Translation (mRNA to protein) | Biomolecules | MCAT | Khan Academy

[@rabihahmad5878]

If I ever actually become a doctor, I am giving $10,000 to Khan Academy. Hold me to it.

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when, not if

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Any updates?

[@johntindell9591]

you are such a honorable teacher. you have made a student like me have the opportunity to all this beautiful knowledge. you sound so passionate! i really admire how you digest the information!

[@Funymoney010]

john tindell I first saw this as you are such a horrible teacher lmao I was about to get super pissed off

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Alex Christensen fr lmao

[@tatianavbotello]

same, i was about to go off hahahah

[@praukefetry7507]

and its all for free im so happy

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Alex Christensen sameeeee

[@AveryShazz]

This is so much clearer than my college professor could ever dream of doing. Thanks for saving my education.

[@kyra1226]

I've had headaches for two weeks while my teacher was trying to explain this, and now in 14 minutes it's all clear.. thanks!

[@vicwillis4295]

always like that

[@petroslazanis8466]

God bless Khan. I literally felt like i was on heroin during my lecture today when the prof was going on about transcription/translaition

[@petroslazanis8466]

Btw, just got an A+ in this course. Praise the Khan.

[@anoosha9768]

@@petroslazanis8466 lmao ik it's late but congratulations

[@chopotronichappiness8917]

@@petroslazanis8466 Congrats man!

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Congratulations man

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[@hannahgrant325]

This man has truly taught me everything I need to know since high school. Thank you for teaching me and giving me an education better than a lot of my professors.

[@franciscasousa7284]

Not gonna fail molecular bio thanks to this 🙏

[@mmaking8664]

hahahha, same here man, does this go into deep enough detail, tho?

[@jade_be_jeweled6845]

MMA king I personally thought it was a great overview but not nearly as in depth as our class is going, great for generally understanding it though

[@mmaking8664]

U r so pretty, are u Malaysian?

[@mmaking8664]

seominty U are so pretty, are u Malaysian?

[@jade_be_jeweled6845]

MMA king lol! That's a k pop idol, not me

[@he110alison]

Good old Sal! Love his voice. These vids got me through my nursing prerequisites. Couldn't have done it without him. This is gold.

[@ShinySephiroth1]

Hands down the best possible explanation I have ever heard. You are a blessing to mankind. Thank you.

[@sachitkoirala]

This is the most clearly explained video on translation I have watched. Simplifies the complex concept. Thank you Khan Academy and the tutor.

[@orange9923]

Sir your teaching is exceptional. I have been struggling to find a good and clear explanation of translation all over youtube but couldn't find one. But guess what. I stumbled upon your beautiful and super simple explanation of the same. Thank you so much.

[@ruthnicolas8061]

God bless khan academy T.T I'm a visual learner and this is just beyond awesome!! I'm understanding, learning, AND I'm inspired by the passion of this teacher!

[@chopotronichappiness8917]

I've always had this problem with these sites in ribosome, like what are they exactly and what are they for?- and now it's clear. Sal you are a blessing ♥

[@Von-dee]

THANK U! My brain was frying up trying to understand this by myself.

[@saraabolsain1483]

like what did happened 2 me 😭

[@truebeliever174]

Me too..

[@deboisdead]

bro you are the only reason that I have not failed hon bio thank you for that

[@saviourkuade]

Why does it look soo simple here😳❤️❤️

[@Ninot97]

i love you for making these videos. such a life saver

[@rockoquels]

I love that every video he does he is as fascinated with the complexities of these structures and processes. Now I pick up plants, give them to friends, and ask, what do you see? If they aren't as passionate and appreciative as this man, I cut them off. What is your name Sir? You are amazing!!

[@kalkidansemere8505]

Life saver as always. Thanks Sal khan!!!

[@HeroDw-n2m]

10:39 AA,PE,EEEE sites that got me bro 🤣

[@yashsoni4962]

This Teacher's voice is super cool and he clears all my doubts and bdw the only reason I love Khan academy's biology part is due to this Teacher's voice

[@staffan144]

It is Sal Khan himself, who started with online math tuttorials for his relative once upon a time.

[@gracegable5597]

Great video, I will definitely pass my Cell Bio exam tomorrow!

[@vee-5697]

Grace Gable did u pass? :p

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Grace Gable 😀😁😁you have to score

[@zainabalradi2306]

if I passed my premedical year I would dedicate my certificate to you

[@vee-5697]

Zainab Al Radi did u pass? :p

[@sfashaikh1187]

Zainab Al Radi gimme ur certificate!

