How We Cured Hepatitis C

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Asianometry

Күн бұрын

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Пікірлер: 494

@whatsoperadoc7050 Жыл бұрын

My uncle was diagnosed literally months before the cure was made available in a study his doctor managed to get him into. Saved his life.

@scottanos9981 Жыл бұрын

Incredible luck!

@paper_gem Жыл бұрын

That doctor is a hero.

@paulmichaelfreedman8334 Жыл бұрын

In 1996, My dad was treated with Interferon-beta for a grawitz tumor in his kidney. 8 inches in diameter, had been labelled terminal. Yet the I-b reduced the tumor to size of a penny. Gave him a couple extra years, after which the cancer returned in the bones. Unfortunately I-b was ineffective in hard tissues. He passed in 2004.

@clevername8832 Жыл бұрын

Hep C takes years to kill.

@cv990a4 Жыл бұрын

@@paulmichaelfreedman8334 there are other tumors/cancers like this - you can knock them back only so often, then they come back and get you. 😠

@poseidon5033 Жыл бұрын

I lost my mom 4 years ago to hep-C related cancer. She got it from a blood transfusion right after I was born, before they developed the detection methods you talked about. I really hope this cure becomes widespread and cheap enough that hep-C can go the way of smallpox.

@nunyabiznes33 Жыл бұрын

Sorry to hear about what happened. Alot of diseases should go the way of smallpox! These microbes/parasites have absolutely no value to this planet.

@pudanielson1 Жыл бұрын

My condolences to you and your family poseidon, it makes me wonder what other things in blood transfusions could cause other problems, since 1976s we've discovered more and more which allows us to purge things like this.

@Graceii800 3 ай бұрын

Being recommended to Dr Abiola on KZbin was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉

@bismillahrabbani9006 11 күн бұрын

I am like your mother, I had a blood transfusion during childbirth due to hemorrhaging blood with each contraction in labor. 7 pints of blood in a transfusion was received back in 1981, before detection of hep c was available at that time. Hep c was detected during recent blood work. I went to the doctor due to severe exhaustion recently and the virus was found. Now, I am doing Ozone IV therapy to clean out my blood, along with detoxing my liver and lymphatic system. I am not sure if I should start taking meds for this, as I am afraid of side effects. I never take any medication.

@gljames24 Жыл бұрын

I didn't know we cured hepatitis c. Thanks for the info.

@Mordecrox Жыл бұрын

I kinda forgot, mostly because headlines were like "cure found, it costs $100k, not a joke or typo", nobody brought it up again so promptly forgot as effectively there was no cure at that price point.

@minyaksayur Жыл бұрын

cure ... for the rich.

@alexcarter8807 Жыл бұрын

Keep in mind "We" means the actual first-world. Not the USA.

@eleventy-seven Жыл бұрын

If your in a blue state the ACA covers it and the price went way down once there were more treatment options. If your in a red state well thats death cults for ya. Sorry. Really.

@dx-ek4vr Жыл бұрын

@@Mordecrox costs $100k, but making the pill probably costs just $15 to make

@iaov Жыл бұрын

I recently Was treated for Hep C... after 6 weeks of treatment no more virus was detected in my blood, treatment continued for another 6 weeks... I am so grateful that there are really smart people in this world that figure these things out!❤️

@SetiSupreme Жыл бұрын

Me too! I had it for 12 years or so and then Finnish government decided to eradicate it from our country and offered the treatment for free to everyone affected. I had the Glecaprevir/pibrentasvir one

@brother9440 11 ай бұрын

@@SetiSupremenow u are free from hep c

@SetiSupreme 11 ай бұрын

@@brother9440 Yes, I am. It's nice to not have worry about my blood.

@oscardeleon253 5 ай бұрын

I got diagnosed with hep c recently, hope mine is curable I’m nervous 🙏🏼

@Graceii800 3 ай бұрын

@SD-fw9li Жыл бұрын

Biology undergrad here u did an awesome job with this video I’m impressed with how many subjects u do these in depth videos on

@Muonium1 Жыл бұрын

I find the Asianometry topics of choice for video exposition are uncannily aligned with my own interests. I followed the trials and lead up to approval of this compound very closely when it happened a decade ago. Also, I recall Kalydeco (ivacaftor), the cure for a very specific type of cystic fibrosis, was also of particularly intense fascination and wonder what the long term status of the treatment's efficacy is today.

