Cooperativity | Biomolecules | MCAT | Khan Academy

Created by Ross Firestone.
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[@nmubunny5975]

I thought the pacing of this video was perfect, but that's just me. I likes that he didn't spend tons of time waiting for him to write stuff out and I could focus on what he was saying vs trying to write it down. Great video!

[@muntahanoormuskan6431]

Couldn't agree more. Why would people think this one's fast? I usually have to speed up the other ones while watching, and still get bored.

[@michaelchada4561]

Great explanation. I feel confident now. Thank you Medicosis perfectionalisis

[@shreeji90]

so whats the hill coefficient? thats what i came here looking for

[@sophiahill3715]

same

[@cameronclifford2477]

Hill coefficient (nH) measures the degree of cooperativity between subunits that bind the ligand in multisubunit proteins

[@m.t1446]

same xD

[@thelastcipher9135]

The hill equation is a function of ligand molecule, say X, such that it's output ranges from 0 to 1. In particular, it's an approximation of the *fractional saturation* which is a ratio of the number of occupied binding sites to the number of binding sites.

[@belindaenow8516]

This was so so explicit. Thank you

[@dragonscape99]

Very helpful! Thank you! But a going a little slower would definitely help.

[@shmkrar1153]

Thank you so much

[@radio146]

Awesome! Please keep doing what you are doing!!

[@AM-rf3zn]

Are we assuming here that active sites are only binding to a specific substrate? (Because Hemoglobin has a greater affinity for CO than O2)

[@WiamWiamlovesJapan]

Hemoglobin is not an enzyme they just share the same allosteric inhibition concept

[@AngelofNever]

Can anyone explain why "non" cooperativity is considered a kind of cooperativity at all?

[@miruz3448]

eh, 3 years later, but essentially it's because when calculating Hill's coefficient and you get a value of "n = 1" then, that protein that you're analyzing doesn't have any coop, essentially it's non-cooperativity. On the other hand, a value of N

[@anitasrivastava17]

EXCELLENT

[@torvoldsvenson1539]

Ya the old style was so much better, doing everything in real time, this is literally like trying to learn by watching in fast forward

[@misssweethearted]

very good!!!!

[@robotikempire]

how is non-cooperative a type of coopertivity. That makes no sense. it doesn't exist but it's still one of the three types.

[@rockface112233]

at first I'm like this gut is way too excited.. then im like woah this is interesting

[@allaalbonijim2748]

I love you.

[@TheJellyFish1000]

Uhh what class was I supposed to have learned this in?

[@Benboy887]

I learned this in a 400-level biochem class which was the first and only biochem class, which was geared towards biology majors, I had to take during undergrad. So I think that may be the same in your case or perhaps you could have seen this in any other upper-level biochemistry course

[@sabgg8794]

I'm learning it in 10th grade idk about u

[@nancygrey23]

how come the active site saturation doesn't increase linearly as concentration of substrate increases?

[@thedarkrose26]

because the when the enzyme has more substrate bound to it it's not able to bind any more substrate to it so its ability to bind levels off

[@senaydaniel6350]

It’s either am slow as hell or this video is fast as hell

[@Minerve426]

Next time, please slow down. The person that was speaking was talking too fast.

[@DUllaBilLa]

slow down your speed

[@cherrie9587]

Are you serious 😂 I need to speed it up to 1.5x to make it bearable..

[@iztibamallikdeeba6914]

Why u had to speak so fast!

[@lucius7872]

.....damn. cant follow these kind of videos that only use letters and numbers. Next time, please use diagrams. thanks.

[@hovhadovah]

Agreed, this was very confusing

[@frankmonney5981]

+Lindsay There were graphs for both of the proteins that he talked about. and those that say its too fast, they can reduce the speed of the video or pause and take notes.