A Deeper Look: How Treatment Works | Living With Ulcerative Colitis and Crohn’s Disease

Click "SHOW MORE" for Important Safety Information. For ENTYVIO (vedolizumab) full Prescribing
Information, including Medication Guide, visit: ssshare.it/PO9y
In this video, we’ll go deeper into the mechanics of ENTYVIO, a biologic treatment for moderate to severe ulcerative colitis (UC) and Crohn’s disease (CD).
Take a simulated journey into the gastrointestinal (GI) tract. Follow the movement of white blood cells through the gut into inflamed GI tissue; look deeply into the partnering of proteins that drive the movement of these cells. Learn how ENTYVIO binds to proteins to help block the movement of gut-directed white blood cells into the GI tissue.
Learn more about ulcerative colitis and Crohn’s disease treatment options:
Important Safety Information and Uses of ENTYVIO® (vedolizumab)
Important Safety Information
• Do not receive ENTYVIO if you have had an allergic reaction to ENTYVIO or any of its ingredients.
• ENTYVIO may cause serious side effects, including:
- Infusion-related and serious allergic reactions can happen while you are receiving ENTYVIO or
several hours after treatment. You may need treatment if you have an allergic reaction. Tell your healthcare provider or get immediate medical help if you get any of these symptoms during or after an infusion of ENTYVIO: rash, itching, swelling of your lips, tongue, throat or face, shortness of breath or trouble breathing, wheezing, dizziness, feeling hot, or palpitations (feel like your heart is racing).
- ENTYVIO may increase your risk of getting a serious infection. Before receiving and during
treatment with ENTYVIO, tell your healthcare provider if you think you have an infection or symptoms of an infection, such as fever, chills, muscle aches, cough, shortness of breath, runny nose, sore throat, red or painful skin or sores on your body, tiredness, or pain during urination.
- People with weakened immune systems can get progressive multifocal leukoencephalopathy
(PML) (a rare, serious brain infection caused by a virus). Although unlikely while receiving ENTYVIO, a risk of PML cannot be ruled out. PML can result in death or severe disability. There is no known treatment, prevention, or cure for PML. Tell your healthcare provider right away if you have any of the following symptoms: confusion or problems thinking, loss of balance, change in the way you walk or talk, decreased strength or weakness on one side of the body, blurred vision, or loss of vision.
- Liver problems can happen in people who receive ENTYVIO. Tell your healthcare provider right
away if you have any of the following symptoms: tiredness, loss of appetite, pain on the right side of your abdomen, dark urine, or yellowing of the skin and eyes (jaundice).
• The most common side effects of ENTYVIO include common cold, headache, joint pain, nausea, fever, infections of the nose and throat, tiredness, cough, bronchitis, flu, back pain, rash, itching, sinus infection, throat pain, and pain in extremities. These are not all the possible side effects of
ENTYVIO. Call your healthcare provider for medical advice about side effects.
• Before receiving ENTYVIO, tell your healthcare provider about all of your medical conditions, including if you: have or think you may have an infection or have infections that keep coming back; have liver problems; have tuberculosis (TB) or have been in close contact with someone with TB; have recently received or are scheduled to receive a vaccine; or if you are pregnant, breastfeeding, plan to become pregnant, or plan to breastfeed.
You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
Uses of ENTYVIO® (vedolizumab)
ENTYVIO is a prescription medicine used in adults for the treatment of:
• moderately to severely active ulcerative colitis
• moderately to severely active Crohn’s disease
For full Prescribing Information, including Medication Guide for ENTYVIO, please visit: ssshare.it/PO9y, and talk with your healthcare provider.
ENTYVIO is a trademark of Millennium Pharmaceuticals, Inc., registered with the U.S. Patent and Trademark Office and is used under license by Takeda Pharmaceuticals U.S.A., Inc.
©2022 Takeda Pharmaceuticals U.S.A., Inc.
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US-VED-1296v2.0 10/22