@sydnerd Жыл бұрын

Thank you so much for this video, my parent contracted HepC a year before I was born. All my childhood I was worried about it. Once the cure came out I was super excited, but later got very depressed once I learned about that it's only available for late stage HepC in most of Europe. I almost encouraged my parent to seek for the cure nevertheless. A few years passed and suddenly health insurance would finally cover it, my parent was yet very skeptical about the actual benefit, couldn't believe what the doctors said. Now my parent is cured, first few months after healing they got a lot of energy, but eventually the energy levels dropped again - apparently a common thing for those who received the cure.

@SiriusTheKid Жыл бұрын

So are they cured?

@johnham8824 Жыл бұрын

your parent ,they, ok.i guess but why ?

@Graceii800 3 ай бұрын

@Graceii800 Ай бұрын

@NikolausUndRupprecht Жыл бұрын

I was totally oblivious to the progress they made. Thanks you for your ever-excellent video essays!

@BillyLapTop Жыл бұрын

India, I believe, challenged Gilead on its pricing and threatened to make the drug themselves despite the obvious patent infringements. Does anyone know how that situation panned out?

@TrollOfReason Жыл бұрын

They denied Gilead's patent request, & began indigenous production. It's created an ongoing medical tourism to India, where traveling halfway across the planet is more affordable than buying a pill at home.

@BillyLapTop Жыл бұрын

@@TrollOfReason Thank you. That certainly is a great work around to help their own people. I guess Gilead et al are still making bank in the west, especially in the U.S. despite the decline of the disease.

@aravindpallippara1577 Жыл бұрын

@@conor7154you do realise that a lot of drug patents are completely stupid and are completely awarded by manipulating the patent laws for variations? India has a patent system but you can't patent innovative processes for the same drug as in the US (which means the patent never actually expires as the company keeps filing new processes when the patent is about to expire), it has to be a new molecule entirely to award patent

@aravindpallippara1577 Жыл бұрын

@@conor7154 does Gilead stop school shootings in the US with their drug patent or something?

@VoidOfDarkness9 Жыл бұрын

In Mongolia Because of India and egypt creating indigenous production they started selling discount to us as altriustic live saving for developing country scheme which made drug became very affordable.

@FA-ft9sq Жыл бұрын

I got diagnosed with hep c a couple years after this drug was approved by the FDA. I remember the big sigh of relief I experienced when my doctor told me that it seems like it cleared on its own and no further treatment is needed after further and subsequent retestings. Apparently about 20% to 35% of those infected with hep c can spontaneously recover. I consider myself very lucky.

@sn1000k Жыл бұрын

I had this happen too. With simultaneous B and C. I was told I was very lucky and I apologized to my body.

@MenkoDany Жыл бұрын

@@sn1000kthat makes *me* want to apologize to your. ody

@clevername8832 Жыл бұрын

@@LibraryofCelsuswow

@ajax700 Жыл бұрын

The human immune system is marvelous and varies a lot along persons. Best wishes.

@simonfarre4907 Жыл бұрын

Same here. My Hep C cleared itself and was told the same thing from my doctor that I should count myself incredibly lucky. Thank the universe that I didn't get HIV or AIDS or something like that.

@Eugenewong794 Жыл бұрын

As a doctor who studied about Hep c, thanks for the background history about this, didn't learn this in med school

@Graceii800 3 ай бұрын

@JohnDonne3PersonGod Жыл бұрын

The (IMO misguided) uproar about the cost of the drug really shouldn't overshadow the fact that curing HCV is one of the biggest medical successes of our lifetime.

@pinkipromise Жыл бұрын

it is cheap compared to the cost of liver transplant

@WellBattle6 Жыл бұрын

And it’s a cure, not like insulin being a treatment and getting jacked up in price by manufacturers

@williamthebonquerer9181 Жыл бұрын

@@WellBattle6nsulin is extremely difficult to make and only a few companies have the ability to make it. It has never been made by an amateur contrary to what people assume. It's cheaper in Europe as the governments cover most of the cost

@TrollOfReason Жыл бұрын

@@williamthebonquerer9181 Mass production of insulin has been around since the early 1930s, & even today production is a matter of keeping the bacteria that actually makes it happy & productive. It's so easy to mass produce that it was cheap for much of the history of the drug & why it's still cheap outside America. The issue isn't one of technology or logistics, it's an issue of market manipulation & lack of regulation.