[@lelyanalmaghrabi2566]

beautful structures!!! i love bio.. very facinating

[@UgwuwnyiMichael]

This should be the best bio class I've ever had

[@GW-jx3cz]

Brilliant Khan, I preferred that to the last video! You're brilliant, thank you! That was the one step nobody explains well and for weeks I couldn't understand it as even the most detailed books I have just bypassed like 'ahem', or 'anyways'!!! Gold stars and medals for you! ;)

[@EnderAnimals4]

20 fewer pages of my $150 textbook I will have to read tonight. Thank you good sir.

[@ritikachatterjee8039]

what we would do without teachers like you? forever indebted to the technology advancement and teachers like you.

[@ivonnenieto8217]

WOW... My professor took TOO LONG to explain this. I needed the visuals

[@dameind.2246]

Many things missing as per NEET syllabus. But still helped me. Thanks.

[@yourfuturedocburenbeiya]

This is so awesome and so clear!! You made this fascinating process come to life and this video wasn’t even animated!! Thank you sir for all you do!!

[@stavroslv9184]

Top Tier explanation. Thank you so much. My book messed up this explanation even if it is quite simple.

[@hazeld8016]

I did not expect that video to go in enough depth for my intro to cell bio exam but it did! Thanks so much!

[@konchittavong697]

You are so good! Thank you for making this video.

[@omermohammedomer4017]

it's helped a lot thanks you just got a new subscriber

[@comedianmalyka2646]

bless him and this channel

[@SadiqHussain-cx8jv]

waaawo hates off sir, thank you so much, you are a true blessing to mankind,

[@jenniferallison4402]

Sal Khan you are a magnificent human being.

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🍔 Hamburger like..... I am hungry now.....3:53 😂😂😂

[@zafarkayani2081]

God bless you and all your team

[@phillipmills5307]

crazy how in 15 minutes i learned more than from a 55 minute lecture

[@zafarkayani2081]

Well done khan academy 👍👍👍👍👍

[@alim2756]

Best explanation ever👏

[@biba4761]

Thanks won't be enough ... I have understand more then the usual when I follow my boring teachers 💜✨ Who is here to revise for his bac?

[@fatemaelzahraasaidmahmoud987]

Thank you for teaching us how to love and appreciate biology ❤❤❤

[@gauravkarna4754]

make a nobel prize for education, and give it to this man.

[@dimplereddy5951]

Thank u soo much... Ur explanation nd teaching method is awesome.... I loved it... Nd I'm never gonna forget this...😉

[@SOhida-w3r]

You're a life saver thank you.

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Saving my life yet again :)

[@zanmak6333]

i wish you go to heaven man wherever its is love from iraq ❤ medicine university

[@areummartha1069]

Thank you so much! You are way better than my teachers in explaining!

[@tankiplayer4323]

Thanks sir I tried to learn Translation but failed… But your video has cleared all my concepts about translation.😊 May God bless you

[@kumbiraideon5505]

This is wonderful. Thank you for a simplified version of translation. Sometimes i prefer watching these summarized videos than reading a book..But i got a question in relation to the 'E, P, A' sites how is it possible that we have an Exit on the 5' yet the mRNA is run thru the ribosome from 5' 3' direction ..Can you assist on that maybe i missed it

[@AdaTrimaj]

I think it is a mistake, the 5-3 direction should be opposite in that video to make sense. Evrything else seems to be okay.

[@thepsychhike7177]

its not a mistake. the E site is on 5' bc the ribosome is moving towards 3' but the codons are still at the same place. so the tRNA which is initially on p site shifts to the E site not bc it is moving towards 5' end but bc the ribosome is moving towards 3' end and the tRNA is still in its position.

[@xochichavez4232]

At this point I should be paying khan academy for my education

[@adventurekitty1016]

I just realized I am rewatching a video my teacher played for us yesterday. Lol. I didn't realize till the T and + confusion.

[@tubhyamroy9105]

The best possible explanation u gave Hands up to this

[@pavellambracht5823]

So, theoretically all proteins start with Methionine?

[@dameind.2246]

Pavel Lambracht Yep. Without AUG, no translation occurs and no protein formed.

[@maheerkhan8500]

Wow. I didn't realize that. *BRAIN FART* :D

[@R-Tex.]

Most of the proteins loose the methionine residue in post-translation processing.

[@josephmoore4764]

In eukaryotic cells and Archea. Prokaryotes use a variant called fMet

[@graciebotsford2674]

That's exactly what I thought about, and I think you are correct.

