Hyperthyroidism Overview (causes, pathophysiology)

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"Hyperthyroidism is defined as elevated Thyroid Hormones (TH) in circulation. Thyroid hormones are important hormones in fetal development and also metabolism. So high thyroid hormone levels as you can imagine will amp up metabolism to a point where it becomes pathological. Hyperthyroidism and thyrotoxicosis refers to the same thing really. However some define hyperthyroidism specifically as increased synthesis of thyroid hormones where as thyrotoxicosis refers to the clinical syndrome of excess circulating thyroid hormones, irrespective of the source. In this video hyperthyroidism will mean high levels of thyroid hormones in circulation causing the signs and symptoms of hyperthyroidism.
Understanding the physiology of the thyroid gland, the hypothalamic, pituitary thyroid axis is important to understanding hyperthyroidism
thyrotropin-releasing hormone (TRH) stimulates the synthesis and secretion of thyroid-stimulating hormone, TSH), which acts at the thyroid to stimulate all steps of TH biosynthesis and secretion. The THs thyroxine (T4) and triiodothyronine (T3) control the secretion of TRH and TSH by negative feedback to maintain physiological levels of the main hormones of the HPT axis.
In hyperthyroidism there is elevation of circulating TH this means there will be a negative feedback loop causing a decrease in TRH and TSH"
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[@gloriag3991]

Crazy how all y’all out in the comments here cuz of a test of some sort & then there’s me: trying to understand what I’ve been diagnosed with 😬 best of luck to every single one of you.

[@jaxbeez08]

I'm super glad that you are doing your research. My son was diagnosed with NF1. If that hadn't happened I wouldn't have become a nurse, and I wouldn't be on Armando's youtube channel watching his video so that I can continue on my next step in higher nursing. Crazy how one moment can change everything! Take your moment, girlfriend, and run with it! So proud that you are learning about it instead of letting others tell you what you "need to do" now. So proud. Good luck!

[@eldelaguacate6705]

well... i'm here cause i'm always so hot that i thought i had this disease lol

[@conniekingston1490]

Thank u .. it’s scared me because they told me I need to be on meds and I’m 19

[@MrsKAS1]

Same here

[@MagiDow]

@@conniekingston1490 i was on those med at 8 years old. I still am to this day now im 20.

[@surajchaubey9653]

Excellent description and very useful information for quick revision. Would love to see a detailed lectures on topics like this...

[@howtomedicate]

Great drawing! It makes your explanation so much clearer! Thank you 👍

[@cooperbrain5446]

All thanks to dr moses on youtube channel for curing me from hyperthyroidism......

[@Lucerozeus]

quality video as always. Thank you Armando.

[@rfqnnda]

this is so understandable and interesting especially for me who an audio visual type in studying, and very helpful for my daily task thank you

[@amatullah.rodaina]

Thank you a million times over! Your videos have been a great help,may God shower you with many blessings,we're forever grateful for the superb content you offer us

[@mirzainternational2023]

Just a question, can we marry a girl who has hyperthyroidism, I heard it effects the pregnancy ?

[@07_prahapsarirupadha67]

You really make it all come easy, thankyou so much!

[@neurosurgerypassion2139]

Thabks for all the help ur doing to medicos across d world ..long live ...god bless u

[@solutionpharmacy]

You are the BEST sir

[@rigrentals5297]

Coincidence i was studying pharma topics on hypo/hyper-thyriodism... I think not. God bless you sir. cant wait for next video.

[@alhanoufa7070]

I have a CD about the etiology and pathophysiology of hyperthyroidism. So thank you a lot 👌

[@aliciapoh4885]

Thank you so much, this is really useful! Your videos always help me to understand better.. so much better!!

[@emmakross9504]

It is heart warming to hear silence again without sound disturbance, all thanks to Dr iyaremoses on KZbin channel for his herbs remedy.

[@vishwasd1744]

Best way of teaching.... easily clears the concepts

[@TheTovin]

Thanks again Armando!

[@xAzntygerx]

Amazing!!

