Longevity - What We Can Learn From Long Lived Mammals | Professor Vera Gorbunova Ep4/4

Here Professor Gorbunova about the naked mole rat and bowhead whale and what adaptions they have to enable them to live longer. From this she discusses how these adaptions might be translated into interventions for humans.
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⏲️Chapters
00:00 Aging in naked mole rats
02:55 Naked mole rat lifespan
04:30 NMR aging adaptions
06:35 Longevity across species
08:40 Bowhead whales lifespan
10:30 Cancer suppression in whales
11:41 Fat in whales
16:50 Further info
Dr Vera Gorbunova is a biologist. As the Doris Johns Cherry Professor at the University of Rochester, she identified high molecular weight hyaluronan as the key mediator of cancer resistance in the naked mole rat
🌐Links in this video
Dr Gorbunova's website
www.sas.rochester.edu/bio/peo...
Sirtuin 6: linking longevity with genome and epigenome stability
pubmed.ncbi.nlm.nih.gov/34281...
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#lifespan #nakedmolerat #Gorbunova

[@ModernHealthspan]

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[@generalbystander1631]

We love Gornubova; she’s thoughtful and charming and knowledgeable.

[@ModernHealthspan]

Hi thanks. We are very grateful to her for coming on the channel!

[@ddutton4716]

Richard, You ask great questions from great guests. Thanks.

[@gprivat812_my_selection6]

Very interesting information about the longevity strategies of different mammals!! 👍👏❗️

[@ModernHealthspan]

Thanks!

[@basicforge]

The late Dr. Ray Peat also talked about naked mole rats and their longevity and linked it at least in part to their living underground in a carbon dioxide rich environment.

[@ModernHealthspan]

Hi thanks for sharing. Interesting, I need to look at it as I don't see that living in a CO2 rich environment would extend lifespan.

[@incognitotorpedo42]

Did he propose a mechanism for CO2-induced life extension? It sounds very dubious to me.

[@PauloWy]

Many Thanks Richard, great interview!

[@ModernHealthspan]

Hi Paulo, thanks!

[@2piecesofwood1pieceofrope]

Patrick Mckeon discusses the naked mole rat in his book, The Oxygen Advantage. The less a species breathes, the longer they live- less oxidative stress. He teaches techniques for breathing less and makes some startling claims.

[@ModernHealthspan]

Hi thanks for sharing, that is interesting. I should look at it in more detail. I wonder how this scales? I don' t think that NMR breath 10 times less than a mouse but they live (at least) 10 times longer.

[@bobmciver6437]

Whales have unique lipid profiles (and collagen distribution)in their blubber and what research we do have shows variations within species depending on latitude and diet and further complicated by migration and fasting cycles and large spherical shape of adipocytes...real headache parceling out relevance to land animals.

[@addictedtochocolateandcoff9582]

true we have better luck studying the giant tortoises that live 200 years, both the seychelles and galapagos

[@ronm6585]

Thanks Richard.

[@ModernHealthspan]

Hi Ron, thanks!

[@bennguyen1313]

Regarding injecting Hyaluronic Acid locally, or inhibiting hyaluronases systemically.. are there any known downside of too much HA? For example, rapamycin also seems to increase lifespan across multiple species, from yeast to mammals.. yet the downside of chronically blocking the nutrient-sensor MTOR in humans, is not just mouth-sores, it inhibits overall muscle growth and repair! Also, IGF->MTOR but ideally we'd want only higher levels of IGF1 in the brain since high mtor activity appears to be associated with dementia. I think to have any practical value, there needs to be a way to measure chronic inflammation.. as that seems to speed up aging. Only then, can studies on exercise, diet/supplements, cold exposure/ sauna, be shown to be useful or not. Studying the individual genes/proteins (Cold-inducible RNA binding protein (CIRP) or Sirtuin 6 ) doesn't seem to help at the macro level.

[@sherm8888]

❤❤❤

[@ModernHealthspan]

😊

[@KasKade7]

Imagine in a century or two everyone sleeping in ice baths to live decades longer. Some kind of temporary hibernation state would slow the aging clock down for sure. Well, we need to survive the prolonged ice baths first. More brown fat like the Wim Hof method? What if the ice water is the only secret of the bowhead whale 200+ year lifespan.

[@ModernHealthspan]

Hi Thanks for the comment. A couple of thoughts on this. Being cold and slow does work for some animals, (e.g. the greenland shark) but not for mammals, who keep their core in a narrow temperature range. I think that the benefit we get from cold exposure is hormetic and would only work in small doses.

[@addictedtochocolateandcoff9582]

humans aren't fish LMAO

[@vicky116]

What's the difference between brown fat and white fat?

[@ModernHealthspan]

Hi Vicky, thanks for your question. Brown fat is brown because it has many mitochondria in it while white fat has very few. The mitochondria in brown fat can generate heat by burning fat without making any ATP, so they are way to keep you warm. It is the mechanism that babies use as they cannot shiver. The idea is that brown fat would help us loose weight as we can burn energy. As I understand it there is not agreement as to whether we can make new brown fat as adults or whether we only have what is left over from when we are babies. But the idea is that cold exposure might create brown fat (or at least something called beige fat) from white fat by causing more mitochondria to grow in the fat cells.

[@sherm8888]

👋👋👋

[@ModernHealthspan]

Thanks!😀

[@michael-qp9xd]

Hi Richard - very good info here. Very much like your interview style - not any silliness or distracting laughing. The professor is very smart but seems ever minute giggly like a young teenager. Is minor point and can overlook to some degree if subject is important but so many hosts and guests with all the giggling when not comedic talk and nothing said really funny. So just distracting. Great you dont take part in this when guest doing. Thanks for all your efforts with programming.