[@maazhaji8904]

Great video, explains tRNA and mRNA interactions so well. My mind can visualize it smoothly now. Also, super interesting fact about the antibiotics at the end!

[@hipsterkitty619]

legendary biology teacher

[@elishaduggan997]

thank you!! got an exam today and it is on this!!

[@_q_sal1]

did you pass

[@rimal9305]

i find this whole process so fascinating thanks for the video its clear u are very passionate

[@mikojiang2606]

Than you SO MUCH for making this video!!! This helps a lot!!!

[@jamessears8289]

i think i missed a detail- does the ribosome float around and kind grab tRNA or are they drawn towards it? or what? how does the ribosome come in contact with tRNA?

[@riggidyrickt7574]

You teach a lot better than my biochemistry professor! Class is pretty much useless for me

[@mobina-9101]

Thia year I'm gonna take University Entrance Exam and i promise i will do my best, and after that I'm gonna come back here and thanks u cuz u teacher did so much for me ♡

[@arghghgh]

how was it

[@Mimmim-mx1py]

Wow cant believe i actually enjoyed science😂 great teaching

[@rabeaahsan2070]

During and after translation, polypeptides may need to be modified before they are biologically active. Post-translational modifications include: removal of translated signal sequences-short tails of amino acids that aid in directing a protein to a specific cellular compartment proper “folding” of the polypeptide and association of multiple polypeptide subunits, often facilitated by chaperone proteins, into a distinct three-dimensional structure proteolytic processing of an inactive polypeptide to release an active protein component, and various chemical modifications (e.g., phosphorylation, methylation, or glycosylation) of individual amino acids.

[@TankP0wnz]

That part at the end about how abx work blew my mind

[@thebeggarsdice6020]

You guys make it all so much more beautiful. Thanks Khan Academy, I'll do well thanks to you.

[@FatimaHamid-c6w]

You are the best ❤️

[@gkumar9496]

The explanation is just wow

[@miniboss6524]

Thank you for being a life saver~~ 🖤

[@paulilicious94]

Nice video. Some people may not know but proteins make up the majority of the biopharmaceutical market for use as a therapeutic

[@ranayasser3882]

Thanks alot.. that's so helpfull 👌👍👍

[@josselynramirez4443]

Super helpful I now fully understand

[@hannahrefaie9849]

Thank You, Sal!

[@ionescurazvan2233]

Awesome! Thank you

[@JS-vo6go]

Thank you so much!!!!

[@payalrathod2852]

taught very nicely...really😀😁😁💕

[@simrenjeonjkook4072]

Very nice Video...Thank you so much for This

[@mohammedburhanuddin303]

Brilliant sir Salman khan😍 From Bangladesh!

[@MHT_Official]

Thank you Sir. You are always a Life Saver in Exam

[@isabellakim7044]

at 12:11, I think you meant to say "then the A-site will be open for another tRNA carrying an amino acid" instead of "for another amino acid carrying tRNA"!

[@agnestee4261]

Thanks! This video is really helpful!

[@coolmatrix15]

we can do this fellow learners!

[@zafarkayani2081]

Very informative video

[@rebelScience]

Guys, I am still puzzled with one question: So we have Chromosomes -> DNA in a nucleus of the cell. Then, we have Translation phase where we get Proteins, but where do Proteins live? Do they live inside the cell (cytoplasm) ? So each cell creates it's own Proteins or each cell creates different proteins and they leave the cell and work 'outside' the cell? And in this case, what is 'outside' the cell? Any material/video, explaining this are more then welcome!

[@pbegum5012]

awesome. i really got it now perfectly.

[@swathibarigela4144]

So well explained 👌

[@maryamsediqi3726]

you are beyond genius 🙏🌹

[@AliHassan-it9lt]

You are a great teacher😍

[@okayokay9715]

you guys are amazing and extremely helpful

[@ainy._nad]

this really help a lot thanks

[@omarreza420]

complicated process it's a whole process how does it know to do that its amazing

[@deru6745]

god bless your soul

[@rikthipranadhik]

This means the whole polypeptide chain binds to a new tRNA at A site every time and the older tRNA they were attached to gets disposed through E site

[@haleynewbold4240]

this was SO helpful thank u

[@aashithapa1913]

You are Amazing. Thank you so much 😊

[@amenostalgique]

this stuff blows my mind

[@jayzelapy]

thank you, your voice makes me sleepy haha