The Clotting Cascade EXPLAINED!

[@ICUAdvantage]

❤ Show your support with an ICU Advantage sticker! 👉🏼 adv.icu/support 💲 10% off EACH Month @ Nurisng Mastery membership: 👉🏼 adv.icu/mastery NOTES for this lesson (and all previous lessons) are availably only to KZbin and Patreon members. Links to join both here ⬇ ► KZbin: adv.icu/ym | ► Patreon: adv.icu/pm

[@ilonaspeicher760]

❤

[@t1g3r2009]

As a Clinical Hematology Professor, I approve! Love your videos!!!

[@ICUAdvantage]

Awesome! So cool to hear this. Thanks so much Luis and glad you enjoy them.

[@ivantarandovskiy4765]

You really approve that calcium is needed for conversion of fibrinogen to fibrin? And that platelet phospholipids are not needed for prothrombinase formation?

[@fredoxychannel923]

I don't know why school teachers can't explain vividly and briefly like this. Thank you man. Keep up the good work 👏 🙌 👍 👌 💪

[@ICUAdvantage]

Thanks so much for that. Really glad I was able to convey the info so it made sense.

[@malikasha]

U mean medical schools?:)

[@fredoxychannel923]

@@malikasha yes med school,.all my doctor teachers know is to make med school a hell life.

[@malikasha]

@@fredoxychannel923 haha I see, dont give up

[@nygeek6471]

Because they don’t actually know it

[@christinafurneri9699]

Some tips to help remember : PT = tennis (played inside) = intrinsic pathway versus aPTT = table tennis (ping-pong, played outside) = extrinsic pathway Common pathway = 10, 5, 2, 1 = like $ currency Intrinsic = numbers 8 through 12 (except 10) Thank you so much ICU Advantage! You have greatly helped this pharmacist prep for hospital residency!

[@ICUAdvantage]

Thanks for sharing that! I really like the currency part! And you are very welcome. Truly happy to know I'm able to help!

[@bonniehuang8696]

Forgive my ignorance, but I thought tennis is played outside and table tennis is played inside?

[@christinafurneri9699]

@@bonniehuang8696 oops! True, I meant the opposite :(

[@igorbesel4910]

I am also teaching from time to time and really can´t get my mind wrapped around this cascade. Great Job wrapping this thing up.

[@ICUAdvantage]

Nice! Happy to help Igor!

[@josetrujillo738]

You are exceptionally well spoken: you speak very clear and explain very nicely.

[@josetrujillo738]

It is very desirable.

[@michaelmoyer1865]

“All bleeding stops eventually”, is my favorite one liner

[@ICUAdvantage]

Haha yes and it’s so true!

[@endotear]

This is amazing. Having learned this about 15 years ago, I really appreciate this concise visual representation and the explanations, makes me remember a lot of things from med school :) Thanks!

[@ICUAdvantage]

You're very welcome! And glad you found it well put together and helpful!

[@myalize1]

Out of all the videos I’ve watched . This is the best one on the cascade

[@ICUAdvantage]

Thank you! Glad I was able to do a good job explaining this rather complex topic

[@lobarita]

Watched and read many things trying to understand this, and this video was what put it all together for me.

[@medicalchalupa9928]

Started scribing in a heme/onc clinic and this video is gonna help a ton

[@ICUAdvantage]

Glad you liked it!

[@kevinmills8617]

This is excellent, from a University College London Professor of biochemistry, I also approve.

[@alejandrohernandez-bb7ct]

superb as always friend. you're the man

[@rebecagainza8399]

Wonderful explanation, thanks

[@ICUAdvantage]

Really glad to hear this and you're welcome! :)

[@BenadiBawanya]

Thankyou so much for this amazing video sir... Understood and grasped because of your clear and amazing teaching skills❤️❤️❤️

[@ObiomaFlorence-dp7js]

Thanks for teaching Really understood everything 😊

[@kenirole2433]

Incredibly easy to follow lesson... thank you

[@ICUAdvantage]

So great to hear this Ken!

[@parkerphelps5202]

Thanks so much for making this video! I was just looking into learning more about this topic the other day. I definitely have a better understanding of it now

[@hannahmacababbad5195]

I particularly enjoyed this presentation!

[@annatendai6809]

Very well simplified and understood 😊

[@RdGdGW]

I absolutely love your lectures.

[@ICUAdvantage]

Thank you so much Rose!

[@Flying.thomson]

Thank you very much sir for this valuable information!!

[@sandhyatelluri2346]

Very well explained. Thank you .

