Inductive Effect on Acidity in Organic Chemistry Vid 6

leah4sci.com/acidbase presents: CARIO I = Induction. The Inductive Effect on acidity in organic chemistry.
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Video 6 in my organic chemistry acid/base series discusses the inductive effect and how it impacts acid/base strength of similar molecules.
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[@340sk]

Leah your videos are amazing !! I cannot believe that I am actually starting to enjoy organic chemistry and it is not something I dread doing. Your videos are so easy to understand and so enjoyable. I am doing a pharmacy degree and there is quite a lot of organic chemistry. Thank you very much for making everything so much easier for me. I appreciate it very much!! Looking forward to more.

[@Leah4sci]

yay, so happy to help you enjoy orgo!!

[@Arethriel]

Thank you for explaining clearly, slowly, with a soothing/presentation voice, using original ideas and for having great visuals!

[@Leah4sci]

You are very welcome!

[@tanmaybamane]

Leah Fisch your Videos help me a lot and i look forward for many of your more immersing and really helpful videos... I got a lot of help in covering Orgo Basics & Naming Organic Compounds THANKS again!

[@Leah4sci]

You're welcome, I'm so happy I could help!

[@TrungLe-tb2jj]

I just thought of a great way to memorize induction. Atom wants to pull “in” the charge and “duct” tape the “ion” to itself.

[@Leah4sci]

Cool! If that helps you remember the term, then by all means! Thanks for sharing.

[@alisa9626]

Hi, I just subbed to your channel and began to explore it. It is very helpful and informative. Thank you so much for your efforts and dedication. I hope you make videos about Mass spectrometry in future. That would be very helpful.

[@Leah4sci]

You're very welcome, I'm so glad I could help! Keep checking back for new videos, and use leah4sci.com/syllabus to match my resources with what you are studying.

[@prahladkarun3641]

at 06:48,is it because of the -COOH bond being attached to an sp2 C(more electronegative than sp3)of the benzene ring that C6-H5-COOH is stronger...due to -I effect??

[@notcookiecutter6989]

great video thank you for using simple but effective explanations and providing good examples.

[@Leah4sci]

You are so welcome. Glad you liked it!

[@santiagocisnerosdominguez972]

oh my lord, thank you so much. My professor took two hours to explain this and i didn´t understand anything!! But you made me understand it in eight minutes. THANK YOU!

[@Leah4sci]

You're very welcome! I'm glad I could help!

[@ClarissaRose]

Thank you for making this video that was helpful!

[@Leah4sci]

You're so welcome!

[@varunvarma6599]

Hi, at 6:11, wouldnt the benzoic molecule have 2 resonance structures, as the benzene ring has resonance by moving the bonds 1 over? I dont understand why the resonance is the same in both compounds.

[@Leah4sci]

Yes, benzene does have resonance in the ring itself, but here we only look at resonance that helps stabilize the carboxylate anion to stabilize the conjugate base. Benzene resonating in the ring has no impact on the negative charge. Benzene resonating OUT of the ring towards the carboxylate would only compete with the O- resonating onto the pi bond thus getting in the way. This type of competing resonance REDUCES the anion stabilization as it brings MORE negativity (from the benzene electrons) towards the negative O making it less than ideal

[@ashishcherian1884]

Thank u sooo much leah....may god bless u

[@Leah4sci]

You're welcome

[@Tess-gr9mk]

You make my life better. Bless your soul.

[@Leah4sci]

Aww thank you!

[@jefftae7287]

Thank you. This helped me quite a bit w my 1st exam.

[@Leah4sci]

Glad it helped!

[@aryadebchatterjee5028]

I am a 11th grade student from India and I can say this has been really helpful to me

[@Leah4sci]

So glad to help

[@beachbuuum]

I am actually starting to enjoy organic chemistry too!

[@Leah4sci]

Great! Thanks for visiting. Don't forget to susbscribe!

[@lilcody69]

So in your Atom video I understood it as for size that the larger the molecule the more stable /happy/unreactive it is, and for Electronegativity the more EN (in the row) want to be negative to make it happy (comparing say C to O, same row different EN). However here I am interpreting it as the more EN in a group is the stronger one. ex @3:45 . They aren't in the same row, but are in the same group so I am trying to figure this out.

[@Leah4sci]

These are great thoughts. Keep in mind that this video discusses the inductive effect, in which a halogen is placed downline from an acidic proton. This phenomenon is different than the comparison of the atom that the acidic proton is directly bonded to. (Which I discussed in the video you mentioned.) Since I don't offer tutoring over social media, to get help with questions like this and more, I recommend joining the organic chemistry study hall. Details: leah4sci.com/join or contact me through my website leah4sci.com/contact/

[@THEaIexaIvarez]

you are helpful thanks for your help!

[@Leah4sci]

You are very welcome!

[@aarshilangalia8982]

THIS IS AMAZING, THANK YOU

[@Leah4sci]

You're very welcome!!!

[@taracheng345]

Hi Leah, I'm not sure if I'm understanding this concept correctly but even though chlorine is more electronegative than bromine, bromine is much larger in size affecting stability of the atom. Therefore bromine would be more stable. Doesn't mean that the structure with bromine is more acidic/stronger acid? Thanks

[@layanification]

+Theresa Sengpraseuth you are right. Electronegativity matters, but for atoms in the same group, the increase in size increases polarizability which increases stability ( ie Cl vs Br). However, this is only if the atom is attached directly to the acidic hydrogen

[@hudamh7479]

Theresa Sengpraseuth but it is not the one attached to H

[@YoyoBear12]

thank you all so much!!! i had this exact question

[@WwSugarCreekwW]

Thank you! great video

[@Leah4sci]

You're very welcome!