[@AnsuyaAnsua]

thank you for your kind information

[@amirza1981]

5 O'clock in the morning... Getting ready for my Pathoanatomy II Exam which includes also the Endocrine System... What else to do then to watch the amazing Armando Hasudungan on 2X Speed. Thx for your amazing videos.

[@howtomedicate]

Haha, I always put on 1,25x. 2x is really next level 😀👍

[@lioong3433]

Good luck!!

[@healthdiscovery7259]

good luck

[@663e2a]

non native here, even 1x speed im barely understand. better to rewind a bit than putting on 0.75x speed

[@NamasteAnni]

Im super scared to go to examination tomorrow. Love from germany. I have 0.01 tsh!!!

[@bubswilliams]

Thank you for the info mate

[@ruchiragarodi6191]

Excellent lecture

[@sama_albairmani]

As always, YOUR ARE THE BEST 😩❤️

[@dominicmiller3700]

Writing from Canada I have had a lot about Dr iyaremoses on KZbin channel herbs medication that it has helped a lot of people get rid of hypothyroidism in just 21days

[@elitokihaste]

Amazing videos and amazing help

[@lalitatehlan]

Beautiful explaination 👍

[@shyamalyashodarasrikantha8589]

Very excellent presentation Thank you❤

[@williamgreenough3491]

Thank you so much, you've basically got me through first year year of medical school with your videos!

[@radia96]

Brilliant video, thank you so much!

[@yogayantra]

thank you so much again

[@hassanjan2194]

Very well explained sir

[@adelaidagaitan4941]

Best video ever

[@imakemusique]

Hyper-excited about this one!

[@MagiDow]

@Tara King i thought it was an illness. Yeah it is no fun since its genetic with my family... Now im born with and meds on it. No cure...

[@Shadow77999]

No pun intended of course

[@cualquiera5187]

@Tara King shut up

[@michellelumiguid5054]

Hello, here to make pathophysio of our cae, thanks for making this video!

[@ndumisomkize174]

Excellent 💯

[@khushboosharma8682]

Thank you ! For this video but i think you should include signs and symptoms also 💜

[@sheulidesiraju6645]

Can you please do a video on Hypothyroidism as well. Thank you Dr

[@thomas.02]

why do people shy away from negative feedback when it is crucial to balance in life

[@alexb-qu3mn]

Thomas Chow hahahaha

[@gustavjanwanggai1674]

Thank you very much for your channel. I just found out that I have Hypothyroidism. It all makes sense now, why have I felt like trash this past year. I was lucky that my hair didn't fall out, but the other symptoms were spot on. I just subscribed; and I'm really looking forward to learning more about this and finding out how to balance myself. There's no more mystery to hypothyroidism. We now know how to deal with it. And thousands of people like you are proof of that. Click here for more information : tinyurl.com/yyycc6rd?HUgio4 >

[@I.am.hooked]

Cuz no one wants to be criticised.

[@thyroidhealing2118]

Love your video! I have started following a diet for 90 days which will completely cure Hypothyroidism if I follow it the right way. It may take longer than 90 days dependant upon how severe my condition is. I am on thyroid meds for 13 years now and I can't wait to take them off any live my life freely with full of energy and zeal!

[@thegoatee6380]

what kind of diet is that? I'm interested to know, please

[@mrakashsingh3938]

Plzz help

[@cooperbrain5446]

All thanks to dr moses on youtube channel for curing me from hyperthyroidism....

[@adilhusain8826]

thanks a lot

[@nareshrathod7489]

Salute to you and your efforts sir for making concept easier to understand. ❤

[@realitydoinz9656]

I am amazed by the effectiveness of the herbal medicine I got from #driyaremoses on KZbin channel, in just two weeks of taking his herbal medication am was cured from hypothyroidism

[@hamreenalmohammad7020]

Awesomeeeeeee . Thank you

[@TariqKhanzaland-mq2fi]

thanks

[@agathiyana3851]

Sir.....please made video on anti arrhythmic drugs

[@louiss.6775]

Wooooow man !!! very clear lecture !!! thanks you're doing a great job

[@caracook2829]

Will you do one one hypothyroidism?

[@brk0093]

Useful one Armando , plzz make tutorials on nervous system , etc

[@aenbiology-lovers7641]

I couldn't find any video of Hypothyroidism. Did you make it sir?

