Introduction to Population Genetics - Lynn Jorde (2012)

[@dr.habibjan4702]

Very nice and informative talk.The speaker is just awesome.Thanks for the upload!

[@Alexandernoda]

patterns of human genetic variation: is used to deciphering human history, inferring individual ancestry, forensics, and finding and understanding desease-causing genes ultimate source of genetic variation is mutation ( human mutation rate is 1.0-2.5x10-8 per bo per generation, we transmit 30-75 new DNA variants with each gamete. how much do we differ? number of aligned DNA base differences in identical twis=0 unrelated humans= 1/1000 human vs. chimp = 1/100 human vs. mouse= 1/6-1/3

[@Alexandernoda]

copy number variants ( deletions/duplications >1000 bp) account for as much as do single nucleotide variants -Among populations ( how much do they differ?) allele frequencies are often used to calculate these. Fst= Htotal- Hs/Htotal Ht= total heterozygosity Hs= average heterozygosity most common genetic variants are shared among populations rare SNPs are much more likely to be population-specific genetic distance measure: Dij =Pi-Pj

[@xiongzhp150]

Thank you, great introduction!

[@shiney94]

I think the 99% of similairity with chimps based on genetics is only true for 'genes' and not the entire genome. For the entire genome, i read it was only 98%.

[@Alexandernoda]

population affiliation cannot accurately predict individual genotypes or traits individual traits or genotypes are shared accross populations and differ only in their frequenciesRace: meaninglessgenetic variation is correlated with geography and tends to be distributed continously across geographic space. race may not be biologically meaningless, but it is biologically imprecise individual ancestry provides more medically useful information tubulation of DNA equence differences among individuals

[@Alexandernoda]

sequence data permit more accurate inferences about population history -microarray SNPs are selected fot higher frequency and diversity in eauropeans -complete DNA sequences are unbiased and include information about rare variants Evidence for mixture between Neanderthals and modern humans mtDNA from 12 neanderthals skeletons showed no evidence of a recent shared polymorphisms only non-africans share DNA with Neanderthals neanderthal DNA sharing is seen in all non-african populations