@1.4142 Жыл бұрын

@@williamthebonquerer9181 The issue isn't patents, which have expired long ago, but regulation on insulin. Only one type of insulin is approved because of all the clinical trials and safety requirements, and the company that makes it has a monopoly. There is little regulation on making your own insulin. The open insulin project is a group of biohackers in oakland who engineered bacteria and yeast to make insulin and are trying to make the tech to produce it cheap and widely available, so that everyone can home brew their own in the future.

@devinbready7949 Жыл бұрын

Hey man, love your videos. Protease is pronounced prow-tee-ayz

@cv990a4 Жыл бұрын

The -ase suffix denotes an enzyme that breaks down something - in this case protein. Hence the pronunciation.

@andrewdunbar828 Жыл бұрын

Such an antitease comment.

@Graceii800 Ай бұрын

@brucewilliams6292 Жыл бұрын

Thank you for doing such great research and videos. Knocked it out of the park!

@jonathankleinow2073 8 ай бұрын

My mother contracted Hepatitis C from a blood transfusion in the 1980s. She became acutely ill in 1990, to the degree that the doctors told my dad he needed to start thinking about what to do as a single father. My mom survived the acute phase but dealt with other health issues, including a brain hemorrhage in 1995. She died in the summer of 2013 after being diagnosed with liver failure and being hospitalized for a severe GI bleed, and I read an article in the NYT that fall about Harvoni. I wish she'd taken better care of herself - she finished a bottle of chardonnay every day, which couldn't have done anything good for her liver. I will always wonder whether, if she had stopped drinking, she would have had the chance to take Harvoni and would still be alive today.

@dogcarman Жыл бұрын

Good video. One small gripe: protease is pronounced “pro-te-ase”. It’s not teasing at all. 😉

@anonsnowman Жыл бұрын

pro tee ay-zz(aze as in haze) great vid!

@irinkamoy Жыл бұрын

I used meds Harvoni for Hepatitis C for 12 weeks - first meds Canada / USA in 2013 . I was in experimental group for Layla University , Chicago . Thank you !!!! Hepatitis never come back . Today is August 2023

@Graceii800 3 ай бұрын

@kansascityshuffle8526 10 ай бұрын

There will never be a cure for greed.

@alexny1173 Жыл бұрын

Really great video as always! I love that you are dipping your toes into more biology and biotech focused topics and I look forward to more. There are certainly many interesting stories to cover. I could suggest the discovery of CRISPR Cas9 and the later patent war between The Doudna and the Zhang lab/Broad institute along with the many improvements and innovations being built on it since then. Also the Merck/Vioxx story, or the technology behind flowcytometry and cell sorting machines. Also the stories behind the development of Cryo-EM or Lightsheet Flourescent Microscopy two very cool and cutting edge technologies.

@rdallas81 Жыл бұрын

I was prescribed Vioxx for years. Then one day my pharmacist said they took it off the market. I also had liver problems too.

@alexny1173 Жыл бұрын

@@rdallas81 rofecoxib (Vioxx) is available again in Canada and you can get Celebrex in the US which is basically the same thing. I think the whole story was a bit overblown. Subsequent studies have shown that most NSAIDs come with an elevated risk of heart attack if taken high dose over long periods (except aspirin which has a protective effect). So Vioxx is probably no worse then ibuprofen in that respect. It was just the first large clinical study that was able to statistically show the effect.

@J-tu3hw Жыл бұрын

It's incredible how excellent scientists and physicians were at determining clinical patterns from observation and then discovering the causative agents.

@reyskidude Жыл бұрын

the moment i heard the word "nanometers" i thought "ah yes.... an Asianometry video, feels like home"

@caonabocruzG Жыл бұрын

Nice vid! Didn't know there was a cure. Hey man, I hope you can talk about Chimei group one day. About how they became a powerhouse in the plastic industry and the Museum they have in Tainan.

@Graceii800 3 ай бұрын

@bb57365 Жыл бұрын

I sold a very ineffective treatment in the late 90’s. Was so glad they finally came out with a cure. There is hope for all diseases.