[@kavitharamu2465]

Armandeeeeyyy 🔥🔥🔥🔥🔥bha

[@DrAli1105]

Sir you are a magician I wish I could teach like you Love from Pakistan

[@dariusrucker2360]

I am so happy to beat my hypothyroidism with Dr iyaremoses on KZbin channel herbs medication

[@emilphoryew9436]

My TSH is .29 but T3 and T4 are within range. What does this mean?

[@nataniasorara6551]

Can u add subtitle please?

[@gr.10adorinaagaci96]

I really admire your intelligence ❤️

[@dantejracera2003]

thanks

[@roymarbun4444]

Horas, Thanks Lae

[@Anousha351]

Which book he uses??

[@isuenarde]

Its a very nice video sir.. Do u have any video on hypothyroidism?

[@hassanjan2194]

Yup he has

[@SR-tu2pb]

Sir please Upload Video on hypothyroidism sir

[@carola5644]

5 weeks ago my FT4 was 12. Now it is 64. (Upper lab limit is 22). What would cause such a quick increase? I feel awful; nausea, vomiting, shaky limbs, super hot, fast resting heart rate of 110bpm. I had 10 days of breast cancer radiation after DCIS in breast diagnosed and after a large area lumpectomy with LICAP reconstruction. Could the breast radiation have played a part? I've had several Hpyerthyroid episodes since my first child was born 17 years ago. Endo though it was graves disease triggered by post partum... But no spells for past 7 years. I'm the worst i have ever been now and I've been hospitalised by it in the past.

[@letni9506]

Is it normal to have extreme fatigue with hyperthyroidism. The doctor said I was definitely hyper and my levels were quite high. Didn't ask for the numbers as i didn't feel the need. But I can't do any form of exercise without feeling sick and feeling absolutely exhausted afterwards. I thought I should have too much energy not too little?

[@Jay-uo1sn]

I asked my doc to do a full thyroid test but she says its anxiety

[@allirahope4417]

me too :(

[@neurosurgerypassion2139]

Expecting microbiology videos armando ..:)

[@maimunabano9873]

Why don't make vedio on hypothyroidism.. waiting sir🤐

[@huzaciciniyuger633]

In general, the cause is a lack of nutritional intake in the form of iodine or iodine. It can occur after consuming large amounts of iodine which induces a mild enzymatic disorder which causes inhibition of hormone synthesis in the thyroid gland. Other causes can include: - Radiation used to treat certain types of cancer - Medicines used to treat hyperthyroidism - Gene mutation with expression in the form of thyroperoxidase, a heme-binding enzyme found in the tyrocyte membrane. - Mutation of the DEHAL1 gene with an expression in the form of iodothyrosine deiodinase, an enzyme that takes iodine molecules from the residue of iodothyrosine compounds for hormone biosynthesis by the thyroid gland. Some of the common symptoms of hyperthyroidism are fatigue, muscle cramps, depression, pallor, goiter, osteoporosis, and lack of sweating. Patients experience decreased heart rate, decreased contraction power and diastolic function, decreased cardiac output and increased systemic vascular resistance; which causes an increase in diastolic pressure and a decrease in systolic pressure. The sooner you start, the sooner you can restore your health. And that's what you want, right? For more information, please visit: ♠_♣ tinyurl.com/fstyhtrye?fesgzreaw > ♠_♣

[@mirzainternational2023]

Just a question, can we marry a girl who has hyperthyroidism, I heard it effects the pregnancy ?

