Harnessing resilience mechanisms to prevent neuronal loss in Alzheimer's disease

In a recent study, Isabel Castanho, PhD, Beth Israel Deaconess Medical Center, Boston, MA, described the relevance of an imbalance in excitatory and inhibitory neurons in cognitive resilience. Single cell transcriptomics revealed a reduced proportion of vulnerable somatostatin-expressing inhibitory neurons in AD but not in resilience, as well as an increase in specific excitatory populations in resilience. Neurodegeneration has a critical role in cognitive impairment in Alzheimer's disease and thus, understanding why neurons survive better in resilient cases compared to AD could help prevent cognitive decline by targeting these protective mechanisms early in the disease. This interview took place at the AD/PD™ 2024 congress in Lisbon, Portugal.
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