Immunoglobulin ( Antibody) IgG, IgM, IgE, IgD, IgA in Hindi ( एंटीबॉडी और इसके प्रकार)

#immunoglobulins
#Antibody
#IgG
#medical_lecture
#dr_najeeb
Continuing Education Activity
Immunoglobulins (Ig) or antibodies are glycoproteins that are produced by plasma cells. B cells are instructed by specific immunogens, for, example, bacterial proteins, to differentiate into plasma cells, which are protein-making cells that participate in humoral immune responses against bacteria, viruses, fungi, parasites, cellular antigens, chemicals, and synthetic substances. The immunogen or antigen reacts with a B-cell receptor (BCR) on the cell surface of B lymphocytes, and a signal is produced that directs the activation of transcription factors to stimulate the synthesis of antibodies, which are highly specific for the immunogen that stimulated the B cell. Furthermore in tissue fluids and serum. This activity describes the physiology and pathophysiology of immunoglobulins.
Describe theIntroduction about 20% of the protein in plasma.
The immunogen or antigen reacts with a B-cell receptor (BCR) on the cell surface of B lymphocytes, and a signal is produced that directs the activation of transcription and serum.
The following are 5 types of immunoglobulins in humans:
IgM
IgG
IgA
IgE
IgD
Function
Basic immunoglobulin Structure and Function
Antibodies or immunoglobulins have two light chains and two heavy chains in a light-heavy-heavy-light structure arrangement. The heavy chains differ among classes. They have one Fc region that mediates biological functions (e.g., the prevention of attachment of the microbes to mucosal surfaces, and neutralization of toxins and viruses.[1]
Immunoglobulin M
IgM has a molecular weight of 970 Kd and an average serum concentration of 1.5 mg/ml. It is mainly produced in the primary immune response to infectious agents or antigens. It is a pentamer and activates the classical pathway of the complement system. IgM is regarded as a potent agglutinin (e.g., anti-A and anti-B isoagglutinin present in type B and type A blood respectively) and a monomer of IgM is used as a B cell receptor (BCR).[2]
Immunoglobulin G
IgG is a monomer with an approximate molecular weight of 146 Kd and a serum concentration of 9.0 mg/mL. IgG is said to be divalent i-e it has two identical antigen-binding sites that comprise 2 L chains and 2 H chains joined by disulfide bonds. IgG is synthesized mostly in the secondary immune response to pathogens. IgG can activate the classical pathway of the complemen system, and it also is highly protective. The four subclasses of IgG include IgG1, IgG2, IgG3, and IgG4. IgG1 is around 65% of the total IgG. IgG2 forms an present in newborns.
Immunoglobulin A
IgA appears in 2 different molecular structures: monomeric (serum) and dimeric structure (secretory). The serum IgA has a molecular weight of 160 Kd and a serum concentration of 3 mg/mL. Secretory IgA (sIgA) has a molecular weight of
It appears in mucosa membranes as a dimer ( activates the alternative pathway of activation of the complement system.[4]
Immunoglobulin E
IgE is a monomer. It has a molecular weight of 188 Kd and a serum concentration of 0.00005 mg/mL. It protects against parasites and also binds to high-affinity receptors on mast cells and basophils causing allergic reactions.[5][6][7][5] IgE is regarded as the most important host defense against different parasitic infections which include Strongyloides stercoralis, Trichinella spiralis, Ascaris lumbricoides, and hookworms Necator americanus and Ancylostoma duodenale.
Immunoglobulin D
IgD is a monomer with a molecular weight of 184 Kd. IgD is present in a meager amount in the serum (0.03 mg/mL) and has an unknown function against pathogens. It is regarded as a BCR.[8] IgD may play an essential role in antigen-triggered lymphocyte differentiation.[9]
Receptors fo
Laboratory Assessment of Immunoglobulins
The quantification of immunoglobulins and the study of their functions are vital for the immunodiagnosis of immunodeficiencies, autoimmunity, hypersensitivity reactions, and inflammatory disorders. The following examinations are routinely performed for the study of the behavior of antibodies[14]:
Quantitative serum immunoglobulins (classes and subclasses)
IgG
IgM
IgA
IgE
IgG antibodies (post-immunization)
Tetanus toxoid
Diphtheria toxoid
Pneumococcal polysaccharide
Polio
This assay evaluates the quality of the immune response after vaccination. In healthy individuals, there is at least a 1:16 titer of antibody.
IgG antibodies (post-exposure)
Measles
Varicella-Zoster
This test is to evaluate the production of antibodies against antigens after the infectious disease has occurred.
Detection of isohemagglutinins (IgM)
Anti-type A blood
Anti-type B blood
Isohemagglutinins are IgM antibodies produced by the immune system in response to bacterial antigens present in the digestive system. It has been shown that their titers may be below 1:4 in antibody deficiency disorders.

