Lactic Acidosis | Lactic Acid | Lab 🧪 ...Why your muscles 💪 get sore! 😱

[@MedicosisPerfectionalis]

🧠 CNS Pharmacology: www.medicosisperfectionalis.com/ 💊 Antibiotics Lectures: www.medicosisperfectionalis.com/

[@rohikhan5848]

Please guide me about lactic acid by genetic How can we reduce it My 9 year child has high lactic acid and some brain cell abnormalty issues please please reply me I am so warid about my this

[@riamustika6741]

I watch your videos three hours per day, and it's almost everyday in this month. Your videos are really awesome. I am just dissapointed why I am too late to find this channel. Thank you so much for all your videos.

[@MedicosisPerfectionalis]

I am honored! Thank you 🙏

[@wml4928790]

You, Sir, are amazing. I am a nursing student and although the information presented in your videos is generally more than I need to know for nursing school, I love to learn the pathophysiology of how the body works. You are very good at explaining and make learning entertaining. Thank you so much for all you do.

[@MedicosisPerfectionalis]

I appreciate you so much! Thank you!

[@lacikins]

Currently doing a review for my upcoming STEP 1 and watching this review. Thank you for taking the time to make these, the fact you add humor to these makes it so much better than listening to a boring lecture.

[@MedicosisPerfectionalis]

I appreciate you, Lacy! Best of luck!

[@JustinDavidRoss]

Little confused about this video's title and intro. Lactic acid is not what causes muscle soreness, is what I'm finding online. Apparently lactate actually helps to reduce pH levels, which were already increased by some other process when* you work out. See sources on this video: kzbin.info/www/bejne/mZXTmX2AmLdghck

[@thebiomechanist4995]

You are correct. This guy knows his biochemistry, but this is outdated. Hydrogen ions build up anaerobic exercise and cause the temporary burn, but not muscle soreness. Chemically speaking, lactate could act as a buffer by accepting hydrogen ions. However, the lactic acid myth was perpetuated because lactate and hydrogen ions were found in blood during studies, so they inferred lactic acid was an intermediate and short lived structure. This makes is doubtful that it does act as a buffer. Anyway, chemistry is not my area of expertise. And like you, I get a little irritated when I see myths perpetuated by otherwise reliable sources.

[@jeroenvanbergen4330]

Also, the liver does not throw lactate in the trash, but turns it back into glucose (gluconeogenesis). Furthermore, adjacent type I muscle fibers may take up lactate and use it as fuel.

[@NowAbundant]

I just found your channel on my search for more information on Lactic Acid and OMGGGGG I love it!!!! Thank you! I'm sure this is a little too much for most but healthcare professionals will Crave this and your personality!!! Thank you 😍❤️💥💯

[@MedicosisPerfectionalis]

Thank you so much 😊

[@Dr.SheldonShelby]

Most awesome Person of the Medical field everr...👏 🙌 💙 ❤ 👌

[@MedicosisPerfectionalis]

Thank you so much 😊

[@justsamira4477]

Agree 👍🏽

[@MedicosisPerfectionalis]

Thank you, Samira!

[@geaninastoica9834]

I can't believe you uploaded this right before my Endocrinology exam. I really needed some confirmation on some of the stuff mentioned! Thanks

[@MedicosisPerfectionalis]

Thank you 🙏 Good luck 🍀

[@neelo14]

Adding humour to your videos make them more intresting.Thankyou👍

[@MedicosisPerfectionalis]

My pleasure 😇

[@davidmwilu5405]

This is the first time I'm watching your video. I'm impressed. Its awesome.

[@Radjehuty]

This probably needs an update as it's old information, even for the year this was posted. We do not really create lactic acid directly. I know medical professionals apparently don't care about the distinction between an acid and its conjugate base, but it is important here. Pyruvate is already in its conjugate base at physiological pH and it's converted directly to Lactate. It was never an acid to begin with. Plus, the pKa of LA is so low it could never be realistically protonated in the conversion of Pyruvate to Lactate at physiological pH. The H+ ions are really a result of a lot of ATP hydrolysis and byproducts of metabolism, so lactate could act as a buffer in a minor sense. Also lactate isn't disposed of, it's converted back to glucose to shift back to the muscles. The pain caused by muscle use is somewhat complex, but it is partially due to the buildup of H+, but also due to microtrauma from extended exertion.

[@teresakilleen7087]

OMG I knew I loved Pathophys(iology) and this is why! So simple when you can break it down. Thanks!!

