Thermophysiological comfort is the capacity of the clothing material that makes the balance of moisture and heat between the body and the environment. It is a property of textile materials that creates ease by maintaining moisture and thermal levels in a human's resting and active states. The selection of textile material significantly affects the comfort of the wearer. Different textile fiber holds individual properties that suit in different environments. Natural fibers breathable and absorbs moisture, and synthetic fibers are hydrophobic; they repel moisture and do not allow air to pass. Different environments demand a diverse selection of clothing materials. Hence the appropriate choice is important, the major determinants that influence Thermophysiological comfort are the permeable construction, heat, and moisture transfer rate.