HIV and AIDS : Pathology

Pathology lecture and lessons of life for living a beautiful life.....
HUMAN IMMUNODEFICIENCY VIRUS (HIV)
_____________________________________________
●LENTIVIRUS (slowly replicating RETROVIRUS) that causes the acquired immunodeficiency syndrome(AIDS)
●a/k/a---“ Slim’s disease “ ( d/t weight loss)
● Commonest secondary immunodeficiency disorder
● Most patients with HIV infection progress to AIDS after a chronic phase lasting from 7 to 10 years.
●Most common mode of spread --- (75% of all cases)Sexual contact ( most commonly from Male to female ).
● Risk of transmission with needle stick injury--- 0.3%.
● Commonest cause of AIDS in children --- Vertical transmission
● BLOOD BANK and HIV ( Harrison18/e page no - 1513 ):-
●Blood collected for transfusion is routinely screened for both HIV-1 and HIV-2
A) HIV transmission is by-------
1) whole blood
2) packed rbc
3) platelets
4) leucocytes
5) plasma
B) No-HIV -Transmission is seen with
( processing procedure will inactivate virus in all given products) ---
1) hyperimmune gammaglobulin
2) hepatitis B immune globulin
3) plasma derived hepatitis B vaccine
4) Rh0 immune globulin
■ HIV Epidemiology:-
● HIV-1 ---- most common type a/w AIDS in the United States, Europe, and Central Africa and India.
● HIV-2----- in West Africa and India.
● HIV-1 three subgroups
1) M(major)
2) O (outlier)
3) N (neither M nor O)
● Group M ( subtypes or clades ;A to K ) ----most common form worldwide
1) Subtype B --- most common in western Europe and United States
2) Subtype E --- most common in Thailand.
3) Subtype C (fastest-spreading type worldwide) --- most common in India, Ethiopia, and Southern Africa.
● Most common cause of AIDS in India--- HIV-1 group-M , Subtype-C.
■ life cycle of HIV:-
● HIV infects cells by using ---- CD4 molecule as receptor and various chemokine receptors as coreceptors.
● CD4 receptors are required for entry of HIV in Brain
a) macrophages /monocytes
b) dendritic cell
c) CD4T cells (worse affected cells)

[@DrDeveshMishra]

Watch out these "Playlist" of "You Tube" channel for: ➖➖➖➖➖➖➖➖➖➖➖➖➖➖ 1) Pathology Lectures By Dr Devesh Mishra : ✅Link: kzbin.info/aero/PLyvX5U1RpOKMrLw3XhcuQ9sn7A7ageEFv 2) Strategies to crack any Exam!: ✅Link : kzbin.info/aero/PLyvX5U1RpOKNtR1VuTQDevD8mX8mn5FNT 3) "OM" means "Orientation and Motivation ".....Lessons for Life...! ✅Link : kzbin.info/aero/PLyvX5U1RpOKOQ1Bm7P-1qKoj_UQWHu0IS 4) DPMA-e-Learning App: ✅Link : kzbin.info/aero/PLyvX5U1RpOKOqt2u-Na_JiWwXrv_SX8iB 5) AIIMS Nov 2019 (More than 30 MCQs/topics came from DPMA e-Learning App): ✅Link : kzbin.info/aero/PLyvX5U1RpOKMmBpC2_hL2oaLF3qS8Rk8w _____________________________________________________________________________________________ *E-learning app for learning knowledge in Medicine through correlation with Pathology basics. *Subscribe and download "DPMA-e-learning" (online app): * Visit our Website : www.idpma.co.in 1) Android link: bit.ly/2QXuP8y 2) iOS link: apple.co/34dgjyq *Contact number for any info: [phone]

[@graphitionvids9748]

Are u have a any scientific paper there is proven hiv is a cuase of aids

[@theplatformofpsychology]

kzbin.info/www/bejne/kIKYqYB9q6h3nbs

[@sheeba8334]

So informative..much love from Kenya

[@DrDeveshMishra]

@@sheeba8334 🕉❤️🙏

[@DipRoy-dh7ph]

😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅😅

[@shahabuddin6149]

Wow super lecture thanks Sir,now clear my concept keep it up sir

[@lydiaogualiri750]

