Mastering Organic Synthesis: Multi-Step Reactions & Retrosynthetic Analysis Explained!

[@rojaslab]

If you enjoyed this video, don't forget to give it a thumbs up, subscribe for more educational content, and hit the notification bell to stay updated! Have questions or specific topics you'd like me to cover? Drop them below, and let's keep the chemistry conversation going! #ScienceCommunity #LearningTogether #OrganicChemistry

[@chemdelic]

Keep up the good work brother

[@serpensinfinitus2719]

This channel should have more views.

[@rojaslab]

That’s kind of you to say. Thank you!

[@warlokyx]

Cool video! Though I think the diazonium reduction needs hypophosphrous acid to work. So H3PO2, not H3PO4. Phosphoric acid is not a reductant and would produce eithrer tribromophenol or the phsphoric acid ester of tribromophenol. Also, an easier way to do the first reaction in the lab is to use sodium cyanide to produce cyclohexyl cyanide, and reflux it in acid after a few water washes to remove sodium bromide and the remaining sodium cianide. The carboxylic acid should crystallize out after cooling back to r.t., so even though you do one extra step, you dont have to work up either steps and you dont have to flamedry glassware or deal with how finicky grignard reagents can be.

[@rojaslab]

Your experience is invaluable in this area. I particularly love when a product just crystallizes out of solution without additional work up!

[@abs0lute-zer061]

One step less for the cyclohexyl bromide to the cyclohexyl methylene bromide would be using the grignard with formaldehyde, aqueous work up, then PBr3

[@rojaslab]

Ayyyyy!!! That's an awesome route!

[@dhanayjibhakate436]

Should have more views

[@rojaslab]

Thank you! I’m just glad you’re here!