@Graceii800 3 ай бұрын

@Farazormal1 Жыл бұрын

I'm once again amazed at the amount of topics you are able to research, understand, and make understandable.

@vi2873 Жыл бұрын

P.S. Protease is "pro-tee-ace", not "pro-teez". Most enzyme names end in the suffix "-ase", which is pronounced as its own syllable with a hard S: basically like "ace". E.g. alanine aminotransfer-ase mentioned earlier in the video or RNA polymer-ase. Protease is built of "prote" for protein and "-ase" for enzyme. Sometimes an enzyme name is constructed by [name of substrate]-ase, like protease (protein substrate), lipase (lipid substrate), nuclease (noo-klee-ace, nucleic acid substrate), telomerase (telomere substrate); and sometimes it's just [function]-ase like aminotransferase (transfers amino acids, lol), DNA polymerase (polymerizes/lengthens strands of cDNA from a DNA template), or reverse transcriptase (produces cDNA from an RNA template). After further investigation I found out that the etymology of this "-ase" ending is basically "someone used this once and we stuck with it" lol. A libfix from the name of the first discovered enzyme, diastase. Sorry, having a biochemistry background, hearing "pro-teez" with the subtitle protease just made me giggle really hard lol.

@Julian-tf8nj Жыл бұрын

Thank you for saving me the effort to write a post like yours. 😅 That "pro-tease" pronunciation initially made me laugh... but then made my ears "bleed" 🤣

@rdallas81 Жыл бұрын

@@Julian-tf8njStop Bitching.

@Maxmaxmax63 Жыл бұрын

More medical/pharmacology stuff! Love this

@NotDmitry Жыл бұрын

Very interesting video! My mom went through Interferon + Ribavarin treatment in early 2010s. The side-effects made it very difficult to be a functional adult with a job, considering the full treatment lasted for about a year. And it was a lot more expensive than 1000 dollars. I'm glad she went though it (still virus-free to this day) but it's good to know that there's a much better alternative these days.

@Graceii800 3 ай бұрын

@ShadySKWASHA Жыл бұрын

I am a recovering addict and this stuff cured me, 3 months of anti virals, cost the state funded insurance like $30k! The meds are so overpriced and they make you feel so bad. I felt like a grandpa after a month, your bones hurt, your super tired and no amount of caffeine helps, it was worth it tho been cured since! Finished my mechanical engineer bachelors and sober!

@SetiSupreme Жыл бұрын

What drug did you take? I had Maviret, it's Glecaprevir/pibrentasvir and experienced literally no side effects. Not even the mildest. Nothing. Was completely cured ❤

@Graceii800 3 ай бұрын

@izoiva Жыл бұрын

My mom was diagnosed with hepatitis C in mid 00s. She was treated with Russian made Interferon alpha type drugs. It has good results, she recoverd, but in mid 10s she developed cirrhosis and died last year in age of 58.

@microdesigns2000 Жыл бұрын

I’m sorry friend.

@izoiva Жыл бұрын

@@microdesigns2000 thanks.

@Graceii800 3 ай бұрын

@stevengill1736 Жыл бұрын

Good one! I have friends that went through both interferon and sofosbuvir, and there's no comparison - the side effects of the former were stunning in scope. Also the treatment lasted 12 months or more compared to four for Sovaldi, which as far as I could tell was free of any side effects at all. The use of AI in developing leads in medicinal chemistry will probably speed up the development of new antivirals and other meds significantly - a subject we're hearing a lot about in the pharmacology world. Thank you kindly for covering this - it's quite a success story...

@FullLengthInterstates Жыл бұрын

to defeat the bug, we must understand the bug 🐛🚀

@VenturiLife Жыл бұрын

Starship Troopers reference! :)

@meisenhut31 Жыл бұрын

Just a quick note: protease is pronounced "pro-tee-ase". Very interesting video and a great job explaining some very complex topics!

@iamwisdomsky Жыл бұрын

more like "pro-tee-ace". as in Ace in ace of hearts.

@The-KP Жыл бұрын

Great video, so thorough. Asianometry is my favorite science channel, for this kind of historical reaching seminar.