Very understandable! God bless you sir😊

[@crazyrobin5]

Sir.. U are a magician..😊🙏

[@anushkapreeti5653]

These type of teacher is all we want.... Respect from heart thanku so much sir❤

[@DrDeveshMishra]

🕉❤️🙏

[@shahabuddin6149]

Wow super explained thanks sir

[@msdahinwal]

Thanq sir..much much needed video

[@surajbharati670]

Thanks sir ❤️ it is very helpful

[@m.usmanriaz986]

gud work keep it up sir plz upload more videos

[@Raghdah_abd]

الشرح كلش حلو عاشت ايدك😅💛

[@mohammadarshadquazi7842]

Very good explanation😊

[@i1111ss]

Thank you so much sir for this and every other lecture you upload 🙏☺

[@theplatformofpsychology]

kzbin.info/www/bejne/kIKYqYB9q6h3nbs

[@tahiransari3917]

Sir pls upload more videos your lecture very helpful

[@sabbubehjad5079]

Sir your Lecture is Very crucial for me. I hope you will upload more videos on The Cholera, TB, syphilis Malaria etc Thank you

[@pritichawda2551]

Absolute legend.

[@pulkitkumar9442]

Thank you so much sir!! U made all the points very clear!!

[@DrDeveshMishra]

Thank u so much. Wishing you great success ahead👍

[@ummehaniridi5226]

You are awesome sir,please cover all the chapters of pathology. It would be really beneficial to us.

[@DrDeveshMishra]

🙌🙏👍🙌

[@meenabarot2037]

Wow. You made it very clear. Thank you 🙏

[@DrDeveshMishra]

🕉👍

[@yuktajoshi382]

Very nicely explained! Thank you Sir..

[@DrDeveshMishra]

🙏🙏🙏🙏🙏

[@dilnapachitiyan5106]

Thanks a lot sir

[@meenabarot2037]

simply awesome!! thank you!!!

[@DrDeveshMishra]

🕉🙏👍

[@roopkrishanpandit5385]

Really Excellent

[@DrDeveshMishra]

🙏🙏🙏🙏🙏👍

[@jengaur6468]

Great lecture sir🙌

[@DrDeveshMishra]

🙏🙏🙏🙏🙏

[@BASAVARC22]

Thank you sir ❤well teaching sir ❤

[@DrDeveshMishra]

🕉❤️🙏👍

[@mamta0322]

Respected sir thanks a lot for this amazing explanation 😇

[@DrDeveshMishra]

🕉🙏👍

[@yinyang.333]

Thanks sir 🙏

[@balnarayana]

Dear Dr. Your teaching is very impressive with appreciation and thanks

[@DrDeveshMishra]

🙏👍🙏

[@theplatformofpsychology]

More about HIV AIDS kzbin.info/www/bejne/kIKYqYB9q6h3nbs

[@dilkibat823]

Point to point clarity thank u sir

[@DrDeveshMishra]

🕉🙏👍

[@easy_medlife2793]

Love from Kashmir.. Very beneficial sir

[@DrDeveshMishra]

🙏🙏🙏🙏🙏👍

[@19ashishyadav66]

Excellent explanation ❤

[@DrDeveshMishra]

🕉👍❤️

[@gurupratappanwar6312]

Thanks sir

[@peerkaiser5]

I love your videos Sir, I've no words to thank u. Sir please make videos of systemic pathology. At least please cover MCI Competencies.

[@DrDeveshMishra]

🙏🙏🙏🙏

[@obianujueze9381]

Wow, this is amazing ❤ You just got new subcriber

[@DrDeveshMishra]

🕉🙏👍❤️

[@navaneeth_us]

Amazing, Sir. Thank you so much. 2/FEB/2022, 12.00 PM IST

[@DrDeveshMishra]

🙏🙏🙏🙏

[@sushmithayadav9584]

Ur the best 🎉sir

[@DrDeveshMishra]

🕉❤️🙏

[@preetisinha9456]

Kindly arrange lectures for PG Pathology students..

[@pragyajain1236]

Wow sir you teach like of extraordinary or high level🧐🧐

[@DrDeveshMishra]

🕉👍🙏

[@pragyajain1236]

@@DrDeveshMishra please sir upload more videos for b.pharma students 2nd sem.