[@ICUAdvantage]

Glad it was helpful!

[@melissarainchild]

thanks for explaining something pretty complex...

[@ICUAdvantage]

You’re welcome and glad I was able to do so in a way that made sense!

[@collin4555]

Very helpful in developing my understanding of my factor VII deficiency hemophilia on a mechanistic level

[@senioracademia1947]

Woah, clear and concise thank you!

[@MariAngelical23]

I finally understand this!! 😊 🙏 thank you so much!!

[@ICUAdvantage]

Woohoo!! Happy to help!

[@MariAngelical23]

Your the best !

[@dianachen4986]

thanks it really helped!!!

[@emekaanikwo8282]

This is awesome.❤ Thanks a lot

[@rolandrojas8473]

Great lecture

[@waseemahmed6990]

Very logical and good explanation, thanks

[@fatimahassan8043]

Thank you sir 😢

[@MrBogombo]

One question, with txa it stops the process of fibrinolysis by binding with plasminogen. Why during a massive hemorrhage is the body trying to breakdown its own clots? Something I could never understand. Great videos!!

[@ivantarandovskiy4765]

Coagulation is much faster than fibrinolysis. Normally, the clot is being lysed after the vessel is regenerated. In massive hemorrhages fibrinolysis does not play big role

[@doc.asifali]

Thank you so much sir.❤

[@bahauddinbaha9045]

Any one who could comment will be very much appreciated, what software or tool has been used in the video for writing ?

[@shubhangikamble3177]

Thank you ❤❤❤❤

[@ICUAdvantage]

You're welcome 😊

[@safnasagar988]

Pretty complicated but explained well❤

[@ICUAdvantage]

Great to hear! And yes, it is quite complicated!

[@dgmnhn2098]

Thanks !

[@franknyambe3965]

You said that activated factor 11 and activated factor 12 are the ones that activate factor 7, and yet in the video illustration is showing otherwise. The video illustration is pointing at activated factor 12 and and activated factor 9. please clarify

[@blessednwachukwu7882]

I thought for a second I was the only one that saw that

[@faithbolding4597]

Love your videos!! Thank you!

[@ICUAdvantage]

Thank you Faith! ❤️

[@MrM49901]

Thabk you so much! This helps very very much!

[@ICUAdvantage]

Glad it helped!

[@cezarzagorneanu5905]

Loved it. Thank you so much 😊

[@ICUAdvantage]

Glad to hear it!

[@hersheygo7931]

thank you so much!

[@ICUAdvantage]

You’re welcome!

[@abesha9928]

Thank you

[@lobarita]

Thanks !!!!!

[@ICUAdvantage]

Yw!!

[@elishevajoseph5301]

Hello! love your videos I've been struggling with this topic for a long time. So thank you! I just have a quick (and rather dumb) question: When you were explaining the intrinsic pathway you said activated factor 12 and 11 activate factor 7 which activates the extrinsic pathway, but you drew the arrow from activated factor 9. Which one is it?😅🙈

[@ICUAdvantage]

Ahh this was my bad! It took me a minute to try and make sense of what was being asked, but once I realized my mistake it all makes sense now. I did draw it correctly, but I completely misread IX as 11 instead of 9. It is activated 9 that activates 7, along with many others. Sorry for the confusion!

[@elishevajoseph5301]

@@ICUAdvantage Thank you so much!!!

[@blessednwachukwu7882]

I'm sorta confused Is it factor XII and IX that actives factor VII or factor XII and XI? Because you said the latter but indicated the former

[@bahiachibi895]

🤩thanks

[@HOOPSZ4LYF]

Where can I find the notes please??? ❤

[@ICUAdvantage]

Hey Larysa! First off, thanks so much for your support! Unfortunately KZbin doesn't make it very clear. If you go to the main "ICU Advantage" KZbin page, then at the top look for "Community" and that is where you will find the link to the notes and the current months password. Let me know if you have any issues and feel free to shoot me an email if you still do! Thank you! -Eddie

[@mikelestala7382]

Notes?

[@michaelburatovich3199]

Every time I teach this pathway, I run out of blackboard space.

[@ICUAdvantage]

Hahaha I could see that!

[@thepalettewhispererasmr1227]

Holy craps...that's why EDDIE WATSON is the GOAT. Complex indeed

[@DavidTiptonJr]

My head hurts 😂

[@ICUAdvantage]

Hahaha yeaaahhh...... this will do that!

[@rashmeechavan8745]

❤

[@shreyansh_sdu_9362]

Flabbergasted

[@Утконос-г5д]

Thanks!!