@ErgonBill Жыл бұрын

I had it during the '70s and never received any treatment as there was none. Full forward 20 years and I was required to vaccinate against Hep B but never sero-converted, which needed to be investigated with routine testing over several years. All the while, I was asymptomatic. Around 10 years further on, I was declared cured by not showing any select antibody activity over a couple of years. One of the lucky ones who required no treatment.

@andrzejr82 Жыл бұрын

Such a good video! Sound like virology is not what you’ve an expert in but you did a great job explaining everything simply and correctly. Only shame is that you didn’t ask anyone how to pronounce ‘protease’, which in your video sounds like it’s a tease delivered by a pro 😉 but honestly, great video and here’s to some day you making another one about the success of the hepC vaccine!

@RobertSpartacus 8 ай бұрын

From India, my uncle was at his final stage before sofusbuvir was available in India. He was kidney recipient already, this saved him. Now he is happily married, hale & healthy.

@5roundsrapid263 9 ай бұрын

My friend’s mother had a blood transfusion in the early ‘80s, before blood was heavily tested. She got hepatitis C, and she thought it was fatal. She’s still around thanks to this.

@Graceii800 3 ай бұрын

@StopChangingUsernamesYouTube Жыл бұрын

It's been well over a decade since I lost my dad to liver failure from hep c, but I'm glad to know fewer will have to go through that going forward.

@ThoughtsEtcEtcEtc Жыл бұрын

Bread analogy is useful but debatable: it’s still bread. When has bread ever infected my liver??

@JohnDuthie Жыл бұрын

Forgot how much I love this channel! Keep up the awesome work Asianometry!

@JohnDuthie Жыл бұрын

The problem is KZbin doesn't recommend related content anymore. The sidebar is full of random crap I might generally enjoy watching regardless of the current topic.

@AgentSmith911 Жыл бұрын

I love the wide, diverse range of topics covered in your videos. Hopefully you'll touch on batteries or more precisely the ones used in BEVs (Battery Electric Vehicles) such as lithium ion batteries or the ones talked about recently by Toyota, the solid state battery.

@woolfel Жыл бұрын

I learned a lot. You're brave for trying to pronounce those medical / chemical names. scientists like to give names that are impossible to say.

@charleschidsey2831 Жыл бұрын

Considering your usual subject matter revolves around silicon related technologies, this foray into virology / molecular biology / immunology must have stretched your comfort zone a bit. I applaud your bravery as this story is multifaceted and difficult to explain to laypeople. As a medical professional, I will say that your presentation was accurate and covered the principal issues quite well. Overall you have provided an excellent primer on the subject. That said, I will offer two tiny nitpicks. ALT (alanine aminotransferase) is generally pronounced as the individual letters by the medical community and “protease” is pronounced as three syllables (pro-tee-ace). Again, outstanding work on your part to put this summary together. Continued good luck to you and your channel from a longtime subscriber.

@vitamincds735 Жыл бұрын

protease is not pronounced as pro-tease, but pro-ti-ase. proteases are enzymes. most enzyme names end in -ase.

@BlahBlahBleh317 Жыл бұрын

Videos like this are what make KZbin great. Keep going and thank you!!

@PinePizza Жыл бұрын

As a labtech (only worked in the medical routine) I am shocked how many methods didn't work in search for Hepatitis C.

@Graceii800 3 ай бұрын

@matt-g-recovers Жыл бұрын

I did this treatment or a chemical very similar about 7 years ago. It was $180,000 for 6 months. I think the name of it sounded very similar but it was different than what you mentioned. I was told it was 95% effective when I did the treatment. And I am cured of hepatitis C.

@Private-GtngxNMBKvYzXyPq Жыл бұрын

Another excellent report. Keep up the great work.

@孫振新 Жыл бұрын

Should also mention Dr. George Kuo, who worked together with Dr.Houghton and Dr.Qui-Lim Choo on the initial discovery but didn’t get the Nobel prize.

@jon649 Жыл бұрын

amazing episode, you should do more drug/sickness related ones

@gtablurt5791 Жыл бұрын

I have both hepatitis B and C and two decades and two years on dialysis. I never lose hope but I am wanting to get some help.