[@jengaur6468]

Sir please make video on Pathophysiology of fever🙏🙏

[@VIKRAMSINGH-tk5oj]

Thankyou so much sir ji 🙏

[@DrDeveshMishra]

🕉🙏👍

[@faraazryder9395]

Thank u sir 😇

[@DrDeveshMishra]

🙏🙌👍🙌

[@maryanxuseen6769]

Thanks dr😊

[@DrDeveshMishra]

🕉❤️🙏

[@neelimapatel3454]

Plz upload same more videos sir

[@yinyang.333]

🙏

[@aqsakiran4119]

Sir plz upload videos on renal pathology

[@16.dharavathjeevan58]

Respected sir thank you lot please make more videos on pathology sir due to pandemic again we are at home ❤️🙏🏼

[@DrDeveshMishra]

🙏🙏🙏🙏🙏👍❤️

[@16.dharavathjeevan58]

🙏🏼

[@prajjwalsankle6285]

Sir please add A video on Coombs Test

[@aqsakiran4119]

Sir plz upload videos on non Hodgkin's lymphoma

[@DrDeveshMishra]

✅ #AIIMS_Nov_2019 more than #30_topics came from Pathology app by Dr Devesh Mishra under “#DPMA-e-Learning App” ✳️ “Subscribe App”- #DPMA_e_Learning #App ❇️ Website : www.idpma.co.in ➖➖➖➖➖➖➖➖➖➖➖➖➖➖➖➖ Topics (High yield topics for NEET PGMEE also) ➖➖➖➖➖➖➖➖➖➖➖➖➖➖➖➖ 1) Apoptosis ( kzbin.info/www/bejne/onaae2yvrsebeq8 ) 2) Chemical Mediators (kzbin.info/www/bejne/fH-1Z2SolJd3n5Y ) 3) Gene Knock out ( kzbin.info/www/bejne/Y6u3opehic9-obM ) 4) CRISPR-Cas9 ( kzbin.info/www/bejne/h4XFm2aggM6EaNU ) 5) IL-4 for Mast cells ( kzbin.info/www/bejne/pZi3fYtrebyZiM0 ) 6) Function of T cells ( kzbin.info/www/bejne/bIbUp4yYbpWer7s ) 7) Gamma Delta T cells ( kzbin.info/www/bejne/gaaXZpKppNOaosU ) 8 ) Scleroderma ( kzbin.info/www/bejne/nouwgXuhmqZ3hcU ) 9) Dermatomyositis ( kzbin.info/www/bejne/mmq2ZoJsi96gnq8 ) 10) Rheumatoid Arthritis ( kzbin.info/www/bejne/Y3TNf5-mo95nhrs ) 11) Type 1 Hypersensitivity Reactions ( kzbin.info/www/bejne/eZqliZmVrpmXasU ) 12) Cyclin and CDK ( kzbin.info/www/bejne/h5nOiJ-opZx8fNU ) 13) vWF and Endothelium ( kzbin.info/www/bejne/jZzQiKGDg7abhpo ) 14) TRALI ( kzbin.info/www/bejne/hZicmaF9r62ZY5o ) 15) Massive Blood Transfusion ( kzbin.info/www/bejne/f2TCdHRpa9ueg7c ) 16) CML ( kzbin.info/www/bejne/bKmoYXR_mZWLapI ) 17) CMV ( kzbin.info/www/bejne/bKmoYXR_mZWLapI ) 18) Mantle cell Lymphoma (kzbin.info/www/bejne/fWqUpHejfbOgbNk ) 19) Small Round Blue cell tumor ( kzbin.info/www/bejne/p5bZgYaAqt53aJo ) 20) Burkitt’s Lymphoma (kzbin.info/www/bejne/mn6qfKRno8-Gbrc ) 21) HOCM - Myocyte disarray (kzbin.info/www/bejne/gZCko3ePgtajq7c ) 22) Alport’s syndrome ( kzbin.info/www/bejne/eIe2lXZ4lptqiMU ) 23) Hepatitis B serology ( kzbin.info/www/bejne/Y5_cdYWLat-dnZI ) 24) Molluscum contagiosum ( kzbin.info/www/bejne/kGWkf4l5odKbiK8 ) 25) HPV infection ( kzbin.info/www/bejne/rneZm4tsqbNnlck ) 26) Bacterial Vaginosis ( kzbin.info/www/bejne/e2K6ipilhayWqqM ) 27) Addison’s Disease ( kzbin.info/www/bejne/qWbTaYh6os9gaJI ) 28) Iron deficiency anemia (Lab investigation ) ( kzbin.info/www/bejne/oKGcl4ycnqZ3Zrs ) 29) Iron deficiency anemia ( Metabolism ) ( kzbin.info/www/bejne/m6CplXilqtZ1brs ) Best wishes to everyone.....