[@MedicosisPerfectionalis]

Thank you 😊

[@vdoubleu-o4u]

Oh my, my lab people are going to love this play list!

[@MedicosisPerfectionalis]

Thank you so much 😊

[@andyspark5192]

Found your channel by searching for acidemia. It's fun to watch your presentations. You should definitely make a video about C0VlD long haulers. For some reasons the average doctors can't find what's going on. They even skip the ABG test. Anaerobic ATP production is in progress, but they can't see it.

[@nyile012]

I really really really wish that one day I become like you .. Thank you for all awesome videos

[@MedicosisPerfectionalis]

You’re very welcome! Work hard, be consistent, and you will be way better than me!

[@Livinggud]

Thanks for all your work! This video was Amazing as always!

[@MedicosisPerfectionalis]

Thank you so much for your continuous support!

[@Zaloomination]

Thanks for this video, very interesting!

[@MedicosisPerfectionalis]

My pleasure!

[@gissie391]

I appreciated a students honesty it iznt showing itself yet what ever it is.

[@justsamira4477]

Amazing! Guys We have to protect this teacher for ever 😍😭😍😭

[@MedicosisPerfectionalis]

Thank you so much 😊 I need airbags 😂😂

[@justsamira4477]

@@MedicosisPerfectionalis 😂😍😂

[@MedicosisPerfectionalis]

😊😊😊

[@mrsamandabernier]

Very helpful, thank-you!

[@MedicosisPerfectionalis]

My pleasure 😇

[@KarenDowning-i6y]

Not sure you monitor this any longer, but could lactic acidosis cause chronic cramping of many many muscle groups constantly throughout the day? Trying to chase down why this happens, and is often initiated by sugar or grain intake. But is a slow burn for happening with any muscle usage at any given moment. Asking about lactic acidosis due to an elevated Anion Gap. Thank you! -Karen

[@lunam7249]

ionic imbalance...typical cramping is sweating to much makes you salt deficient....eat more salt 1 hr before and during exercise and see...magnesium deficit also

[@otakootako4006]

Thank uuu so much 😍😍

[@MedicosisPerfectionalis]

Welcome!

[@mh2blade]

dude your channel is criminally under subscribed! wonderful review.

[@MedicosisPerfectionalis]

Thank you ☺️

[@mzmz12345]

Is lactic acidosis a feature of both hypo & hyperglycaemia?

[@markoridjimiloradovic8817]

Hello there.. one simple question.. and to be short.. why I feel more calm after hard physical work and less sleep night (3-4 hours) then sleeping 7-8 hours?

[@lunam7249]

part2 = over exertion will produce insomnia = not cool....if your overly nervous your adrenal glands are a little bit overactive

[@sarojaravva9072]

Super explanation

[@Nikolegker]

Loved your video! Great review of a very important topic, I didn't know about D-lactate in short bowel syndrome. Thanks for your videos, they have really helped me close gaps and improve as a physician. I especially love your coagulation series! I do have a question however: Over the last years, there has been increasing evidence and discussion against the use of bicarbonate for the treatment of lactic acidosis, even in very low pH. The rationale is that you only fix the extracellular pH but don't correct the intracellular or mitochondrial pH (and that's where it counts!). Bicarbonate gets metabolized to lactate in the liver, which kind of beats the purpose of giving it. There is also evidence of improved cardiac contractility in acidic pH, which might be beneficial for a patient in shock. Not to mention bicarbonate's many potential complications like potential cerebral edema. Would you still give NaHCO3 in this condition? What about tromethamine or earlier, more aggressive dialysis?

[@prathikhg7181]

Sir you are the best Plsss make some more videos

[@MedicosisPerfectionalis]

Sure! Thank you so much 😊

[@hasanhas00n1]

bro i just want to know how i can improve my muscle recovery

[@sydruff]

this is my new favorite video

[@MedicosisPerfectionalis]

Thank you 😊

[@infodiff]

Hi medicosis is it the lactic acid or the hydrogen ion that causes the burn when we exercise? i think the lactate gives you a few atp's and the charged hydrogen ion causes the burn. Lactic acid does not cause the burn as such. :) Love your videos.

[@neoforce6263]

It’s very late but yea you are totally right from what I now it’s the hydrogen ion that causes the burn and it he lactate that can actually reduce it

[@rainicascadia5514]

I'm so very grateful for you and your channel♥ Might you make a video about MTHFR? Thank you! ♥

[@MedicosisPerfectionalis]

Thank you 🙏 Unfortunately, I don’t!