@JonathanShyhJangNyau Жыл бұрын

Love the starship trooper reference 😂

@chiraldude Жыл бұрын

Protease, pronounced with 3 syllables prow·tee·ayz. Pretty much any biological term that ends in "ase" will pronounce the ending as ayz.

@v.e.7236 Жыл бұрын

This would have been nice to have back when I went through chemo for Hep C. My regimen consisted of a twice weekly shot of Interferon, in tandem w/ Ribavirin, and it was brutal! I lost 50 lbs over a six month period and was experiencing severe bouts of tachacardia, which would make me pass out and I'd wake up to find myself on the floor w/ a bloody nose or big bruise somewhere. smh

@wutangmuslin Жыл бұрын

Hope you're doing well now.

@staceyclark8796 11 ай бұрын

That's a shame. I'm so sorry you went through that.

@thesquatchdoctor3356 Жыл бұрын

Well done on simplifying the absurd complexity of biotechnology to something palatable

@sunalwaysshinesonTVs Жыл бұрын

Yhe visual of the girl with a gun shot wound to the chest getting a blood transfusion is by far my fav.

@stefanodadamo6809 Жыл бұрын

A haemophilic older friend of mine had the virus with no symptoms, he was completely cured some years ago. Good news.

@DrAugurk Жыл бұрын

I'm assuming he also got contaminated by Factor VIII from bayer? My uncle also got it, in addition to HIV from it. Unfortunately, after he was cured from his hep, he heard he already had gotten cancer from the hep and died shortly after.

@stefanodadamo6809 Жыл бұрын

@@DrAugurk something like that. He's very competent (his brother, also but less gravely haemophilic, is a doctor) and can speak at length of drugs and treatments for his condition.

@gentrelane Жыл бұрын

Your videos are so consistently high quality. Thanks for sharing

@couchetard1984 Жыл бұрын

Another fantastic mini doc. I am working my way through your library and I feel as though I've finally found a school that I can enjoy.

@punditgi Жыл бұрын

Spellbinding story! Bravo, sir! 🎉😊

@W333L Жыл бұрын

I work for gilead. I have some gripes with some of their pricing, but 1000 for a CURE is a great deal. With a single-use treatment cost being that low, the failure in this case is government healthcare support for low income patients.

@JamesChurchill Жыл бұрын

Except it's not 1000 for a cure, it's 1000 for a single dose, and a cure requires 50 doses...

@Yostuba Жыл бұрын

I've had hep C twice. Once while getting a random STD screening they told me I had hep C my thankfully my body was fighting the virus off naturally. I got tested a few more times and they took my blood and other samples for research made me awnser some questions and oddly gave me 50$ for each of these 4 testings. Three years later while in the hospital they told me I had very early hep C and was confused. I did the treatment in 2021 thank god its covered in Canada. I wanted to die I felt like shit for months. I know someone who did the old treatment in the 90's, they have so many allergies now and other heath problems. While doing treatment they were constantly in pain, it was like chemo. Hep c is rather scary it can live on surfaces for a long time, the virus has mutated like crazy. And now we're seeing Hep D and other forms pop up. Even A&B infects a bunch of people every year its important to get the vax for hep BOTH OF THEM the second booster is super important without it the vax is worthless. a Its gross how companies are able to charge 50k for treatment, considering much like TB how dangerous hepatitis is. You do not want people having a, b or c and spreading that shit around. "I've heard" people buying it off the darkweb due to India being able to make any medicine with no fucks given about laws(Along with other medications). Its real and much much cheaper, customs can still take it away if they find it tho and even threaten charges on you. Would suck having the government stealing your treatment because you cant afford "their" treatment. I hate American pharma companies, only support euro/japanese ones.

@Graceii800 3 ай бұрын

@rmp3499 Жыл бұрын

In 2017 I was prescribed Zepatier for Hep c. It worked well for me. Viral load tested zero virus 3 times after meds were finished.

@Mattatron-kx1qn 11 ай бұрын

I just started the sofosbuvir today. Kinda worried about side effects. Anyone have experience with this?

@campkohler9131 Жыл бұрын

Unbelievably complicated work!

@ferashamdan4252 Жыл бұрын

شكرا لك سيدي الكريم. حلقة ممتعة ومفيدة.

@mikaljan316 Жыл бұрын

superb content!!! absolutely impressed!! great video!!