[@randaburaideh4905]

thank you for clearing things out

[@Leah4sci]

You're very welcome!

[@meeowdy]

very helpful, thank you!

[@Leah4sci]

You're welcome!

[@christinenguyen856]

Hello, Leah can you explain to me why alkoxide is a stronger base then a hydroxide?

[@Leah4sci]

I'm sorry, but I don't offer tutoring through KZbin comments. For help with this and more, I recommend joining the organic chemistry study hall. Full details: leah4sci.com/join

[@TheJacinta20]

Does the electron-withdrawing group weaken the O-H bond? If so, why?

[@Leah4sci]

For help with this and more, I recommend joining the organic chemistry study hall. Full details: leah4sci.com/join

[@el-crucio6223]

Great concepts

[@Leah4sci]

Thanks!

[@maxkonto9462]

so good...

[@Leah4sci]

you're very welcome!

[@muhammadhasan1253]

is it the reason for two acidic amino acids having different pKa?

[@Leah4sci]

I'm sorry, but I don't offer tutoring through KZbin comments. For help with this and more, I recommend joining the orgo study hall. Full details: leah4sci.com/join

[@chhayamukherjee5866]

Which of the HC-COOH and H3C-COOH will be more acidic? And why??

[@Leah4sci]

I'm sorry, but I don't offer tutoring through KZbin comments. For help with questions like this and more, I recommend you join the organic chemistry study hall. Details: leah4sci.com/join

[@al23057374]

Another great video!!!!! how u got 2 thumbs down I will never know. Maybe they thought you explained it too well?

[@Leah4sci]

lol, thanks so much!

[@pg7619]

im a bit confused on 3:51 isnt the Br stronger because its a bigger atom than Cl as stated in the previous video

[@onepunchkatz6789]

that trend only applies when a halogen is only bonded to a hydrogen aton.. eg HBr , HI, HCl and HF .. in this case HI is the stronger acid followed by Br ...

[@piyushranjan490]

Can you please compare the acidity of formic acid as well?

[@Leah4sci]

I'm sorry, but I don't offer tutoring through KZbin comments. For help with this and more, I recommend joining the organic chemistry study hall. Full details: leah4sci.com/join

[@kshitizsharma9285]

Good explanation

[@Leah4sci]

Thanks! make sure to subscribe :)

[@julianamoreira5729]

Thank you 😊

[@Leah4sci]

You're welcome 😊

[@crisjerichomabutas139]

Left to right acidity increase top to bottom acidity increase as size increase. Am I right?

[@Leah4sci]

You are correct! But make sure it’s not just something you memorized, make sure you understand why

[@spurti]

I have a question so if we increase the number of carbon then you somewhat increase the strength of electro negativity of carbon like adding up all the individual electronegative value of carbon??

[@Leah4sci]

No, that is not the case. Remember that a straight chain of carbons, by itself, would be completely nonpolar. (No difference in electronegativity values from one end to the other.) The inductive effect comes into play when you have a difference in electronegativity between neighboring atoms. For example, adding a halogen on to that chain of carbons.

[@spurti]

@@Leah4sci ohh thanks for clearing out my doubts.

[@NewWesternFront]

good question

[@harshmanjhu7048]

Now its clear. Thanks

[@Leah4sci]

It's not?

[@harshmanjhu7048]

Sorry NOW ITS CLEAR. 😁😁😁

[@meenabarot2037]

God bless you!

[@Leah4sci]

Aww thanks!

[@xiaotongfei4224]

Just want to be clarified, what is resonance in simple definition?

[@Leah4sci]

To learn more about resonance, make sure to watch my Resonance Structures series, especially the first video titled 'What is Resonance?' at Leah4sci.com/Resonance

[@710771able]

Thank you very much

[@Leah4sci]

You're welcome!

[@manasbharadwaj8667]

Wat abt -I and +I effect.....u were really helpful btw..thanks

[@Leah4sci]

Glad it helped! What about -l and +l?

[@ST0KED67]

Why doesnt the resonance of the benzene ring contribute to the stabilization of the acid

[@Leah4sci]

I'm sorry, but I don't offer tutoring over KZbin comments. For help with this and more I recommend joining the orgo study hall. Full details: leah4sci.com/join

[@ST0KED67]

Leah4sci Sorry no money good talk to you though

[@SamitaSarkar]

More stable conjugate base = stronger acid.

[@ST0KED67]

Samita Sarkar Samita you are mvp

[@stianclar]

What do you mean "you're not going to show that for this kind of molecule" (5:50) ? You didn't explain why.

[@Leah4sci]

I meant the resonance form already drawn is the major contributor and pulling out the electron density from the ring does not serve our purposes of ranking the acidity of the two compounds based on the inductive effect.

[@wajidaliali7782]

Ma'am Will both negatively charged atom not repel each other....??

[@bonbonpony]

They will, but they can only move apart so much before other forces kick in (like the rigidity of those sigma bonds that connect them to the carbon).

[@Leah4sci]

I would need some more context for this question. If you ever find you need help with this topic again, feel free to reach out through my website at Leah4sci.com/contact

[@suprajaganta7567]

what's the meaning of A in cario?

[@tomeekun]

Atom size

[@Leah4sci]

A is for Atom, I cover it in another video within this series

[@user-pn1or2xw6z]

Good

[@Leah4sci]

glad you liked it

[@ewwxaca]

I LOVE YOU FOREVER

[@Leah4sci]

Thank you!

[@curtpiazza1688]

🎉 😊

[@Leah4sci]

Thanks!

[@user-mm7wg2eh1i]

✅✅

[@Leah4sci]

thanks so much!