focus to brain energy
33:58 The future improvement of psychiatry
37:54 Conclusion
#MetabolicMind
#KetoForMentalHealth
#MetabolicPsychiatry
#BipolarTreatment
#KetogenicMetabolicTherapy
#NutritionalKetosis
#MentalIllness
#Bipolar
#GLP1
#Ozempic
#Wegovy
#weightloss
#AlternativeTreatment

[@vonticehembree6083]

I am on a ketogenic diet and I also take an glp1 initially to treat diabetes. I have lost 61 lbs, and reversed my diabetes , my other chronic conditions have reversed as well. The food noise is gone , cognitive function has skyrocketed . I am also taking cod liver oil for cognitive and cardiovascular health and my dr is very pleased. My A1c is 5.3 down from a 12. I’ll never change from Keto / carnivore bc I’m healthier now at 57 than I was at age 35

[@metabolicmind]

Thank you for sharing your experiences with keto!

[@beabeauty]

Wow ! This is amazing. Thank you for sharing

[@fractalbeans9513]

On a ketogenic diet (strictly 0 carbs and zero seed and vegetable oils, no fiber) for 5 months; A1c down to 5.0 from 11.5 in 5 months, no GLP1

[@vonticehembree6083]

@@fractalbeans9513that is awesome , I’m certainly on my way , took me a while to go strict keto /carnivore but now that I have I think it will be much easier to get off Mounjaro . Thank you for the inspiration !

[@rossgooding7423]

Eating healthy is actually a lot cheaper considering the insanely high cost of the pharmaceutical treatments like wegovy, ozempic, etc…

[@fractalbeans9513]

Absolutely! If diet can regulate insulin and GLP=1 among other issues, without the barely studied side effects of these drugs, why not prescribe that instead? Edited to add: actually, my grocery bill has gone dramatically down after switching to animal-based (meat cooked from scratch; eggs; I don't tolerate dairy, it seems), not to mention how much easier shopping is now.

[@mohammed7423]

Keto helped my anxiety

[@ruthruth7782]

Great to hear an experienced clinician speaking-not trying to sell anything- aiming to serve people and relieve suffering. The integrity of the clinician is primary

[@r-type4945]

I have a Canadian friend who took part in a study on Ozempic a few years ago. During that time not only his weight dropped, but also his activity and socializing levels significantly increased, two things he quite struggled with in his life (beside his weight). He appeared less anxious too. He didn't refer it as a direct effect of the substance, but we always thought there might be a connection. This talk was therefore quite enlightening. I'm still very sceptical towards meds, as I think those same effects can be achieved by changes of diet and lifestyle (as pointed out in the interview), but on the other hand many of us are too depressed and lethargic to make that shift by ourselves.

[@beabeauty]

❤ yes it’s difficult but I’m going to try to treat myself with ketogenic diet since my docs have not helped me .

[@Smokeycam1]

He's an allopathic who's not quite there yet. Keep working on him. I hear him saying that they are thinking about keto as a tool. He has a knee-jerk acceptance of Glp1 agonists for experimentation.

[@fractalbeans9513]

Keto diets don't sponsor; big pharma does.

[@leonaedwards7104]

No drugs is better proper nutrition is best. I had 46 years of depression went keto over a year ago and stopped all meds.

[@beabeauty]

Thank you! That’s awesome that you are disciplined and have found root cause for your depression. And I hope we see some patients will need help/time to adjust to the keto diet , especially those of us with Carbohydrate addiction. And I have been on keto ( low carb carnivore based) with positive results in my 30s but now that my psych treatment have affected my metabolism and I’m 80 pounds heavier, and in menopause at age 53, they are many factors in play. Just something to think about.

[@leonaedwards7104]

@@beabeautyI am 73 there is bipolar and adhd throughout my family.

[@Chris-ed1pw]

Loved this video. The more avenues of research into the brain energy mental health model, the better!

