How to Design a Total Synthesis

[@debakshikashyap9892]

Okay sir..i just want to tell u one thing i m doing masters in chemistry with organic specialization and i have learnt more reaction and reagents from this video then my entire 5 yrs as chemistry major.. please upload more video...ur students are really lucky to know all this stuff so early..thank you sir..thank you very very much h🙏🙏

[@chemistryunleashed4348]

Thanks, Debakshi, Kashyap! I am so glad that my videos are helping you. To see a huge free collection of my organic chemistry videos, specifically, please check out chemistry.teambootcamp.com/

[@Felixkeeg]

I like how you keep your students attention with this sorta interactive lecturing stlye

[@chemistryunleashed4348]

Thanks, Flelixkeeg. I'm glad you're enjoying my videos. I apologize, by the way, for my delayed response. I've been swamped with so much work this semester that I haven't been able to reply to my KZbin comments as swiftly as usual. Anyway, thanks for watching and posting. Please have a wonderful day!

[@Felixkeeg]

Nothing to apologize for, it's still finales season after all and professors have just about as much work to do as we have.

[@chemistryunleashed4348]

Thanks, Felixkeeg. I appreciate your patience and understanding. A good day to you!

[@Hello_Friends]

Mike Christiansen but is this project your interest and self work....

[@chemistryunleashed4348]

Kind of. I make these videos mostly for my university students who are actually taking my classes. I assign them to watch certain videos according to a schedule I give them. Unsurprisingly, I also have lots of people who watch them from all over the world, because I place them here on KZbin.

[@timecode37]

Sounds like someone from an early 2000s Call of Duty lobby is teaching you chemistry

[@kevinbyrne4538]

A useful introduction on how to build bigger molecules from smaller ones and on formulating the strategy for doing so. Thank you for posting this video.

[@lunchbr4ke528]

Thank you so much for this lecture, I’m currently in the third semester of my Bachelors in Chemistry at the University of Vienna, Austria. I’ll be (re)taking the Organics 1 exam next week and this surely helped a lot! :)

[@chemistryunleashed4348]

You are VERY welcome, LunchBr4ke! I am so glad that my videos are helping! I wish you great success with your studies. Thanks for watching and commenting!

[@jacobjamar]

Not boring at all. I really enjoyed watching your video.

[@chemistryunleashed4348]

I'm glad to hear that, Jacob. Thanks for your kind words and thanks for watching!

[@Moritz___]

wow that was interesting! will enjoy more of this content soon!!! Ty have a nice one

[@chemistryunleashed4348]

Thanks!

[@sportshighlights4188]

Hey can you talk a little bit louder? I cant hear you.

[@jhyland87]

Smartass, lol.

[@jhyland87]

Great video! I find this very fascinating.

[@movax20h]

Is there some reasonably formatted cheat sheet (with conditions and approximate yields, and specificity notes) of various reactions, common and less-common, that are useful in synthesis. Something like 6-10 pages long, with various schemes. Everybody remember the simple ones, even from high school, but the more esoteric ones are sometimes then ones you struggle to find.

[@chemistryunleashed4348]

Yes indeed. The best resource I can recommend is chemistry.teambootcamp.com/, which is also free. You can also go to datbootcamp.com and get a free trial membership, which includes access to condensed reactions lists. I make tons of videos for that site, so the style and approach are similar. Does that sound okay?

[@GitMunny1]

Thank you for the information!

[@usernamehere94]

Is sodium cyanide used to replace the carboxylic acid because carbon is more elecronegative than sodium, making the carbon bound to the sodium partially negative?

[@NapoleonGelignite]

Aaron Forbes - you got it backwards. The sodium cyanide reacts to give the carboxylate

[@chemistryunleashed4348]

That is correct, Aaron Forbes. When exposed to H3O+ and heat, the cyanides (CN) transform into carboxylic acids (COOH).

[@chemistryunleashed4348]

Aaron Forbes got it correct below. When exposed to H3O+ and heat, the cyanides (CN) transform into carboxylic acids (COOH). Does that make sense okay?

[@NapoleonGelignite]

@@chemistryunleashed4348 - I read it as he was saying the nitrile substitutes the carboxylate. Not the nitrile is the precursor group to the carboxylate.

[@chemistryunleashed4348]

@@NapoleonGelignite You may be right, Andy, that this is what Aaron was asking. I'm not completely sure, but hopefully Aaron's question did get answered somewhere along the way, because I was really late to the game in responding. Thanks so much for responding and helping out! Please have a wonderful day!

[@a.s3748]

Taught me alot

[@spiderdude2099]

Lol, I have that textbook you reference it’s actually a great textbook

[@Hello_Friends]

i m from India..where do u teach

[@chemistryunleashed4348]

In Utah (western U.S.)

[@Hello_Friends]

Mike Christiansen thank u sir...please upload any video about pericyclic and photosynthetic reactions

[@chemistryunleashed4348]

I will put these on my list of videos I should make in the future. Unfortunately, I am currently working on a very intense video-making project that prohibits me from making very many new KZbin videos anytime soon. I apologize for that, Krisha. With that said, there is a fantastic book that summarizes pericyclic reactions very well. I highly recommend it: "Strategic Applications of Named Reactions in Organic Synthesis," 1st edition, by Kurti and Czako.

[@Hello_Friends]

Mike Christiansen thank u sir

[@chemistryunleashed4348]

You are welcome, Krishna. Have a great day!

[@ranjanpaudel698]

thank u ser....this helped me.......

[@Anderson_Hwang]

Thanks so much for this lecture. Now I know that phenylacetic acid comes from benzyl bromide and a cyanide. Then if I treat the phenylacetic acid with CH3-Li it converts into phenylacetone. Now with reductive amination of the phenylacetone I could get racemic Methamphetamine /:)

[@Anderson_Hwang]

@lilou zekabyle replace the H of an NH2 with a CH3? Just use iodomethane. Sn2 reaction

[@nicougrikify]

have a few months before i understand what the hell is going on here..haha. what is the class called and what year is it ?

[@chemistryunleashed4348]

nicougrikifyThis particular video is for undergraduate organic chemistry lab, which at my institution is called CHEM 2315 (first semester) and 2325 (second semester). These courses are usually taken by students during their sophomore years.

[@cm-ns9vv]

@@chemistryunleashed4348 How do you design CH4 ---? ---> CH3-CH2-C = O-NH2 synthesis ?👆👆

[@cm-ns9vv]

@@chemistryunleashed4348 I am waiting for you teacher

[@ivantimofeev2233]

@@cm-ns9vv did you really expect a response to a several year old comment reply? LOOOL

[@iamsonedisoncahaya4845]

Is that Methamphetamine?

[@chemistryunleashed4348]

No, but there are some structural similarities, such as the aromatic ring.

[@BashirAhmad-ju7ib]

Plz make a vidio also on the synthesis of Al Cu Ag Fe doped tio2 nano structure

[@flixerstudios1862]

Lol he knew what he was doing when he put in phenyl acetic acid

[@chemistryunleashed4348]

Indeed! A very simple choice.

[@noahway13]

What is that creepy woman in right of screen in beginning?

[@yams3954]

Ngl I came cuz I wanna learn to make LSD

[@thecasualfront7432]

Ahh the disconnection approach