[@IndianMedicalLecture]

Notes 👇👇 gkqalf.on-app.in/app/home?orgCode=gkqalf&referrer=

[@Freefire72345]

sir ye Application hindi me nahi hai kya?

[@_shivanisen3914]

Thank you sirr

[@medilover]

I need always that kind of teachers but I never found ..... Koi bhi topic utha le apke channel ki vo smjh to Anni hi Anni h ... Thank a lot guru ji 🙏📿

[@user-ln2se7cd7p]

clg valo se fees vaps lena padega....😂

[@jyotibarwal6810]

Haaaa padatee toh kuchh h nhiiii busss timepass karke chale jate h

[@ringtoneboyd]

😅😅😂

[@surabhimaurya3506]

😂😂😂😂😂😂😂😂😂❤❤❤

[@user-lq1zr3qo2k]

Sir apke lecture mujhe bahut useful sabit hue hain in second semester MSc class mein so thank you so much sir

[@Kumarsahilsujit]

Thank you so much sir apki Hindi aur English medium ki vajah se samjh aur paper'me me bhi bahut help mili h , Bahut Bahut abhari h apke sir ❤❤❤

[@IshuThakur-le5mb]

Sir aapki class hme bahut acchi lagi

[@Realmen18]

Sir aapka jawab nahi🤗🤗🤗🤗

[@AnkitSharma-nc6gi]

Osm. Sir well explained

[@priyaraj2929]

.. j. J j jjj j jjj j j j j jj j. J j jjj j j j j j QQ

[@ishniyabehrvi750]

Keep it up

[@mohdjawadjawad8461]

Thanks so much for this information on this topic and I will definitely keep this in my mind as I get more information about this topic

[@ajaypatel4476]

सरलता से समझाए आप thank you sir 🙏😁

[@SURAJVERMA-xn6og]

Excellent 👍 👍 👍 👍

[@aminnarihatya6763]

Make some more video sir it is very helpful for me

[@shrutikumar1726]

Thank you so much sir🙏 Very amazing class

[@RajniVinare]

Very nice explaination explaination sir 😊

[@sinduvlogs]

Thankyou so much sir my girli,ivg, tritment

[@SaritaKumari-yq6td]

Hypersensitivity reaction ka video bana dijiye please 😊

[@bhaiyafiske2653]

Excellent sir 🤞 thank you much 🙏

[@dileepbaghel07]

Nice

[@JyotiSingh-vc7zc]

Well explain

[@rajanSortsvideo]

Thank you you make always this type knowledgeable video

[@srivastavharsh9809]

Explain in simple and easy way thanks sir!👍

[@anshikasingh1857]

It's very helpful.... thank you so much 😊

[@smartromantictv..1517]

Most teaching

[@ektaprajapati5689]

Osam explain video sir 👌

[@roshnidubey4160]

Your explanation is very helpful for youu and thankuui for this good explanation

[@pukugour2738]

👍

[@champadhali6746]

Thank you so.. much sir🙏

[@anshitashukla5497]

Thank you sir your video is very helpful ❤

[@user-xt4sb2qt6h]

Thanku so much sir🙂☺️🙌

[@divyeshkarmur33]

Wow! I what a explanation

[@ragineebisen7480]

Exelent explain 🙏

[@nursingstudent816]

Nice study 😊😊😊😊

[@pinkinagar6333]

👌👌

[@aminnarihatya6763]

Osm

[@smileyvlog2416]

Very well explained ☺️

[@manishajadeja502]

Thankyou sir apki class must h ese hi vedios bnate raho😊 or hame bhejte raho

[@RahulSulya]

very nice sir ji

[@user-fp6nq1sv8w]

Nice sir you are best teacher ❤

[@ankitaagrahari658]

Thanks sir it's is very easy language explained 🙏🙏🙏🙏🙏🙏🙏🙏🙏

[@mohdjawadjawad8461]

Again thank you so much for your time with us we appreciate 🎉

[@jahnavisingh6038]

Amazing explain

[@arunmeghval3732]

Sir aap bhut accha pdate ho❤

[@PoojaSinghParmar-gc3kd]

Your explanation way is very easy thank you sir. For explain in easy language 🥰🙏🙏🙏

[@nimraansari4346]

Sir bohot achha samjhate hai aap bohot bohot shukriya ❤❤

[@chanchalkanel6811]

Thank you so much sir

[@PremKumar-mz2qr]

Well done sir ...