[@meenakshichouhan4147]

Excellent teaching sir

[@DrDeveshMishra]

🕉🙏

[@rhythmbhalodia7886]

Amazing lecture covering everything we need to know about HIV. 1 doubt sir... Which helps in penetrating host cell?... Gp120 or CCR5/CXCR4

[@DrDeveshMishra]

Both

[@rhythmbhalodia7886]

@@DrDeveshMishra Sir there was a ini pyq where we have to select 1 from, Which helps in penetrating into host cell ? A) gp41, B) gp120 C) CCR5 D) CXCR4

[@doctoryash7907]

Awesome sir❤

[@DrDeveshMishra]

🙏🙏🙏🙏🙏

[@akshaysapkal2010]

Respected sir.. I have completed B pharmacy . Really awesome lecture.. Informative❤

[@DrDeveshMishra]

🕉🙏❤️

[@neeraz8184]

Hello sir I have one dout in hiv 1 &2 and they have lot of strains and subtypes so the antibody test and fourth generation test and rna pcr test can detect all types of hiv strains and subtypes ??? Please give me reply sir

[@eshietgodwin2786]

🤲🔥

[@DrDeveshMishra]

🕉👍🙏

[@drmohdabubakar1294]

Please upload sir how to study glomerular (em/LM/ structure

[@DrDeveshMishra]

Surely

[@religossip]

CCR5 are not present on t-cells

[@NimmakayalaPreetam]

Sir,where is the HIV DNA formed!In cytoplasm or host nucleus?

[@saurabhpandeychairman3064]

Plz explain spegra tablet

[@syedzubairmeer9549]

Hi sir please answer....hiv test ka window period kitna hota ha

[@homeopathymedicos3849]

sir HIV 2 is most commonly present in West africa and india as per as Robins and Harsh mohan.

[@user-ub8tb1vw9b]

Yes

[@user-ub8tb1vw9b]

But it means HIV 2 most ofyern founded in africa and asia ...But Not more than HIV 1 . I hope u got this point

[@saurabhpandeychairman3064]

H.i.v patient ko नींद की दवाई दी जा सकती है?

[@jrf_aspirants7397]

17:25 sir they not Africans they Northern Europian people who having mutations against gp120 ‘s coreceptor.

[@DrDeveshMishra]

In southern african also it is seen👍

[@angelkichunayakkishor5646]

Sir you didn't say about HIV-2

[@toufiqalam8762]

NHL is not most common HIV malignancy . in robbins page no. 253 kaposi sarcoma is most common

[@DrDeveshMishra]

Follow this data which i have said these are WHO annd Harrison updates👍

[@shreeshyampareek5154]

Dear Sir Most sexual transmission has occurred among homosexual man. From Robbins But in lecture u r saying that M to F transmission is most common. Plz solve this controversy

[@DrDeveshMishra]

Thats the US data, even u can see in next paragraph its written , Globally Heterosexual transmission is most common

[@RA-ZIA]

@@DrDeveshMishra exactly sir.. It's written there

[@mamtarajbhar3380]

Hello sir I had unprotected sex at the age 19 now my age is 25 .is their any risk bcoz till now I don't see any symptoms and now I become more healthy and fit as compare to past .i don't have any problem. Now that boy got married and have 1 child whom I was in relationship.can I safe now?

[@DrDeveshMishra]

Get RTPCR done for yourself

[@shahabalam3348]

Isn’t most common route male to male?

[@DrDeveshMishra]

🕉 No