Jeff Lichtman (Harvard) Part 1: Connectomics: seeking neural circuit motifs

www.ibiology.org/neuroscience...
Talk Overview: The human brain is extremely complex with much greater structural and functional diversity than other organs and this complexity is determined both by one's experiences and one's genes. In Part 1 of his talk, Lichtman explains how mapping the connections in the brain (the connectome) may lead to a better understanding of brain function. Together with his colleagues, Lichtman has developed tools to label individual cells in the nervous system with different colors producing beautiful and revealing maps of the neuronal connections.
Using transgenic mice with differently colored, fluorescently labeled proteins in each neuron (Brainbow mice), Lichtman and his colleagues were able to follow the formation and destruction of neuromuscular junctions during mouse development. This work is the focus of Part 2.
In Part 3, Lichtman asks whether some day it might be possible to map all of the neural connections in the brain. He describes the technical advances that have allowed him and his colleagues to begin this endeavor as well as the enormous challenges to deciphering the brain connectome.
Speaker Bio: Jeff Lichtman's interest in how specific neuronal connections are made and maintained began while he was a MD-PhD student at Washington University in Saint Louis. Lichtman remained at Washington University for nearly 30 years. In 2004, he moved to Harvard University where he is Professor of Molecular and Cellular Biology and a member of the Center for Brain Science.
A major focus of Lichtman's current research is to decode the map of all the neural connections in the brain. To this end, Lichtman and his colleagues have developed exciting new tools and techniques such as "Brainbow" mice and automated ultra thin tissue slicing machines.

[@IceHawk2504]

I really appreciate the effort and time put into this. Free education is the step towards a better humanity. Thank you, Jeff Lichtman, for your contribution.

[@colin_kakama]

Love to watch this as I work 😁💪 thanks for making this free , you're spreading awareness and building a better world because of it.

[@neuroraul9669]

Muchas gracias por su aporte, experiencias como estas enriquecen a la humanidad, saludos desde Chile

[@itsReallyLou]

Thank you for an incredibly informative, and at the same very enjoyable lecture! You are an amazingly pleasant person.

[@mamunbmb]

Amazing talk!

[@enricoiraldo9057]

I cannot possibly be watching this for free

[@MasterBagels100]

You can (or, may) modify the speed of the video in setting and get through the entire series much quicker

[@imeldamacias1108]

Thanks for your wonderful Informacion I’m glad you’re doing this vídeos 🙏🤗😊

[@gabrielaaneiros76]

wow great lecture

[@adamloavenbruck329]

Thanks a lot

[@mrshah2043]

Very interesting

[@leokch2009]

just curious, the video was uploaded in 2014, but dictionary that Prof Lichtman referred to is 2019 ??? @26:24

[@naimulhaq9626]

Cells get constantly damaged, needing constant repair/regeneration. I saw a U-Tube video, explaining cells in our heart producing protein ejecting phosphorous, failing which the valves get damaged. An American company marketed a medicine that repaired the valves, resulting in healthy valves. I wonder if there is a medicine that repair the muscles of the lungs, for I think my lungs and heart are weak and had a bypass already, 12 years ago. Can anyone help me please?

[@citizenschallengeYT]

23:40 cultures of our mindscape

[@ZigSputnik]

Excellent lecture but he does need to look at the camera when he isn't looking at the graphic.

[@famillejonathandespres]

We will need such a technology to revive cryonics patients, and in general more knowledge than that but good thing to have for now. :) in 2014!

[@dariagrigoryevar]

Great thanks. nonetheless i don't agree that animals don't study and don't go to "school", studies about velvet monkeys for exemple shows that young make a threat vocalisation for each flying object and later they start to distinguish predators-birds from the falling object like a leaf for exemple

[@RonJohn63]

26:45 The 2019 edition of M-W in a 2014 video. Back... to the future!!!

[@CaptainCody7]

That's why he is so smart!

[@user-nn9rl4wk8w]

Please add subtitles!!!

[@scicommlab]

Павел Головинский They are added - there was a KZbin glitch that was preventing them from showing up. You should see the subtitles option now. Thank you!

[@leif1075]

@@scicommlab Why does he say humans are not that intelligent around 23:00?

[@darodarius5196]

why is a guy like me a garbage boy keep listening to presentations like this with immense passion?!

[@poolplayer3446]

21:43 "In fact for us it takes about a year to walk. There's no other animal that takes so long to walk." - How about chimpanzees? He oversimplifies development and learning of other animals, although it may be just a "hypothesis"

[@sg-km4hv]

this professor doesn'tknow much about brains

[@RonJohn63]

He seems to be a strong believer in "tabula rasa", which has been discredited even in humans.