[@katgirl8146]

That's a functional medicine term. He is likely unaware.

[@sleeplesscrafter]

So if I would have raised my ph with alkaline drops, I would not have been so sore that I couldn’t walk after just doing a few exercises? I take propranolol for my heart. Would that cause problems?

[@ClappOnUpp]

I love this!

[@MedicosisPerfectionalis]

Thank you 🙏

[@dariocautiero]

This video should be updated. There’s a lot of misinformation considering new research on Lactate

[@AllThingsFitnessandLifestyle]

My range was 1.0, why do they repeat it? Also, I don't breathe enough or cool down after working out, so could that elevate it?

[@chaimaasalhi9646]

Thank you 😊 perfectly explained as always 👏 Please a question : Since lactic acid is not calculated , but it's measured , so in that case osmolar gap should be >10 ?? How can it be

[@MedicosisPerfectionalis]

Are you talking about the anion gap or the osmolar gap?

[@mrsamandabernier]

Mccardles is the only glycogen storage disease I know without looking it up lol, but I'll Google it and learn the rest. Thanks!

[@MedicosisPerfectionalis]

McCardle is correct!

[@samyan_saleem4252]

Thank u🙃

[@MedicosisPerfectionalis]

My pleasure 😇

[@fairwind8676]

Does lactate raise blood sugar?

[@veronikakopecka1527]

Great and "I will kick your gluteus minimus" made me really laugh 😂

[@MedicosisPerfectionalis]

:)

[@SO2310]

I have seen 3 videos telling what you are telling. But none is it mentioned what is causing the pain. I did once 3 rounds in rowingmachine in high intence training where after my 3rd round I could not move in over 20 minutes. That day I was told it was because of lactic acid but you could than give me another explenation. Please do tell me what it was if not lactic acid causing my pain and being unable to move.

[@MedicosisPerfectionalis]

Hey Sir, How can I know the cause of your pain over the internet?

[@lunam7249]

lactic acid stimulate pain nerves

[@theofficialjizzy]

So can i prevent lactating with a low carb diet?

[@lunam7249]

no..there is no preventing lactate acid,

[@firstlast9813]

So, if I breathe higher concentrations of O2 and take an extra iron dosage (before and O2 during a REALLY intense workout), I'll have less pain after? (Forgive my ignorance, I'm an engineering major)

[@MedicosisPerfectionalis]

I don’t understand this reasoning! Can you elaborate, please?

[@valjean2036]

He is saying if he breaths to get more oxygen in his body and takes iron , since you d eplete iron after a workout. He wont have as much pain!

[@valjean2036]

I understood him clearly on what he was meaning. I'm not sure what part confused you. It was clear

[@firstlast9813]

@@MedicosisPerfectionalis 😄 I included the extra iron dose thinking my blood cells would absorb more oxygen. The reasoning was along the lines of acid prevention

[@lunam7249]

training will build endurance = less pain = less lactic acid...O2 is dangerous if you arent a medical doctor....to much and you will stop breathing and die

[@soccerandtrack10]

3:40 but i cant sit in those chairs anymore because of the acid.

[@HeartBreakDillon]

I need your help I really might not make it

[@vincenttran6509]

Hodge twins reference?

[@MedicosisPerfectionalis]

Yeeeeeeeeeeeeeaaaaaahhh!

[@Livinggud]

@@MedicosisPerfectionalis love it!

[@MedicosisPerfectionalis]

😊😊

[@donnagarner6007]

Okay, you know most of us aren't drs or scientists. So can dehydration cause this lactic acidosis? I guess you are making vids for students??

[@shellycolson9365]

OK now I'm going to ask about covid shot and covid because I never had these issues till the pfizer covid shot . I now have musle issues !

[@lunam7249]

no more jabs!!

[@AJTV_Editz]

Wrong!!! Lactic Acid or Lactate accumulation does not cause muscle fatigue during exercise it actually serves as a fuel source during strenuous bouts of exercise. Hydrogen Ions can contribute a small amount towards muscle fatigue but actually, lactate accumulation is helping not hindering

[@soccerandtrack10]

6:27 insomnias,right?...,because the energy?...😂😂

[@Urunam]

Von Geirke Cori Anderson Hers

[@123hoda]

God ! ...you're so fucking smart 🔥🔥🔥 😍😍😍 can some one simplify it better 🤔😬 ,love your humor as usual 😅😇

[@MedicosisPerfectionalis]

Thank you so much 😊

[@rauldeandrade]

I'm confused. Hasn't this been disproven?