[@Realmen18]

Thank you so much sir🥰🥰🥰

[@manoramatantuway4172]

excellent 🤞

[@pakhisharma9447]

Mujhe apki class acche se samjh aati h

[@sukdevsahu9258]

ग्रेटेस्ट वीडियो थैंक यू

[@suhasniurao5944]

Thank you sir

[@KajalSingh-Ak88]

Nice one sir

[@shalini6151]

Thnk u so much 😊

[@chandawaskel2606]

Tq so much sir ji😊

[@sanjaygilhare6640]

Thank u sir ji❤😊

[@virbhansingh203]

Thank you sir ji

[@PriyaNimkar-me2yz]

Excellent

[@mirzasufiyan3047]

all dot clear ❤

[@vaishnaviawale5706]

Very nice💯

[@manjumalviya6458]

Sir very well explains

[@user-tt3dx8ww5r]

Thanks sir ❤

[@anjalibhardwaj9557]

Thank you 🙏😊

[@khushimishra1510]

Thanks❤

[@user-hf8ot4gj6w]

Thanks you❤

[@ramjanam4499]

Very nice sir

[@amitpal4000]

Thanks sar 🙏

[@jyotigautam8713]

V nice video

[@prernajyoti1130]

Thanks sir😘🥰🥰

[@nileshgaware5727]

Nice sir

[@monikasoni131]

Thanks🙏🙏🙏🙏🙏

[@vaishalimaahii]

Very well explained 👍 I'll definitely share it with my friends 😌

[@rupalinaosham333]

Thanks

[@kanchanmishra1858]

Sir you are very well teach

[@chandaniverma7363]

Thinkyou Sir

[@swatipathak4510]

Very nice sir 💯

[@Amar-fd8ek]

GAMED trick to remember all Ig ❤❤

[@varshakunwar2834]

I think prevent means rokna hota h.

[@SloWni...]

Same here 😅

[@tarunbhataniya1063]

😂

[@anjaliswarnkar_]

Sir app bsc biotechnology mein bioteck ka full course complete complete kariye sir please

[@sudhirkumarmehta8854]

Hemoglobin , structure, Function ka chapter complete video sir

[@pakhisharma9447]

Sir I am student bsc me chahti hun agr mujhe koi bhi topic mein problem h nhi kr paa rahi hun toh aap clear krne mein help kre

[@Ankit.khilery]

Prevent means stop/rokna 🛑

[@umeshchandrasemwal4922]

Me product manufacturers me hu sir👌👌👌🙏

[@vinaymehra5029]

Thank you sir ji 🫡

[@sulochanadigal]

Very nice sir👍

[@MP_16_RIDER_]

Very nice

[@umeshchandrasemwal4922]

Good morning sir 🙏me apse bat krni and product manufacturers se judna chahata hun

[@kukisimon]

Best

[@laxminpatel95]

Very nice sir but nursing ke syllabus bhi cover krke padha dijiye na sir according to the semester exam hai sir

[@raonikpawar6176]

Sir apke samjhane ka tarika bahut achha hai❤

[@rammotekam-ll7tz]

Sirhindi

[@rammotekam-ll7tz]

Mebhi notbook

[@nilamvaskale]

Tq

[@anizurislam6858]

Sir es video bmlt me jorurat hee yaa nahi

[@Shalini.singh12394]

Sir urea cycle ka vdo bna dijiye

[@reenakuldeep308]

👌

[@tulsiramlodhi9976]

Sir please pharmacology ki video banaiy

[@smartromantictv..1517]

Super nice

[@drmonikakedar350]

Asthma and other atopic conditions me IgE raised hota hai...

[@dassahab9001]

Sir please hypersensitivity and type of hypersensitivity pr video bnao

[@NehaSharma-do6ft]

Nice sir make some more video 👍

[@pakhisharma9447]

Sir mujhe apki vdo se hi nanotechnology topic complete पड़ना हैं क्या आप ये topic clear kr sakte h sir

[@pakhisharma9447]

Hindi English mein dono mein sir nanotechnology complete