[@ScuzoidMelee]

A month ago I could lift my legs out of bed. After a lot of struggle, finally got to the hospital. Elevated T4, very low potassium, clean MRI, clean auto-immune disease results. None of the 4 doctors I saw a month ago mentioned iodine, so I assume my levels were appropriate? Went on Methimazole for a month, but at least 20 of the past days one of two scenarios would happen. In the morning seemingly random muscle groups (although never biceps, back, or shoulders) would experience near paralysis from the moment I woke for about 3-5 hours. These muscles wouldn't ever be in pain until I tried to move joints associated with the muscle. I'd be able to move these joints 1/10th or so of their normal range before they'd just hit a wall where no matter how much I forced it, the joint wouldn't move any further. The other possibility for the day was in the evening, seemingly random muscle groups (although never the back or abs) would behave as if I went very heavy at the gym on these muscles the day before. I'd have full mobility with these muscle groups, they just were incredibly fatigued. Highly elevated heart rate throughout all of this, although it's certainly possible this elevated heart rate existed for at least a short time before the hospital visit a month ago. Blood pressure has been perfect throughout. Currently waiting on a new set of blood work and a call from the endocrinologist. Given that the reason I searched this video is because the paralysis happened again this morning two days after my last Methimazole, seems likely that medication did nothing for me. Male, 39.

[@krizziapanuelos4985]

How r u now

[@ScuzoidMelee]

@@krizziapanuelos4985 Ended up on prednisone. First night was terrible. Then the whole hyper thyroidism was gone. My endocrin doc has no clear explanation as to why any of this happened, or if she does, she's keeping it to herself until/if it ever comes back.

[@SheynneDavis7723]

Hi my result in FT4 is 26.66 does this mean I have hyperthyroidism

[@krizziapanuelos4985]

@@SheynneDavis7723 if it is higher than the reference value then yes. I have elevated ft3, ft4 and low TSH. My doctor diagnosed me with Hyeprthyroidism.

[@SheynneDavis7723]

@@krizziapanuelos4985 what happens po pag hyperthyroidism. Lalaki ba yung thyroid natin like yung May goiter?

[@zzzzzzzzzz6381]

thousands of videos but cant see how we get hyperthyroid .. is it because of smoking? eating rice? smoking weed? drinking alcohol or thinking negative things?

[@bhaveerathod2373]

i have all of the symptoms except for a higher metabolism? this is very frustrating because ive been doing so much for weight loss but i just can't lose it instead im gaining???

[@jinmin3471]

It's probably bcs of ur meds side effect or other issues

[@Sertao2013]

Can hyperthyroidism cause woman to have hot flashes ? If so how do you stop it from causing it to happen ?

[@cocoreo89]

QUESTION: I believe overdosing on Levothyroxine made me hyperthyroid.... is there a cure? I was fine before my doctor put me on levothyroxine for no reason. I am no longer taking the medication but now my new doctor wants to put me on Methimazole for hyperthyroidism.....HELP!

[@nelsonjv1]

Hi I took methemizol too found out I was allergic to it swollen hands and more specifically swollen joints couldn’t even dress my self. Make sure to test if your allergic to it alternative to meth would be Propelethulicyl or PTU for short.

[@cocoreo89]

nelsonjv1 oh wow ok good to know. I’ll have to ask my doctor next month. Thanks!

[@cindybrown3920]

I have an isolated case of a high T4(5.2), T3 and TSH are within normal range. What could this mean?

[@SheynneDavis7723]

I have the same question my my FT4 is 24.66 and 1.57 TSH

[@brooketaylor6469]

Have you ever tried herbal medications it worked for me with no side effects whatsoever with the help of DR MABOSA HERBAL on KZbin

[@TheTardisDreamer]

I potentially have multiple problems with my thyroid and can certify that thyroid problems are awful and frustrating and difficult to diagnose sometimes. :/ It's been about 6 months since I was first found to have hyperthyroidism, and I still don't have a concrete diagnosis of what is going on. I could have two issues going on. And taking six tablets a day of a beta blocker just to mask some of the symptoms is a bit annoying.

[@sergioalvarez5349]

How are you doing now?

[@anirudhhasinghpanwar682]

You good now?

[@smruthinarra6170]

One thing, Pituitary adenoma already indicates it is a benign tumor, so its not like it can be benign or malignant...if its malignant its called pituitary carcinoma...otherwise great work!!!