@Addictedtocollecting01 Жыл бұрын

Have I mentioned how much I love this channel? No?? Well, I do.. Thank you for all your hard work. 😊

@froodsmash Жыл бұрын

I would love a longer deep dive video from you! I would suggest a topic, but you are better at picking them than I could hope to be XD

@me0101001000 Жыл бұрын

Just for my own purposes, would you be willing to include a pastebin link in your description to a list of sources? I love your content, but I always like to do more reading, especially with something as exciting as this.

@petersouthernboy6327 Жыл бұрын

I am now ready for medical school. Thanks!

@Vicky-Hugh-Martini Жыл бұрын

11:18 Sliding in a meme I see.

@JamesMadisonsSpiritAnimal Жыл бұрын

All i know is, one day i went to the doctor, she asked me why i hadent cured my hep C, i told her i knew many ppl who went through interferon and i was scared...not of the treatment..rather tha it wouldnt work. She looked at me weird and said.."oh no we have a cure now, you take a pill for month andnits gone" It was unreal. Im cured.

@crackwitz Жыл бұрын

Nice Starship Troopers reference :D

@sean_vikoren Жыл бұрын

When you said: "...regularly injects drugs.", my mind's eye showed me a hospital, with little, sharp, sparks for every needle. When darkness blinds you, try flipping it, for size.

@TCDooM Жыл бұрын

Thanks! Awesome. Good to know! Love the show 😀😀

@blip_bloop Жыл бұрын

Fantastic episode!

@veramulatov Жыл бұрын

Ask him in New York

@kevinbyrne4538 Жыл бұрын

16:28 -- not "pro - tease" but "pro - tee - ace"

@Brighton24601 Жыл бұрын

Was about to post this. The pronunciation seems weird, but it’s because the -ase suffix is used throughout biology and chemistry to indicate a chemical that cuts something else. If you want to name a chemical that cuts a protein, it’s a prote-ase. If you want to cut a nucleotide (like DNA and RNA), then you use a a nuclease (new-klee-ace). And if you want to cut a polymer, you use a polymerase. Chemical nomenclature really likes its suffixes and prefixes.

@Brighton24601 Жыл бұрын

However, the starship troopers reference makes up for any other issues. Pronunciation is forgettable, but the heroes of Klendathu will live forever.

@kevinbyrne4538 Жыл бұрын

@@Brighton24601 -- Well, he's not a biochemist, so this little error is forgivable. His videos are always well researched and well presented. He impresses me.

@BillYenair0077 9 ай бұрын

Having my three middle fingers severed off in 2009 and a heart attack in 2015 and a rigorous heart check in 2017 my Hep C was obviously never detected in all the blond test. In 2021 I moved to a small town I like to call Mexico, Texas. I wonder if there is a connection. I’m glad I haven’t drank booze in 37 years.

@bb57365 10 ай бұрын

I sold an inferior biotech drug from Amgen in the late 90’s. The name was Infergen. Ribaviron was used as a combination agent along with Interferon to increase its efficacy. These drugs were major failures with many side effects. The main issue was the disease’s ability to mutate. I was absolutely blown away when a cure was discovered. This is why the pharmaceutical/biopharma industry is so important in the discovery of these groundbreaking discoveries.

@bb57365 10 ай бұрын

Ribavirin. He meant.

@adilsongoliveira Жыл бұрын

Loved the Starship Troopers reference :)

@BillYenair0077 9 ай бұрын

28 pills of Harvoni cost $33,000. That’s right 33 THOUSAND. I can’t afford one pill, let alone 2 months worth. I told the prescriber “looks like I’m gonna die from this keyrap”. He sent my prescription to UPTON, an organization that may qualify me for $5 co-pay. It’s my only hope for now.

@maxheadrom3088 Жыл бұрын

I had friends who died because the side effects of the first treatment were unbearable. Nice video! Thanks!

@6thface Жыл бұрын

Having to take a pill the rest of your life is hardly a cure.

@RainbowLovingRainbow Жыл бұрын

This kind of reminds me of HIV in a way. RNA viruses (I believe all viruses are RNA based as it has to match with another strand to duplicate, just like DNA does when a cell undergoes mitosis) don’t have great transcription checking (basically spellcheck for RNA). In the case of HIV, there is no transcription check which leads to significant changes during each replication. This single failure to spellcheck is why HIV hasn’t been able have a vaccine created. The only thing we can do is interfere with its duplication processes. That’s why HIV requires several drugs in combination as attacking the virus with a single vector leads to resistance. Gilead essentially only produces antiviral medication; predominantly HIV treatment.