[@kenadams5504]

I'm on a keto diet for almost a year , and don't spend more money on wholefoods because I don't need to snack or eat as often (just two meals per day). Why do these speakers not mention that its no extra over-all cost on keto , despite the seemingly higher price of meats/fish etc .!?

[@GhostOfRT300]

💯

[@metabolicmind]

Great point!

[@fractalbeans9513]

Great point! I've been on zero-carb ketogenic diet for just 5 months, and improvement is remarkable; still a long way to go but Ozempic & Co are struggling so hard to get on the NHS and ruin people's lives, scares the living daylight out of me!

[@beabeauty]

Thank you Dr McIntyre for your compassion. As a bipolar patient I find it sad that we have to wait so long to see improvement in treatment options for Mental health (and so many SSRI, & mood stabilizers, antipsychotics have led many of us to metabolic disorder). Or perhaps it’s the chicken v egg. ?

[@The_New_Abnormal_World_Order]

This is fascinating however the side effects of these drugs are very worrying.

[@jameskantor0459]

I have found GLP1 medications to have low side effects specially when compared to the usual antidepresants

[@beabeauty]

Yes the side effects of poly pharma for many of us with depression, anxiety and mood/mental health disorder are likely worse over time. Especially if we are treating the symptoms and not root cause! Speaking from experience and hoping these Dr and NP will treat using these evidence based treatment, and also teach patients diet /lifestyle to allow Pt off the GLP 1 agonist at some point.

[@cosetteworld]

As a 45 year old autistic woman and activist it's deeply demoralizing to hear autism called a "condition of childhood" like this. It is a developmental difference but take your OWN advice here. Words matter. Framing it this way perpetuates harmful stereotypes that contribute to people like me getting the help we need. That is why autism is the least employable of all disabilities. So much misinformation like this. The lay person will not know "disorder of childhood" is technically called a developmental disorder and can be diagnosed at any age. They only know they heard a "world-renowned expert in psychiatry" call it something only kids get, so I must be lying, crazy, or "making excuses" when I say I am autistic.

[@astorybookfinish5055]

Superb discernment regarding the use of descriptive phrasing.

[@bonnieo8]

I listen leiten Yep you do c look Moment in mind. Ive always thought that autism was usually diagnosed in childhood, but not limited to that timeframe.

[@bonnieo8]

Gees! My phone is adding all bunch of extra letters. I will listen to this conversation with your comment in mind.

[@metabolicmind]

Thank you for your comment. That is an excellent point that autism is not only a condition of childhood. Thank you for pointing that out.

[@susanbeever5708]

Glp -1 stimulates TRPV1 that increases insulin that in turn increases more TRPV1 that then puts glucose into the cell independent of the insulin receptor-> too much reactive oxygen species in excess of the cell’s antioxidants -> inflammation and peroxidation in the body. A TRPV1 antagonist decreased lipid peroxidation in PCOS women with metabolic syndrome. Epileptic Children on oxcarbazepine that increases TRPV1 have significant increase in LP(a), broken bones and heart disease over time. Beware too much up-regulation of glp-1, it may help initially in the obese patient with toxic lipid metabolism however there are caveats of its integration with TRP receptor pathophysiology. Lastly, too much TRPV1 -> hypoosmolality-> too much TRPV4 -> atherosclerosis, osteoporosis, aneurysm and more.

[@richardmathews8250]

Could you please do a video on migraines, I'd like to share with a friend, thanks.

[@metabolicmind]

We dont have a video on that, but heres an educational guide that may be helpful. www.dietdoctor.com/low-carb/migraines-cluster-headaches

[@richardmathews8250]

@@metabolicmind Thank you

[@markmacdonald1849]

Spoilt it with his commendations to the mRNA people...what else is he getting wrong?

[@ygillham]

Absolutely. switched him off after that. Dr Malone is the man who should have been given the prize not these other two. This fella lost all credibility for me.

[@MichaelBLive]

Excellent discussion. It gives me hope to hear researchers such as your guest.