[@Karma-wg5he]

I’m confused about myself, I’m 15 and my thyroid level a year ago was 2.5 which my doctor said is very high and I should be extremely skinny because of how fast my metabolism should be. A little while after I started losing weight but in the span of 2 months I only lost 36 pounds. I was 154 previously (I’m 5’7 so I’m not obese) so yes I became slim. After a while I noticed I gained 20 pounds very quickly (4 months after) I figured that my thyroid hormone was either becoming normal or running out. I wanted to find out so I got retested about a week ago and I figured out that my thyroid is at 1.8 which is still high but not as severe as it used to be. Even at the current level that it is my doctor said I should be very skinny. I haven’t lost any weight in a while Infact I gain weight easily. I don’t have an autoimmune either so I’m very confused? Why would it ever cause weight gain?

[@naomipaterson9300]

I’m not a doctor, but if you’re 15 then you’ve still got a lot of growing to do, it will likely fluctuate anyway until you’re fully grown, thyroid issues may cause more fluctuations too, but it’s good to keep a record and go back to the doctors if it’s drastic changes :)

[@kiraPh1234k]

"in the span of 2 months I only lost 36 pounds." That is extremely fast weight loss. More than twice what is considered healthy to lose in that period of time. That's near 4.5 pounds per week, which is about how much you can expect to lose with a 2250 calorie deficit every day, that is extreme. I'm 5'6" and 170lbs, putting my BMR at about 1750 calories and if I had a sedentary life, about 2100 calories per day to maintain that weight. My activity level puts it closer to 2700-3000/day to maintain my weight. To lose 4.5 lbs per week I would have to add in 2250 calories of exercise in every day, or eat only ~750 calories per day or some combination of the two, but any such combination is extreme. I know elevated TH increases your BMR, but I only mean to point out how extreme it sounds to say that you "only" lost 4.5lbs per week.

[@Paulina-bj1pi]

even if your organism needs bigger amount of calories, and you provide the surplus of them, you gain weight. Some people may need 2200, if they eat 2100 then they lose weight,yet you may need 2600, you eat 2700, you gain weight.

[@Karma-wg5he]

@@kiraPh1234k Yeah it was really fast lol idk what I was talking about. My thyroids are pretty normal now which I'm happy about because my anxiety and nausea is significantly lower. I did regain some of the weight and I am at 144 pounds now so I'm on a healthy diet to reach my goal and I honestly still lose weight really quickly when I diet. I lose 2-5 pounds a week but I'm not starving I'm just slightly lowering my calorie intake and eating healthier. I think the reason why I had thyroid fluctuations was because of puberty. Not long after I turned 13 (I'm now 16) I gained so much weight I think I was almost 20 pounds overweight and that lasted until I was well into being 14 then it suddenly switched, and I had high thyroid. Thank God I'm normal now.

[@kiraPh1234k]

@@Karma-wg5he Nice! Glad you're doing better, hormone imbalances don't sound fun.

[@tanzinasha4665]

❤❤❤❤

[@Hadjer_369]

🙏🙏🙏

[@yasmeenb9742]

💝

[@murigeshchandrashekarkatti3084]

1 St comment😁

[@jowettogumizama4157]

😂😂😂😂

[@kavitakavii3263]

In this video, you spread very good information. People who suffer from hyperthyroidism. It causes pain and swelling in the joints. My sister suffered from this. It makes her life difficult. But after using planet Ayurveda's product she is fine now. We recommend everyone to prefer Ayurveda. Why we use that medicines which cause side effects if we have natural treatment.

[@nelsonjv1]

What Ayurveda specifically cured hyperthyroidism?

[@murigeshchandrashekarkatti3084]

Supppppeeeeeeeerrrrrrrr

[@nasman6410]

5:15

[@nasman6410]

6:04

[@nasman6410]

10:49

[@Cin9999]

Spelling error in the thumbnail

[@floflyberlin7392]

👍

[@JDeffenb]

"Hypterthyroidism" whoops

[@mattpowless5280]

I was wondering if anybody else noticed that

[@Shadow77999]

I like how everyone in the comment section is skinny 😂

[@bardhylgjoleka7609]

How do you know that

[@marieholmes7765]

#DRIYAREMOSES CHANNEL

[@neetstudent4856]

Sir i am indian please clear English

[@beverlycrouch8864]

I got rid of my hypothyroidism 2019 September with the help of #drobaedo on KZbin much love from Huston 🇺🇸💕