[@lunam7249]

this vid is correct

[@patrickday6822]

Why does the everyone pick on the laboratory! I’m a clinical laboratory scientist I’m great at my job and am a specialist in Hematology and Body Fluids.

[@Lameimpalaa]

*me, a lab tech watching your video at **6:50* 😦😢😔

[@MedicosisPerfectionalis]

I was joking!

[@___xyz___]

How can measuring the presence of both be a useful marker of any medical condition if lactic acid and lactate do two completely different things? If you know that either one of them is high, but not which, you can't draw any conclusions if the symptoms that manifest from either don't look the same. Are you just gonna say "well I see you have high lactate/lactic acid, and I also see that you have muscle pain, so I'm going to assume those are related". That's not scientifically sound.

[@MedicosisPerfectionalis]

Correlation is not the same as causation. However, correlation is not nothing. If a patient comes in with fever and a new heart murmur...Are they related? May be they are not, or may be they are (e.g. bacterial endocarditis). The purpose of an individual physicial sign or lab result is not necessarily to CONFIRM the diagnosis with 100% accuracy...It's to add more clues and pieces until we can solve the puzzle. Moreover, if the patient has muscle pain, we won't rely solely on the lactate (or lactatic acid). There is the history, physical exam, other labs (e.g. creatinine, creatinine kinase, creatinie phosphokinase, myoglobin, EMG), imaging (e.g. MRI), and muscle biopsy. Hope it helps!

[@LoLokMan-v1d]

终于知道无氧运动为啥叫无氧运动了,

[@vdoubleu-o4u]

06:43 heyyyy lol

[@MedicosisPerfectionalis]

I was joking 🙃

[@brandonleeBrando]

Lactic acid is not the cause of muscle soreness

[@dgm5975]

🤣🤣 love your humor

[@MedicosisPerfectionalis]

Thank you 😊

[@gissie391]

No it isnt its tears in muscles.until ypu hit oxygen system.

[@Itzzdanas]

1:11 i dare u

[@SherriP]

2 chronicles 7 :14 If my people, which are called by my name, shall humble themselves, and pray, and seek my face, and turn from their wicked ways; then will I hear from heaven, and will forgive their sin, and will heal their land. Believe in Jesus as the son of God who died and rose three days later and you are saved eternally. Seek Him and know Him. He's so awesome always so faithful and good. in Jesus name ask Him anything too. Happy Holidays everyone and celebrate Jesus every day. Awesome do awesome He is 🙏💕

[@user-maath]

👍❤️

[@gissie391]

Antipsychotics antibiotics slow hepatic function down neuroleptics.

[@ABC-fv7ow]

👍

[@MedicosisPerfectionalis]

Thank you 🙏

[@sweithshetty1180]

But why is the caption only Vietnamese?

[@MedicosisPerfectionalis]

Is it really?

[@sweithshetty1180]

@@MedicosisPerfectionalis it's actually

[@robinschafer597]

"lack of oxygen" ... "waste product" ... phrases that will end your career as an exercise physiologist...

[@HanTor-lf6jx]

This guy is at risk of being canceled by people with feelings

[@rhyguy6260]

hold up i thought lactate was process of making milk

[@MedicosisPerfectionalis]

:)

[@siddhanthravichandran3245]

thats lactation

[@donnagarner6007]

You are pretty funny anyway!

[@MedicosisPerfectionalis]

Thank you 😊

[@elbarain2440]

This is too much Information for all at once.

[@Alleycat1111]

Shut up...? 🤣 I like your style...

[@MedicosisPerfectionalis]

Thank you:)

[@lets_go_birding9096]

LOL, "woke chem prof"!

[@builtwaydifferent9063]

You lost me

[@Davion_savant]

Annoying

[@tiagoperdigao6113]

This is highly inaccurate

[@powerPryamids]

Watch channel sci.show on KZbin Does lactic acid cause..... u will be amazed 1.Lactic is natural 2.Lactate is synthetic Do you know why the 2nd one gives you pain because it's missing a proton. The 1st one I mentioned is not gonna give you anything anything but amazingness And why because God put that here on Earth so do you ever wonder why the names are quite almost alike and there's no research not enough research done on the number one that I mentioned but isn't research the ongoing documents and research and people's testimonies but do you hawell testimonies but you ever find it odd though that the FDA won't do anything about that no it's because they want you to buy the 1 that they make so you can eventually get cancer