Lecture 6-Subepidermal Vesiculobullous Disorders

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0:44 Pauc iinflammtory or inflammatory Then the type of inflammation - eosinophils, netus, lymhpocytes 1:15 Pauci inflammatory PCT Porphyria cutanea tarda 1:15 Blisters and erosions+ photosensitivity Festoning = dermal papillar retain ther eoutline ie they are not collapsed as dermis is sclerosed Caterpiller bodies Reddulication of basement membrane - can be seen in vessel walls -- highlight with PAS Psuedopoyria si drug-related cant distinguish on histology Epidermolysis bullosa acuisite 4:20 Acquired disorder type 7 antibodies in blood No festonning or thickening of basement membrane in vessel walls Cell poor Bullous phemphigoid - Linear IgG and C3mon IMF Eosinophillic rich subepidermal blisters Bullous pemphigoid 6:50 Older pt, subepidermal split, Eosinophils Negative nikosky sign, C3 and IgG linear deposition basement membrane Differential for eosinophil risj Bullous drig eruption Bullous arthropod 8:26 Herpes gestationis Neutrophilic rich subepidermal blisters Dermatitis herpetiforms- 10:00 Subepidermal multilocular blister with papillary neutrophilic microabscesses that may contain eosinophils, basal cell vacuolization Dermal infiltrate is mixed, with lymphocytes, histiocytes and abundant neutrophils Karyorrhexis (nuclear dust within dermis) is characteristic No vasculitis Granular IgA on IMF 11:35 Linear IgA dermatoSIS Subepidemral split, neuts, homogenous band of IgA at the dermal-epidermal junction; no anti-endomysial or anti-tissue transglutaminase IgA antibodies; not gluten sensitive 12:33 Lupus Full house IMF, Hair follciles cicatricial pemphigoid 12:58 Olde rpt mucocal involement Subepidermal split - mostly neuts Lymphocyte rich subepidermal blisters Bullous lichen planus 13:25 Hyperkeratois , no parakeratois Wedge shaped hypergramulosis Lichenoid infiltrate at DEJ associated with dyskeratosis Max Joseph split/space

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