@eleventy-seven Жыл бұрын

The latest Hep C cures are Proteas inhibitors and your right that they are similar to HIV drugs. They are much less toxic then the earlier Interferon Ribaviren combos.

@molinodealfonsoaceitesalfo5175 Жыл бұрын

Like Sulfamides in some bacteria...makes a malthusian method do not kill bacteria...or FUNGUS... on the other hand ...protease inhibitors has a very bad history ...im talking about AZT (zidovudine) and a lot of drugs..m

@jameshatton4211 Жыл бұрын

There is a cure for HIV and it was found for a guy that was HIV positive and had developed cancer? They put him through immunotherapy and by chance it cured his cancer and also his HIV?

@JamesChurchill Жыл бұрын

@@jameshatton4211A person being cured doesn't mean we have a cure. There are people who are naturally immune to HIV, and the case you refer to was an instance where the patient got a bone marrow transfusion from such a person. It's not something we can replicate and there are a LOT of reasons you don't want to do it unless it's absolutely necessary. Current HIV treatments are far safer, cheaper and easier.

@dannyleung2796 Жыл бұрын

I believe a mRNA vaccine for hepatitis is on the horizon but again, price is the biggest obstacle.

@pvt.ltd.yt_industries Жыл бұрын

Interesting.

@MitzvosGolem1 Жыл бұрын

Childhood leukemia now 99% curable.. Would be a good subject for this channel 👍

@molinodealfonsoaceitesalfo5175 Жыл бұрын

No endeed

@MegaChickenPunch Жыл бұрын

there are like 100 different leukemia types but yeah buddy 99%

@aljoa4350 Жыл бұрын

Im impressed by level of knowledge you have on this topic! I now wonder if you studied any medical or biology related major.

@mkedzier123 Жыл бұрын

$1000 pill - but only in US. In countries that have public health system prices that public health care provider pays are much, much lower. US health system truly is broken.

@flaminiasantuzzi231 Жыл бұрын

Can confirm. I'm Romanian, my dad took it some years ago (Harvoni). It did not work because of the shitheads doctors that didn"t test him to find out the virus' genotype( it doesn"t work on all genotypes). But the public insurance agency paid for his treatment. He's now 71, had Hep. C for 29 years now.

@saintbman Жыл бұрын

I wonder why Dr Qui-Lim Choo was not awarded the Nobel Prize

@tcveatch Жыл бұрын

Protease has three syllables

@carloschau9310 Жыл бұрын

How are you able to research, understand, and present things in this easy-to-absorb manner I could not understand

@jjackmanster Жыл бұрын

Great history but incomplete. What is the current cost of the drug in various countries? It is my understanding that Gilead soon began selling Sofosbuvir, then Harvoni, at sharply reduced prices to national health systems. I recall hearing that a full course of one of the cures was made available in Egypt (which has a high incidence of hep C) a year or two after the drug was introduced. To cite the intro price of $1000 per pill without noting the dramatic price cuts is unfair to Gilead.

@justasjagminas1362 Жыл бұрын

Any plans for a video about Lithuania's laser industry?

@MikeGaruccio Жыл бұрын

Excellent video! Curious about the statement at the end about eradication requiring a vaccine though. If the existing drugs represent a cure, and non-human infections aren’t a major concern, wouldn’t it be possible to eradicate the virus with aggressive treatment? Obviously not an easy thing to do, but neither is vaccine based eradication.

@JohnDuthie Жыл бұрын

Cure =/= Vaccine. One is to fight an existing disease rather than immunizing for protection against future disease.

@pwnd331 Жыл бұрын

i find it odd you would not eleborate and make sure everyone understands how bad the price is, since like you said, it is the one compotent holding back most of its effectiveness. the fact this company was bought and prices hiked to get a maximum profit from a life saving drug. the monetary cost of saving millions of lives....if the government for example had just bought and released the patent. its mind blowing how many people are dieing for a profit which 90% of goes to a couple hundred millionaires...