Journal Club: The Ketogenic Diet Reshapes Cancer Metabolism & the Gut Microbiome | Ep.58

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In this journal club episode, Victoria Field is joined by Dr. Angela Poff and Dr. Dominic D’Agostino to dive into two groundbreaking studies shaping our understanding of metabolism and its role in health and disease. The team explores the nuances of a recent randomized controlled trial on ketogenic diets, free sugar restriction, and their effects on glucose tolerance, lipid metabolism, and the gut microbiome. Then, they tackle a cutting-edge study uncovering the molecular mechanisms of ketogenic diets in reshaping cancer metabolism through lysine beta-hydroxybutylaration.
From the clinical implications of these findings to the potential of ketone supplementation, this episode is packed with insights for researchers, clinicians, and health enthusiasts. Don’t miss the opportunity to learn how these discoveries could shape the future of precision medicine.
🔍 Study 1: Ketogenic diet but not free-sugar restriction alters glucose tolerance, lipid metabolism, peripheral tissue phenotype, and gut microbiome: RCT www.cell.com/c...
🔍 Study 2: Ketogenic diet reshapes cancer metabolism through lysine β-hydroxybutyrylation: www.nature.com...
Referenced study related to cardiometabolic health - Carbohydrate Restriction-Induced Elevations in LDL-Cholesterol and Atherosclerosis: The KETO Trial: www.jacc.org/d...
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In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. Listen to this episode on your favorite podcast player, and if you like it, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!

[@margaretoconnor874]

Have been following Dominic for a long time, originally on Diet Doctor, and as a non science person, appreciate the work he is doing on the importance of keto. Also love the cancer connection and metabolism that people don’t want to listen to. Excellent podcast and keep up the good work to all of you.

[@MetabolicHealthSummit]

Thank you for sharing that and for being here! We really appreciate you listening!

[@lavenderlamp]

This is fascinating stuff. I'm going back to keto because it did seem to have a regenerative impact. And plain and simple, I felt good on keto. I'm 67, just retired from the corporate world, opening a small business. Gotta keep the brain and body moving at their peak!

[@homomorphic]

Keto is just the natural diet. You went "back to" whatever it was when you were doing when you weren't keto. Ketosis is just a normal metabolic state for the human organism.

[@lavenderlamp]

Agree! I went off track last holiday season and stayed off for a year. Totally my fault and being hooked on sugar and carbs.

[@prunelle19]

Seems like these 2 papers are excellent news, providing evidences and a lot of hope for cancer patients

[@MetabolicHealthSummit]

We agree!

[@prometheas]

What a great ep. Love these journal clubs.

[@homomorphic]

I have been free sugar restricted (but not carb restricted) keto for 2 years. It is fricken amazing. m 60yrs LMHR no meds BP: 100/70 ALT: 16 Fasting insulin: 2.9 Fasting glucose: 75 A1C: 4.9 ACCAM IMT: 0.68 hsCRP: 0.9 LDL: 112 ApoB: 110 VO2 Max: 64

[@johnbierma9834]

Yes that cancer paper is profound‼️. Having the lay translation is so valuable to me👍

[@MetabolicHealthSummit]

We're so happy to hear the episode was helpful!

[@docl123]

Excellent presentation. Curious why Thomas Seyfried l' work wasn't mentioned

[@perrysebastian6928]

There are sometimes omissions made by the authors - in terms of context - but that in the end is a failure of the journal, journal editors, and the reviewers they choose. Journals market themselves to those who have funding. More citation rankings would be desirable.

[@cgaumerd]

The length and voice pitch of the advertisement are really annoying. What a turn off.

[@davidgreene8608]

I was keto before it beamed a cultish fad. After 4 years my testosterone tanked, my sleep sucked, my competitive running suffered. Could never recover. I looked like I lived in a concentration camp. I then went back to 4O% healthy carbs, 40% protein and 20% fat. My life improved within 10 days. My running times are better. Setting PRs. My muscle mass I good. Sleep good. Energy good. I now enjoy food again. Eliminating healthy carbs will cause one to end up with health issues in the long run. Goodbye restrictive living in the cult

[@ricksikora7270]

I'm like you as far as macros. My brother on the other hand has been a keto proponent for over 15 years. Absolute machine of a man, former Army Ranger. Strength, endurance, low body fat. We are all very different.

[@joyallen2415]

We were talking about cancer not gym performance

[@prometheas]

I believe your story. But your story and your body are your own, and I hope you can appreciate that a bunch of the rest of us feel fantastic and are performing brilliantly on keto. I also encourage you to reconsider characterizing folks who do find success in keto (or whatever) as a “cult”. It’s dismissive, reductive, and just outright crummy.

[@johnbierma9834]

It’s clearly a carb biased paper. It is politicized. I get so tired of the biased interpretation of the data.